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https://www.readbyqxmd.com/read/29218951/-research-on-compatibility-of-prescriptions-including-ginseng-radix-et-rhizoma-and-trogopterus-dung-based-on-complex-network-analysis
#1
Meng-Wen Li, Xin-Sheng Fan, Ling-Shan Zhang, Cong-Jun Wang
The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scale-free complex network method are utilized to explore its practical characteristics, with comparison between modern and ancient ones. The results indicate that malignant neoplasms, coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218950/-meta-analysis-of-yiqi-huoxue-method-in-treating-idiopathic-membranous-nephropathy
#2
Qi-Yan Zheng, Lu-Ying Sun, Hua-Nan Jin, Qian Zhou, Wen Zhang, Ya-Hui Wang
The incidence of idiopathic membranous nephropathy (IMN) is increasing year by year, and the clinical research on Chinese medicine treatment of INM is also growing. This study aims to evaluate the efficiency and safety of Yiqi Huoxue method for IMN. Data sources used were from PubMed, EMbase, the Cochrane Library, CBM, CNKI, Wanfang and VIP database. Two researchers independently screened the literature and extracted data. RevMan 5.3 software was used for Meta analysis, and the evidences were graded for the outcomes according to GRADE system by using GRADEprofiler 3...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29217189/an-unusual-racemic-c12-norabietane-diterpene-and-a-new-abietane-diterpene-alkaloid-from-salvia-miltiorrhiza-bunge
#3
Xue-Ge Pan, Jun He, Xiao-Xue Wang, Jia Zhang, Bing-Zhi Ma, Wei-Ku Zhang, Jie-Kun Xu
A rare C12-norabietane diterpene racemate (1) and a new abietane diterpene alkaloid (2) were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were established by comprehensive spectroscopic analyses, and 1 was successfully resolved by chiral HPLC, demonstrating that 1 is racemic. The absolute configurations of 1a [(+)-miltiorolide A], 1b [(-)-miltiorolide A], and 2 were determined using TDDFT-ECD calculations. 1a and 1b are the first examples of enantiomeric C12-norabietane diterpenes featuring an isobutylene with a tetrahydronaphthalene-butyrolactone ring system...
December 4, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29212498/salvianolic-acid-b-protects-against-lipopolysaccharide-induced-behavioral-deficits-and-neuroinflammatory-response-involvement-of-autophagy-and-nlrp3-inflammasome
#4
Pei Jiang, Yujin Guo, Ruili Dang, Mengqi Yang, Dehua Liao, Huande Li, Zhen Sun, Qingyan Feng, Pengfei Xu
BACKGROUND: The NLRP3 inflammasome activation and neuroinflammation are known to be involved in the pathology of depression, whereas autophagy has multiple effects on immunity, which is partly mediated by the regulation of inflammasome and clearance of proinflammatory cytokines. Given the emerging evidence that autophagy dysfunction plays an essential role in depression, it is very likely that autophagy may interact with the inflammatory process in the development and treatment of depression...
December 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29211948/simultaneous-determination-of-polysaccharides-and-21-nucleosides-and-amino-acids-in-different-tissues-of-salvia-miltiorrhiza-from-different-areas-by-uv-visible-spectrophotometry-and-uhplc-with-triple-quadrupole-ms-ms
#5
Xiang Xiang, Xiuxiu Sha, Shulan Su, Zhenhua Zhu, Sheng Guo, Hui Yan, Dawei Qian, Jin-Ao Duan
Salvia miltiorrhiza, a traditional Chinese medicine, is a widely used herbal medicine to treat cardiovascular and cerebrovascular diseases. In this study, ultraviolet-visible spectrophotometry and ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry analytical methods for rapidly quantifying polysaccharides, 21 nucleosides and amino acids in S.miltiorrhiza were established to determine 17 samples of different tissues from different areas. Based on the total contents, hierarchical clustering analysis and principal components analysis were performed to classify these samples...
December 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29207614/danshen-improves-survival-of-patients-with-advanced-lung-cancer-and-targeting-the-relationship-between-macrophages-and-lung-cancer-cells
#6
Ching-Yuan Wu, Jong-Yuh Cherng, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Yin-Yin Lin, Yu-Shih Lin, Li-Hsin Shu, Yu-Ching Cheng, Hung Te Liu, Ming-Chu Lu, Jthau Lung, Pau-Chung Chen, Hui Kuan Lin, Kuan-Der Lee, Ying-Huang Tsai
In traditional Chinese medicine, Salvia miltiorrhiza Bunge (danshen) is widely used in the treatment of numerous cancers. However, its clinical effort and mechanism in the treatment of advanced lung cancer are unclear. In our study, the in vivo protective effort of danshen in patients with advanced lung cancer were validated using data from the National Health Insurance Research Database in Taiwan. We observed in vitro that dihydroisotanshinone I (DT), a bioactive compound in danshen, exerts anticancer effects through many pathways...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207086/tan-iia-inhibits-h1299-cell-viability-through-the-mdm4%C3%A2-iap3-signaling-pathway
#7
Yukun Zu, Jianning Wang, Wei Ping, Wei Sun
Tanshinone IIA (Tan IIA), as a bioactive compound extracted from the dried roots of Salvia miltiorrhiza (also known as Danshen), is known to inhibit cancer cell proliferation and induce apoptosis. However, the mechanisms underlying the function of Tan IIA in cancer cell apoptosis remain to be elucidated The aim of the present study was to identify the molecular mechanisms underlying the anti‑cancer effects of Tan IIA in p53‑deficient H1299 cells. Tan IIA was demonstrated to suppress murine double minute 4 (MDM4) expression in a time‑ and dose‑dependent manner through the inhibition of MDM4 mRNA synthesis...
November 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207039/effective-component-of-salvia%C3%A2-miltiorrhiza-in-promoting-cardiomyogenic-differentiation-of-human-placenta%C3%A2-derived-mesenchymal-stem-cells
#8
Kun Li, Jieqiong Song, Qian Zhao, Bo Wang, Yunli Zhang, Xuezhe Wang, Tiantian Tang, Shizheng Li
Our previous study indicated that Salvia miltiorrhiza (SM) induced human placenta‑derived mesenchymal stem cells (hPDMSCs) to differentiate into cardiomyocytes, however, the effective component of SM in promoting cardiomyogenic differentiation remained to be elucidated. In the present study, the most commonly examined components of SM, including danshensu, salvianolic acid B, protocatechuic aldehyde, tanshinone I (TS I), TS IIA and cryptotanshinone, were used to determine the effective components of SM in promoting cardiomyogenic differentiation...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206198/genome-wide-comprehensive-analysis-the-molecular-phylogenetic-evaluation-and-tissue-specific-expression-of-sabath-gene-family-in-salvia-miltiorrhiza
#9
Bin Wang, Shiqiang Wang, Zhezhi Wang
The plant SABATH gene family is a group of O-methyltransferases (O-MTs), which belongs to the S-adenosyl-l-methionine-dependent methyltransferases (SAM-MTs). The resulting reaction products of SABATH genes play an important role in various processes of plant development. In this study, a total of 30 SABATH genes were detected in Salvia miltiorrhiza, which is an important medicinal plant, widely used to treat cardiovascular disease. Multiple sequence alignment and phylogenetic analyses showed that SmSABATH genes could be classified into three groups...
December 5, 2017: Genes
https://www.readbyqxmd.com/read/29196883/magnesium-lithospermate-b-suppresses-lipopolysaccharide-induced-neuroinflammation-in-bv2-microglial-cells-and-attenuates-neurodegeneration-in-lipopolysaccharide-injected-mice
#10
Yaojun Tai, Yujiao Qiu, Zhicheng Bao
Chronic inflammation in the brain plays a critical role in major neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Microglia, the resident macrophages and intrinsic components of the central nervous system (CNS), appear to be the main effectors in this pathological process. Magnesium lithospermate B (MLB) is one of the major bioactive components of Radix Salviae miltiorrhizae, which has been documented to protect neurons against multiple types of neuronal injury...
December 1, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29196256/diverse-responses-of-tanshinone-biosynthesis-to-biotic-and-abiotic-elicitors-in-hairy-root-cultures-of-salvia-miltiorrhiza-and-salvia-castanea-diels-f-tomentosa
#11
Dongfeng Yang, Yumin Fang, Pengguo Xia, Xiaodan Zhang, Zongsuo Liang
Salvia miltiorrhiza (S. miltiorrhiza) and Salvia castanea Diels f. tomentosa (S. castanea) are both used for treatment of cardiovascular diseases. They have the same bioactive compound tanshinones, but whose contents are hugely different. This study illustrated diverse responses of tanshinone biosynthesis to yeast extract (YE) and Ag+ in hairy roots of the two species. YE enhanced both the growth and tanshinone biosynthesis of two hairy roots, and contributed more to tanshinone accumulation in S. castanea than that in S...
November 28, 2017: Gene
https://www.readbyqxmd.com/read/29185738/oxazole-containing-diterpenoids-from-cell-cultures-of-salvia-miltiorrhiza-and-their-anti-hiv-1-activities
#12
Dewu Zhang, Jiamei Guo, Min Zhang, Xiao Liu, Mingyu Ba, Xiaoyu Tao, Liyan Yu, Ying Guo, Jungui Dai
Four new oxazole-containing diterpenoids, salvianans A-D (1-4), along with three known diterpenoids (5-7), were isolated from Salvia miltiorrhiza cell cultures. The structures of the new compounds were elucidated using spectroscopic methods and single-crystal X-ray diffraction. The evaluation for their anti-HIV-1 activities revealed that 2 and 3 displayed inhibitory activities with IC50 values of 0.03 and 1.2 μM, respectively. The time of addition (TOA) assay and long terminal repeat (LTR) luciferase reporter assay results indicated that compound 2 was an HIV-1 transcription inhibitor and might be a lead compound of antiviral agents acting on HIV-1 transcription...
November 29, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29171356/antifatigue-properties-of-tanshinone-iia-in-mice-subjected-to-the-forced-swimming-test
#13
Chueh-Yu Lin, Yan-Shu Jhang, Shang-Chi Lai, En-Li Chen, I-Hsin Lin, Tung-Wu Chang, Yu-Wei Tseng, Vaishnavi Seenan, Jane Shiung, Ming-Hua Chen, Yun-Chen Chiang, Tsung-I Chen, Yin-Jeh Tzeng
CONTEXT: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear. OBJECTIVE: To study the antifatigue properties of Tan IIA and its underlying mechanisms. MATERIALS AND METHODS: In program I, three mouse groups were separately subjected to three gavages with 0, 1 and 6 mg/kg Tan IIA and forced swimming test (FST) weekly for 8 weeks; in program II, one gavage with 0, 2 and 10 mg/kg Tan IIA was administered plus FST weekly for 4 weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29171242/-absorption-and-transport-of-isoflavonoid-compounds-from-tongmai-formula-across-human-intestinal-epithelial-caco-2-cells-in-vitro
#14
Fu-Rong Wang, Xiu-Wei Yang
Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1∶1∶1. The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper. The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-β-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranoside, genistein-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (ambocin), 3'-hydroxymirificin, 6″-O-β-D-xylosylpuerarin, biochanin A-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-β-D-glucopyranoside, daidzein-7-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside, and daidzein-7-O-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29164984/salvianolic-acid-a-a-novel-pi3k-akt-inhibitor-induces-cell-apoptosis-and-suppresses-tumor-growth-in-acute-myeloid-leukemia
#15
Renzhi Pei, Ting Si, Ying Lu, Jeff Xiwu Zhou, Lei Jiang
Salvianolic acid A (SAA), one of the main derivatives of Salvia miltiorrhiza, has been shown to possess anti-inflammatory and anti-thrombotic activities. Its role in inhibiting tumor growth, however, remains elusive. The aim of this study was to investigate the effect of SAA on acute myeloid leukemia (AML). Here, SAA showed a dose-dependent cell viability inhibition and apoptosis induction in AML cells. At the molecular level, SAA increased the expression of Bak and decreased the expression of Bcl-xL, following by PARP cleavage and caspase-3 activation...
November 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29163163/guanxin-danshen-formulation-protects-against-myocardial-ischemia-reperfusion-injury-induced-left-ventricular-remodeling-by-upregulating-estrogen-receptor-%C3%AE
#16
Xuehong Deng, Xiaoyan Xing, Guibo Sun, Xudong Xu, Haifeng Wu, Guang Li, Xiaobo Sun
Background: Guanxin Danshen formulation (GXDSF) is a traditional Chinese herbal recipe recorded in the Chinese Pharmacopeia since 1995 edition, which consists of Salviae miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Dalbergiae odoriferae Lignum. Our previous research suggested GXDSF had positive effect on cardiovascular disease. Therefore, the aim of this study was to elucidate the effects of GXDSF on myocardial ischemia reperfusion injury-induced left ventricular remodelling (MIRI-LVR). Methods: The effects of GXDSF on cardiac function were detected by haemodynamics and echocardiograms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29160857/synergistic-effects-of-danshen-salvia-miltiorrhizae-radix-et-rhizoma-and-sanqi-notoginseng-radix-et-rhizoma-combination-in-angiogenesis-behavior-in-eahy-926-cells
#17
Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chunguang Li, Alan Bensoussan, Kelvin Chan
Background: This study investigated the combination effects of the Danshen and Sanqi herb pair on angiogenesis in vitro. Methods: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their angiogenic effects in the human vascular endothelial EAhy 926 cell line via cell proliferation, cell migration and tube formation activities against the damage to the cells exerted by DL-homocysteine (Hcy) and adenosine (Ado). The type of interaction (synergistic, antagonistic, additive) between Danshen and Sanqi was analyzed using combination index (CI) and isobologram models...
November 21, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29151553/chinese-single-herbs-and-active-ingredients-for-postmenopausal-osteoporosis-from-preclinical-evidence-to-action-mechanism
#18
Jing Lin, Jun Zhu, Yan Wang, Na Zhang, Hans-Jürgen Gober, Xuemin Qiu, Dajin Li, Ling Wang
Postmenopausal osteoporosis is a systemic metabolic skeletal disease generally ascribable to a dearth of estrogen. Whether traditional Chinese medicine is effective in management of postmenopausal osteoporosis remains unclear. This article reviews the experimental evidence of both in vitro and in vivo preclinical studies with the theme of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis. It includes three single herbs (Herba Epimedium, Rhizoma Drynariae, and Salvia miltiorrhiza) and eight active ingredients (saikosaponins, linarin, echinacoside, sweroside, psoralen, poncirin, vanillic acid, and osthole)...
2017: Bioscience Trends
https://www.readbyqxmd.com/read/29133791/network-pharmacology-exploration-reveals-endothelial-inflammation-as-a-common-mechanism-for-stroke-and-coronary-artery-disease-treatment-of-danhong-injection
#19
Ming Lyu, Chun-Lin Yan, Hai-Xin Liu, Tai-Yi Wang, Xin-Hui Shi, Jin-Ping Liu, John Orgah, Guan-Wei Fan, Ji-Hong Han, Xiao-Ying Wang, Yan Zhu
Although Danhong injection (DHI) is the most widely prescribed Chinese medicine for both stroke and coronary artery disease (CAD), its underlying common molecular mechanisms remain unclear. An integrated network pharmacology and experimental verification approach was used to decipher common pharmacological mechanisms of DHI on stroke and CAD treatment. A compound-target-disease & function-pathway network was constructed and analyzed, indicating that 37 ingredients derived from DH (Salvia miltiorrhiza Bge., Flos Carthami tinctorii and DHI) modulated 68 common targets shared by stroke and CAD...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132906/a-selective-knockout-method-for-discovery-of-minor-active-components-from-plant-extracts-feasibility-and-challenges-as-illustrated-by-an-application-to-salvia-miltiorrhiza
#20
Xue-Yan Li, Hong-Jin Tang, Liu Zhang, Lin Yang, Ping Li, Jun Chen
Natural products have been recognized to play an invaluable role in drug discovery. However, efficient discovery of minor active constituents from natural sources is challenging due to the low abundance and complex matrices. In this study, we developed a selective knockout method to discover minor bioactive components from complex phytochemical mixtures, using a Chinese medicine as an example. Based on the chromatographic fingerprint, six major components in the ethyl acetate extract of the root of Salvia miltiorrhiza (EASM) were selectively knocked out via high-resolution peak fraction (HRPF) approach...
October 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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