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salvia miltiorrhiza

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https://www.readbyqxmd.com/read/28544528/micellar-electrokinetic-capillary-chromatography-fingerprints-combined-with-multivariate-statistical-analyses-to-evaluate-the-quality-consistency-and-predict-the-fingerprint-efficacy-relationship-of-salviae-miltiorrhizae-radix-et-rhizoma-danshen
#1
Yujing Zhang, Lanping Yang, Jing Zhang, Min Shi, Guoxiang Sun
Micellar electrokinetic capillary chromatography fingerprinting combined with quantification was successfully established and applied to evaluate the quality consistency of Danshen, which is a medicinal herb used to treat various diseases, especially coronary cerebrovascular diseases. A background electrolyte composed of 20 mmol/L sodium tetraborate, 90 mmol/L orthoboric acid, 25 mmol/L sodium phosphate monobasic dehydrate and 65 mmol/L sodium dodecyl sulfate was used to separate compounds. To optimize micellar electrokinetic capillary chromatography conditions, a response surface strategy was set up for orthogonal experimental design...
May 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28542554/sodium-tanshinone-iia-sulfonate-stimulated-cl-secretion-in-mouse-trachea
#2
Peng-Xiao Chen, Yi-Lin Zhang, Jia-Wen Xu, Ming-Hao Yu, Jie-Hong Huang, Lei Zhao, Wen-Liang Zhou
Sodium tanshinone IIA sulfonate (STS) is a derivate of tanshinone IIA, a lipophilic compound in Salvia miltiorrhiza. This study aimed to investigate the effect of STS on ion transport in mouse tracheal epithelium and the mechanisms underlying it. Short-circuit current (Isc) was measured to evaluate the effect of STS on transepithelial ion transport. Intracellular Ca2+ imaging was performed to observe intracellular Ca2+ concentration ([Ca2+]i) changes induced by STS in primary cultured mouse tracheal epithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28535007/protective-effect-of-salvia-miltiorrhiza-bunge-on-5-fluorouracil-induced-oral-mucositis
#3
Do Rim Kim, Jinsung Kim, Ja Young Oh, Ha Young Kim, Young Joo Kim, Mun Seog Chang
Oral mucositis is a common side-effect caused by chemotherapy or radiotherapy occurring in the majority of cancer patients and is characterized by inflammation and ulcers in the oral mucosa. In the present study, we examined the protective effects of Salvia miltiorrhiza Bunge (SM) on oral mucositis induced by 5-fluorouracil (5-FU) in human pharyngeal cells and golden Syrian hamsters. We investigated the proliferation and antioxidant abilities of SM using MTT, 2-diphenyl-1-picrylhydrazyl (DPPH) and reactive oxygen species (ROS) assays in vitro...
May 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28529539/jiangtang-decoction-ameliorate-diabetic-nephropathy-through-the-regulation-of-pi3k-akt-mediated-nf-%C3%AE%C2%BAb-pathways-in-kk-ay-mice
#4
Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu, Xue-Mei Wang
BACKGROUND: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28521399/acetonitrile-extract-of-salvia-miltiorrhiza-radix-exhibits-growth-inhibitory-effects-on-prostate-cancer-cells-through-the-induction-of-cell-cycle-arrest-and-apoptosis
#5
June Lee, Bu Young Choi, Young-Sam Keum
In the present study, the effects of the acetonitrile or water extracts from 400 selected traditional medicinal plants on the growth of PC-3 cells were investigated, and it was demonstrated that an acetonitrile extract of Salvia miltiorrhiza Radix exhibited the most marked cytotoxic effects on PC-3 cells. It was observed that the acetonitrile extract of S. miltiorrhiza Radix induced marked cell cycle arrest and apoptosis in PC-3 cells through the generation of intracellular reactive oxygen species. It was also demonstrated that oral administration of the acetonitrile extract of S...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28513773/attenuation-of-renal-ischemic-reperfusion-injury-by-salvianolic-acid-b-via-suppressing-oxidative-stress-and-inflammation-through-pi3k-akt-signaling-pathway
#6
Z G Ma, H Q Xia, S L Cui, J Yu
Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. The objective of the current study was to examine whether SAB exerts a renoprotective effect by attenuating oxidative stress and inflammatory response through activating phosphatidylinositol 3-kinase/serine-threonine kinase B (PI3K/Akt) signaling pathway in a renal ischemic reperfusion rat model. Forty Sprague-Dawley male rats (250-300 g) were obtained and split into four groups with ten rats in each group...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28511681/chromosome-engineering-of-escherichia-coli-for-constitutive-production-of-salvianic-acid-a
#7
Liang Zhou, Qi Ding, Guo-Zhen Jiang, Zhen-Ning Liu, Hai-Yan Wang, Guang-Rong Zhao
BACKGROUND: Salvianic acid A (SAA), a valuable natural product from herbal plant Salvia miltiorrhiza, exhibits excellent antioxidant activities on food industries and efficacious therapeutic potential on cardiovascular diseases. Recently, production of SAA in engineered Escherichia coli was established via the artificial biosynthetic pathway of SAA on the multiple plasmids in our previous work. However, the plasmid-mediated system required to supplement expensive inducers and antibiotics during the fermentation process, restricting scale-up production of SAA...
May 16, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28508121/overexpression-of-smmyb9b-enhances-tanshinone-concentration-in-salvia-miltiorrhiza-hairy-roots
#8
Jingxian Zhang, Lubin Zhou, Xiaoyu Zheng, Jinjia Zhang, Li Yang, Ronghui Tan, Shujuan Zhao
A Salvia miltiorrhiza R2R3-MYB gene, SmMYB9b , has been cloned and characterized. Overexpression of SmMYB9b resulted in a significant improvement of tanshinones, the lipophilic active ingredients in danshen hairy roots. Plant R2R3-MYB transcription factors play important roles in various physiological and biochemical processes. Danshen (Salvia miltiorrhiza bunge) is a valuable medicinal herb with tanshinones and salvianolic acids as the principal bioactive ingredients. A number of putative R2R3-MYB transcription factors have been identified in the plant, but their function remains to be studied...
May 15, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28497986/literature-review-of-traditional-chinese-medicine-on-the-treatment-of-coronary-heart-disease-in-recent-20-years-in-china
#9
Ping Gong, Yue Li, Chengzeng Yao, Hui Guo, Hui Hwang, Xiaobing Liu, Yan Xu, Xiaolong Wang
OBJECTIVE: To analyze the patterns and differences of Chinese herbs in the treatment of coronary heart disease (CHD) in different time periods and different regions in recent 20 years. DESIGN: The literature of controlled clinical trials that focuses on Chinese herbs treating CHD published in China National Knowledge Internet and Wanfang database from January 1, 1996 to December 31, 2015 were screened to analyze the patterns of herb utilization using SPSS 21.0. RESULTS: A total of 1250 articles were enrolled in total covering 29 regions...
May 12, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28494732/pharmacokinetics-of-botanical-drugs-and-plant-extracts
#10
Gina Paola Domínguez Moré, Paola Andrea Cárdenas, Geison M Costa, Cláudia M O Simões, Diana Marcela Aragón
Botanical drugs contain plant extracts, which are complex mixtures of compounds. As with conventional drugs, it is necessary to validate their efficacy and safety through preclinical and clinical studies. However, pharmacokinetic studies for active constituents or characteristic markers in botanical drugs are rare. The objective of this review was to investigate the global state of the art in pharmacokinetic studies of active ingredients present in plant extracts and botanical drugs. A review of pharmacokinetics studies of chemical constituents of plant extracts and botanical drugs was performed, with a total of 135 studies published between January 2004 and February 2015 available in recognized scientific databases...
May 9, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28489029/comparative-analysis-of-the-major-chemical-constituents-in-salvia-miltiorrhiza-roots-stems-leaves-and-flowers-during-different-growth-periods-by-uplc-tq-ms-ms-and-hplc-elsd-methods
#11
Huiting Zeng, Shulan Su, Xiang Xiang, Xiuxiu Sha, Zhenhua Zhu, Yanyan Wang, Sheng Guo, Hui Yan, Dawei Qian, Jinao Duan
Salvia miltiorrhiza is a traditional Chinese herbal medicine containing multiple components that contribute to its notable bioactivities. This article investigated the distribution and dynamic changes of chemical constituents in various parts of S. miltiorrhiza from different growth periods. An ultra-high performance liquid chromatography-triple quadrupole mass spectrometer (UPLC-TQ-MS/MS) and high-performance liquid chromatography coupled with evaporative light scattering detector (HPLC-ELSD) methods were developed for accurate determination of 24 compounds (including phenolic acids, flavonoids, triterpenes, and saccharides) in S...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28487814/qualitative-and-quantitative-characterization-of-monosaccharide-components-of-salvia-miltiorrhiza-liguspyragine-hydrochloride-and-glucose-injection
#12
Fa-Huan Ge, Xian-Peng Ma, Jin-Fang Ma, Chang-Qiong Bi, Tian-Ling Chen, Xiang-Dong Zhang, Xue Xiao
Salvia miltiorrhiza, liguspyragine hydrochloride, and glucose injection (SLGI) was made of Salvia miltiorrhiza Bge., liguspyragine hydrochloride, glucose, and glycerin. There were many kinds of monosaccharide components in SLGI, which might be from the raw material and Salvia miltiorrhiza Bge. Separation was performed on a Phenomenex Luna C18 analytical column (250 mm × 4.6 mm i.d., 5 μm, AccuStandard Inc., USA) at 30°C. The mobile phase consisted of two solvents: 0.1 mol/L phosphate-buffered saline (pH 6...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28487717/identification-of-a-novel-5-epieremophilene-synthase-from-salvia-miltiorrhiza-via-transcriptome-mining
#13
Xin Fang, Chen-Yi Li, Yue Yang, Meng-Ying Cui, Xiao-Ya Chen, Lei Yang
Salvia miltiorrhiza, a medicinal plant in China, has been used for thousands of years to treat coronary heart diseases. Although biosynthesis of tanshinones, a group of diterpenoids in S. miltiorrhiza, has been extensively investigated, to date we know little about the formation of monoterpenes and sesquiterpenes in this medicinal plant. Here, we report the characterization of three sesquiterpene synthases, named SmSTPS1, SmSTPS2, and SmSTPS3, which catalyzed the formation of a new compound, (-)-5-epieremophilene...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28485251/salvia-miltiorrhiza-extract-dihydrotanshinone-induces-apoptosis-and-inhibits-proliferation-of-glioma-cells
#14
Yong Cao, Bin Huang, Changqing Gao
Dihydrotanshinone, a functional food in China, is an effective anti-cardiovascular disease substance isolated from Salvia miltiorrhiza (S. miltiorrhiza). Glioma is considered to be fatal due to its poor prognosis and few effective therapeutic options. In this study, we investigated the anticancer effects of S. miltiorrhiza extract dihydrotanshinone on human glioma SHG-44 cells, by using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide assay, Hoechst 33258 nuclear staining, Annexin V/propidium iodide double staining, as well as western blot analysis...
May 8, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28475366/minor-compounds-of-the-high-purity-salvianolic-acid-b-freeze-dried-powder-from-salvia-miltiorrhiza-and-antibacterial-activity-assessment
#15
Junliang Zhang, Xue Zhang, Jianbin Zhang, Moying Li, Daijie Chen, Tong Wu
The study explored the isolation and characterisation of three compounds of high purity salvianolic acid B freeze-dried powder extracted from Salvia miltiorrhiza Bunge. A new salvianolic acid, salvianolic acid V (2) together with two known compounds (3-4) was identified. The antibacterial activity tests showed that compound 2 combined with clinical antibiotics such as Levofloxacin or Colistin sulphate together exhibited potent effects against MRSA or Acinetobacter baumanii. This report has considerably extended our knowledge about the diversity and bioactivity of caffeic acid derivatives from S...
May 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28473993/salvia-miltiorrhiza-roots-against-cardiovascular-disease-consideration-of-herb-drug-interactions
#16
REVIEW
Feng Chen, Li Li, Dan-Dan Tian
Salvia miltiorrhiza root (Danshen) is widely used in Asia for its cardiovascular benefits and contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to be responsible for its therapeutic efficacy. This review summarized the effects of these bioactive components from S. miltiorrhiza roots on pharmacokinetics of comedicated drugs with mechanic insights regarding alterations of protein binding, enzyme activity, and transporter activity based on the published data stemming from both in vitro and in vivo human studies...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28469657/fermented-chinese-formula-shuan-tong-ling-attenuates-ischemic-stroke-by-inhibiting-inflammation-and-apoptosis
#17
Zhi-Gang Mei, Ling-Jing Tan, Jin-Feng Wang, Xiao-Li Li, Wei-Feng Huang, Hua-Jun Zhou
The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae (Gegen), salvia miltiorrhiza (Danshen), radix curcuma (Jianghuang), hawthorn (Shanzha), salvia chinensis (Shijianchuan), sinapis alba (Baijiezi), astragalus (Huangqi), panax japonicas (Zhujieshen), atractylodes macrocephala koidz (Baizhu), radix paeoniae alba (Baishao), bupleurum (Chaihu), chrysanthemum (Juhua), rhizoma cyperi (Xiangfu) and gastrodin (Tianma), whose aqueous extract was fermented with lactobacillus, bacillus aceticus and saccharomycetes...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28465251/danshen-injection-prevents-heart-failure-by-attenuating-post-infarct-remodeling
#18
Lingyan Wang, Jiahui Yu, Patrick Asare Fordjour, Xiaoxue Xing, Hui Gao, Yanyan Li, Lingyan Li, Yan Zhu, Xiumei Gao, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood circulation and dispel blood stasis. Danshen decoction or liquor-fried Danshen (with grain-based liquor) which is cool in nature is traditionally used to 'cool the blood' and reduce the swelling of sores and abscesses...
April 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28464779/anti-inflammatory-and-antioxidant-agents-from-salvia-genus-lamiaceae-an-assessment-of-the-current-state-of-knowledge
#19
Marco Bonesi, Monica R Loizzo, Rosaria Acquaviva, Giuseppe A Malfa, Francesca Aiello, Rosa Tundis
BACKGROUND: Salvia species are known for their biological properties in many countries and might potentially provide novel therapeutic agents. This review provides an overview of the available literature on the anti-inflammatory and antioxidant effects of Salvia species. METHODS: Using bibliographic databases, particularly PubMed, this review aims to add new information to the list of Salvia species, including S. ceratophylla, S. chloroleuca, S. fruticosa, S. lachostachys, S...
May 2, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28459519/diterpenoid-tanshinones-the-extract-from-danshen-radix-salviae-miltiorrhizae-induced-apoptosis-in-nine-human-cancer-cell-lines
#20
Li Shen, Zhaohuan Lou, Guangshun Zhang, Guanhua Xu, Guangji Zhang
OBJECTIVE: To identify the active anti-tumor constituents in the extract from Danshen (Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions. METHODS: First, we introduced a two-step counter- current chromatography to extract the therapeutically active diterpenoid, tanshinone from Danshen (Radix Salviae Miltiorrhizae). The cholecystokinin (CCK-8) method was used to evaluate the inhibitory effect of diterpenoid tanshinone in liver cancer QGY-7703, lung cancer PC9, lung cancer A549, gastric cancer MKN-45, gastric cancer HGC-27, colon cancer HCT116, myeloma cellU266/ RPMI8226, and human breast cancer MCF-7 in vitro...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
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