Paul E Hanna, Tianqi Ouyang, Ismail Tahir, Nurit Katz-Agranov, Qiyu Wang, Lea Mantz, Ian Strohbehn, Daiana Moreno, Destiny Harden, James E Dinulos, Duru Cosar, Harish Seethapathy, Justin F Gainor, Sachin J Shah, Shruti Gupta, David E Leaf, Florian J Fintelmann, Meghan E Sise
BACKGROUND: Creatinine-based estimated glomerular filtration rate (eGFRCRE ) may overestimate kidney function in patients with sarcopenia. While cystatin C-based eGFR (eGFRCYS ) is less affected by muscle mass, it may underestimate kidney function in patients with obesity. We sought to evaluate the relationship between body composition defined by computed tomography (CT) scans and discordance between creatinine, eGFRCRE and eGFRCYS in adult patients with cancer. METHODS: This study is a cross-sectional study of consecutive adults with cancer with an abdominal CT scan performed within 90 days of simultaneous eGFRCRE and eGFRCYS measurements between May 2010 and January 2022...
April 22, 2024: Journal of Cachexia, Sarcopenia and Muscle