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https://www.readbyqxmd.com/read/28738667/toe-grip-strength-in-middle-aged-individuals-as-a-risk-factor-for-falls
#1
Ryota Tsuyuguchi, Satoshi Kurose, Takayuki Seto, Nana Takao, Satoshi Tagashira, Hiromi Tsutsumi, Shingo Otsuki, Yutaka Kimura
BACKGROUND: Toe grip strength is the force of a toe on a surface. The objective of this study was to investigate the relationship between falls in middle-aged individuals and physical strength factors such as toe grip strength and knee extension strength. METHODS: The subjects were 194 middle-aged individuals (388 feet) who were independent in daily life, received no nursing care, and participated in a health sports event organized by a sports club. We evaluated the body composition, blood pressure, vascular age, systemic response, bone density, knee extension strength, and toe grip strength, and examined their relationship using a self-administered questionnaire survey...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28738451/psychiatric-comorbidity-in-patients-with-irritable-bowel-syndrome-at-a-tertiary-care-center-in-northern-india
#2
Yuman Kawoos, Zaid A Wani, Showkat A Kadla, Irfan A Shah, Arshad Hussain, M Maqbool Dar, Mushtaq A Margoob, Kouser Sideeq
Background/Aims: Irritable bowel syndrome (IBS) is a chronic psycho-physiological disorder. It is considered to be the most common functional gastrointestinal disorder, and about 50.0-90.0% of IBS patients have associated psychiatric comorbidity. We aimed to study psychiatric comorbidities in patients with IBS visiting a tertiary care center. Methods: This was a cross-sectional case-control study conducted over a duration of one and a half years from January 2014 to July 2015...
July 21, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28738421/cardiovascular-disease-among-transgender-adults-receiving-hormone-therapy-a-narrative-review
#3
Carl G Streed, Omar Harfouch, Francoise Marvel, Roger S Blumenthal, Seth S Martin, Monica Mukherjee
Recent reports estimate that 0.6% of adults in the United States, or approximately 1.4 million persons, identify as transgender. Despite gains in rights and media attention, the reality is that transgender persons experience health disparities, and a dearth of research and evidence-based guidelines remains regarding their specific health needs. The lack of research to characterize cardiovascular disease (CVD) and CVD risk factors in transgender populations receiving cross-sex hormone therapy (CSHT) limits appropriate primary and specialty care...
July 25, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28738341/unmet-care-needs-in-the-oldest-old-primary-care-patients-with-cognitive-disorders-results-of-the-agecode-and-agequalide-study
#4
Janine Stein, Alexander Pabst, Tobias Luck, Dagmar Lühmann, Kathrin Heser, Frank Jessen, Horst Bickel, Edelgard Mösch, Michael Pentzek, Angela Fuchs, Birgitt Wiese, Silke Mamone, Hans-Helmut König, Christian Brettschneider, Jochen Werle, Martin Scherer, Wolfgang Maier, Siegfried Weyerer, Steffi G Riedel-Heller
BACKGROUND: In the future, an increase in health care needs in the elderly is expected. Reports on unmet care needs of the oldest old with cognitive disorders are pending. This study aims at exploring unmet needs in the oldest old primary care patients with mild cognitive impairment (MCI) and dementia. Furthermore, the association between sociodemographic and clinical factors and unmet needs ought to be analyzed. METHODS: Based on the study "Needs, Health Service Use, Costs and Health-Related Quality of Life in a Large Sample of Oldest-Old Primary Care Patients (85+)" (AgeQualiDe), 749 patients (unimpaired, MCI, and dementia) aged 85 years and older, their relatives (n = 421), and general practitioners (GPs) (n = 607) were assessed...
July 25, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738263/prenatal-exposure-to-pm2-5-and-birth-weight-a-pooled-analysis-from-three-north-american-longitudinal-pregnancy-cohort-studies
#5
Maria José Rosa, Ashley Pajak, Allan C Just, Perry E Sheffield, Itai Kloog, Joel Schwartz, Brent Coull, Michelle Bosquet Enlow, Andrea A Baccarelli, Kathi Huddleston, John E Niederhuber, Martha María Téllez Rojo, Robert O Wright, Chris Gennings, Rosalind J Wright
A common practice when analyzing multi-site epidemiological data is to include a term for 'site' to account for unmeasured effects at each location. This practice should be carefully considered when site can have complex relationships with important demographic and exposure variables. We leverage data from three longitudinal North American pregnancy cohorts to demonstrate a novel method to assess study heterogeneity and potential combinability of studies for pooled analyses in order to better understand how to consider site in analyses...
July 21, 2017: Environment International
https://www.readbyqxmd.com/read/28738236/early-predictors-of-study-success-in-a-dutch-advanced-nurse-practitioner-education-program-a-retrospective-cohort-study
#6
Ercolie R Bossema, Tineke H J M Meijs, Jeroen W B Peters
BACKGROUND: Study delay and attrition are major concerns in higher education. They cost time and effort, and threaten the availability of higher qualified professionals. Knowing early what factors contribute to delay and attrition may help prevent this. OBJECTIVE: The aim of this study was to examine whether student characteristics, including a literature study report grade as a proxy of cognitive abilities, predicted study success in a dual advanced nurse practitioner education program...
July 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28738121/incidence-risks-and-types-of-infections-in-pediatric-long-term-care-facilities
#7
Lisa Saiman, Philip Maykowski, Meghan Murray, Bevin Cohen, Natalie Neu, Haomioa Jia, Gordon Hutcheon, Edwin Simpser, Linda Mosiello, Luis Alba, Elaine Larson
Importance: The population of infants, children, and adolescents cared for at pediatric long-term care facilities is increasing in complexity and size and thus consumes substantial health care resources. Infections are a significant cause of morbidity and mortality in this population, but few recent data describe their incidence and effects. Objectives: To describe the types of infections diagnosed in residents of pediatric long-term care facilities, calculate infection rates, and identify risk factors for respiratory tract infections (RTIs)...
July 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28738105/psychosocial-and-behavioral-aspects-of-pain-and-perception-of-oral-health
#8
Miriane Lucindo Zucoloto, João Maroco, Juliana Alvares Campos
AIMS: To evaluate the contribution of the psychosocial and behavioral aspects of pain to the perception of oral health in a sample of Brazilian dental patients. METHODS: This cross-sectional study involved 436 patients who sought dental care in the School of Dentistry of São Paulo State University and who reported some type of orofacial pain. The study group's mean age (± standard deviation [SD]) was 39.9 ± 13.6 years, and the sample was 74.5% female. The Portuguese version of the Oral Health Impact Profile Short Form (OHIP-14) and the Multidimensional Pain Inventory (MPI) were used...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28738090/maternal-25-oh-d-concentrations-%C3%A2-40-ng-ml-associated-with-60-lower-preterm-birth-risk-among-general-obstetrical-patients-at-an-urban-medical-center
#9
Sharon L McDonnell, Keith A Baggerly, Carole A Baggerly, Jennifer L Aliano, Christine B French, Leo L Baggerly, Myla D Ebeling, Charles S Rittenberg, Christopher G Goodier, Julio F Mateus Niño, Rebecca J Wineland, Roger B Newman, Bruce W Hollis, Carol L Wagner
BACKGROUND: Given the high rate of preterm birth (PTB) nationwide and data from RCTs demonstrating risk reduction with vitamin D supplementation, the Medical University of South Carolina (MUSC) implemented a new standard of care for pregnant women to receive vitamin D testing and supplementation. OBJECTIVES: To determine if the reported inverse relationship between maternal 25(OH)D and PTB risk could be replicated at MUSC, an urban medical center treating a large, diverse population...
2017: PloS One
https://www.readbyqxmd.com/read/28738070/determinants-associated-with-deprivation-in-multimorbid-patients-in-primary-care-a-cross-sectional-study-in-switzerland
#10
Silja Leiser, Anouk Déruaz-Luyet, A Alexandra N'Goran, Jérôme Pasquier, Sven Streit, Stefan Neuner-Jehle, Andreas Zeller, Dagmar M Haller, Lilli Herzig, Patrick Bodenmann
BACKGROUND: Deprivation usually encompasses material, social, and health components. It has been shown to be associated with greater risks of developing chronic health conditions and of worse outcome in multimorbidity. The DipCare questionnaire, an instrument developed and validated in Switzerland for use in primary care, identifies patients subject to potentially higher levels of deprivation. OBJECTIVES: To identifying determinants of the material, social, and health profiles associated with deprivation in a sample of multimorbid, primary care patients, and thus set priorities in screening for deprivation in this population...
2017: PloS One
https://www.readbyqxmd.com/read/28737997/adolescent-and-young-adult-cancer-survivors-experiences-of-the-healthcare-system-a-qualitative-study
#11
Elizabeth A May, Brittany C McGill, Eden G Robertson, Antoinette Anazodo, Claire E Wakefield, Ursula M Sansom-Daly
PURPOSE: To qualitatively examine the experiences of diagnosis and treatment, and attitudes toward ongoing healthcare of adolescent and young adult (AYA) survivors of AYA cancer, to determine barriers to healthcare engagement in the early survivorship period. METHODS: Forty-two participants aged between 15 and 25 years were recruited between February 2013 and October 2015 as part of a larger Australia-wide study. This study analyzed data collected through a semistructured telephone interview...
July 24, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28737994/impact-of-a-patient-support-program-on-patient-adherence-to-adalimumab-and-direct-medical-costs-in-crohn-s-disease-ulcerative-colitis-rheumatoid-arthritis-psoriasis-psoriatic-arthritis-and-ankylosing-spondylitis
#12
David T Rubin, Manish Mittal, Matthew Davis, Scott Johnson, Jingdong Chao, Martha Skup
BACKGROUND: AbbVie provides a free-to-patient patient support program (PSP) to assist adalimumab-treated patients with medication costs, nurse support, injection training, pen disposal, and medication reminders. The impact of these services on patient adherence to adalimumab and direct medical costs associated with autoimmune disease has not been assessed. OBJECTIVE: To quantify the relationship between participation in a PSP and outcomes (adalimumab adherence, persistence, and direct medical costs) in patients initiating adalimumab treatment...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737990/cost-effectiveness-of-novel-agents-in-medicare-patients-with-multiple-myeloma-findings-from-a-u-s-payer-s-perspective
#13
Ying Chen, David R Lairson, Wenyaw Chan, Jinhai Huo, Xianglin L Du
BACKGROUND: Since multiple myeloma (MM) incurs a substantial economic burden in care management, more and more discussion has been generated in recent years about the costs of novel antimyeloma drugs and their associated value. Because of these costs, economic assessment that quantifies value of care over the long-term is essential. OBJECTIVE: To determine the cost-effectiveness (measured as cost per life-year saved) of front-line novel agent-based therapy use among a cohort of elderly patients with MM in a real-world setting...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737988/patterns-of-care-for-biologic-dosing-outliers-and-nonoutliers-in-biologic-naive-patients-with-rheumatoid-arthritis
#14
Thomas Delate, Roxanne Meyer, Daniel Jenkins
BACKGROUND: Although most biologic medications for patients with rheumatoid arthritis (RA) have recommended fixed dosing, actual biologic dosing may vary among real-world patients, since some patients can receive higher (high-dose outliers) or lower (low-dose outliers) doses than what is recommended in medication package inserts. OBJECTIVE: To describe the patterns of care for biologic-dosing outliers and nonoutliers in biologic-naive patients with RA. METHODS: This was a retrospective, longitudinal cohort study of patients with RA who were not pregnant and were aged ≥ 18 and < 90 years from an integrated health care delivery system...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737986/real-world-adherence-and-persistence-to-oral-disease-modifying-therapies-in-multiple-sclerosis-patients-over-1-year
#15
Kristen M Johnson, Huanxue Zhou, Feng Lin, John J Ko, Vivian Herrera
BACKGROUND: Disease-modifying therapies (DMTs) are indicated to reduce relapse rates and slow disease progression for relapsing-remitting multiple sclerosis (MS) patients when taken as prescribed. Nonadherence or non-persistence in the real-world setting can lead to greater risk for negative clinical outcomes. Although previous research has demonstrated greater adherence and persistence to oral DMTs compared with injectable DMTs, comparisons among oral DMTs are lacking. OBJECTIVE: To compare adherence, persistence, and time to discontinuation among MS patients newly prescribed the oral DMTs fingolimod, dimethyl fumarate, or teriflunomide...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737985/evaluation-of-patient-migration-patterns-and-related-health-care-costs-within-a-national-medicare-advantage-prescription-drug-plan-after-implementation-of-an-oxycodone-hcl-extended-release-access-restriction
#16
Chi-Chang Chen, Ajita P De, Brian Sweet, Rolin L Wade
BACKGROUND: Health plans use formulary restrictions (e.g., prior authorization, step therapy, tier change, nonformulary status) in an effort to control cost and promote quality, safety, and appropriate prescription utilization. Some Medicare payers perceive that the inclusion of certain agents, such as branded oxycodone HCl extended-release tablets (OERs), on their formularies is associated with attracting high-cost members to the plan. OBJECTIVE: To evaluate disenrollment rates, patient migration, and subsequent health care costs among OER users who disenrolled from a national Medicare Advantage Prescription Drug plan (study-MAPD) in the plan year following OER nonformulary restriction...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737978/risk-of-violence-among-patients-in-psychiatric-treatment-results-from-a-national-census
#17
Solveig Osborg Ose, Solfrid Lilleeng, Ivar Pettersen, Torleif Ruud, Jaap van Weeghel
BACKGROUND: Adverse media coverage of isolated incidents affects the public perception of the risk of violent behavior among people with mental illness. However, the risk of violence is studied most frequently among inpatients, which falsely exaggerates the prevalence of people with mental illness because the majority of individuals receive treatment as outpatients. AIM: To estimate the prevalence of the risk of violence among inpatients and outpatients in psychiatric treatment, as well as the associations with gender, age, socio-economic status and co-morbid substance use disorders in all major diagnostic categories...
July 24, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28737775/fertility-preservation-issues-in-pediatric-hematopoietic-stem-cell-transplantation-practical-approaches-from-the-consensus-of-the-pediatric-diseases-working-party-of-the-ebmt-and-the-international-bfm-study-group
#18
A Balduzzi, J-H Dalle, K Jahnukainen, M von Wolff, G Lucchini, M Ifversen, K T Macklon, C Poirot, T Diesch, A Jarisch, D Bresters, I Yaniv, B Gibson, A M Willasch, R Fadini, L Ferrari, A Lawitschka, A Ahler, N Sänger, S Corbacioglu, M Ansari, R Moffat, A Dalissier, E Beohou, P Sedlacek, A Lankester, C D De Heredia Rubio, K Vettenranta, J Wachowiak, A Yesilipek, E Trigoso, T Klingebiel, C Peters, P Bader
Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy...
July 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737649/race-age-and-geography-impact-hepatitis-c-genotype-distribution-in-the-united-states
#19
Stuart C Gordon, Sheri Trudeau, Jia Li, Yueren Zhou, Loralee B Rupp, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Mei Lu
GOALS: To determine the impact of geography and patient characteristics on hepatitis C virus (HCV) genotype and subtype distribution in a large sample of patients under routine clinical care BACKGROUND:: HCV genotype impacts disease course and response to treatment. Although several studies have reported genotype distribution within specific US populations, there are no comprehensive descriptions in large, geographically diverse cohorts. STUDY: Using data from the Chronic Hepatitis Cohort Study, we present the distribution of HCV genotypes (GT) and subtypes (ST) among a racially diverse cohort of over 8000 HCV-infected patients from four large US health systems...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28737623/an-observational-study-of-severe-pertussis-in-100-infants-%C3%A2-120-days-of-age
#20
James D Cherry, Kristen Wendorf, Brooke Bregman, Deborah Lehman, Delma Nieves, John S Bradley, Wilbert H Mason, Linette Sande-Lopez, Merrick Lopez, Myke Federman, Tempe Chen, Dean Blumberg, Samantha Johnston, Hayden T Schwenk, Peggy Weintrub, Kevin K Quinn, Kathleen Winter, Kathleen Harriman
BACKGROUND: Pertussis in young infants is a unique, severe, afebrile, cough illness that is frequently fatal. METHODS: All pertussis cases ≤ 120 days of age admitted to a pediatric intensive care unit (PICU) in California between October 1, 2013 and April 25, 2015 were evaluated. RESULTS: Of 100 pertussis patients ≤ 120 days of age admitted to PICU's, there were 5 deaths. The white blood cell (WBC) counts in the fatal cases were significantly higher than in the non-fatal cases...
July 20, 2017: Pediatric Infectious Disease Journal
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