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Dalal Asker
Carotenoids are valuable natural colorants that exhibit numerous health promoting properties, and thus are widely used in food, feeds, pharmaceutical and nutraceuticals industries. In this study, we isolated and identified novel microbial sources that produced high-value carotenoids using high throughput screening (HTS). A total of 701 pigmented microbial strains library including marine bacteria and red yeast was constructed. Carotenoids profiling using HPLC-DAD-MS methods showed 88 marine bacterial strains with potential for the production of high-value carotenoids including astaxanthin (28 strains), zeaxanthin (21 strains), lutein (1 strains) and canthaxanthin (2 strains)...
September 30, 2018: Food Chemistry
Awanis Azizan, Muhammad Safwan Ahamad Bustamam, M Maulidiani, Khozirah Shaari, Intan Safinar Ismail, Norio Nagao, Faridah Abas
Microalgae are promising candidate resources from marine ecology for health-improving effects. Metabolite profiling of the microalgal diatom, Chaetoceros calcitrans was conducted by using robust metabolomics tools, namely ¹H nuclear magnetic resonance (NMR) spectroscopy coupled with multivariate data analysis (MVDA). The unsupervised data analysis, using principal component analysis (PCA), resolved the five types of extracts made by solvents ranging from polar to non-polar into five different clusters. Collectively, with various extraction solvents, 11 amino acids, cholesterol, 6 fatty acids, 2 sugars, 1 osmolyte, 6 carotenoids and 2 chlorophyll pigments were identified...
May 7, 2018: Marine Drugs
Hiroaki Iwasaka, Ryo Koyanagi, Ryota Satoh, Akiko Nagano, Kenshi Watanabe, Kanako Hisata, Noriyuki Satoh, Tsunehiro Aki
Labyrinthulomycetes have been regarded as a promising industrial source of xanthophylls, including astaxanthin and canthaxanthin, polyunsaturated fatty acids such as docosahexaenoic acid and docosapentaenoic acid, ω-3 oils, and terpenic hydrocarbons, such as sterols and squalene. A Thraustochytrid, Aurantiochytrium sp. KH105 produces carotenoids, including astaxanthin, with strong antioxidant activity. To gain genomic insights into this capacity, we decoded its 97-Mbp genome and characterized genes for enzymes involved in carotenoid biosynthesis...
April 9, 2018: Genes
Kenshi Watanabe, Kim Hazel V Arafiles, Risa Higashi, Yoshiko Okamura, Takahisa Tajima, Yukihiko Matsumura, Yutaka Nakashimada, Keisuke Matsuyama, Tsunehiro Aki
The marine eukaryotic microheterotroph thraustochytrid genus Aurantiochytrium is a known producer of polyunsaturated fatty acids, carotenoids, and squalene. We previously constructed a lipid fermentation system for Aurantiochytrium sp. strains using underutilized biomass, such as canned syrup and brown macroalgae. To improve the productivity, in this study, Aurantiochytrium sp. RH-7A and RH-7A-7 that produced high levels of carotenoids, such as astaxanthin and canthaxanthin, were isolated through chemical mutagenesis...
April 9, 2018: Journal of Oleo Science
Shivakumara Siddaramappa, Vandana Viswanathan, Saravanamuthu Thiyagarajan, Anushree Narjala
The order Sphingomonadales is a taxon of bacteria with a variety of physiological features and carotenoid pigments. Some of the coloured strains within this order are known to be aerobic anoxygenic phototrophs that contain characteristic photosynthesis gene clusters (PGCs). Previous work has shown that majority of the ORFs putatively involved in the biosynthesis of C40 carotenoids are located outside the PGCs in these strains. The main purpose of this study was to understand the genetic basis for the various colour/carotenoid phenotypes of the strains of Sphingomonadales...
April 5, 2018: Microbial Genomics
C F Challiol, A Bastien, J M Giambruni, N Fernandez Meijide
INTRODUCTION: Canthaxanthin is a chemical product used to tan the skin. Its most frequent adverse effect is canthaxanthin retinopathy. PURPOSE/ METHODS: Report, case series. RESULTS: Two female patients, one 42 years-old and the other 72 years-old, with signs of retinopathy due to canthaxanthin. Complete ophthalmology examinations were carried out. The peripheral fovea birefringent deposits with internal retinal involvement were studied using multimodal imaging...
March 21, 2018: Archivos de la Sociedad Española de Oftalmología
Kanchana Rueksomtawin Kildegaard, Belén Adiego-Pérez, David Doménech Belda, Jaspreet Kaur Khangura, Carina Holkenbrink, Irina Borodina
Astaxanthin is a red-colored carotenoid, used as food and feed additive. Astaxanthin is mainly produced by chemical synthesis, however, the process is expensive and synthetic astaxanthin is not approved for human consumption. In this study, we engineered the oleaginous yeast Yarrowia lipolytica for de novo production of astaxanthin by fermentation. First, we screened 12 different Y. lipolytica isolates for β-carotene production by introducing two genes for β-carotene biosynthesis: bi-functional phytoene synthase/lycopene cyclase ( crtYB ) and phytoene desaturase ( crtI ) from the red yeast Xanthophyllomyces dendrorhous ...
December 2017: Synthetic and Systems Biotechnology
Z Z Ren, Q F Zeng, J P Wang, X M Ding, S P Bai, Z W Su, Y Xuan, K Y Zhang
Three experiments were conducted to investigate the effects of maternal dietary canthaxanthin (CX) and 25-hydroxycholecalciferol (25-OH-D3) supplementation on antioxidant status and calcium-phosphate metabolism of progeny ducks. Cherry Valley duck breeders (38 wk old) were fed either a control diet or the same diet plus CX (6 mg/kg) and 25-OH-D3 (0.069 mg/kg) for 32 weeks. Experiments 1, 2, and 3 were conducted with progeny ducks hatched from eggs laid by duck breeder hens at 54, 62, and 70 wk of age, respectively...
April 1, 2018: Poultry Science
Jason K Gurchiek, Han Bao, Maria Agustina Domínguez-Martín, Sarah E McGovern, Claire E Marquardt, Jerome D Roscioli, Soumen Ghosh, Cheryl A Kerfeld, Warren F Beck
The orange carotenoid protein (OCP) mediates nonphotochemical quenching (NPQ) mechanisms in cyanobacteria. A bound ketocarotenoid serves as a sensor of midvisible light intensity and as a quencher of phycocyanobilin excitons in the phycobilisome. The photochemical mechanism that triggers conversion of the protein from a resting, orange state (OCPO ) to an active, red state (OCPR ) after optical preparation of the S2 state of the carotenoid remains an open question. We report here that the fluorescence spectrum and quantum yield of the bound carotenoids in OCPO report important details of the motions that follow optical preparation of the S2 state...
February 15, 2018: Journal of Physical Chemistry. B
Jie Jia, Yuxian Wang, Yueying Liu, Yuhong Xiang
The interaction between the food colorant canthaxanthin (CA) and human serum albumin (HSA) in aqueous solution was explored by using fluorescence spectroscopy, three-dimensional fluorescence spectra, synchronous fluorescence spectra, UV-vis absorbance spectroscopy, circular dichroism (CD) spectra and molecular docking methods. The thermodynamic parameters calculated from fluorescence spectra data showed that CA could result in the HSA fluorescence quenching. From the KSV change with the temperature dependence, it was concluded that HSA fluorescence quenching triggered by CA is the static quenching and the number of binding sites is one...
March 2018: Luminescence: the Journal of Biological and Chemical Luminescence
M Umar Faruk, F F Roos, F Cisneros-Gonzalez
A meta-analysis was conducted to evaluate the effect of the carotenoid canthaxanthin on production performance in layer hens. The data set contained 576 performance measurements from 34 trials. The trials were all conducted according to a similar experimental protocol from 1997 to 2012. The age of the animals ranged from 21 to 65 weeks. The experimental diets were predominantly wheat/SBM based, fed in mash form ad libitum. Depending on the trial and the treatment group considered, canthaxanthin supplementation was in the range of 0 to 8 mg/kg of feed...
January 1, 2018: Poultry Science
Nam Young Kim, Woon Yong Choi, Soo Jin Heo, Do Hyung Kang, Hyeon Yong Lee
OBJECTIVES: This work aimed to enhance anti-skin cancer activities of Apostichopus japonicus , spiky sea cucumber, through ultrasonification extraction process at low temperature. METHODS: Dried Apostichopus japonicus was extracted with an ultrasonification process at 50°C and 95 kHz for two hours (UE), and anti-skin cancer activities of the extract from the UE were also compared with those from conventional extraction processes using hot water (WE) or 70% ethanol at 80°C (EE) for 12 hours...
2017: Journal of Healthcare Engineering
Viktor A Anashkin, Yulia V Bertsova, Adalyat M Mamedov, Mahir D Mamedov, Alexander M Arutyunyan, Alexander A Baykov, Alexander V Bogachev
Light-driven H(+), Cl(-) and Na(+) rhodopsin pumps all use a covalently bound retinal molecule to capture light energy. Some H(+)-pumping rhodopsins (xanthorhodopsins; XRs) additionally contain a carotenoid antenna for light absorption. Comparison of the available primary and tertiary structures of rhodopsins pinpointed a single Thr residue (Thr216) that presumably prevents carotenoid binding to Na(+)-pumping rhodopsins (NaRs). We replaced this residue in Dokdonia sp. PRO95 NaR with Gly, which is found in the corresponding position in XRs, and produced a variant rhodopsin in a ketocarotenoid-synthesising Escherichia coli strain...
October 5, 2017: Photosynthesis Research
Marilise Nogueira, Eugenia M A Enfissi, Maria E Martínez Valenzuela, Guillaume N Menard, Richard L Driller, Peter J Eastmond, Wolfgang Schuch, Gerhard Sandmann, Paul D Fraser
Ketocarotenoids are high-value pigments used commercially across multiple industrial sectors as colorants and supplements. Chemical synthesis using petrochemical-derived precursors remains the production method of choice. Aquaculture is an example where ketocarotenoid supplementation of feed is necessary to achieve product viability. The biosynthesis of ketocarotenoids, such as canthaxanthin, phoenicoxanthin, or astaxanthin in plants is rare. In the present study, complex engineering of the carotenoid pathway has been performed to produce high-value ketocarotenoids in tomato fruit (3...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
Hubert Antolak, Joanna Oracz, Anna Otlewska, Dorota Żyżelewicz, Dorota Kręgiel
The aim of the study was to identify and quantitatively assess of carotenoids and isoprenoid quinones biosynthesized by six different strains of acetic acid bacteria, belonging to genus Asaia, that are common beverage-spoiling bacteria in Europe. Bacterial cultures were conducted in a laboratory liquid culture minimal medium with 2% sucrose. Carotenoids and isoprenoid quinones were investigated using UHPLC-DAD-ESI-MS analysis. In general, tested strains of Asaia spp. were able to produce 10 carotenoids and 3 isoprenoid quinones: menaquinone-7, menaquinone-8, and ubiquinone-10...
September 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sheida Hedjazi, Seyed Hadi Razavi
Cellulosic nanocrystals from different origins were made to stabilize the canthaxanthin (CTX) in pickering emulsion. Nanocrystals were obtained by hydrochloric acid hydrolysis. Dynamic light scattering (DLS) demonstrated that the length of solid particles were in the range of 112nm-4000nm. AFM indicated the needle-like shape of the cotton cellulose nanocrystals (CCNs) and bacterial cellulose nanocrystals (BCNs) and also illustrated the thickness of the particles to be 6 and 7nm respectively. The crystallinity of both BCNs and CCNs was higher than the cellulose source they were isolated (CL: 75...
January 2018: International Journal of Biological Macromolecules
Yuki Inoue, Masamitsu Shimazawa, Ryota Nagano, Yoshiki Kuse, Kei Takahashi, Kazuhiro Tsuruma, Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka, Hideaki Hara
Carotenoids, in particular astaxanthin, possess potent antioxidant capabilities. Astaxanthin also induces NF-E2-related factor 2 (Nrf2), which plays a major regulatory role in the antioxidative response. However, little is known whether the carotenoid, by-products of astaxanthin, activate Nrf2. Toward this end, we screened eight astaxanthin analogs for Nrf2 activation in murine photoreceptor cell line, 661 W, by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). In addition, we monitored cell death in 661 W cells pretreated with astaxanthin analogs or only pretreated for 6 h with astaxanthin analogs and then exposed to light...
July 2017: Journal of Pharmacological Sciences
Riccardo Spezia, Stefan Knecht, Benedetta Mennucci
Carotenoids can play multiple roles in biological photoreceptors thanks to their rich photophysics. In the present work, we have investigated six of the most common carbonyl containing carotenoids: echinenone, canthaxanthin, astaxanthin, fucoxanthin, capsanthin and capsorubin. Their excitation properties are investigated by means of a hybrid density functional theory (DFT) and multireference configuration interaction (MRCI) approach to elucidate the role of the carbonyl group: the bright transition is of ππ* character, as expected, but the presence of a C[double bond, length as m-dash]O moiety reduces the energy of nπ* transitions which may become closer to the ππ* transition, in particular as the conjugation chain decreases...
July 5, 2017: Physical Chemistry Chemical Physics: PCCP
Kaitlin L Sparrow, Kingsley K Donkor, Nancy J Flood, Peter P Marra, Andrew G Pillar, Matthew W Reudink
Carotenoid-based plumage coloration plays a critical role for both inter- and intrasexual communication. Habitat and diet during molt can have important consequences for the development of the ornamental signals used in these contexts. When molt occurs away from the breeding grounds (e.g., pre-alternate molt on the wintering grounds, or stopover molt), discerning the influence of habitat and diet can be particularly important, as these effects may result in important carryover effects that influence territory acquisition or mate choice in subsequent seasons...
April 2017: Ecology and Evolution
C E V Bonilla, A P Rosa, A Londero, C B S Giacomini, C Orso, M O Fernandes, S J Paixão, D V Bonamigo
This study was designed to evaluate the effect of corn or sorghum diet and canthaxanthin (CX) supplementation on performance in broiler breeders. A total of 440 females with similar body weight (BW) (3.71 ± 0.14 kg) and 60 roosters were placed in an open-sided house with 20 pens, randomly distributed in a factorial arrangement (2 × 2). There were 4 diets of 2 ingredients; corn (CO) or sorghum (SO) and 2 levels of CX; 6 mg/kg (CX) and 0 mg/kg (NCX) totaling 5 replicate pens of 22 females and 3 males each, from 42 to 65 wk, divided in 2 periods (from wk 42 to 53 and wk 54 to 65)...
June 1, 2017: Poultry Science
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