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https://www.readbyqxmd.com/read/29786649/kudzu-leaf-extract-suppresses-the-production-of-inducible-nitric-oxide-synthase-cyclooxygenase-2-tumor-necrosis-factor-alpha-and-interleukin-6-via-inhibition-of-jnk-tbk1-and-stat1-in-inflammatory-macrophages
#1
Seok Hyun Eom, So-Jung Jin, Hee-Yeong Jeong, Youngju Song, You Jin Lim, Jong-In Kim, Youn-Hyung Lee, Hee Kang
Kudzu ( Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep) is a perennial leguminous vine, and its root and flower have been used for herbal medicine in Asia for a long time. Most dietary flavonoids are reported to be concentrated in its root, not in its aerial parts including leaves. In this study, we investigated whether kudzu leaf and its major constituent, robinin (kaempferol-3- O -robinoside-7- O -rhanmoside) possessed anti-inflammatory activity. To test this hypothesis, we used peritoneal macrophages isolated from BALB/c mice and stimulated the cells with lipopolysaccharide (LPS) or LPS plus interferon (IFN)-γ...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29767812/tolerance-of-subzero-winter-cold-in-kudzu-pueraria-montana-var-lobata
#2
Heather A Coiner, Katharine Hayhoe, Lewis H Ziska, Jeff Van Dorn, Rowan F Sage
The use of species distribution as a climate proxy for ecological forecasting is thought to be acceptable for invasive species. Kudzu (Pueraria montana var. lobata) is an important invasive whose northern distribution appears to be limited by winter survival; however, kudzu's cold tolerance thresholds are uncertain. Here, we used biogeographic evidence to hypothesize that exposure to - 20 °C is lethal for kudzu and thus determines its northern distribution limit. We evaluated this hypothesis using survival tests and electrolyte leakage to determine relative conductivity, a measure of cell damage, on 14 populations from eastern North America...
May 16, 2018: Oecologia
https://www.readbyqxmd.com/read/29587545/puerarin-loaded-peg-pe-micelles-with-enhanced-anti-apoptotic-effect-and-better-pharmacokinetic-profile
#3
Wenqun Li, Junyong Wu, Jiang Zhang, Jingjing Wang, Daxiong Xiang, Shilin Luo, Jianhe Li, Xinyi Liu
Puerarin (PUE) is the most abundant isoflavonoid in kudzu root. It is widely used as a therapeutic agent for the treatment of cardiovascular diseases. However, the short elimination half-life, poor-bioavailability, and acute intravascular hemolysis of PUE are the main obstacles to its widespread clinical applications. Whereas PEG-PE micelles possess the ability to release medicine slowly, enhance the cellular uptake of drugs and improve their biocompatibility. Therefore, it was aim to fabricate puerarin-loaded PEG-PE (PUE@PEG-PE) micelles to improve the pharmaceutical properties of drugs...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29498696/synergistic-effects-of-salvianolic-acid-b-and-puerarin-on-cerebral-ischemia-reperfusion-injury
#4
Chengli Ling, Jianming Liang, Chun Zhang, Ruixiang Li, Qianqian Mou, Jin Qin, Xiaofang Li, Jianxin Wang
Ischemic stroke (IS) is characterized by the sudden loss of blood circulation to an area of the brain, resulting in a corresponding loss of neurologic function. It has been a worldwide critical disease threatening to the health and life of human beings. Despite significant progresses achieved, effective treatment still remains a formidable challenge due to the complexity of the disease. Salvianolic acid B (Sal-B) and Puerarin (Pue) are two active neuroprotectants isolated from traditional Chinese herbs, Salvia miltiorrhiza and Kudzu root respectively, which have been used for the prevention and treatment of IS for thousands of years in China...
March 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29490067/degree-day-requirements-for-kudzu-bug-hemiptera-plataspidae-a-pest-of-soybeans
#5
Jessica I Grant, William O Lamp
Understanding the phenology of a new potential pest is fundamental for the development of a management program. Megacopta cribraria Fabricius (Hemiptera: Plataspidae), kudzu bug, is a pest of soybeans first detected in the United States in 2009 and in Maryland in 2013. We observed the phenology of kudzu bug life stages in Maryland, created a Celsius degree-day (CDD) model for development, and characterized the difference between microhabitat and ambient temperatures of both kudzu, Pueraria montana (Lour.) Merr...
April 2, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29393465/puerarin-inhibits-non-small-cell-lung-cancer-cell-growth-via-the-induction-of-apoptosis
#6
Yefang Hu, Xi Li, Ling Lin, Siting Liang, Jian Yan
Puerarin, an isoflavone isolated from Kudzu roots, has been demonstrated to have beneficial effect on cardiovascular and cerebral vascular diseases. Recently research has revealed that puerarin exerts an anticancer role in many different types of cancer. The aim of the present study was to investigate the antitumor effects of puerarin on non-small cell lung cancer (NSCLC). Treatment of puerarin significantly inhibited the growth of NSCLC cell lines as determined by CCK-8 kit in vitro. Flow cytometry results indicated that puerarin treatments promoted NSCLC cell apoptosis...
April 2018: Oncology Reports
https://www.readbyqxmd.com/read/29345333/effects-and-mechanism-of-puerarin-on-the-human-retinoblastoma-cells
#7
Chao Yang, Xiaohui Fan, Shuxia Fan
Puerarin is an isoflavonoid that is extracted from Kudzu root and is considered to have an anti-tumor effect. In the present study, the effects of puerarin on human retinoblastoma cells and the related pathways was determined. The retinoblastoma (RB) cell lines were used in this study. Cell viability and proliferation was measured by MTT assay. Cell cycle and apoptosis was determined by flow cytometry. The expression of caspase-3 and apoptosis-related proteins were detected by Western blotting following puerarin treatment...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29244731/comparative-therapeutic-effects-of-plant-extract-synthesized-and-traditionally-synthesized-gold-nanoparticles-on-alcohol-induced-inflammatory-activity-in-sh-sy5y-cells-in-vitro
#8
Ashok K Singh
The present study describes potential beneficial and adverse effects of plant-extract synthesized gold nanoparticles (AuNPs) on ethanol toxicity in SH-SY5Y cells. Although kudzu root extract (K), edible-gum extract (G), alone or in combination (KG), reduced Au3+ into AuNPs, the extract's composition and the reaction temperature determined their size (AuNPKG(90<50<37) < AuNPK (90,50<37) < AuNPG (90<50) ; the subscript KG, K, or G is extract identification and numerical vales are reaction temperature in Celsius) and biological properties (AuNPKG (90,50>37) < AuNPK (90,50>37) < AuNPG (90,50) )...
December 15, 2017: Biomedicines
https://www.readbyqxmd.com/read/29223058/discrimination-of-geographical-origin-and-detection-of-adulteration-of-kudzu-root-by-fluorescence-spectroscopy-coupled-with-multi-way-pattern-recognition
#9
Leqian Hu, Shuai Ma, Chunling Yin
In this work, fluorescence spectroscopy combined with multi-way pattern recognition techniques were developed for determining the geographical origin of kudzu root and detection and quantification of adulterants in kudzu root. Excitation-emission (EEM) spectra were obtained for 150 pure kudzu root samples of different geographical origins and 150 fake kudzu roots with different adulteration proportions by recording emission from 330 to 570nm with excitation in the range of 320-480nm, respectively. Multi-way principal components analysis (M-PCA) and multilinear partial least squares discriminant analysis (N-PLS-DA) methods were used to decompose the excitation-emission matrices datasets...
March 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29218115/erratum-preventive-effects-of-kudzu-root-on-bone-loss-and-cartilage-degradation-in-ovariectomized-rats
#10
Yunyun Luo, Shuang Zheng, Yujia Ding, Yueqin Dai, Yi Zhou, Ruifeng Xiang, Anne C Bay-Jensen, Morten A Karsdal, Per Qvist, Qinlong Zheng
[This corrects the article on p. 3517 in vol. 9, PMID: 28804568.].
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29029301/attractiveness-of-host-plants-at-different-growth-stage-to-kudzu-bug-megacopta-cribraria-heteroptera-plataspidae-behavioral-responses-to-whole-plant-and-constitutive-volatiles
#11
L Yang, X P Hu, E van Santen, X N Zeng
The kudzu bug, Megacopta cribraria (Fabricius), is an invasive pest of soybeans, Glycine max (L.) Merr., that has recently been detected in the United States. This study investigated whether there was a differential attraction of adult bugs to soybean growth stages, and whether the attraction was related to soybean constitutive volatiles. Greenhouse choice assays examined the behavioral orientation preference of adult bugs exposed to four growth stages of whole soybean plants: vegetative (V2), flowering (R1), pod (R3), and seed (R5)...
December 5, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028996/cold-tolerance-of-megacopta-cribraria-hemiptera-plataspidae-an-invasive-pest-of-soybeans
#12
Jessica I Grant, William O Lamp
Kudzu bug, Megacopta cribraria Fabricius (Hemiptera: Plataspidae), first discovered in the United States in 2009, is an invasive pest of soybeans. From 2013 to 2016, Maryland has been the northern limit of its distribution in the United States. We sought to determine the physiological cold temperature limits, timing of movement to overwintering locations, and to characterize overwintering microhabitat temperature. We measured supercooling point (SCP) on three populations from distinct USDA plant hardiness zones in Maryland and Virginia between October and December of 2015...
December 8, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29028992/spatial-distribution-of-megacopta-cribraria-hemiptera-plataspidae-adults-eggs-and-parasitism-by-paratelenomus-saccharalis-hymenoptera-platygastridae-in-soybean
#13
Ian A Knight, Phillip M Roberts, Wayne A Gardner, Kerry M Oliver, Francis P F Reay-Jones, Dominic D Reisig, Michael D Toews
Since 2014, populations of the kudzu bug, Megacopta cribraria (F.) (Hemiptera: Plataspidae), have declined in the southeastern United States and seldom require treatment. This decline follows the discovery of Paratelenomus saccharalis (Dodd; Hymenoptera: Platygastridae), a non-native egg parasitoid. The objective of this project was to observe the temporal and spatial dynamics of P. saccharalis parasitism of kudzu bug egg masses in commercial soybean fields. Four fields were sampled weekly for kudzu bugs and egg masses at a density of one sample per 0...
December 8, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28927631/formulation-and-characterization-of-o-w-emulsions-stabilized-using-octenyl-succinic-anhydride-modified-kudzu-starch
#14
Yiguo Zhao, Nauman Khalid, Gaofeng Shu, Marcos A Neves, Isao Kobayashi, Mitsutoshi Nakajima
Kudzu starch esterified with octenyl succinic anhydride (OSA) was used as a food-grade emulsifier to formulate O/W emulsions. In addition, the difference between the physicochemical properties and emulsifying ability of native kudzu starch and those of OSA-modified kudzu starch was investigated. Granules of the OSA-modified kudzu starches increased in size after gelatinization. The interfacial tension between soybean oil and gelatinized OSA-modified kudzu starch was lower than that of kudzu starch. The droplet size of O/W emulsions decreased to 186nm at 100MPa after three passes...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28898994/how-well-do-growing-season-dynamics-of-photosynthetic-capacity-correlate-with-leaf-biochemistry-and-climate-fluctuations
#15
Danielle A Way, Joseph R Stinziano, Henry Berghoff, Ram Oren
Accurate values of photosynthetic capacity are needed in Earth System Models to predict gross primary productivity. Seasonal changes in photosynthetic capacity in these models are primarily driven by temperature, but recent work has suggested that photoperiod may be a better predictor of seasonal photosynthetic capacity. Using field-grown kudzu (Pueraria lobata (Willd.) Ohwi), a nitrogen-fixing vine species, we took weekly measurements of photosynthetic capacity, leaf nitrogen, and pigment and photosynthetic protein concentrations and correlated these with temperature, irradiance and photoperiod over the growing season...
July 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28830209/puerarin-improves-vascular-insulin-resistance-and-cardiovascular-remodeling-in-salt-sensitive-hypertension
#16
Chunxiang Tan, Aimei Wang, Chan Liu, Yao Li, Yuepin Shi, Ming-Sheng Zhou
Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28807875/bioactive-isoflavones-from-pueraria-lobata-root-and-starch-different-extraction-techniques-and-carbonic-anhydrase-inhibition
#17
Andrei Mocan, Simone Carradori, Marcello Locatelli, Daniela Secci, Stefania Cesa, Adriano Mollica, Simona Riga, Andrea Angeli, Claudiu T Supuran, Christian Celia, Luisa Di Marzio
Kudzu, the dried root of an important edible plant (Pueraria lobata), is used in Traditional Chinese Medicine for the important nutritional value strictly related to its isoflavone derivatives. These compounds characterize the quality of kudzu contained in different preparations, as pharmaceutical ingredient as well as dietary/food supplement (e.g. starch). The optimization of the isoflavones recovery, monitored by HPLC-PDA, through different innovative and conventional extraction techniques, e.g. microwave-assisted, ultrasound-assisted and conventional extraction, represented a suitable challenge in food industry and natural products evaluation...
February 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28804568/preventive-effects-of-kudzu-root-on-bone-loss-and-cartilage-degradation-in-ovariectomized-rat
#18
Yunyun Luo, Shuang Zheng, Yujia Ding, Yueqin Dai, Yi Zhou, Ruifeng Xiang, Anne C Bay-Jensen, Morten A Karsdal, Per Qvist, Qinlong Zheng
The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28791618/boosting-isoprene-production-via-heterologous-expression-of-the-kudzu-isoprene-synthase-gene-kisps-into-bacillus-spp-cell-factory
#19
Lamis Gomaa, Michael E Loscar, Haggag S Zein, Nahed Abdel-Ghaffar, Abdelhadi A Abdelhadi, Ali S Abdelaal, Naglaa A Abdallah
Isoprene represents a key building block for the production of valuable materials such as latex, synthetic rubber or pharmaceutical precursors and serves as basis for advanced biofuel production. To enhance the production of the volatile natural hydrocarbon isoprene, released by plants, animals and bacteria, the Kudzu isoprene synthase (kIspS) gene has been heterologously expressed in Bacillus subtilis DSM 402 and Bacillus licheniformis DSM 13 using the pHT01 vector. As control, the heterologous expression of KIspS in E...
August 8, 2017: AMB Express
https://www.readbyqxmd.com/read/28705501/morphology-crystallinity-pasting-thermal-and-quality-characteristics-of-starches-from-adzuki-bean-vigna-angularis-l-and-edible-kudzu-pueraria-thomsonii-benth
#20
Chagam Koteswara Reddy, Fei Luan, Baojun Xu
Starches were isolated from adzuki bean (Vigna angularis L.) and edible kudzu (Pueraria thomsonii Benth) and investigated for their physico-chemical, morphological, pasting, crystallinity, thermal and FT-IR spectroscopic characteristics. Statistical analysis of physico-chemical and functional characteristics showed significant (p<0.05) difference between isolated starches from adzuki bean and edible kudzu. The XRD pattern of starches from adzuki bean and edible kudzu showed A-type with reflections (2θ) at 15...
December 2017: International Journal of Biological Macromolecules
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