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M A Ahmad, A K Najmi, M Mujeeb, M Akhtar
AIM: The role of guggulipid was evaluated in high fat diet and middle cerebral artery occlusion (MCAO) induced ischemic cerebral dysfunctions in rats of either sex. MATERIALS AND METHODS: Ethyl acetate extract of guggul known as guggulipid was prepared and administered to rats. Animals were divided into 9 groups, consisting 6 rats, each receiving different treatments per orally for 8 weeks. Control group rats received normal control diet while rest of the other groups animals were fed high fat diet (HFD) for 8 weeks...
August 2016: Drug Research
Vishnu Kumar Awasthi, Farzana Mahdi, Ramesh Chander, Ashok Kumar Khanna, Jitendra Kumar Saxena, Ranjana Singh, Abbas Ali Mahdi, Raj Kumar Singh
The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of Triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats. Feeding with C. tora seed extract at the dose of 500 mg/kg, b.w. exerted significant lipid lowering effect as assessed by the reversal of plasma levels of total cholesterol, phospholipids, triglyceride and reactivation of post heparin lipolytic activity...
January 2015: Indian Journal of Clinical Biochemistry: IJCB
M V Mithila, Farhath Khanum
Guggulsterone or guggulipid is a steroidal constituent present in the neutral fraction of gum resin of Commiphora mukul, commonly known as guggul. The traditional uses of guggul-resin extract are well documented in the Ayurveda-where it is prescribed to treat a variety of ailments including lipid-related disorders such as obesity and arteriosclerosis. The hypolipidemic activity of the extracts known since ancient times can be traced to the two closely related steroidal ketones, E-guggulsterone and Z-guggulsterone...
September 2014: Journal of Dietary Supplements
Mohd Afroz Ahmad, Abul Kalam Najmi, Mohd Mujeeb, Mohd Akhtar
This study was designed to test the pre-treatment doses of guggulipid (50 mg/kg), aspirin (100 mg/kg) per orally and co-administration of both drugs for 28 days followed by middle cerebral artery occlusion - a model of focal cerebral ischemia in rats. Middle cerebral artery was occluded for two hours, followed by reperfusion for 22 hours for the induction of focal cerebral ischemia in rats. Neurobehavioral tests like locomotor activity and grip strength tests were performed before sacrificing the animal...
September 2014: Toxicology Mechanisms and Methods
Rituraj Niranjan, Rajasekar Nagarajan, Kashif Hanif, Chandishwar Nath, Rakesh Shukla
Neuroinflammation has been considered to be an integrated part of human neurodegenerative diseases. In this study, we examined the effect of guggulipid on cell proliferation, nitrite release, interleukin IL-6 and IL-1 beta release, and expression of COX-2 and glial fibrillary acidic protein (GFAP) in LPS-stimulated U373MG cells. LPS significantly stimulated human astrocytoma cells U373MG by up-regulating these neuroinflammatory mediators. Guggulipid alone had no effect on the cell proliferation of U373MG cells...
March 2014: Neurological Sciences
Sachin Goyal, Gurudas Khilnani, Indrajeet Singhvi, Shivali Singla, Ajeet K Khilnani
CONTEXT: Guggulipid is a neutral fraction of ethyl acetate extract of gum resin of the tree Commiphora mukul Engl. (Burseraceae) and used in Ayurvedic medicine for treatment of neurological disorders. OBJECTIVES: The present study was undertaken to assess the antiallodynic and antihyperalgesic activities of guggulipid in rats. MATERIALS AND METHODS: The screening study included the CCI and L5-L6 SNL models of neuropathic pain. Guggulipid (100 and 50 mg/kg) or saline was administered intraperitoneally in a blinded, randomized manner from postoperative day (POD) 7 to 13...
December 2013: Pharmaceutical Biology
Rituraj Niranjan, N Rajasekar, Chandishwar Nath, Rakesh Shukla
Oxidative stress plays an important role in the pathophysiology of Parkinson's disease (PD) but its mechanism is still not properly explored. Cyclooxygenase-2 (COX-2) inhibition has also been known a major neuroprotective strategy in the various 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) induced models of Parkinson's disease (PD) but its role in astrocytes is still not properly understood. The present study demonstrated that, guggulipid and nimesulide (preferentially selective COX-2 inhibitor) treatment of rat astrocytoma cells, C6 for 24 h significantly decreased MPTP (400 μM) induced nitrative and oxidative stress and intracellular calcium ion (Ca(2+)) level...
December 5, 2012: Chemico-biological Interactions
Jingbo Huang, Jiri Frohlich, Andrew P Ignaszewski
With a growing number of dietary interventions that claim to improve lipid profile, it is important to ensure that these claims are evidence based. The objective of this study was to make recommendations for dietary regimens by analyzing their effectiveness and the level of evidence. We searched MEDLINE as well as the Cochrane Database of Systematic Reviews for nutritional studies. Meta-analyses and randomized controlled trials published in English and including data on the effect on blood lipid levels were used...
July 2011: Canadian Journal of Cardiology
Syed Ghulam Musharraf, Naveed Iqbal, Umair Gulzar, Azhar Ali, Muhammad Iqbal Choudhary, Atta-Ur-Rahman
A high performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of the hypolipidemic agents, E- and Z-isomers of guggulsterone in Commiphora mukul resin, guggulipid (ethyl acetate extract of resin), and its pharmaceutical formulation, was developed. The developed system was efficient enough to separate both isomers from their conger, 17,20-dihydroguggulsterone. HPTLC glass plates, pre-coated with silica gel 60F-254, were used as a stationary phase. The mobile phase consisted of toluene:acetone (9...
September 10, 2011: Journal of Pharmaceutical and Biomedical Analysis
Rituraj Niranjan, Chandishwar Nath, Rakesh Shukla
Neuroinflammation is an integral part of neurodegenerative diseases. Lipo-polysacharide (LPS) induces reactive astrogliosis, the cellular manifestation of neuroinflammation, in various models of neurological diseases, but its mechanism of action is still not properly known. The effect of guggulipid and nimesulide on LPS-induced neuroinflammatory changes is also not properly understood. This work demonstrated the mechanism of actions of guggulipid and nimesulide on inflammatory genes expressions in LPS-stimulated rat astrocytoma cells, C6...
July 2011: Cellular and Molecular Neurobiology
Rebecca J Leeman-Neill, Raja R Seethala, Shivendra V Singh, Maria L Freilino, Joseph S Bednash, Sufi M Thomas, Mary C Panahandeh, William E Gooding, Sonali C Joyce, Mark W Lingen, Daniel B Neill, Jennifer R Grandis
Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal. The epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription (STAT)-3 signaling pathway is known to play a key role in HNSCC growth, survival, and prognosis, thereby serving as a potential therapeutic target in the treatment of HNSCC. In the current study, the 4-nitroquinoline-1-oxide (4-NQO)-induced murine model of oral carcinogenesis was utilized to investigate the chemopreventive activities of compounds that target the EGFR-STAT3 signaling pathway...
February 2011: Cancer Prevention Research
Takanori Yamada, Satoshi Osawa, Yasushi Hamaya, Takahisa Furuta, Akira Hishida, Masayoshi Kajimura, Mutsuhiro Ikuma
BACKGROUND: Guggulsterone, a plant polyphenol guggulipid, has several antitumour effects and acts as an antagonist for the farnesoid X receptor. Although bile acids induce caudal-related homeobox 2 (CdX2), a transcription factor essential for intestinal development and gut tumourigenesis, the effects of guggulsterone on regulation of CdX2 in the gut are unknown. MATERIALS AND METHODS: Regulation of CdX2 expression by treatment with bile acids and/or guggulsterone was analysed by immunoblot analysis in human gut-derived adenocarcinoma, Bic-1 cells...
June 2010: Anticancer Research
Vishnu Kumar, Pradyumn Singh, Ramesh Chander, Farzana Mahdi, Sushma Singh, Ranjana Singh, Ashok Kumar Khanna, Jitendra Kumar Saxena, Abbas Ali Mahdi, Vinod Kumar Singh
The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p...
December 2009: Indian Journal of Biochemistry & Biophysics
Rituraj Niranjan, Pradeep Kumar Kamat, Chandishwar Nath, Rakesh Shukla
AIM OF THE STUDY: The present study was designed to investigate effect of guggulipid, a drug developed by CDRI and nimesulide on LPS stimulated neuroinflammatory changes in rat astrocytoma cell line (C6). MATERIALS AND METHODS: Rat astrocytoma cells (C6) were stimulated with LPS (10 microg/ml) alone and in combinations with different concentrations of guggulipid or nimesulide for 24h of incubation. Nitrite release in culture supernatant, ROS in cells, expressions of COX-2, GFAP and TNF-alpha in cell lysate were estimated...
February 17, 2010: Journal of Ethnopharmacology
Mary P McGowan, Suzanne Proulx
Hyperlipidemia is a risk factor for the development of coronary heart disease. Many patients decline prescription lipid-lowering agents and opt instead for supplements. Before any supplement can be routinely recommended it is crucial to examine the types of clinical trials that have been performed, the mechanism by which a supplement is felt to alter lipids, the population studied, potential adverse effects, and the possibility that investigators might be biased. Clinical trial evidence strongly supports the notion that both red yeast rice and plant stanols and sterols effectively lower low-density lipoprotein (LDL) cholesterol...
November 2009: Current Atherosclerosis Reports
Rebecca J Leeman-Neill, Sarah E Wheeler, Shivendra V Singh, Sufi M Thomas, Raja R Seethala, Daniel B Neill, Mary C Panahandeh, Eun-Ryeong Hahm, Sonali C Joyce, Malabika Sen, Quan Cai, Maria L Freilino, Changyou Li, Daniel E Johnson, Jennifer R Grandis
Treatment of human head and neck squamous cell carcinoma (HNSCC) cell lines with guggulsterone, a widely available, well-tolerated nutraceutical, demonstrated dose-dependent decreases in cell viability with EC(50)s ranging from 5 to 8 microM. Guggulsterone induced apoptosis and cell cycle arrest, inhibited invasion and enhanced the efficacy of erlotinib, cetuximab and cisplatin in HNSCC cell lines. Guggulsterone induced decreased expression of both phosphotyrosine and total signal transducer and activator of transcription (STAT)-3, which contributed to guggulsterone's growth inhibitory effect...
November 2009: Carcinogenesis
Claire L Cornick, Barbara H Strongitharm, Gary Sassano, Christopher Rawlins, Andrew E Mayes, Alison N Joseph, Jacqueline O'Dowd, Claire Stocker, Ed Wargent, Michael A Cawthorne, A Louise Brown, Jonathan R S Arch
The ethyl acetate extract of the gum of the guggul tree, Commiphora mukul (guggulipid), is marketed for the treatment of dyslipidaemia and obesity. We have found that it protects Lep(ob)/Lep(ob) mice from diabetes and have investigated possible molecular mechanisms for its metabolic effects, in particular those due to a newly identified component, commipheric acid. Both guggulipid (EC(50)=0.82 microg/ml) and commipheric acid (EC(50)=0.26 microg/ml) activated human peroxisome proliferator-activated receptor alpha (PPARalpha) in COS-7 cells transiently transfected with the receptor and a reporter gene construct...
October 2009: Journal of Nutritional Biochemistry
Jeong-Yeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Suresh Ambati, Clifton A Baile
Genistein (G), an isoflavone, and guggulsterone (GS), the active substance in guggulipid, have been reported to possess therapeutic effects for obesity. In the present study, we investigated the effects of combinations of G plus GS on apoptosis and adipogenesis in 3T3-L1 cells. In mature adipocytes, G and GS individually caused apoptosis, but combination of G plus GS significantly increased apoptosis, more than either compound alone. Furthermore, G plus GS caused a greater increase in procaspase-3 cleavage, Bax expression, cytochrome c release, and proteolytic cleavage of PARP than either compound alone...
2007: BioFactors
Jeong-Yeh Yang, Mary Anne Della-Fera, Clifton A Baile
OBJECTIVE: To determine the effects of guggulsterone (GS), the active substance in guggulipid, on apoptosis, adipogenesis, and lipolysis using 3T3-L1 cells. METHODS AND PROCEDURES: For apoptosis and lipolysis experiments, mature adipocytes were treated with GS isomers. Viability, apoptosis, and caspase 3/7 activation were quantified using MTS, enzyme-linked immunosorbent assay (ELISA), caspase-Glo 3/7 activity assay, respectively. The expression of cytochrome c was demonstrated by western blot...
January 2008: Obesity
Leslie K Nies, Alicia A Cymbala, Sheila L Kasten, Donald G Lamprecht, Kari L Olson
OBJECTIVE: To review the literature on select alternative therapies for the management of dyslipidemia. DATA SOURCES: Searches of MEDLINE and PubMed (1965-March 2006) were conducted using the key terms omega-3-fatty acids, policosanol, plant stanols and sterols, flaxseed, red yeast rice, guggulipid, garlic, fiber, almonds, and cholesterol and/or lipids. STUDY SELECTION AND DATA EXTRACTION: Meta-analyses, published in English and involving adults, that incorporated randomized, controlled trials on alternative therapies for dyslipidemia were reviewed...
November 2006: Annals of Pharmacotherapy
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