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https://www.readbyqxmd.com/read/28324887/association-between-hypoxic-volume-and-underlying-hypoxia-induced-gene-expression-in-oropharyngeal-squamous-cell-carcinoma
#1
Yae-Eun Suh, Katherine Lawler, Rhonda Henley-Smith, Lucy Pike, Russell Leek, Sally Barrington, Edward W Odell, Tony Ng, Francesco Pezzella, Teresa Guerrero-Urbano, Mahvash Tavassoli
BACKGROUND: Hypoxia imaging is a promising tool for targeted therapy but the links between imaging features and underlying molecular characteristics of the tumour have not been investigated. The aim of this study was to compare hypoxia biomarkers and gene expression in oropharyngeal squamous cell carcinoma (OPSCC) diagnostic biopsies with hypoxia imaged with (64)Cu-ATSM PET/CT. METHODS: (64)Cu-ATSM imaging, molecular and clinical data were obtained for 15 patients...
March 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28290475/the-development-of-loop-mediated-isothermal-amplification-lamp-assays-for-the-rapid-authentication-of-five-forbidden-vegetables-in-strict-vegetarian-diets
#2
Meng-Shiou Lee, Ting-Ying Su, Yi-Yang Lien, Shyang-Chwen Sheu
Plant-based food ingredients such as garlic, Chinese leek, Chinese onion, green onion and onion are widely used in many cuisines around the world. However, these ingredients known as the "five forbidden vegetables" (FFVs) are not allowed in some vegetarian diets. In this study, a loop-mediated isothermal amplification (LAMP) assay was developed for the detection of FFVs using five respective LAMP primer sets. The specific primers targeted the ITS1-5.8S-ITS2 nuclear ribosomal DNA sequence regions among the five vegetables...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276920/getting-men-in-the-room-perceptions-of-effective-strategies-to-initiate-men-s-involvement-in-gender-based-violence-prevention-in-a-global-sample
#3
Erin A Casey, Cliff Leek, Richard M Tolman, Christopher T Allen, Juliana M Carlson
As engaging men in gender-based violence prevention efforts becomes an increasingly institutionalised component of gender equity work globally, clarity is needed about the strategies that best initiate male-identified individuals' involvement in these efforts. The purpose of this study was to examine the perceived relevance and effectiveness of men's engagement strategies from the perspective of men around the world who have organised or attended gender-based violence prevention events. Participants responded to an online survey (available in English, French and Spanish) and rated the effectiveness of 15 discrete engagement strategies derived from earlier qualitative work...
February 21, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28253644/erratum-concurrent-measures-of-contralateral-suppression-of-transient-evoked-otoacoustic-emissions-and-of-auditory-steady-state-responses-j-acoust-soc-am-140-3-2027-2038-2016
#4
Ian B Mertes, Marjorie R Leek
No abstract text is available yet for this article.
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28194188/primum-non-nocere-first-do-no-harm-and-then-feed-peanut
#5
Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P Mack, Linda Kirste, Christine McCusker, Sandeep Kapur
The Addendum Guidelines for the Prevention of Peanut Allergy in the United States-Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early about Peanut (LEAP), LEAP-On and Enquiring about Tolerance trials created a paradigm shift in food allergy prevention. The "take home" messages of this guideline include that peanut should be introduced early in the first year of life, and for the majority of infants, peanut can be introduced at home...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28186805/simultaneous-bistability-of-a-qubit-and-resonator-in-circuit-quantum-electrodynamics
#6
Th K Mavrogordatos, G Tancredi, M Elliott, M J Peterer, A Patterson, J Rahamim, P J Leek, E Ginossar, M H Szymańska
We explore the joint activated dynamics exhibited by two quantum degrees of freedom: a cavity mode oscillator which is strongly coupled to a superconducting qubit in the strongly coherently driven dispersive regime. Dynamical simulations and complementary measurements show a range of parameters where both the cavity and the qubit exhibit sudden simultaneous switching between two metastable states. This manifests in ensemble averaged amplitudes of both the cavity and qubit exhibiting a partial coherent cancellation...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28172893/p297-fecal-calprotectin-accurately-predicts-symptomatic-relapse-in-children-and-adolescents-with-inflammatory-bowel-disease-in-clinical-remission
#7
K Diederen, D Hoekman, A Leek, V Wolters, M Benninga, T Hummel, T de Meij, B Koot, M Tabbers, M Benninga, A Kindermann
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28171598/widespread-splicing-of-repetitive-element-loci-into-coding-regions-of-gene-transcripts
#8
Miranda M Darby, Jeffrey T Leek, Ben Langmead, Robert H Yolken, Sarven Sabunciyan
No abstract text is available yet for this article.
November 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28144174/an-early-record-of-meloidogyne-fallax-from-ireland
#9
Olivera Topalović, John F Moore, Toon Janssen, Wim Bert, Gerrit Karssen
Root-knot nematodes, Meloidogyne spp., cause huge economic losses worldwide. Currently, three Meloidogyne spp. are present on the quarantine A2 list of EPPO, Meloidogyne chitwoodi, Meloidogyne fallax and Meloidogyne enterolobii. As a quarantine organism, Meloidogyne fallax has been detected in England and Northern Ireland on sport turf in 2011, and in England on leek in 2013. However, its presence in Ireland has probably been overlooked since 1965, when Mr. John F. Moore and Dr. Mary T. Franklin had detected a new Meloidogyne species for that time...
2017: ZooKeys
https://www.readbyqxmd.com/read/28138990/raised-faecal-calprotectin-is-associated-with-subsequent-symptomatic-relapse-in-children-and-adolescents-with-inflammatory-bowel-disease-in-clinical-remission
#10
K Diederen, D R Hoekman, A Leek, V M Wolters, T Z Hummel, T G de Meij, B G P Koot, M M Tabbers, M A Benninga, A Kindermann
BACKGROUND: Reliable data on inflammatory biomarkers for predicting relapse of paediatric inflammatory bowel disease (IBD) are lacking. AIM: To investigate the predictive value of faecal calprotectin (FC) and CRP for symptomatic relapse in pediatric IBD in clinical remission. METHODS: In this cross-sectional cohort study, patients <18 years with Crohn's disease or ulcerative colitis in clinical remission ≥3 months were included. At baseline, clinical and biochemical disease activity were assessed using the abbreviated-Pediatric Crohn's Disease Activity Index or Pediatric Ulcerative Colitis Activity Index, and FC and CRP respectively...
January 31, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28134423/tobacco-chewing-and-risk-of-gastric-cancer-a-case-control-study-in-yemen
#11
F A Al-Qadasi, S A Shah, H F Ghazi
This study aimed to assess the risk factors for gastric cancer in Yemen. A hospital-based case-control study of 70 cases and 140 controls was carried out in Sana'a city between May and October 2014. A structured questionnaire was used to collect information through direct interview. Living in rural areas, tobacco chewing and drinking untreated water were significant risk factors for gastric cancer. Frequent consumption of chicken, cheese, milk, starchy vegetables, cucumber, carrots, leeks, sweet pepper, fruit drinks, legumes and olive oil were associated significantly with decreased risk of gastric cancer...
January 23, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28107356/integrity-of-induced-pluripotent-stem-cell-ipsc-derived-megakaryocytes-as-assessed-by-genetic-and-transcriptomic-analysis
#12
Kai Kammers, Margaret A Taub, Ingo Ruczinski, Joshua Martin, Lisa R Yanek, Alyssa Frazee, Yongxing Gao, Dixie Hoyle, Nauder Faraday, Diane M Becker, Linzhao Cheng, Zack Z Wang, Jeff T Leek, Lewis C Becker, Rasika A Mathias
Previously, we have described our feeder-free, xeno-free approach to generate megakaryocytes (MKs) in culture from human induced pluripotent stem cells (iPSCs). Here, we focus specifically on the integrity of these MKs using: (1) genotype discordance between parent cell DNA to iPSC cell DNA and onward to the differentiated MK DNA; (2) genomic structural integrity using copy number variation (CNV); and (3) transcriptomic signatures of the derived MK lines compared to the iPSC lines. We detected a very low rate of genotype discordance; estimates were 0...
2017: PloS One
https://www.readbyqxmd.com/read/28106796/preparative-scale-resolution-of-enantiomers-enables-accelerated-drug-discovery-and-development
#13
Hanna Leek, Shalini Andersson
The provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agro-chemistry and biotechnology. In drug discovery and development, the enantiomers of a chiral drug depict unique chemical and pharmacological behaviors in a chiral environment, such as the human body, in which the stereochemistry of the chiral drugs determines their pharmacokinetic, pharmacodynamic and toxicological properties. We present a number of challenging case studies of up-to-kilogram separations of racemic or enriched isomer mixtures using preparative liquid chromatography and super critical fluid chromatography to generate individual enantiomers that have enabled the development of new candidate drugs within AstraZeneca...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28038678/human-splicing-diversity-and-the-extent-of-unannotated-splice-junctions-across-human-rna-seq-samples-on-the-sequence-read-archive
#14
Abhinav Nellore, Andrew E Jaffe, Jean-Philippe Fortin, José Alquicira-Hernández, Leonardo Collado-Torres, Siruo Wang, Robert A Phillips Iii, Nishika Karbhari, Kasper D Hansen, Ben Langmead, Jeffrey T Leek
BACKGROUND: Gene annotations, such as those in GENCODE, are derived primarily from alignments of spliced cDNA sequences and protein sequences. The impact of RNA-seq data on annotation has been confined to major projects like ENCODE and Illumina Body Map 2.0. RESULTS: We aligned 21,504 Illumina-sequenced human RNA-seq samples from the Sequence Read Archive (SRA) to the human genome and compared detected exon-exon junctions with junctions in several recent gene annotations...
December 30, 2016: Genome Biology
https://www.readbyqxmd.com/read/27999077/analysis-of-dithiocarbamate-fungicides-in-vegetable-matrices-using-hplc-uv-followed-by-atomic-absorption-spectrometry
#15
Josephine Al-Alam, Laura Bom, Asma Chbani, Ziad Fajloun, Maurice Millet
A simple method combining ion-pair methylation, high-performance liquid chromatography (HPLC) analysis with detection at 272 nm and atomic absorption spectrometry was developed in order to determine 10 dithiocarbamate fungicides (Dazomet, Metam-sodium, Ferbam, Ziram, Zineb, Maneb, Mancozeb, Metiram, Nabam and Propineb) and distinguish ethylenbisdithiocarbamates (EBDTCs) Zineb, Maneb and Mancozeb in diverse matrices. This method associates reverse phase analysis by HPLC analysis with detection at 272 nm, with atomic absorption spectrometry in order to distinguish, with the same extraction protocol, Maneb, Mancozeb and Zineb...
December 19, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27998093/cucurbit-7-uril-tetramethylrhodamine-conjugate-for-direct-sensing-and-cellular-imaging
#16
Andrew T Bockus, Lauren C Smith, Amy G Grice, Omar A Ali, Carolyn C Young, William Mobley, Ashley Leek, James L Roberts, Brittany Vinciguerra, Lyle Isaacs, Adam R Urbach
This paper describes the design and synthesis of a conjugate (Q7R) comprising the synthetic host cucurbit[7]uril (Q7) linked to the fluorescent dye tetramethylrhodamine (TMR), and the characterization of its optical and guest-binding properties as well as its cellular uptake. Q7R was synthesized in two steps from monofunctionalized azidobutyl-Q7 and NHS-activated TMR. The fluorescence of Q7R is quenched upon guest binding, and this observable was used to determine equilibrium dissociation constant (Kd) values...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27979194/a-strategy-for-the-evaluation-of-an-analytical-approach-for-selected-pesticide-residues-in-complex-agricultural-product-matrices-a-case-study-of-leek
#17
Yanyan Xu, Ninghui Song, Qin Zhang, Jining Liu, Guosong Chen, Lili Shi, Jikui Wang
In order to choose a sensitive, selective, simple, rapid, cost-effective and reliable analytical method for a given complex sample, a strategy was proposed for the evaluation of an analytical approach to determining multi-pesticide residue in complex agricultural product matrices, using leek as an example. In this work, the matrix effect of most of pesticides were in the range of -50% to -90%. A simple thin layer chromatography (TLC) was used to evaluate the effect of cleanup. The results agree well with that of matrix effect described above...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27979090/a-study-on-biomimetic-immunoassay-capillary-electrophoresis-method-based-on-molecularly-imprinted-polymer-for-determination-of-trace-trichlorfon-residue-in-vegetables
#18
Jie Li, Juxiu Lu, Xuguang Qiao, Zhixiang Xu
Pesticide residue in vegetables is a serious problem that has adverse effects on human health. In our study, we designed and synthesized a molecularly imprinted polymer that can selectively recognize trichlorfon. Using the polymer material as biomimetic antibody, we developed a biomimetic immunoassay-capillary electrophoresis method with improved sensitivity for the detection of trichlorfon. We evaluated the competitive reactions between HRP labeled trichlorfon hapten and free trichlorfon with the biomimetic antibody...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27955886/generation-characterization-and-reuse-of-solid-wastes-from-a-biodiesel-production-plant
#19
Fernando Jorge Santos Oliveira, Daniele Dos Santos Santana, Simone Soraya Brito Costa, Lenise Diniz Oliveira, Vitor Silva Liduino, Eliana Flávia Camporese Servulo
The aim of this study was to identify and characterize industrial solid wastes generated by a biodiesel production plant in Brazil, as well as to present strategies for the management of these materials. This plant produces every year around 100,000tons of biodiesel from vegetable oils and animal fats. The methodology of the study included technical visits, interviews with the operational and environmental management staff as well as analysis of documents, reports and computerized data systems. An approach to reduce the generation of hazardous waste was investigated...
December 7, 2016: Waste Management
https://www.readbyqxmd.com/read/27914370/concurrent-measures-of-contralateral-suppression-of-transient-evoked-otoacoustic-emissions-and-of-auditory-steady-state-responses
#20
Ian B Mertes, Marjorie R Leek
Contralateral suppression of otoacoustic emissions (OAEs) is frequently used to assess the medial olivocochlear (MOC) efferent system, and may have clinical utility. However, OAEs are weak or absent in hearing-impaired ears, so little is known about MOC function in the presence of hearing loss. A potential alternative measure is contralateral suppression of the auditory steady-state response (ASSR) because ASSRs are measurable in many hearing-impaired ears. This study compared contralateral suppression of both transient-evoked otoacoustic emissions (TEOAEs) and ASSRs in a group of ten primarily older adults with either normal hearing or mild sensorineural hearing loss...
September 2016: Journal of the Acoustical Society of America
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