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https://www.readbyqxmd.com/read/28445154/role-of-delta-like-4-in-jagged1-induced-tumour-angiogenesis-and-tumour-growth
#1
Chern Ein Oon, Esther Bridges, Helen Sheldon, Richard C A Sainson, Adrian Jubb, Helen Turley, Russell Leek, Francesca Buffa, Adrian L Harris, Ji-Liang Li
Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands are upregulated but their relative effects and interactions in tumour biology, particularly in tumour response to therapeutic intervention are unclear. Here we demonstrate that DLL4 and JAG1 displayed equal potency in stimulating Notch target genes in HMEC-1 endothelial cells but had opposing effects on sprouting angiogenesis in vitro...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28435350/effects-of-arbuscular-mycorrhizal-fungi-and-soil-conditions-on-crop-plant-growth
#2
Sang Joon Kim, Ju-Kyeong Eo, Eun-Hwa Lee, Hyeok Park, Ahn-Heum Eom
We investigated the effects on various crops of inoculation with species of arbuscular mycorrhizal fungi (AMF) in soils from different sources and selected AMF species suitable for domestic environment-friendly farming. Effects on plants varied with the AMF species used. In carrot, Scutellospora heterogama, Acaulospora longula, and Funneliformis mosseae had a positive effect on growth of the host, whereas AMF had only weak effects on the growth of red pepper and leek. AMF inoculation had positive effects on the growth of carrot and sorghum...
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28434710/shifting-the-paradigm-in-gas-chromatography-mass-spectrometry-pesticide-analysis-using-high-resolution-accurate-mass-spectrometry
#3
S Uclés, A Uclés, A Lozano, M J Martínez Bueno, A R Fernández-Alba
In the last 10 years, the majority of the pesticide food control laboratories moved from GC-MS to GC-MS/MS as the preferred analytical technique to address GC amenable compounds. The main reason for this change was the negative impact on the single stage GC-MS analysis caused by the interference from coeluting matrix compounds. The new development of gas chromatography coupled to high resolution accurate mass spectrometry (GC-HRAMS) provides opportunities to overcome such matrix interferences as a result of its much higher selectivity; allowing laboratories to carry out full-scan analysis covering the most exigent analytical performance criteria...
April 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28426177/an-efficient-cleanup-method-coupled-with-gas-chromatography-and-mass-spectrometry-for-multi-pesticides-residue-analysis-in-complex-plant-matrices
#4
Xinquan Wang, Peipei Qi, Xiangyun Wang, Qian Zhang, Zhiwei Wang, Xiahong Xu, Hao Xu, Hu Zhang, Qiang Wang
We aimed to develop an efficient cleanup method for multi-pesticides residue analysis in complex plant matrices, shallot, ginger, garlic, onion, leek and celery. Column chromatography was used as the cleanup method and fabricated with florisil and graphitized carbon black as the adsorbents. The amount of the graphitized carbon black adsorbent and the choice of the elution solvent were systematically investigated for exploring the best combination. The target pesticides covered organochlorine, pyrethroid and organophosphorus pesticides, and were 38 in total...
April 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28402916/potential-of-chopped-heath-biomass-and-spent-growth-media-to-replace-wood-chips-as-bulking-agent-for-composting-high-n-containing-residues
#5
J Viaene, B Reubens, K Willekens, C Van Waes, S De Neve, B Vandecasteele
We investigated the potential of C-rich byproducts to replace wood chips as bulking agent (BA) during composting. The impact of these alternatives on the composting process and on compost stability and characteristics was assessed. Three BA (chopped heath biomass and spent growth media used in strawberry and tomato cultivation) were used for processing leek residues in windrow composting. All BA resulted in stable composts with an organic matter (OM) content suitable for use as soil amendment. Using chopped heath biomass led to high pile temperatures and OM degradation and a nutrient-poor compost with high C/P ratio appropriate for increasing soil organic carbon content in P-rich soils...
April 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28400006/microbiological-quality-of-selected-ready-to-eat-leaf-vegetables-sprouts-and-non-pasteurized-fresh-fruit-vegetable-juices-including-the-presence-of-cronobacter-spp
#6
Anna Berthold-Pluta, Monika Garbowska, Ilona Stefańska, Antoni Pluta
Bacteria of the genus Cronobacter are emerging food-borne pathogens. Foods contaminated with Cronobacter spp. may pose a risk to infants or adults with suppressed immunity. This study was aimed at determining the microbiological quality of ready-to-eat (RTE) plant-origin food products available on the Polish market with special emphasis on the prevalence of Cronobacter genus bacteria. Analyses were carried out on 60 samples of commercial RTE type plant-origin food products, including: leaf vegetables (20 samples), sprouts (20 samples) and non-pasteurized vegetable, fruit and fruit-vegetable juices (20 samples)...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28398307/reproducible-rna-seq-analysis-using-recount2
#7
Leonardo Collado-Torres, Abhinav Nellore, Kai Kammers, Shannon E Ellis, Margaret A Taub, Kasper D Hansen, Andrew E Jaffe, Ben Langmead, Jeffrey T Leek
No abstract text is available yet for this article.
April 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28368017/risk-assessment-of-candidatus-liberibacter-solanacearum-transmission-by-the-psyllids-bactericera-trigonica-and-b-tremblayi-from-apiaceae-crops-to-potato
#8
C A Antolinez, A Fereres, A Moreno
Candidatus Liberibacter solanacearum (Lso) is bacterium transmitted by psyllids to Solanaceae and Apiaceae plants. So far, Lso is found in Europe affecting Apiaceae. In the Mediterranean region, Bactericera trigonica is the only known vector of Lso, but the leek-onion psyllid Bactericera tremblayi is another widespread psyllid and potential vector of Lso. Commonly, carrot, leek and potato are cultivated in the same zones and it is uncertain if these psyllid species are able to transmit Lso to potato plants...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28366564/systematic-investigations-of-peak-deformations-due-to-co-solvent-adsorption-in-preparative-supercritical-fluid-chromatography
#9
Emelie Glenne, Hanna Leek, Magnus Klarqvist, Jörgen Samuelsson, Torgny Fornstedt
Strangely shaped overloaded bands were recently reported using a standard supercritical fluid chromatographic system comprising a diol column as the stationary phase and carbon dioxide with methanol as the mobile phase. Some of these overloaded elution profiles appeared strongly deformed and even had "anti-Langmuirian" shapes although their solute compounds had "Langmuirian" adsorption. To obtain a more complete understanding of the generality of these effects, the investigation was expanded to cover also other common co-solvents, such as ethanol, 2-propanol, and acetonitrile, as well as various stationary phase materials, such as silica, and 2-ethylpyridine...
March 22, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28363419/the-importance-of-ion-pairing-in-peptide-purification-by-reversed-phase-liquid-chromatography
#10
Dennis Åsberg, Annika Langborg Weinmann, Tomas Leek, Richard J Lewis, Magnus Klarqvist, Marek Leśko, Krzysztof Kaczmarski, Jörgen Samuelsson, Torgny Fornstedt
The adsorption mechanism for three peptides was studied under overloaded conditions through adsorption isotherm measurements in the presence of an ion-pairing reagent, trifluoroacetic acid (TFA), on an end-capped C18-bonded stationary phase. The overall aim of the study was to obtain a better understanding of how the acetonitrile and the TFA fractions in the eluent affected the overloaded elution profiles and the selectivity between peptides using mechanistic modelling and multivariate design of experiments...
March 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28324887/association-between-hypoxic-volume-and-underlying-hypoxia-induced-gene-expression-in-oropharyngeal-squamous-cell-carcinoma
#11
Yae-Eun Suh, Katherine Lawler, Rhonda Henley-Smith, Lucy Pike, Russell Leek, Sally Barrington, Edward W Odell, Tony Ng, Francesco Pezzella, Teresa Guerrero-Urbano, Mahvash Tavassoli
BACKGROUND: Hypoxia imaging is a promising tool for targeted therapy but the links between imaging features and underlying molecular characteristics of the tumour have not been investigated. The aim of this study was to compare hypoxia biomarkers and gene expression in oropharyngeal squamous cell carcinoma (OPSCC) diagnostic biopsies with hypoxia imaged with (64)Cu-ATSM PET/CT. METHODS: (64)Cu-ATSM imaging, molecular and clinical data were obtained for 15 patients...
April 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28290475/the-development-of-loop-mediated-isothermal-amplification-lamp-assays-for-the-rapid-authentication-of-five-forbidden-vegetables-in-strict-vegetarian-diets
#12
Meng-Shiou Lee, Ting-Ying Su, Yi-Yang Lien, Shyang-Chwen Sheu
Plant-based food ingredients such as garlic, Chinese leek, Chinese onion, green onion and onion are widely used in many cuisines around the world. However, these ingredients known as the "five forbidden vegetables" (FFVs) are not allowed in some vegetarian diets. In this study, a loop-mediated isothermal amplification (LAMP) assay was developed for the detection of FFVs using five respective LAMP primer sets. The specific primers targeted the ITS1-5.8S-ITS2 nuclear ribosomal DNA sequence regions among the five vegetables...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276920/getting-men-in-the-room-perceptions-of-effective-strategies-to-initiate-men-s-involvement-in-gender-based-violence-prevention-in-a-global-sample
#13
Erin A Casey, Cliff Leek, Richard M Tolman, Christopher T Allen, Juliana M Carlson
As engaging men in gender-based violence prevention efforts becomes an increasingly institutionalised component of gender equity work globally, clarity is needed about the strategies that best initiate male-identified individuals' involvement in these efforts. The purpose of this study was to examine the perceived relevance and effectiveness of men's engagement strategies from the perspective of men around the world who have organised or attended gender-based violence prevention events. Participants responded to an online survey (available in English, French and Spanish) and rated the effectiveness of 15 discrete engagement strategies derived from earlier qualitative work...
February 21, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28253644/erratum-concurrent-measures-of-contralateral-suppression-of-transient-evoked-otoacoustic-emissions-and-of-auditory-steady-state-responses-j-acoust-soc-am-140-3-2027-2038-2016
#14
Ian B Mertes, Marjorie R Leek
No abstract text is available yet for this article.
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28194188/primum-non-nocere-first-do-no-harm-and-then-feed-peanut
#15
Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P Mack, Linda Kirste, Christine McCusker, Sandeep Kapur
The Addendum Guidelines for the Prevention of Peanut Allergy in the United States-Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early about Peanut (LEAP), LEAP-On and Enquiring about Tolerance trials created a paradigm shift in food allergy prevention. The "take home" messages of this guideline include that peanut should be introduced early in the first year of life, and for the majority of infants, peanut can be introduced at home...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28186805/simultaneous-bistability-of-a-qubit-and-resonator-in-circuit-quantum-electrodynamics
#16
Th K Mavrogordatos, G Tancredi, M Elliott, M J Peterer, A Patterson, J Rahamim, P J Leek, E Ginossar, M H Szymańska
We explore the joint activated dynamics exhibited by two quantum degrees of freedom: a cavity mode oscillator which is strongly coupled to a superconducting qubit in the strongly coherently driven dispersive regime. Dynamical simulations and complementary measurements show a range of parameters where both the cavity and the qubit exhibit sudden simultaneous switching between two metastable states. This manifests in ensemble averaged amplitudes of both the cavity and qubit exhibiting a partial coherent cancellation...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28172893/p297-fecal-calprotectin-accurately-predicts-symptomatic-relapse-in-children-and-adolescents-with-inflammatory-bowel-disease-in-clinical-remission
#17
K Diederen, D Hoekman, A Leek, V Wolters, M Benninga, T Hummel, T de Meij, B Koot, M Tabbers, M Benninga, A Kindermann
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28171598/widespread-splicing-of-repetitive-element-loci-into-coding-regions-of-gene-transcripts
#18
Miranda M Darby, Jeffrey T Leek, Ben Langmead, Robert H Yolken, Sarven Sabunciyan
No abstract text is available yet for this article.
November 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28144174/an-early-record-of-meloidogyne-fallax-from-ireland
#19
Olivera Topalović, John F Moore, Toon Janssen, Wim Bert, Gerrit Karssen
Root-knot nematodes, Meloidogyne spp., cause huge economic losses worldwide. Currently, three Meloidogyne spp. are present on the quarantine A2 list of EPPO, Meloidogyne chitwoodi, Meloidogyne fallax and Meloidogyne enterolobii. As a quarantine organism, Meloidogyne fallax has been detected in England and Northern Ireland on sport turf in 2011, and in England on leek in 2013. However, its presence in Ireland has probably been overlooked since 1965, when Mr. John F. Moore and Dr. Mary T. Franklin had detected a new Meloidogyne species for that time...
2017: ZooKeys
https://www.readbyqxmd.com/read/28138990/raised-faecal-calprotectin-is-associated-with-subsequent-symptomatic-relapse-in-children-and-adolescents-with-inflammatory-bowel-disease-in-clinical-remission
#20
K Diederen, D R Hoekman, A Leek, V M Wolters, T Z Hummel, T G de Meij, B G P Koot, M M Tabbers, M A Benninga, A Kindermann
BACKGROUND: Reliable data on inflammatory biomarkers for predicting relapse of paediatric inflammatory bowel disease (IBD) are lacking. AIM: To investigate the predictive value of faecal calprotectin (FC) and CRP for symptomatic relapse in pediatric IBD in clinical remission. METHODS: In this cross-sectional cohort study, patients <18 years with Crohn's disease or ulcerative colitis in clinical remission ≥3 months were included. At baseline, clinical and biochemical disease activity were assessed using the abbreviated-Pediatric Crohn's Disease Activity Index or Pediatric Ulcerative Colitis Activity Index, and FC and CRP respectively...
January 31, 2017: Alimentary Pharmacology & Therapeutics
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