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https://www.readbyqxmd.com/read/29755057/processes-and-outcomes-of-a-community-based-participatory-research-driven-health-needs-assessment-a-tool-for-moving-health-disparity-reporting-to-evidence-based-action
#1
Tabia Henry Akintobi, Elise Lockamy, Lisa Goodin, Natalie D Hernandez, Tanesha Slocumb, Daniel Blumenthal, Ronald Braithwaite, Larry Leeks, Micah Rowland, Thomas Cotton, LaShawn Hoffman
BACKGROUND: The community-based participatory research (CBPR)-driven health needs assessment was a tool used to inform community-led, -implemented, and -sustained research and prevention strategies. METHODS: The Morehouse School of Medicine Prevention Research Center (MSM PRC) research and prevention initiatives are implemented in direct response to priorities identified through this process and tool. Led by a community-majority coalition board, the assessment coupled state and city secondary data with primary survey data collected by and from community residents...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29735100/multidirectional-investigations-on-different-parts-of-allium-scorodoprasum-l-subsp-rotundum-l-stearn-phenolic-components-in-vitro-biological-and-in-silico-propensities
#2
Adriano Mollica, Gokhan Zengin, Marcello Locatelli, Carene Marie Nancy Picot-Allain, Mohamad Fawzi Mahomoodally
Allium species have been widely used for culinary and medicinal purposes. This study attempts for the first time to investigate into the enzyme inhibitory potential of different plant parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn, also known as wild garlic or leek in Turkey. The antioxidant and enzyme inhibitory potential of the flower, stem, and bulb extracts of A. scorodoprasum were assessed using in vitro bio-assays. The phenolic composition of the different plant parts was also established...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29722786/polymapr-linkage-analysis-and-genetic-map-construction-from-f1-populations-of-outcrossing-polyploids
#3
Peter M Bourke, Geert van Geest, Roeland E Voorrips, Johannes Jansen, Twan Kranenburg, Arwa Shahin, Richard G F Visser, Paul Arens, Marinus J M Smulders, Chris Maliepaard
Motivation: Polyploid species carry more than two copies of each chromosome, a condition found in many of the world's most important crops. Genetic mapping in polyploids is more complex than in diploid species, resulting in a lack of available software tools. These are needed if we are to realise all the opportunities offered by modern genotyping platforms for genetic research and breeding in polyploid crops. Results: polymapR is an R package for genetic linkage analysis and integrated genetic map construction from bi-parental populations of outcrossing autopolyploids...
May 2, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29710852/association-of-insulin-resistance-with-bone-strength-and-bone-turnover-in-menopausal-chinese-singaporean-women-without-diabetes
#4
Maria Kalimeri, Francesca Leek, Nan Xin Wang, Huann Rong Koh, Nicole C Roy, David Cameron-Smith, Marlena C Kruger, Christiani Jeyakumar Henry, John J Totman
Insulin resistance (IR) is accompanied by increased areal or volumetric bone mineral density (aBMD or vBMD), but also higher fracture risk. Meanwhile, imbalances in bone health biomarkers affect insulin production. This study investigates the effect of IR on proximal femur and lumbar spine BMD, femoral neck bending, compressive and impact strength indices (Composite Strength Indices) and circulating levels of parathyroid hormone (PTH), C-telopeptide of Type I collagen (CTx-1) and 25(OH) Vitamin D₃, in a cohort of 97 healthy, non-obese, menopausal Chinese-Singaporean women...
April 30, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29705936/microsatellite-analysis-and-marker-development-in-garlic-distribution-in-est-sequence-genetic-diversity-analysis-and-marker-transferability-across-alliaceae
#5
Karina Barboza, Vanesa Beretta, Perla C Kozub, Cecilia Salinas, Mauro M Morgenfeld, Claudio R Galmarini, Pablo F Cavagnaro
Allium vegetables, such as garlic and onion, have understudied genomes and limited molecular resources, hindering advances in genetic research and breeding of these species. In this study, we characterized and compared the simple sequence repeats (SSR) landscape in the transcriptomes of garlic and related Allium (A. cepa, A. fistulosum, and A. tuberosum) and non-Allium monocot species. In addition, 110 SSR markers were developed from garlic ESTs, and they were characterized-along with 112 previously developed SSRs-at various levels, including transferability across Alliaceae species, and their usefulness for genetic diversity analysis...
April 28, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29681684/the-evidence-of-proteases-in-sprouted-seeds-and-their-application-for-animal-protein-digestion
#6
Rafał I Rawski, Przemysław T Sanecki, Małgorzata Dżugan, Klaudia Kijowska
It has been experimentally proven that germinated plant seeds, such as leek, red clover, broccoli, and others contain proteases, which are able to digest animal protein such as gelatin, bovine albumin, casein, and egg albumin. Preliminary tests were carried out with the use of a semi-qualitative gelatin test, which is often applied to prove the presence of fruit enzymes. Quantitative examinations were carried out with the use of a ninhydrin reaction for amino acid determination as well as the Bradford and Smith methods for protein determination...
2018: Chemické Zvesti
https://www.readbyqxmd.com/read/29616365/multi-institutional-quantitative-phantom-study-of-yttrium-90-pet-in-pet-mri-the-mr-quest-study
#7
Nichole M Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P DiFilippo, Kimberly Jackson, Stephan G Nekolla, Mathias Lukas, Michael Tapner, Parag J Parikh, Richard Laforest
BACKGROUND: Yttrium-90 (90 Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little is known about the precise location of the microspheres once they are administered. Recently, there has been growing interest post-radioembolization imaging using positron-emission tomography (PET) for quantitative dosimetry and identifying lesions that may benefit from additional salvage therapy...
April 4, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29514223/improving-the-value-of-public-rna-seq-expression-data-by-phenotype-prediction
#8
Shannon E Ellis, Leonardo Collado-Torres, Andrew Jaffe, Jeffrey T Leek
Publicly available genomic data are a valuable resource for studying normal human variation and disease, but these data are often not well labeled or annotated. The lack of phenotype information for public genomic data severely limits their utility for addressing targeted biological questions. We develop an in silico phenotyping approach for predicting critical missing annotation directly from genomic measurements using well-annotated genomic and phenotypic data produced by consortia like TCGA and GTEx as training data...
March 5, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29502280/depression-posttraumatic-stress-and-relationship-distress-in-parents-of-very-preterm-infants
#9
Leanne Winter, Paul B Colditz, Matthew R Sanders, Roslyn N Boyd, Margo Pritchard, Peter H Gray, Koa Whittingham, Kylee Forrest, Rebecca Leeks, Lachlan Webb, Louise Marquart, Karen Taylor, Judith Macey
To determine the prevalence, associated factors, and relationships between symptoms of depression, symptoms of posttraumatic stress (PTS), and relationship distress in mothers and fathers of very preterm (VPT) infants (< 32 weeks). Mothers (n = 323) and fathers (n = 237) completed self-report measures on demographic and outcome variables at 38 days (SD = 23.1, range 9-116) postpartum while their infants were still hospitalised. Of mothers, 46.7% had a moderate to high likelihood of depression, 38...
March 3, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29499230/regional-variation-in-the-characteristics-incidence-and-outcomes-of-out-of-hospital-cardiac-arrest-in-australia-and-new-zealand-results-from-the-aus-roc-epistry
#10
Ben Beck, Janet Bray, Peter Cameron, Karen Smith, Tony Walker, Hugh Grantham, Cindy Hein, Melanie Thorrowgood, Anthony Smith, Madoka Inoue, Tony Smith, Bridget Dicker, Andy Swain, Emma Bosley, Katherine Pemberton, Michael McKay, Malcolm Johnston-Leek, Gavin D Perkins, Graham Nichol, Judith Finn
INTRODUCTION: The aim of this study was to investigate regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in Australia and New Zealand. METHODS: This was a population-based cohort study of OHCA using data from the Aus-ROC Australian and New Zealand OHCA Epistry over the period of 01 January 2015-31 December 2015. Seven ambulance services contributed data to the Epistry with a capture population of 19.8 million people...
May 2018: Resuscitation
https://www.readbyqxmd.com/read/29496188/evaluation-of-supercritical-fluid-chromatography-coupled-to-tandem-mass-spectrometry-for-pesticide-residues-in-food
#11
Víctor Cutillas, María Martínez Galera, Łukasz Rajski, Amadeo R Fernández-Alba
Supercritical fluid chromatography coupled to triple quadrupole mass spectrometry has been evaluated for pesticide residues in food. In order to check its advantages and limitations it was developed a method to identify and quantify 164 pesticides in three different matrices (tomato, orange and leek). A carbon dioxide gradient with methanol (containing 1 mM ammonium formate) was used allowing a flow rate of 1.5 mL/min that made the total run time of 12 min without any problem of overpressure. Addition of a post column flow 150 μL/min of Methanol with ammonium formate/formic acid was necessary to improve the ionization...
April 13, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29491851/-pantoea-ananatis-genetic-diversity-analysis-reveals-limited-genomic-diversity-as-well-as-accessory-genes-correlated-with-onion-pathogenicity
#12
Shaun P Stice, Spencer D Stumpf, Ron D Gitaitis, Brian H Kvitko, Bhabesh Dutta
Pantoea ananatis is a member of the family Enterobacteriaceae and an enigmatic plant pathogen with a broad host range. Although P. ananatis strains can be aggressive on onion causing foliar necrosis and onion center rot, previous genomic analysis has shown that P. ananatis lacks the primary virulence secretion systems associated with other plant pathogens. We assessed a collection of fifty P. ananatis strains collected from Georgia over three decades to determine genetic factors that correlated with onion pathogenic potential...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29490507/hikers-poisoned-veratrum-steroidal-alkaloid-toxicity-following-ingestion-of-foraged-veratrum-parviflorum
#13
Mehruba Anwar, Matthew Turner, Natalija Farrell, Wendy B Zomlefer, Owen M McDougal, Brent W Morgan
INTRODUCTION: Steroidal alkaloids are found in plants of the genus Veratrum. Their toxicity manifests as gastrointestinal symptoms followed by a Bezold-Jarisch reflex: hypopnea, hypotension, and bradycardia. Some Veratrum steroidal alkaloids are also teratogens interfering with the hedgehog-2 signaling pathway, which causes cyclopsia and holoprosencephaly. We present a case of accidental poisoning from Veratrum parviflorum mistaken for the edible Allium tricoccum (ramps, wild leek). CASE HISTORY: A 27-year-old man and his 25-year-old wife presented to the emergency department with nausea, vomiting, hypotension, and bradycardia after foraging and ingesting plants that they believed to be a local native species of wild leek...
February 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29419334/survey-of-four-groups-of-cumulative-pesticide-residues-in-12-vegetables-in-15-provinces-in-china
#14
Xiaomin Xu, Lingyun Li, Xiaodong Huang, Huan Lin, Guangyang Liu, Donghui Xu, Jianhui Jiang
The present study investigated the concentrations of residues of four groups of pesticides in the People's Republic of China: organophosphorus, carbamate, pyrethroid, and triazine pesticides. Twenty-six pesticides were examined using gas chromatography-tandem mass spectrometry and liquid chromatography-tandem mass spectrometry in 2,169 samples of 12 typical vegetables collected from 15 provinces in China. The results showed that 908 (41.9%) samples were positive, with 133 (6.1%) samples exceeding the limit legal in China...
March 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29412902/development-of-direct-competitive-biomimetic-immunosorbent-assay-based-on-quantum-dot-label-for-determination-of-trichlorfon-residues-in-vegetables
#15
Qiurui Liu, Mingdi Jiang, Zeliang Ju, Xuguang Qiao, Zhixiang Xu
A direct competitive biomimetic immunosorbent assay method based on molecularly imprinted polymer was developed for the determination of trichlorfon. A CdSe/ZnS quantum dot label was used as the marker. The hydrophilic imprinted film was synthesized directly on the surface of a 96-well plate, and characterized by Fourier-transform infrared spectroscopy and thermo-gravimetric analyses. The method exhibited high stability, selectivity, and sensitivity. Under optimal conditions, the limits of detection and sensitivity of the biomimetic immunosorbent assay method were 9...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29390743/auditory-stream-segregation-of-iterated-rippled-noises-by-normal-hearing-and-hearing-impaired-listeners
#16
Daniel E Shearer, Michelle R Molis, Keri O Bennett, Marjorie R Leek
Individuals with hearing loss are thought to be less sensitive to the often subtle variations of acoustic information that support auditory stream segregation. Perceptual segregation can be influenced by differences in both the spectral and temporal characteristics of interleaved stimuli. The purpose of this study was to determine what stimulus characteristics support sequential stream segregation by normal-hearing and hearing-impaired listeners. Iterated rippled noises (IRNs) were used to assess the effects of tonality, spectral resolvability, and hearing loss on the perception of auditory streams in two pitch regions, corresponding to 250 and 1000 Hz...
January 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29323125/author-correction-hot-carrier-cooling-mechanisms-in-halide-perovskites
#17
Jianhui Fu, Qiang Xu, Guifang Han, Bo Wu, Cheng Hon Alfred Huan, Meng Lee Leek, Tze Chien Sum
The original version of this Article omitted an affiliation of Cheng Hon Alfred Huan: 'Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Innovis #08-03 138634, Singapore'.This has now been corrected in both the PDF and HTML versions of the article.
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29280016/virome-analysis-of-lily-plants-reveals-a-new-potyvirus
#18
Yongqiang Li, Anning Jia, Yan Qiao, Jun Xiang, Yongjiang Zhang, Wenhe Wang
Lily plants exhibiting virus-like symptoms of leaf yellowing, twisting and brownish necrotic spots were collected, and next-generation sequencing of small RNAs was conducted to identify the associated viruses. Cucumber mosaic virus, lily symptomless virus and a hitherto unrecorded potyvirus, tentatively named "lily yellow mosaic virus" (LYMV), were detected. The genomic RNA of LYMV was 9811 nt in length, encoding a large polyprotein of 3,124 amino acids with a predicted Mr of 353.3 kDa. BLAST analysis showed that LYMV shared a high degree of amino acid sequence identity with Thunberg fritillary mosaic virus (55%), bean yellow mosaic virus (52%), clover yellow vein virus (51%), leek yellow stripe virus (51%), and lily mottle virus (52%), and these viruses clustered together in a phylogenetic tree...
April 2018: Archives of Virology
https://www.readbyqxmd.com/read/29244806/cellular-selectivity-of-aav-serotypes-for-gene-delivery-in-neurons-and-astrocytes-by-neonatal-intracerebroventricular-injection
#19
Sean L Hammond, Ashley N Leek, Evan H Richman, Ronald B Tjalkens
The non-pathogenic parvovirus, adeno-associated virus (AAV), is an efficient vector for transgene expression in vivo and shows promise for treatment of brain disorders in clinical trials. Currently, there are more than 100 AAV serotypes identified that differ in the binding capacity of capsid proteins to specific cell surface receptors that can transduce different cell types and brain regions in the CNS. In the current study, multiple AAV serotypes expressing a GFP reporter (AAV1, AAV2/1, AAVDJ, AAV8, AAVDJ8, AAV9, AAVDJ9) were screened for their infectivity in both primary murine astrocyte and neuronal cell cultures...
2017: PloS One
https://www.readbyqxmd.com/read/29163472/the-kynurenine-pathway-as-a-novel-link-between-allergy-and-the-gut-microbiome
#20
REVIEW
Aaron P Van der Leek, Yarden Yanishevsky, Anita L Kozyrskyj
In the past few decades, the indoleamine 2,3 dioxygenase (IDO) subset of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism has been the subject of much research in the area of immune tolerance. In this review, we aim to incorporate new findings on this pathway in relation to allergy and the gut microbiome, while providing a comprehensive overview of the pathway itself. Stimulated by interferon gamma, IDO acts as a tolerogenic, immunosuppressive enzyme to attenuate allergic responses by the induction of the KYN-IDO pathway, resultant depletion of TRP, and elevation in KYN metabolites...
2017: Frontiers in Immunology
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