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https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#1
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938532/modulation-of-gdf11-expression-and-synaptic-plasticity-by-age-and-training
#2
Emanuela De Domenico, Giovanna D'Arcangelo, Isabella Faraoni, Mattia Palmieri, Virginia Tancredi, Grazia Graziani, Paola Grimaldi, Lucio Tentori
The Growth Differentiation Factor 11 (GDF11) has been controversially involved in the aging/rejuvenation process. To clarify whether GDF11 is differently expressed during aging, we have evaluated GDF11 levels in skeletal muscles and hippocampi of young and old mice, sedentary or subjected to a 12-weeks triweekly training protocol. The results of real-time PCR and Western blot analyses indicate that skeletal muscles of sedentary old mice express higher levels of GDF11 compared to young animals (p < 0.05)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938523/hypothermia-induced-by-anesthesia-regulates-various-signals-expressions-in-the-hippocampus-of-animals
#3
Huimei Hao, Shanshan Wang
Though important for a variety of medical procedures, general anesthesia is not a problem free. Some anesthetics have been suggested to affect a number of signals, which are associated with memory consolidation and cognition. In the present study, we attempted to investigate the molecular mechanism of anesthesia-regulated processes. We found that under hypothermic condition, anesthetic of isoflurane enhances various signals expression in hippocampus, including Hspd1, Actb, Mgst1, THBS4, Syp, C1QC, Serpine, Plat, and Ngf, which were related to cellular stress, neural plasticity responses, and hippocampal injury...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938452/dose-specific-effects-of-di-isononyl-phthalate-on-the-endocannabinoid-system-and-on-liver-of-female-zebrafish
#4
Isabel Forner-Piquer, Francesca Maradonna, Giorgia Gioacchini, Stefania Santangeli, Marco Allarà, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali
Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among them, the Di-isononyl phthalate (DiNP) has been recently used to replace the bis(2-ethylhexyl) phthalate (DEHP). Nowadays, there is evidence that DiNP is an Endocrine Disrupting Chemical (EDC), however little is known about its effects on the Endocannabinoid System (ECS) and lipid metabolism. Hence, the aim of our study was to investigate the effects of DiNP on the ECS in zebrafish liver and brain and on hepatic lipid storage...
August 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938384/-iatrogenic-segmental-defect-how-i-debride-high-energy-open-tibial-fractures
#5
Brendan R Southam, Michael T Archdeacon
High-energy, open tibial shaft fractures may result in significant comminution, bone loss, and soft tissue injuries. Early, thorough debridement of all nonviable tissue is of critical importance in treating these fractures as an inadequate initial debridement increases the risk of infection and nonunion. Large iatrogenic bone and soft tissue defects can result from debridement and will require subsequent reconstruction by both orthopaedic and plastic surgeons. Although a variety of approaches exist to address these reconstructions, successful management of bone defects remains a considerable challenge...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938371/reply-ibuprofen-does-not-increase-bleeding-risk-in-plastic-surgery-a-systematic-review-and-meta-analysis
#6
Brian P Kelley, Jeffrey H Kozlow
No abstract text is available yet for this article.
September 20, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938370/the-evolution-of-photography-and-three-dimensional-imaging-in-plastic-surgery
#7
Carlo M Oranges, Florian M Thieringer, Daniel F Kalbermatten, Martin Haug, Dirk J Schaefer
No abstract text is available yet for this article.
September 20, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938369/ibuprofen-does-not-increase-bleeding-risk-in-plastic-surgery-a-systematic-review-and-meta-analysis
#8
Xue-Fei Liu, Xiao-Feng Wang, Yang-Yan Yi
No abstract text is available yet for this article.
September 20, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938367/increasing-diversity-in-plastic-surgery
#9
Charalampos Siotos, David Cui, Scott D Lifchez, Damon S Cooney, Gedge D Rosson, Carisa M Cooney
No abstract text is available yet for this article.
September 20, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938365/why-the-p-value-alone-is-not-enough-the-need-for-confidence-intervals-in-plastic-surgery-research
#10
Osama A Samargandi, Mona Al-Taha, Kit Moran, Sarah Al Youha, Michael Bezuhly
BACKGROUND: The p-value is one of the most utilized descriptors in statistical analysis; however, when reported in isolation, it does not convey the effect size of a treatment. The reporting of confidence intervals (CIs) is an essential adjunct to determine the clinical value of treatment, as it permits an assessment of the effect size. The authors assessed the reporting of CIs in clinical trials within the plastic surgery literature. METHODS: The seven highest impact plastic surgery journals were screened using MEDLINE for clinical trials in the years 2006, 2009, 2012, and 2015...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938364/the-role-of-tranexamic-acid-in-plastic-surgery-review-and-technical-considerations
#11
Rod J Rohrich, Min-Jeong Cho
Minimizing blood loss during surgery is critical, and many modalities have been used to decrease unwanted surgical bleeding. Among many methods, use of pharmacological agents such as anti-fibrinolytic drugs have been shown to significantly reduce blood loss and the rates of postoperative blood transfusion in many literatures. Tranexamic acid is an anti-fibrinolytic agent that has been widely used in other surgical specialties, especially in cardiac, orthopedic, and trauma surgery . Despite its known benefits, the use of tranexamic acid in plastic surgery is extremely limited, primarily because most plastic surgery procedures do not involve the extent of blood loss that can lead to anemia and the need for blood transfusion, as is common in major orthopedic and cardiac surgery procedures...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938363/reconstruction-of-the-heel-middle-foot-sole-and-plantar-forefoot-with-the-medial-plantar-artery-perforator-mpap-flap-clinical-experience-with-28-cases
#12
Mario F Scaglioni, Daniel Rittirsch, Pietro Giovanoli
INTRODUCTION: Defects in the weight-bearing region of the foot sole can represent a substantial restriction in quality of life and pose a challenge for reconstructive plastic surgery.The purpose of this article is to report our experience with the use of medial plantar artery perforator (MPAP) flap for reconstruction of defects of the foot sole in 3 different regions: heel, middle foot sole and plantar forefoot. PATIENTS AND METHODS: From January 2003 to May 2016, 28 patients (13 males and 15 females) with an average age of 54 years (range 12 to 84 y...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938326/progress-on-botulinum-toxin-type-a-induced-pain-relief-in-the-field-of-plastics
#13
Xiaona Lu, Guocheng Chen, Pengjie Ren, Yan Yang, Fei Fan
OBJECTIVE: To retrospectively evaluate the effectiveness of Botulinum Toxin Type A (BTX-A) injections relieve pain in the field of plastic surgery and postoperative rehabilitation, and discuss the analgesic mechanism of BTX- A in plastics and related research progress. METHODS: From appearance to September 1, 2016, PUBMED, EMBASE, and Web of Science were searched, using the key words related to "Botulinum Toxin Type A" and "Pain." Furtherly, nonplastic surgery-related literature was excluded by manual screening...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938144/the-associative-brain-at-work-evidence-from-paired-associative-stimulation-studies-in-humans
#14
REVIEW
A Suppa, A Quartarone, H Siebner, R Chen, V Di Lazzaro, P Del Giudice, Walter Paulus, J C Rothwell, U Ziemann, J Classen
The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases...
September 5, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28938084/the-evolving-understanding-of-dopamine-neurons-in-the-substantia-nigra-and-ventral-tegmental-area
#15
Stephanie C Gantz, Christopher P Ford, Hitoshi Morikawa, John T Williams
In recent years, the population of neurons in the ventral tegmental area (VTA) and substantia nigra (SN) has been examined at multiple levels. The results indicate that the projections, neurochemistry, and receptor and ion channel expression in this cell population vary widely. This review centers on the intrinsic properties and synaptic regulation that control the activity of dopamine neurons. Although all dopamine neurons fire action potentials in a pacemaker pattern in the absence of synaptic input, the intrinsic properties that underlie this activity differ considerably...
September 22, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/28937977/phase-changes-in-neuronal-postsynaptic-spiking-due-to-short-term-plasticity
#16
Mark D McDonnell, Bruce P Graham
In the brain, the postsynaptic response of a neuron to time-varying inputs is determined by the interaction of presynaptic spike times with the short-term dynamics of each synapse. For a neuron driven by stochastic synapses, synaptic depression results in a quite different postsynaptic response to a large population input depending on how correlated in time the spikes across individual synapses are. Here we show using both simulations and mathematical analysis that not only the rate but the phase of the postsynaptic response to a rhythmic population input varies as a function of synaptic dynamics and synaptic configuration...
September 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28937919/neurosurgical-management-of-a-rare-congenital-supratentorial-neurenteric-cyst-with-associated-nasal-dermal-sinus-case-report
#17
Paul MacMahon, Stanca Iacob, Sarah E Bach, Eric T Elwood, Julian J Lin, Anthony M Avellino
The authors describe the case of a patient with the classic clinical presentation and radiographic features of a nasal dermal sinus with an associated intracranial cyst; however, histopathology revealed that the intracranial cyst was neurenteric instead of the typical epidermoid or dermoid cyst. Preoperative assessment included CT and MRI, which revealed a direct communication between the patient's nasal polypoid lesion and the anterior skull base via the foramen cecum. At the hands of a multidisciplinary plastic surgery and neurosurgery team, the patient underwent concurrent gross-total resection of the nasal polypoid lesion, the intracranial intradural cystic lesion, and their interconnecting tract...
September 15, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28937832/aberrant-plasticity-in-the-hippocampus-after-neonatal-seizures
#18
Xiaoqian Zhang, Huiling Qu, Ying Wang, Shanshan Zhao, Ting Xiao, Chuansheng Zhao, Weiyu Teng
Neonatal seizures are the most frequent type of neurological disorder and those newborn babies that experience seizures carry an increased risk of epileptogenesis and other long-term morbidities. The newly generated dentate granule cells (DGCs) integrate functionally into the mature hippocampal network by continuously forming connections with their targets but this process of adult neurogenesis can be influenced by seizures. When compared to adult seizures, neonatal seizures may exert different effects on neurogenesis due to the high resistance of the newborn's neurons to cell death combined with the inherent high sensitivity to seizures in the immature brain...
September 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28937819/should-i-change-or-should-i-go-phenotypic-plasticity-and-matching-habitat-choice-in-the-adaptation-to-environmental-heterogeneity
#19
Pim Edelaar, Roger Jovani, Ivan Gomez-Mestre
It can be challenging for organisms to achieve a good match between their phenotypic characteristics and environmental requirements that vary in space and time. The evolution of adaptive phenotypes can result from genetic differentiation at the population level. Individuals, however, could also change their phenotype (adaptive plasticity) or select an environment because it matches with their phenotype (matching habitat choice). It is poorly known under which conditions these different solutions to environmental heterogeneity evolve and whether they operate together...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937811/maladaptive-plasticity-masks-the-effects-of-natural-selection-in-the-red-shouldered-soapberry-bug
#20
Meredith L Cenzer
Natural selection can produce local adaptation, but local adaptation can be masked by maladaptive plasticity. Maladaptive plasticity may arise as a result of gene flow producing novel gene combinations that have not been exposed to selection. In the 1980s, populations of the red-shouldered soapberry bug (Jadera haematoloma) were locally adapted to feed on the seeds of a native host plant and an introduced host plant; by 2014, local differentiation in beak length had been lost, likely as a consequence of increased gene flow...
October 2017: American Naturalist
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