keyword
MENU ▼
Read by QxMD icon Read
search

human malaria challenge

keyword
https://www.readbyqxmd.com/read/29041927/diagnostic-performance-of-the-loop-mediated-isothermal-amplification-lamp-based-illumigene-%C3%A2-malaria-assay-in-a-non-endemic-region
#1
Anne-Sophie De Koninck, Lieselotte Cnops, Mattias Hofmans, Jan Jacobs, Dorien Van den Bossche, Jan Philippé
BACKGROUND: Light microscopy and antigen-based rapid diagnostic tests are the primary diagnostic tools for detecting malaria, although being labour-intensive and frequently challenged by lack of personnel's experience and low levels of parasite density. The latter being especially important in non-endemic settings. Novel molecular techniques aim to overcome this drawback. The objective of this study was to assess the diagnostic performance of the illumigene malaria assay(®) (Meridian Bioscience) compared to microscopy, RDT and real-time PCR...
October 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29036170/quantifying-the-effects-of-temperature-on-mosquito-and-parasite-traits-that-determine-the-transmission-potential-of-human-malaria
#2
Lillian L M Shapiro, Shelley A Whitehead, Matthew B Thomas
Malaria transmission is known to be strongly impacted by temperature. The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies. These studies, some dating back to the early part of last century, are often poorly controlled, have limited replication, explore a narrow range of temperatures, and use a mixture of parasite and mosquito species. Here, we use a single pairing of the Asian mosquito vector, An. stephensi and the human malaria parasite, P...
October 16, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28988930/comparison-of-two-methods-for-transformation-of-plasmodium-knowlesi-direct-schizont-electroporation-and-spontaneous-plasmid-uptake-from-plasmid-loaded-red-blood-cells
#3
Roberto R Moraes Barros, Tyler J Gibson, Whitney A Kite, Juliana M Sá, Thomas E Wellems
Human infections from Plasmodium knowlesi species present challenges to malaria control in Southeast Asia. P. knowlesi also offers a model for other human malaria species including Plasmodium vivax. P. knowlesi parasites can be cultivated in the laboratory, and their transformation is standardly performed by direct electroporation of schizont-infected red blood cells (RBCs) with plasmid DNA. Here we show that the efficiency of direct electroporation is exquisitely dependent on developmental age of the schizonts...
October 5, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28987173/parasitic-and-fungal-infections
#4
Nikolaus Deigendesch, Jean Costa Nunez, Werner Stenzel
Parasitic infections of the central nervous system (CNS) comprise a plethora of infectious agents leading to a multitude of different disease courses and thus diagnostic and therapeutic challenges. The prevalence of different pathogens is basically dependent on geographic and ethnic backgrounds, its infectious route frequently involving a third party, such as flies or domestic animals. The present review focuses on cerebral malaria due to Plasmodium falciparum infection, and Toxoplasma gondii encephalitis. Fungi produce a large variety of inflammatory conditions of the CNS with a variegated spectrum of signs and symptoms, which may involve the meninges and the brain parenchyma, where they produce cerebritis or abscesses and granulomatous lesions, respectively...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28962615/daf-shielded-baculovirus-vectored-vaccine-enhances-protection-against-malaria-sporozoite-challenge-in-mice
#5
Mitsuhiro Iyori, Daisuke S Yamamoto, Miako Sakaguchi, Masanori Mizutani, Sota Ogata, Hidesato Nishiura, Takahiko Tamura, Hiroyuki Matsuoka, Shigeto Yoshida
BACKGROUND: Previous studies have shown that the baculovirus-vectored vaccine based on the "baculovirus dual expression system (BDES)" is an effective vaccine delivery platform for malaria. However, a point of weakness remaining for use of this vaccine platform in vivo concerns viral inactivation by serum complement. In an effort to achieve complement resistance, the gene encoding the human decay-accelerating factor (hDAF) was incorporated into the BDES malaria vaccine expressing the Plasmodium falciparum circumsporozoite protein (PfCSP)...
September 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28936226/challenges-in-modeling-complexity-of-neglected-tropical-diseases-a-review-of-dynamics-of-visceral-leishmaniasis-in-resource-limited-settings
#6
REVIEW
Swati DebRoy, Olivia Prosper, Austin Mishoe, Anuj Mubayi
OBJECTIVES: Neglected tropical diseases (NTD), account for a large proportion of the global disease burden, and their control faces several challenges including diminishing human and financial resources for those distressed from such diseases. Visceral leishmaniasis (VL), the second-largest parasitic killer (after malaria) and an NTD affects poor populations and causes considerable cost to the affected individuals. Mathematical models can serve as a critical and cost-effective tool for understanding VL dynamics, however, complex array of socio-economic factors affecting its dynamics need to be identified and appropriately incorporated within a dynamical modeling framework...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28927422/proximity-to-vector-breeding-site-and-risk-of-plasmodium-vivax-infection-a-prospective-cohort-study-in-rural-ethiopia
#7
Alexander Nissen, Jackie Cook, Eskindir Loha, Bernt Lindtjørn
BACKGROUND: Despite falling incidence and mortality since the turn of the century, malaria remains an important global health challenge. In the future fight against malaria, greater emphasis will have to be placed on understanding and addressing malaria caused by the Plasmodium vivax parasite. Unfortunately, due to years of neglect and underfunding, there are currently many gaps in knowledge of P. vivax malaria. The aims of the present study were to explore the association between distance to vector breeding site and P...
September 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28923897/controlled-human-malaria-infection-applications-advances-and-challenges
#8
Danielle I Stanisic, James S McCarthy, Michael F Good
Controlled Human Malaria Infection (CHMI) entails deliberate infection with malaria parasites either by mosquito bite or direct injection of sporozoites or parasitised erythrocytes. When required, the resulting blood-stage infection is curtailed by the administration of anti-malarial drugs. Inducing a malaria infection via inoculation with infected blood was first used as a treatment (malariotherapy) for neurosyphilis in Europe and the United States in the early 1900s. More recently, CHMI has been applied to the fields of malaria vaccine and drug development where it is used to evaluate products in well-controlled early phase proof-of-concept clinical studies thus facilitating progression of only the most promising candidates for further evaluation in malaria-endemic areas...
September 18, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28914184/elements-of-effective-community-engagement-lessons-from-a-targeted-malaria-elimination-study-in-lao-pdr-laos
#9
Bipin Adhikari, Christopher Pell, Koukeo Phommasone, Xayaphone Soundala, Palingnaphone Kommarasy, Tiengkham Pongvongsa, Gisela Henriques, Nicholas P J Day, Mayfong Mayxay, Phaik Yeong Cheah
BACKGROUND: Mass drug (antimalarial) administration (MDA) is currently under study in Southeast Asia as part of a package of interventions referred to as targeted malaria elimination (TME). This intervention relies on effective community engagement that promotes uptake and adherence in target communities (above 80%). OBJECTIVE: Based on the experienced of designing and implementing the community engagement for TME in Laos, in this article we aim to present the elements of effective community engagement for mass antimalarial administration...
2017: Global Health Action
https://www.readbyqxmd.com/read/28903890/human-parasitic-diseases-in-bulgaria-2013-2014
#10
Iskra Rainova, Rumen Harizanov, Iskren Kaftandjiev, Nina Tsvetkova, Ognyan Mikov, Eleonora Kaneva
BACKGROUND: In Bulgaria, more than 20 autochthonous human parasitic infections have been described and some of them are widespread. Over 50 imported protozoan and helminthic infections represent diagnostic and therapeutic challenge and pose epidemiological risk due to the possibility of local transmission. AIMS: To establish the distribution of autochthonous and imported parasitic diseases among the population of the country and to evaluate their significance for the public health system...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28903777/modest-heterologous-protection-after-plasmodium-falciparum-sporozoite-immunization-a-double-blind-randomized-controlled-clinical-trial
#11
Jona Walk, Isaie J Reuling, Marije C Behet, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Thorsten Janssen, Karina Teelen, Johannes H W de Wilt, Quirijn de Mast, André J van der Ven, Ernest Diez Benavente, Susana Campino, Taane G Clark, Martijn A Huynen, Cornelus C Hermsen, Else M Bijker, Anja Scholzen, Robert W Sauerwein
BACKGROUND: A highly efficacious vaccine is needed for malaria control and eradication. Immunization with Plasmodium falciparum NF54 parasites under chemoprophylaxis (chemoprophylaxis and sporozoite (CPS)-immunization) induces the most efficient long-lasting protection against a homologous parasite. However, parasite genetic diversity is a major hurdle for protection against heterologous strains. METHODS: We conducted a double-blind, randomized controlled trial in 39 healthy participants of NF54-CPS immunization by bites of 45 NF54-infected (n = 24 volunteers) or uninfected mosquitoes (placebo; n = 15 volunteers) against a controlled human malaria infection with the homologous NF54 or the genetically distinct NF135...
September 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28888945/mathematical-model-for-the-spread-of-drug-resistance-in-plasmodium-falciparum-parasite-considering-transmission-conditions
#12
REVIEW
Mario Cañón, Hernando Diaz, Andrés Olarte
Antimalarial drugs have been used as one of the main strategies for controlling this disease. However, the spread of drug resistance in the Plasmodium falciparum parasite has generated major challenges for the control of malaria. For this reason, it is necessary to develop an efficient policy considering the parasite behavior in relation to drug treatment and epidemiological parameters. To achieve this goal, we propose a mathematical model that describes the dynamics of parasite population considering the transmission effects between mosquitoes and humans...
December 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28886443/antiplasmodial-activities-of-dyes-against-plasmodium-falciparum-asexual-and-sexual-stages-contrasted-uptakes-of-triarylmethanes-brilliant-green-green-s-e142-and-patent-blue-v-e131-by-erythrocytes
#13
Louis-Jérôme Leba, Jean Popovici, Yannick Estevez, Stéphane Pelleau, Eric Legrand, Lise Musset, Christophe Duplais
The search for safe antimalarial compounds acting against asexual symptom-responsible stages and sexual transmission-responsible forms of Plasmodium species is one of the major challenges in malaria elimination programs. So far, among current drugs approved for human use, only primaquine has transmission-blocking activity. The discovery of small molecules targeting different Plasmodium falciparum life stages remains a priority in antimalarial drug research. In this context, several independent studies have recently reported antiplasmodial and transmission-blocking activities of commonly used stains, dyes and fluorescent probes against P...
August 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28871201/protective-immunity-differs-between-routes-of-administration-of-attenuated-malaria-parasites-independent-of-parasite-liver-load
#14
Simone Haeberlein, Séverine Chevalley-Maurel, Arifa Ozir-Fazalalikhan, Hester Koppejan, Beatrice M F Winkel, Jai Ramesar, Shahid M Khan, Robert W Sauerwein, Meta Roestenberg, Chris J Janse, Hermelijn H Smits, Blandine Franke-Fayard
In humans and murine models of malaria, intradermal immunization (ID-I) with genetically attenuated sporozoites that arrest in liver induces lower protective immunity than intravenous immunization (IV-I). It is unclear whether this difference is caused by fewer sporozoites migrating into the liver or by suboptimal hepatic and injection site-dependent immune responses. We therefore developed a Plasmodium yoelii immunization/boost/challenge model to examine parasite liver loads as well as hepatic and lymph node immune responses in protected and unprotected ID-I and IV-I animals...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870214/plasmodium-vivax-genetic-diversity-and-heterozygosity-in-blood-samples-and-resulting-oocysts-at-the-thai-myanmar-border
#15
Ingfar Soontarawirat, Chiara Andolina, Richard Paul, Nicholas P J Day, Francois Nosten, Charles J Woodrow, Mallika Imwong
BACKGROUND: Polyclonal blood-stage infections of Plasmodium vivax are frequent even in low transmission settings, allowing meiotic recombination between heterologous parasites. Empirical data on meiotic products are however lacking. This study examined microsatellites in oocysts derived by membrane feeding of mosquitoes from blood-stage P. vivax infections at the Thai-Myanmar border. METHODS: Blood samples from patients presenting with vivax malaria were fed to Anopheles cracens by membrane feeding and individual oocysts from midguts were obtained by dissection after 7 days...
September 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28820709/performance-of-a-high-sensitivity-rapid-diagnostic-test-for-plasmodium-falciparum-malaria-in-asymptomatic-individuals-from-uganda-and-myanmar-and-naive-human-challenge-infections
#16
Smita Das, Ihn Kyung Jang, Becky Barney, Roger Peck, John C Rek, Emmanuel Arinaitwe, Harriet Adrama, Maxwell Murphy, Mallika Imwong, Clare L Ling, Stephane Proux, Warat Haohankhunnatham, Melissa Rist, Annette M Seilie, Amelia Hanron, Glenda Daza, Ming Chang, Tomoka Nakamura, Michael Kalnoky, Paul Labarre, Sean C Murphy, James S McCarthy, Francois Nosten, Bryan Greenhouse, Sophie Allauzen, Gonzalo J Domingo
Sensitive field-deployable diagnostic tests can assist malaria programs in achieving elimination. The performance of a new Alere™ Malaria Ag P.f Ultra Sensitive rapid diagnostic test (uRDT) was compared with the currently available SD Bioline Malaria Ag P.f RDT in blood specimens from asymptomatic individuals in Nagongera, Uganda, and in a Karen Village, Myanmar, representative of high- and low-transmission areas, respectively, as well as in pretreatment specimens from study participants from four Plasmodium falciparum-induced blood-stage malaria (IBSM) studies...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28810866/the-development-of-an-ivermectin-based-attractive-toxic-sugar-bait-atsb-to-target-anopheles-arabiensis
#17
Frank Chelestino Tenywa, Athumani Kambagha, Adam Saddler, Marta Ferreira Maia
BACKGROUND: An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in the persistence of malaria transmission. It is now accepted that in order to eliminate malaria, new complementary vector control approaches must be developed. This study describes the development of a sugar-baited resting place containing a toxic dose of ivermectin for the control of Anopheles arabiensis...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28810125/cheminformatic-analysis-of-antimalarial-chemical-space-illuminates-therapeutic-mechanisms-and-offers-strategies-for-therapy-development
#18
Julia Nogueira Varela, María Fernanda Lammoglia Cobo, Sandip V Pawar, Vikramaditya G Yadav
The clear and present danger of malaria, which has been amplified in recent years by climate change, and the progressive thinning of our drug arsenal over the past two decades raise uncomfortable questions about the current state and future of antimalarial drug development. Besides suffering from many of the same technical challenges that affect drug development in other disease areas, the quest for new antimalarial therapies is also hindered by the complex, dynamic life cycle of the malaria parasite, P. falciparum, in its mosquito and human hosts, and its role thereof in the elicitation of drug resistance...
September 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28797253/first-record-of-anopheles-stephensi-in-sri-lanka-a-potential-challenge-for-prevention-of-malaria-reintroduction
#19
A G Gayan Dharmasiri, A Yashan Perera, Jeevanie Harishchandra, Hemantha Herath, Kandasamy Aravindan, H T R Jayasooriya, Gaya R Ranawaka, Mihirini Hewavitharane
BACKGROUND: The major malaria vector in Sri Lanka is reported to be Anopheles culicifacies with Anopheles subpictus, Anopheles annularis, and Anopheles varuna considered as potential vectors. The occurrence of Anopheles stephensi, which is the key vector of urban malaria in India and the Middle East, had never been reported from Sri Lanka. METHODS: A series of entomological investigations were carried out by the Anti Malaria Campaign, Ministry of Health, Sri Lanka during December 2016 to April 2017 in two localities of the Mannar District in the Northern Province of the country...
August 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28782517/structural-analysis-of-owl-monkey-mhc-dr-shows-that-fully-protective-malaria-vaccine-components-can-be-readily-used-in-humans
#20
Carlos F Suárez, Laura Pabón, Ana Barrera, Jorge Aza-Conde, Manuel Alfonso Patarroyo, Manuel Elkin Patarroyo
More than 50 years ago the owl monkey (genus Aotus) was found to be highly susceptible to developing human malaria, making it an excellent experimental model for this disease. Microbes and parasites' (especially malaria) tremendous genetic variability became resolved during our malaria vaccine development, involving conserved peptides having high host cell binding activity (cHABPs); however, cHABPs are immunologically silent and must be specially modified (mHABPs) to induce a perfect fit into major histocompatibility complex (MHC) molecules (HLA in humans)...
September 30, 2017: Biochemical and Biophysical Research Communications
keyword
keyword
65199
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"