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IASLC classification

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https://www.readbyqxmd.com/read/27746963/the-iaslc-lung-cancer-staging-project-proposal-for-the-classification-of-lung-cancers-with-multiple-pulmonary-sites-of-involvement-the-first-step-toward-finding-optimal-treatment
#1
COMMENT
https://www.readbyqxmd.com/read/27740967/kras-mutation-is-a-significant-prognostic-factor-in-early-stage-lung-adenocarcinoma
#2
Kyuichi Kadota, Camelia S Sima, Maria E Arcila, Cyrus Hedvat, Mark G Kris, David R Jones, Prasad S Adusumilli, William D Travis
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR) mutations has been investigated in lung adenocarcinomas; however, their prognostic value remains controversial. In our study, we sought to investigate the prognostic significance of driver mutations using a large cohort of early-stage lung adenocarcinomas. We reviewed patients with pathologic early-stage, lymph node-negative, solitary lung adenocarcinoma who had undergone surgical resection (1995 to 2005; stage I/II=463/19). Tumors were classified according to the IASLC/ATS/ERS classification and genotyped by Sequenom MassARRAY system and polymerase chain reaction-based assays...
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27713056/cross-disciplinary-analysis-of-lymph-node-classification-in-lung-cancer-on-computed-tomography
#3
Ahmed H El-Sherief, Charles T Lau, Nancy A Obuchowski, Atul C Mehta, Thomas W Rice, Eugene H Blackstone
BACKGROUND: Accurate and consistent regional lymph node classification (N) is an important element in the staging and multidisciplinary management of lung cancer. Regional lymph node definition sets-lymph node maps-have been created to standardize N. In 2009, the International Association for the Study of Lung Cancer (IASLC) introduced a lymph node map to supersede all pre-existing lymph node maps. AIM: To study if, and how lung cancer specialists apply the IASLC lymph node map when classifying thoracic lymph nodes encountered on computed tomography (CT) during lung cancer staging...
October 3, 2016: Chest
https://www.readbyqxmd.com/read/27687964/the-iaslc-mesothelioma-staging-project-proposals-for-revisions-of-the-n-descriptors-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-pleural-mesothelioma
#4
David Rice, Kari Chansky, Anna Nowak, Harvey Pass, Hedy Kindler, Lynn Shemanski, Isabelle Opitz, Sergi Call, Seiki Hasegawa, Kemp Kernstine, Cansel Atinkaya, Federico Rea, Philippe Nafteux, Valerie W Rusch
INTRODUCTION: Nodal categories for malignant pleural mesothelioma are derived from the lung cancer staging system and have not been adequately validated. The International Association for the Study of Lung Cancer developed a multinational database to generate evidence-based recommendations to inform the eighth edition of the TNM classification of malignant pleural mesothelioma. METHODS: Data from 29 centers were entered prospectively (n = 1566) or by transfer of retrospective data (n = 1953)...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27687963/the-iaslc-mesothelioma-staging-project-proposals-for-revisions-of-the-t-descriptors-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-pleural-mesothelioma
#5
Anna K Nowak, Kari Chansky, David C Rice, Harvey I Pass, Hedy L Kindler, Lynn Shemanski, Andrea Billé, Robert C Rintoul, Hasan F Batirel, Charles F Thomas, Joseph Friedberg, Susana Cedres, Marc de Perrot, Valerie W Rusch
INTRODUCTION: The current T component for malignant pleural mesothelioma (MPM) has been predominantly informed by surgical data sets and consensus. The International Association for the Study of Lung Cancer undertook revision of the seventh edition of the staging system for MPM with the goal of developing recommendations for the eighth edition. METHODS: Data elements including detailed T descriptors were developed by consensus. Tumor thickness at three pleural levels was also recorded...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27639313/lung-adenocarcinomas-correlation-of-computed-tomography-and-pathology-findings
#6
J G Cohen, E Reymond, A Jankowski, E Brambilla, F Arbib, S Lantuejoul, G R Ferretti
Adenocarcinoma is the most common histologic type of lung cancer. Recent lung adenocarcinoma classifications from the International Association for the Study of Lung cancer, the American Thoracic Society and the European Respiratory Society (IASLC/ETS/ERS, 2011) and World Health Organization (WHO, 2015) define a wide range of adenocarcinoma types and subtypes featuring different prognosis and management. This spectrum of lesions translates into various CT presentations and features, which generally show good correlation with histopathology, stressing the key role of the radiologist in the diagnosis and management of those patients...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27545006/elucidating-genomic-characteristics-of-lung-cancer-progression-from-in-situ-to-invasive-adenocarcinoma
#7
Chanida Vinayanuwattikun, Florence Le Calvez-Kelm, Behnoush Abedi-Ardekani, David Zaridze, Anush Mukeria, Catherine Voegele, Maxime Vallée, Dewajani Purnomosari, Nathalie Forey, Geoffroy Durand, Graham Byrnes, James Mckay, Paul Brennan, Ghislaine Scelo
To examine the diversity of somatic alterations and clonal evolution according to aggressiveness of disease, nineteen tumor-blood pairs of 'formerly bronchiolo-alveolar carcinoma (BAC)' which had been reclassified into preinvasive lesion (adenocarcinoma in situ; AIS), focal invasive lesion (minimally invasive adenocarcinoma; MIA), and invasive lesion (lepidic predominant adenocarcinoma; LPA and non-lepidic predominant adenocarcinoma; non-LPA) according to IASLC/ATS/ERS 2011 classification were explored by whole exome sequencing...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27535389/lung-cancer-staging-and-prognosis
#8
Gavitt A Woodard, Kirk D Jones, David M Jablons
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was developed by the International Association for the Staging of Lung Cancer (IASLC) Lung Cancer Staging Project by a coordinated international effort to develop data-derived TNM classifications with significant survival differences. Based on these TNM groupings, current 5-year survival estimates in NSLCC range from 73 % in stage IA disease to 13 % in stage IV disease. TNM stage remains the most important prognostic factor in predicting recurrence rates and survival times, followed by tumor histologic grade, and patient sex, age, and performance status...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27524912/two-gene-signature-improves-the-discriminatory-power-of-iaslc-ats-ers-classification-to-predict-the-survival-of-patients-with-early-stage-lung-adenocarcinoma
#9
Yifeng Sun, Likun Hou, Yu Yang, Huikang Xie, Yang Yang, Zhigang Li, Heng Zhao, Wen Gao, Bo Su
BACKGROUND: In this study, we investigated the contribution of a gene expression-based signature (composed of BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR) to survival prediction for early-stage lung adenocarcinoma categorized by the new International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS) classification. We also aimed to verify whether gene signature improves the risk discrimination of IASLC/ATS/ERS classification in early-stage lung adenocarcinoma...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27496649/the-histologic-classifications-of-lung-adenocarcinomas-are-discriminable-by-unique-lineage-backgrounds
#10
Haichuan Hu, Zhengliang Sun, Yuan Li, Yiliang Zhang, Hang Li, Yang Zhang, Yunjian Pan, Lei Shen, Rui Wang, Yihua Sun, Haiquan Chen
OBJECTIVES: Lung adenocarcinomas are a heterogeneous set of diseases with distinct genetic and histologic characteristics. Besides the discovery of oncogenic mutations and introduction of the histologic classifications (2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society and 2015 WHO), increasing evidence has linked this intertumor heterogeneity to the lung lineage-specific pathways and lineage genes. Therefore, in this study, we assessed the gene expression of identified lung lineage genes to study their role in distinguishing lung adenocarcinoma diversities...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27456862/prognostic-value-of-mmp9-activity-level-in-resected-stage-i-b-lung-adenocarcinoma
#11
Yongfeng Yu, Zhengping Ding, Hong Jian, Lan Shen, Lei Zhu, Shun Lu
The clinical outcomes of patients with early-stage non-small cell lung cancer (NSCLC) have remained unsatisfactory after complete surgical resection. The objective of this study was to explore the prognostic value of matrix metalloproteinase 9 (MMP9) activity level in Chinese patients with stage I B lung adenocarcinoma. A sensitive and validated method was employed for determining the activity of MMP9 in human lung adenocarcinoma cells in vitro. Then, the association was examined between the level of MMP9 enzymatic activity and clinical outcomes...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27448762/the-iaslc-lung-cancer-staging-project-methodology-and-validation-used-in-the-development-of-proposals-for-revision-of-the-stage-classification-of-nsclc-in-the-forthcoming-eighth-edition-of-the-tnm-classification-of-lung-cancer
#12
Frank C Detterbeck, Kari Chansky, Patti Groome, Vanessa Bolejack, John Crowley, Lynn Shemanski, Catherine Kennedy, Mark Krasnik, Michael Peake, Ramón Rami-Porta
INTRODUCTION: Stage classification provides a consistent language to describe the anatomic extent of disease and is therefore a critical tool in caring for patients. The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer developed proposals for revision of the classification of lung cancer for the eighth edition of the tumor, node, and metastasis (TNM) classification, which takes effect in 2017. METHODS: An international database of 94,708 patients with lung cancer diagnosed in 1999-2010 was assembled...
September 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27423392/do-new-pn-subclassifications-proposed-by-iaslc-s-lung-cancer-staging-project-agree-with-ypn-categories-after-trimodality-therapy-for-initial-n2-disease
#13
Hakyoung Kim, Yong Chan Ahn, Hongryull Pyo, Dongryul Oh, Jae Myoung Noh, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Minju Lee, Jungho Han
INTRODUCTION: The International Association for the Study of Lung Cancer's lung cancer staging project has recently proposed a new subclassification of pN1-2 based on multiplicity of involved nodal stations and presence of skip metastasis. The authors investigated whether this new subclassification agrees with the ypN categories after trimodality therapy for initially N2 disease. METHODS: From March 2001 until June 2014, trimodality therapy consisting of preoperative thoracic radiation therapy concurrent with weekly platinum-based doublet chemotherapy and surgical resection was successfully undertaken in 508 patients after histopathologic confirmation of N2 disease...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27401643/three-dimensional-ground-glass-opacity-ratio-in-ct-images-can-predict-tumor-invasiveness-of-stage-ia-lung-cancer
#14
Woo Sik Yu, Sae Rom Hong, Jin Gu Lee, Jae Seok Lee, Hee Suk Jung, Dae Joon Kim, Kyung Young Chung, Chang Young Lee
PURPOSE: We investigated the relationship between various parameters, including volumetric parameters, and tumor invasiveness according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification. MATERIALS AND METHODS: We retrospectively reviewed 99 patients with completely resected stage IA lung adenocarcinoma. The correlation between several parameters [one-dimensional ground glass opacity (1D GGO) ratio, two-dimensional (2D) GGO ratio, three-dimensional (3D) GGO ratio, 1D solid size, 2D solid size, and 3D solid size] and tumor invasiveness according to IASLC/ATS/ERS classification was investigated using receiver operating characteristic (ROC) analysis...
September 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27356985/-grading-of-lung-cancer
#15
R M Bohle, P A Schnabel
In comparison with other tumor entities there is no common generally accepted grading system for lung cancer with clearly defined criteria and clinical relevance. In the recent fourth edition of the World Health Organization (WHO) classification from 2015 of tumors of the lungs, pleura, thymus and heart, there is no generally applicable grading for pulmonary adenocarcinomas, squamous cell carcinomas or rarer forms of carcinoma. Since the new IASLC/ATS/ERS classification of adenocarcinomas published in 2011, 5 different subtypes with significantly different prognosis are proposed...
July 2016: Der Pathologe
https://www.readbyqxmd.com/read/27335292/-revision-of-the-tnm-stage-grouping-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-lung-cancer
#16
Bo Ye, Heng Zhao
The currently adopted staging system for lung cancer is the seventh edition of the TNM staging edited by Union for International Cancer Control (UICC) in January, 2009. In recent years, with the advances of techniques in lung cancer diagnosis and the treatment trends towards precision treatment modalities such as individualized therapy and molecular targeted therapy, the survival and prognosis of lung cancer has been significantly improved. The old staging standard is difficult to satisfy the currentrapidly developing clinical needs...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27335291/-changes-of-2015-who-histological-classification-of-lung-cancer-%C3%A2-and-the-clinical-significance
#17
Xin Yang, Dongmei Lin
Due in part to remarkable advances over the past decade in our understanding of lung cancer, particularly in area of medical oncology, molecular biology, and radiology, there is a pressing need for a revised classification, based not on pathology alone, but rather on an integrated multidisciplinary approach to classification of lung cancer. The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27198445/89p-investigating-the-potential-utility-of-the-alternative-iaslc-nodal-staging-classification-in-nsclc
#18
T Edwards, H Al-Najjar, P Crosbie, J Martin, A Chaturvedi, M Evison, R Booton
No abstract text is available yet for this article.
April 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27185994/imaging-of-spaces-of-neck-and-mediastinum-by-endoscopic-ultrasound
#19
REVIEW
Malay Sharma, Amit Pathak, Abid Shoukat, Piyush Somani
Endoscopic ultrasound (EUS) of the mediastinum was pioneered by gastroenterologists, and it was taken up by pulmonologists when the smaller-diameter endobronchial ultrasound (EBUS) scope was designed after a few years. The pulmonologists' approach remained largely confined to entry from the trachea, but they soon realized that the esophagus was an alternative route of entry by the EBUS scope. The new generations of interventionists are facing the challenge of learning two techniques (EUS and EBUS) from two routes (esophagus and trachea)...
May 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27137345/lung-adenocarcinoma-staging-using-the-2011-iaslc-ats-ers-classification-a-pooled-analysis-of-adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma
#20
Madhusmita Behera, Taofeek K Owonikoko, Anthony A Gal, Conor E Steuer, Sungjin Kim, Rathi N Pillai, Fadlo R Khuri, Suresh S Ramalingam, Gabriel L Sica
BACKGROUND: Lung adenocarcinoma accounts for almost 60% of non-small-cell lung cancer. According to the 2011 International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) classification and 2015 World Health Organization classification of tumors of the lung, lepidic-predominant adenocarcinomas ≤ 3 cm in size can be classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma, lepidic predominant...
March 30, 2016: Clinical Lung Cancer
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