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https://www.readbyqxmd.com/read/29027312/cyclophilin-a-expression-and-its-prognostic-significance-in-lung-adenocarcinoma
#1
Noriyuki Nakano, Shingo Sakashita, Ryota Matsuoka, Yoshihiko Murata, Aya Shiba-Ishii, Naohiro Kobayashi, Yukio Sato, Masayuki Noguchi
Cyclophilin A (CypA) has been reported to be upregulated in malignant tumors. CypA expression is thought to be associated with acquisition of tumor growth and anti-apoptotic function. Although upregulation of CypA has been reported in lung adenocarcinoma, its clinicopathological significance and roles in malignant progression remain unclear. Here we investigated the implications of CypA expression for outcome in patients with lung adenocarcinoma. Lung adenocarcinoma specimens from 198 cases were selected and reclassified according to the World Health Organization classification (4th edition) and the Noguchi classification...
October 12, 2017: Pathology International
https://www.readbyqxmd.com/read/29027309/the-importance-of-symptoms-in-the-longitudinal-variability-of-clusters-in-copd-patients-a-validation-study
#2
Juan P de Torres, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Borja Cosio, Ciro Casanova
BACKGROUND AND OBJECTIVE: Cluster analysis has been utilized to explore phenotypic heterogeneity in chronic obstructive pulmonary disease (COPD). To date, little is known about the longitudinal variability of clusters in COPD patients. We aimed to evaluate the 2-year cluster variability in stable COPD patients. METHODS: We evaluated the following variables in COPD patients at baseline and 2 years later: age, gender, pack-year history, body mass index (BMI), modified Medical Research Council (MMRC) scale, 6-min walking distance (6MWD), spirometry and COPD Assessment Test (CAT)...
October 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29026165/appropriate-surgical-modalities-for-stages-t2a-and-t2b-in-the-eighth-tnm-classification-of-lung-cancer
#3
Fenglong Bie, Xiao Qu, Xudong Yang, Zhaofei Pang, Yufan Yang, Shaorui Liu, Wei Dong, Jiajun Du
Patients with tumors of 3 to 5 cm were divided into stages T2a (3 to 4 cm) and T2b (4 to 5 cm) based on the 8(th) tumor-node-metastasis staging system for lung cancer. The objective of our study was to explore appropriate surgical modalities for the new stages, T2a and T2b. We selected 6,996 node-negative non-small-cell lung cancer patients with tumor sizes of 3 to 5 cm, diagnosed between 2009 and 2013, from the Surveillance, Epidemiology, and End Results (SEER) program. The Pearson [Formula: see text]...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024544/squamous-cell-carcinoma-in-serous-effusions-avoiding-pitfalls-in-this-rare-encounter
#4
Christopher LePhong, Elizabeth W Hubbard, Stuart Van Meter, Laurentia Nodit
BACKGROUND: With advent of personalized medicine, precise classification of malignant tumors becomes essential. Squamous cell carcinoma (SCC) is rarely found in serous effusions and has morphologic and immunohistochemical (IHC) overlap with other neoplasms. METHODS: 17-year review identified 49 fluids from 26 patients where SCC was recognized. RESULTS: SCC was more frequent in pleural fluid (84%) and rare in other effusions. Lung SCC was common (65%), followed by head and neck (16%), with other origins less represented...
October 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29023689/difference-of-lower-airway-microbiome-in-bilateral-protected-specimen-brush-between-lung-cancer-patients-with-unilateral-lobar-masses-and-control-subjects
#5
Hai-Xia Liu, Li-Li Tao, Jing Zhang, Ying-Gang Zhu, Yu Zheng, Dong Liu, Min Zhou, Hui Ke, Meng-Meng Shi, Jie-Ming Qu
The functional role of respiratory microbiota has attracted an accumulating attention recently. However, the role of respiratory microbiome in lung carcinogenesis is mostly unknown. This study aimed to characterize and compare bilateral lower airway microbiome of lung cancer patients with unilateral lobar masses and control subjects. Protected bronchial specimen brushing samples were collected from 24 lung cancer patients with unilateral lobar masses (paired samples from cancerous site and the contralateral noncancerous site) and 18 healthy controls undergoing bronchoscopies and further analyzed by 16S rRNA amplicon sequencing...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29022170/modified-staging-system-for-pulmonary-carcinoids-on-the-basis-of-lung-cancer-tnm-system
#6
O Abdel-Rahman
BACKGROUND: Pulmonary carcinoids are being staged along the lines of lung cancer American Joint Committee on Cancer (AJCC) staging system. The current study evaluated the prognostic value of a modified staging system for patients with pulmonary carcinoid. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was searched through SEER*Stat program. Through recursive partitioning analysis and subsequent decision tree formation, suggested stages were constructed...
October 11, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29019755/interstitial-lung-disease-in-children-made-easier%C3%A2-well-almost
#7
Thomas R Semple, Michael T Ashworth, Catherine M Owens
Interstitial lung disease (ILD) in pediatric patients is different from that in adults, with a vast array of pathologic conditions unique to childhood, varied modes of presentation, and a different range of radiologic appearances. Although rare, childhood ILD (chILD) is associated with significant morbidity and mortality, most notably in conditions of disordered surfactant function, with respiratory failure in 100% of neonates with surfactant protein B dysfunction and 100% mortality without lung transplantation...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29017393/expression-of-hsa-let-7b-5p-hsa-let-7f-5p-and-hsa-mir-222-3p-and-their-putative-targets-hmga2-and-cdkn1b-in-typical-and-atypical-carcinoid-tumors-of-the-lung
#8
Pietro Di Fazio, Moritz Maass, Silvia Roth, Christian Meyer, Joana Grups, Peter Rexin, Detlef K Bartsch, Andreas Kirschbaum
Typical and atypical carcinoid tumors belong to the neuroendocrine lung tumors. They have low recurrence and proliferation rate, lymph node, and distant metastases. Nevertheless, these tumors have shown a more aggressive behavior. In the last years, microRNAs were screened as new tumor markers for their potential diagnostic and therapeutic relevance. The expression of hsa-let-7b-5p, hsa-let-7f-5p, hsa-miR-222-3p, and their targets HMGA2 (high-mobility group A2) and CDKN1B (cyclin-dependent kynase inhibitor 1B, p27(kip1)) was evaluated in this rare small group of patients...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28989563/generative-method-to-discover-emphysema-subtypes-with-unsupervised-learning-using-lung-macroscopic-patterns-lmps-the-mesa-copd-study
#9
Jingkuan Song, Jie Yang, Benjamin Smith, Pallavi Balte, Eric A Hoffman, R Graham Barr, Andrew F Laine, Elsa D Angelini
Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes: centrilobular emphysema (CLE), panlobular emphysema (PLE) and paraseptal emphysema (PSE). Automated classification methods based on supervised learning are generally based upon the current definition of emphysema subtypes, while unsupervised learning of texture patterns enables the objective discovery of possible new radiological emphysema subtypes. In this work, we use a variant of the Latent Dirichlet Allocation (LDA) model to discover lung macroscopic patterns (LMPs) in an unsupervised way from lung regions that encode emphysematous areas...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28987562/the-revision-of-8th-edition-tnm-stage-criteria-is-more-accurate-in-prediction-postoperative-survival-for-sclc-patients
#10
Jian Li, Yongsheng Zhao, Chuan Li, Longfei Zhu, Chengwu Liu, Lunxu Liu
OBJECTIVES: The 8th edition TNM lung cancer classification was enacted in January 2017. An important change is the old T2a was revised to new T2a and T2b. Whether a postoperative survival difference exists between the two stages is still undefined. The purpose of this study is to investigate the postoperative outcomes of small cell lung cancer (SCLC) patients and compare the survival difference between the two stages. METHODS: Data of patients with SCLC who underwent surgery between October 2005 and August 2013 at our institute were reviewed...
October 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28986041/improvement-in-tnm-staging-of-pulmonary-neuroendocrine-tumors-requires-histology-and-regrouping-of-tumor-size
#11
Maria Cattoni, Eric Vallières, Lisa M Brown, Amir A Sarkeshik, Stefano Margaritora, Alessandra Siciliani, Pier Luigi Filosso, Francesco Guerrera, Andrea Imperatori, Nicola Rotolo, Farhood Farjah, Grace Wandell, Kimberly Costas, Catherine Mann, Michal Hubka, Stephen Kaplan, Alexander S Farivar, Ralph W Aye, Brian E Louie
OBJECTIVE: Neuroendocrine tumors of the lung are currently staged with the 7th edition TNM non-small cell lung cancer staging system. This decision, based on data analysis without data on histology or disease-specific survival, makes its applicability limited. This study proposes a specific staging system for these tumors. METHODS: We retrospectively analyzed 510 consecutive patients (female/male, 313/197; median age, 61 years; interquartile range, 51-70) undergoing lung resection for a primary neuroendocrine tumor between 2000 and 2015 in 8 centers...
September 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28984373/pulmonary-ultrasound-scoring-system-for-intubated-critically-ill-patients-and-its-association-with-clinical-metrics-and-mortality-a-prospective-cohort-study
#12
David M Tierney, Lori L Boland, Josh D Overgaard, Joshua S Huelster, Ann Jorgenson, James P Normington, Roman R Melamed
PURPOSE: Pulmonary ultrasound (PU) examination at the point-of-care can rapidly identify the etiology of acute respiratory failure (ARF) and assess treatment response. The often-subjective classification of PU abnormalities makes it difficult to document change over time and communicate findings across providers. The study goal was to develop a simple, PU scoring system that would allow for standardized documentation, have high interprovider agreement, and correlate with clinical metrics...
October 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28974912/cardiovascular-comorbidities-of-rheumatoid-arthritis-in-taiwanese-adults-a-retrospective-single-center-study
#13
Ning-Sheng Lai, Chun-Lung Wang, Ming-Chi Lu, Malcolm Koo
OBJECTIVE: To evaluate the association between rheumatoid arthritis (RA) and cardiovascular comorbidities, including hyperlipidemia, hypertension, and diabetes, in Taiwanese patients based on the data from medical records. MATERIALS AND METHODS: A retrospective study was performed using the computerized medical records from a regional hospital located in southern Taiwan. A total of 2293 patients (age range 30-79 years) with a diagnosis of RA (International Classification of Diseases, Ninth Revision, Clinical Modification code 714...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28972958/immunoexpression-analysis-of-selected-jak-stat-pathway-molecules-in-non-small-cell-lung-cancer-patients
#14
Dorota Pastuszak-Lewandoska, Daria Domańska-Senderowska, Jacek Kordiak, Adam Antczak, Karolina H Czarnecka, Monika Migdalska-Sęk, Ewa Nawrot, Justyna M Kiszałkiewicz, Ewa Brzeziańska-Lasota
INTRODUCTION Signal transducer and activator of transcription (STAT) proteins are critically involved in tumorigenesis in various cancers, including lung tumors. OBJECTIVES To analyze the immunoexpression levels of three STAT proteins: STAT3, STAT5, and STAT6 in their phosphorylated forms, STAT inhibitors PIAS3 and SOCS3, and additionally COX-2, as potential diagnostic and/or prognostic markers in lung cancer. PATIENTS AND METHODS The study involved 71 patients diagnosed with non-small cell lung cancer (NSCLC)...
September 30, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28969046/gene-methylation-biomarkers-in-sputum-as-a-classifier-for-lung-cancer-risk
#15
Shuguang Leng, Guodong Wu, Donna M Klinge, Cynthia L Thomas, Elia Casas, Maria A Picchi, Christine A Stidley, Sandra J Lee, Seena Aisner, Jill M Siegfried, Suresh Ramalingam, Fadlo R Khuri, Daniel D Karp, Steven A Belinsky
CT screening for lung cancer reduces mortality, but will cost Medicare ∼2 billion dollars due in part to high false positive rates. Molecular biomarkers could augment current risk stratification used to select smokers for screening. Gene methylation in sputum reflects lung field cancerization that remains in lung cancer patients post-resection. This population was used in conjunction with cancer-free smokers to evaluate classification accuracy of a validated eight-gene methylation panel in sputum for cancer risk...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966837/a-methodology-for-texture-feature-based-quality-assessment-in-nucleus-segmentation-of-histopathology-image
#16
Si Wen, Tahsin M Kurc, Yi Gao, Tianhao Zhao, Joel H Saltz, Wei Zhu
CONTEXT: Image segmentation pipelines often are sensitive to algorithm input parameters. Algorithm parameters optimized for a set of images do not necessarily produce good-quality-segmentation results for other images. Even within an image, some regions may not be well segmented due to a number of factors, including multiple pieces of tissue with distinct characteristics, differences in staining of the tissue, normal versus tumor regions, and tumor heterogeneity. Evaluation of quality of segmentation results is an important step in image analysis...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28966322/the-structure-of-a-chronic-total-occlusion-and-its-safe-treatment-in-a-patient-with-chronic-thromboembolic-pulmonary-hypertension
#17
Shun Minatsuki, Masaru Hatano, Hisataka Maki, Jiro Ando, Issei Komuro
A pouching defect, which is a type of angiographic classification in chronic thromboembolic pulmonary hypertension (CTEPH), is equivalent to a chronic total occlusion (CTO). Thus far, treating CTO involves high risk of the lung bleeding and is difficult because the structure and treating strategy have not been clarified, yet treating it has great potential to improve hemodynamic status and ventilation perfusion mismatch. Here, we describe a case of successfully treated the CTO. In this case, we treated it safely by two balloon pulmonary angiography (BPA) sessions...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28965239/burkholderia-cepacia-complex-in-cystic-fibrosis-in-a-brazilian-reference-center
#18
Priscila Dentini, Fernando Augusto Lima Marson, Luciana Cardoso Bonadia, Carmen Sílvia Bertuzzo, Antônio Fernando Ribeiro, Carlos Emílio Levy, José Dirceu Ribeiro
The Burkholderia cepacia complex (BCC) can cause a severe decline in lung function in cystic fibrosis (CF). Our objective was to determine the BCC prevalence and to evaluate its clinical impact on CF. Clinical and laboratory variables were determined for CF patients with BCC (Group-A = 50 patients) and without BCC (Group-B = 134 patients). The microorganisms were identified by biochemical tests, the Vitek2(®)Compact test, recA-PCR and recA-nested-PCR with species-specific primers and DNA sequencing. The patients were evaluated by the Shwachman-Kulczycki score (SKCS), Bhalla score (BS), spirometry and body mass index (BMI)...
September 30, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28964798/phenotypic-clusters-predict-outcomes-in-a-longitudinal-interstitial-lung-disease-cohort
#19
Ayodeji Adegunsoye, Justin M Oldham, Jonathan H Chung, Steven M Montner, Cathryn Lee, Leah J Witt, Danielle Stahlbaum, Rene S Bermea, Lena W Chen, Scully Hsu, Aliya N Husain, Imre Noth, Rekha Vij, Mary E Strek, Matthew Churpek
BACKGROUND: The current interstitial lung disease (ILD) classification has overlapping clinical presentations and outcomes. Cluster analysis modeling is a valuable tool in identifying distinct clinical phenotypes in heterogeneous diseases. However, this approach has yet to be implemented in ILD. METHODS: Using cluster analysis, we identified novel ILD phenotypes among subjects from a longitudinal ILD cohort and stratified outcomes by phenotypic clusters compared to subgroups by current American Thoracic Society (ATS)/European Respiratory Society (ERS) ILD classification criteria...
September 27, 2017: Chest
https://www.readbyqxmd.com/read/28964610/correlation-of-clinicopathologic-features-and-lung-squamous-cell-carcinoma-subtypes-according-to-the-2015-who-classification
#20
Rongrong Chen, Zhengping Ding, Lei Zhu, Shun Lu, Yongfeng Yu
AIMS: This study aimed to determine the relationship between clinicopathologic features and lung squamous cell carcinoma (LSCC) subtypes according to the 2015 WHO classification. METHODS: We identified 824 operable LSCC patients undergoing a complete surgical resection at Shanghai Chest Hospital between April 2015 and January 2017. Immunohistochemistry was used to investigate the clinicopathologic features. RESULTS: Among them, the percentages of LSCC subtypes were 66...
September 19, 2017: European Journal of Surgical Oncology
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