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lung classification

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https://www.readbyqxmd.com/read/29450713/radiomic-signature-as-a-diagnostic-factor-for-histologic-subtype-classification-of-non-small-cell-lung-cancer
#1
Xinzhong Zhu, Di Dong, Zhendong Chen, Mengjie Fang, Liwen Zhang, Jiangdian Song, Dongdong Yu, Yali Zang, Zhenyu Liu, Jingyun Shi, Jie Tian
OBJECTIVES: To distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC) based on a radiomic signature METHODS: This study involved 129 patients with non-small cell lung cancer (NSCLC) (81 in the training cohort and 48 in the independent validation cohort). Approximately 485 features were extracted from a manually outlined tumor region. The LASSO logistic regression model selected the key features of a radiomic signature. Receiver operating characteristic curve and area under the curve (AUC) were used to evaluate the performance of the radiomic signature in the training and validation cohorts...
February 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29448054/rage-induced-changes-in-the-proteome-of-alveolar-epithelial-cells
#2
Charles A Downs, Nicholle M Johnson, George Tsaprailis, My N Helms
The receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor and member of the immunoglobulin superfamily. RAGE is constitutively expressed in the distal lung where it co-localizes with the alveolar epithelium; RAGE expression is otherwise minimal or absent, except with disease. This suggests RAGE plays a role in lung physiology and pathology. We used proteomics to identify and characterize the effects of RAGE on rat alveolar epithelial (R3/1) cells. LC-MS/MS identified 177 differentially expressed proteins and the PANTHER Classification System further segregated proteins...
February 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29446758/localized-thin-section-ct-with-radiomics-feature-extraction-and-machine-learning-to-classify-early-detected-pulmonary-nodules-from-lung-cancer-screening
#3
Shu-Ju Tu, Chih-Wei Wang, Kuang-Tse Pan, Yi-Cheng Wu, Chen-Te Wu
Lung cancer screening aims to detect small pulmonary nodules and decrease the mortality rate. However, studies from large-scale clinical trials of lung cancer screening showed false-positive rate is high and positive predictive value is low. To address these problems, it is highly needed to have a technical approach for accurate malignancy differentiation among these early-detected nodules. We studied the clinical feasibility of an additional protocol of localized thin-section CT for further assessment on these recalled patients from lung cancer screening tests...
February 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29436722/the-prognosis-of-different-distant-metastases-pattern-in-prostate-cancer-a-population-based-retrospective-study
#4
Jiafeng Shou, Qi Zhang, Shuai Wang, Dahong Zhang
BACKGROUND: The present of metastases is a poor prognostic factor in prostate cancer, but the prognostic impact of different distant metastases pattern is unclear. The aim of this study is to investigate the impact of different distant metastases pattern on the survival of patients with stage IV prostate cancer. METHODS: Data queried for this study include prostate cancer (2010-2014) from the Surveillance, Epidemiology, and End Results (SEER) program. Metastatic distribution information was provided for bone, brain, liver and lung...
February 13, 2018: Prostate
https://www.readbyqxmd.com/read/29436168/feasibility-study-of-individualized-optimal-positioning-selection-for-left-sided-whole-breast-radiotherapy-dibh-or-prone
#5
Hui Lin, Tianyu Liu, Chengyu Shi, Saskia Petillion, Isabelle Kindts, Caroline Weltens, Tom Depuydt, Yulin Song, Ziad Saleh, Xie George Xu, Xiaoli Tang
The deep inspiration breath hold (DIBH) and prone (P) position are two common heart-sparing techniques for external-beam radiation treatment of left-sided breast cancer patients. Clinicians select the position that is deemed to be better for tissue sparing based on their experience. This approach, however, is not always optimum and consistent. In response to this, we develop a quantitative tool that predicts the optimal positioning for the sake of organs at risk (OAR) sparing. Sixteen left-sided breast cancer patients were considered in the study, each received CT scans in the supine free breathing, supine DIBH, and prone positions...
February 13, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29434993/prediction-of-decannulation-oral-intake-recovery-overall-survival-and-lung-metastasis-following-oral-malignant-tumor-resection-and-reconstruction
#6
Hidenori Suzuki, Ikuo Hyodo, Yasuhisa Hasegawa
The present study investigated whether tongue base and mandibular bone defects were associated with the rate of decannulation and oral intake recovery, and survival time, including overall and lung metastasis-free survival time, in patients that underwent oral malignant tumor (OMT) resection with reconstruction. A total of 105 patients that underwent OMT resection with laryngeal preservation and reconstruction were recruited. The extent of defects was classified according to Urken's classification. The rates of decannulation and oral intake recovery were assessed with the Kaplan-Meier method...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434341/hyalinizing-clear-cell-carcinoma-of-the-bronchial-glands-presentation-of-three-cases-and-pathological-comparisons-with-salivary-gland-counterparts-and-bronchial-mucoepidermoid-carcinomas
#7
Manabu Takamatsu, Yukiko Sato, Mariko Muto, Hiroko Nagano, Hironori Ninomiya, Rie Sakakibara, Satoko Baba, Seiji Sakata, Kengo Takeuchi, Sakae Okumura, Yuichi Ishikawa
Hyalinizing clear cell carcinoma of the bronchial glands is a very rare tumor. Since only five reports describing six tumors have been published to date, only a little is known about specific histologic findings and clinical features. Because of its rarity, hyalinizing clear cell carcinoma has not been described in the latest WHO classification of pulmonary tumors yet. Here we present three cases of bronchial hyalinizing clear cell carcinomas, confirmed by both fluorescence in situ hybridization (FISH) and RT-PCR, focusing on histologic and immunohistochemical characteristics in a comparison with three cases of salivary gland origin...
February 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29433528/effect-of-socioeconomic-inequalities-on-cholecystectomy-outcomes-a-10-year-population-based-analysis
#8
Ping Lu, Nan-Ping Yang, Nien-Tzu Chang, K Robert Lai, Kai-Biao Lin, Chien-Lung Chan
BACKGROUND: Although numerous epidemiological studies on cholecystectomy have been conducted worldwide, only a few have considered the effect of socioeconomic inequalities on cholecystectomy outcomes. Specifically, few studies have focused on the low-income population (LIP). METHODS: A nationwide prospective study based on the Taiwan National Health Insurance dataset was conducted during 2003-2012. The International Classification of ICD-9-CM procedure codes 51...
February 13, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29432063/approach-to-pulmonary-hypertension-from-ct-to-clinical-diagnosis
#9
Felipe Aluja Jaramillo, Fernando R Gutierrez, Federico G Díaz Telli, Sebastian Yevenes Aravena, Cylen Javidan-Nejad, Sanjeev Bhalla
Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary circulation. It may be idiopathic or arise in the setting of other clinical conditions. Patients with PH tend to present with nonspecific cardiovascular or respiratory symptoms. The clinical classification of PH was recently revised at the World Health Organization symposium in Nice, France, in 2013. That consensus statement provided an updated classification based on the shared hemodynamic characteristics and management of the different categories of PH...
February 12, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29428212/computed-tomography-window-blending-feasibility-in-thoracic-trauma
#10
Jacob C Mandell, Jeremy R Wortman, Tatiana C Rocha, Les R Folio, Katherine P Andriole, Bharti Khurana
RATIONALE AND OBJECTIVES: This study aims to demonstrate the feasibility of processing computed tomography (CT) images with a custom window blending algorithm that combines soft-tissue, bone, and lung window settings into a single image; to compare the time for interpretation of chest CT for thoracic trauma with window blending and conventional window settings; and to assess diagnostic performance of both techniques. MATERIALS AND METHODS: Adobe Photoshop was scripted to process axial DICOM images from retrospective contrast-enhanced chest CTs performed for trauma with a window-blending algorithm...
February 7, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29427194/the-relationship-between-nutritional-status-and-handgrip-strength-in-adult-cancer-patients-a-cross-sectional-study
#11
Şenay Burçin Alkan, Mehmet Artaç, Neslişah Rakıcıoğlu
PURPOSE: Malnutrition is a common complication in head, neck and lung cancer patients, particularly in cases of gastrointestinal system (GIS) cancer. Therefore, an assessment of malnutrition is crucial for early nutritional interventions. It was conducted as a cross-sectional study to evaluate nutritional status of adult cancer patients. METHODS: The nutritional status of 104 cancer patients (52 GIS and 52 non-GIS cancer cases) using a Patient-Generated Subjective Global Assessment (PG-SGA), handgrip strength, certain anthropometric measurements and food consumption in and outside of the hospital were assessed...
February 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29425462/challenges-in-pulmonary-hypertension-controversies-in-treating-the-tip-of-the-iceberg
#12
Jason M Elinoff, Richa Agarwal, Christopher F Barnett, Raymond L Benza, Michael J Cuttica, Ahmed M Gharib, Michael P Gray, Paul M Hassoun, Anna R Hemnes, Marc Humbert, Todd M Kolb, Tim Lahm, Jane A Leopold, Stephen C Mathai, Vallerie V McLaughlin, Ioana R Preston, Erika B Rosenzweig, Oksana A Shlobin, Virginia D Steen, Roham T Zamanian, Michael A Solomon
The Critical Care Medicine Department of the National Institutes of Health Clinical Center and the Pulmonary Hypertension Association held a joint symposium to discuss "Challenges in Pulmonary Hypertension: Beating, Breathing, and Beyond." Communities of interest including patient advocates, clinicians, and academic investigators gathered together to raise awareness and highlight the challenges in diagnosing and treating pulmonary hypertension (PH). The current symposium focused on whether or not pulmonary arterial hypertension specific treatments are warranted as therapies for PH due to heart failure with preserved ejection fraction, interstitial lung disease, and pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis...
February 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29425066/whole-blood-gene-expression-profiling-predicts-severe-morbidity-and-mortality-in-cystic-fibrosis-a-5-year-follow-up-study
#13
Milene T Saavedra, Bradley S Quon, Anna Faino, Silvia M Caceres, Katie R Poch, Linda A Sanders, Kenneth C Malcolm, David P Nichols, Scott D Sagel, Jennifer L Taylor-Cousar, Sonia M Leach, Matthew Strand, Jerry A Nick
RATIONALE: Cystic fibrosis pulmonary exacerbations accelerate pulmonary decline and increase mortality. Previously, we identified a 10-gene leukocyte panel measured directly from whole blood, which indicates response to exacerbation treatment. We hypothesized that molecular characteristics of exacerbations could also predict future disease severity. OBJECTIVE: We tested whether a 10-gene panel measured from whole blood could identify patient cohorts at increased risk for severe morbidity and mortality, beyond standard clinical measures...
February 9, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29424557/proteomic-biomarkers-for-lung-cancer-progression
#14
Yanjiao Ren, Shishun Zhao, Dandan Jiang, Xin Feng, Yexian Zhang, Zhipeng Wei, Zhongyu Wang, Wenniu Zhang, Qing F Zhou, Yong Li, Hanxu Hou, Ying Xu, Fengfeng Zhou
AIM: Lung adenocarcinoma (LUAD) and lung squamous-cell carcinoma (LUSC) are two major subtypes of lung cancer and constitute about 70% of all the lung cancer cases. The patient's lifespan and living quality will be significantly improved if they are diagnosed at an early stage and adequately treated. Methodology & results: This study comprehensively screened the proteomic dataset of both LUAD and LUSC, and proposed classification models for the progression stages of LUAD and LUSC with accuracies 86...
February 9, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29421915/esophageal-motor-disorders-are-frequent-during-pre-and-post-lung-transplantation-can-they-influence-lung-rejection
#15
Constanza Ciriza de Los Ríos, Fernando Canga Rodríguez-Valcárcel, Alicia de Pablo Gafas, Isabel Castel de Lucas, David Lora Pablos, Gregorio Castellano Tortajada
BACKGROUND: lung transplantation (LTx) is a viable option for most patients with end-stage lung diseases. Esophageal motor disorders (EMD) are frequent in candidates for LTx, but there is very little data about changes in esophageal motility post-LTx. AIM: the aim of our study was to assess esophageal motor disorders by high resolution manometry (HRM) both pre-LTx and six months post-LTx in patients with and without organ rejection. STUDY: HRM (Manoscan®) was performed in 57 patients both pre-LTx and six months post-LTx...
February 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29419895/pulmonary-artery-perfusion-versus-no-perfusion-during-cardiopulmonary-bypass-for-open-heart-surgery-in-adults
#16
REVIEW
Katrine B Buggeskov, Lars Grønlykke, Emilie C Risom, Mao Ling Wei, Jørn Wetterslev
BACKGROUND: Available evidence has been inconclusive on whether pulmonary artery perfusion during cardiopulmonary bypass (CPB) is associated with decreased or increased mortality, pulmonary events, and serious adverse events (SAEs) after open heart surgery. To our knowledge, no previous systematic reviews have included meta-analyses of these interventions. OBJECTIVES: To assess the benefits and harms of single-shot or continuous pulmonary artery perfusion with blood (oxygenated or deoxygenated) or a preservation solution compared with no perfusion during cardiopulmonary bypass (CPB) in terms of mortality, pulmonary events, serious adverse events (SAEs), and increased inflammatory markers for adult surgical patients...
February 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29416694/prognostic-and-clinicopathological-significance-of-microrna-494-overexpression-in-cancers-a-meta-analysis
#17
Zhenxian Xiang, Min Sun, Zewei Yuan, Chunxiao Zhang, Jun Jiang, Sihao Huang, Bin Xiong
MicroRNA-494 was revealed as an attractive prognostic biomarker in recent studies. Nevertheless, the prognostic value of microRNA-494 in cancers remains controversial. Current meta-analysis aims to elucidate the precise predictive value of microRNA-494 in various cancers. Eligible studies were identified through multiple search strategies, the hazard ratios (HRs) and their confidence interval (CI) for patient prognostic outcomes were extracted and estimated. The pooled results of fifteen studies indicated that elevated expression of microRNA-494 implies a good overall survival of cancer patients (HR = 0...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414335/the-gains-in-life-expectancy-by-ambient-pm2-5-pollution-reductions-in-localities-in-nigeria
#18
Tunde O Etchie, Ayotunde T Etchie, Gregory O Adewuyi, Ajay Pillarisetti, Saravanadevi Sivanesan, Kannan Krishnamurthi, Narendra K Arora
Global burden of disease estimates reveal that people in Nigeria are living shorter lifespan than the regional or global average life expectancy. Ambient air pollution is a top risk factor responsible for the reduced longevity. But, the magnitude of the loss or the gains in longevity accruing from the pollution reductions, which are capable of driving mitigation interventions in Nigeria, remain unknown. Thus, we estimate the loss, and the gains in longevity resulting from ambient PM2.5 pollution reductions at the local sub-national level using life table approach...
January 29, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29413512/the-revised-gold-2017-copd-categorization-in-relation-to-comorbidities
#19
Kathrin Kahnert, Peter Alter, David Young, Tanja Lucke, Joachim Heinrich, Rudolf M Huber, Jürgen Behr, Margarethe Wacker, Frank Biertz, Henrik Watz, Robert Bals, Tobias Welte, Hubert Wirtz, Felix Herth, Jørgen Vestbo, Emiel F Wouters, Claus F Vogelmeier, Rudolf A Jörres
INTRODUCTION: The COPD classification proposed by the Global Initiative for Obstructive Lung Disease was recently revised, and the A to D grouping is now based on symptoms and exacerbations only. Potential associations with comorbidities have not been assessed so far. Thus the aim of the present study was to determine the relationship between the revised (2017) GOLD groups A-D and major comorbidities. METHODS: We used baseline data from the COPD cohort COSYCONET...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29413083/time-for-a-change-is-idiopathic-pulmonary-fibrosis-still-idiopathic-and-only-fibrotic
#20
Paul J Wolters, Timothy S Blackwell, Oliver Eickelberg, James E Loyd, Naftali Kaminski, Gisli Jenkins, Toby M Maher, Maria Molina-Molina, Paul W Noble, Ganesh Raghu, Luca Richeldi, Marvin I Schwarz, Moises Selman, Wim A Wuyts, David A Schwartz
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically fatal lung disease characterised by subpleural fibrosis, subepithelial fibroblast foci, and microscopic honeycombing. Although understanding of the pathogenic mechanisms continues to evolve, evidence indicates that distal airway and alveolar epithelial cells are central drivers of the disease. In this Viewpoint, we review the history of naming and classifications used to define the disease now referred to as IPF, in the context of understanding the clinical presentation, causes, and pathogenesis of the disease...
February 2018: Lancet Respiratory Medicine
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