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lung classification

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https://www.readbyqxmd.com/read/29667885/radiomics-approach-to-prediction-of-occult-mediastinal-lymph-node-metastasis-of-lung-adenocarcinoma
#1
Yan Zhong, Mei Yuan, Teng Zhang, Yu-Dong Zhang, Hai Li, Tong-Fu Yu
OBJECTIVE: The purpose of this study was to evaluate the prognostic impact of radiomic features from CT scans in predicting occult mediastinal lymph node (LN) metastasis of lung adenocarcinoma. MATERIALS AND METHODS: A total of 492 patients with lung adenocarcinoma who underwent preoperative unenhanced chest CT were enrolled in the study. A total of 300 radiomics features quantifying tumor intensity, texture, and wavelet were extracted from the segmented entire-tumor volume of interest of the primary tumor...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667778/dna-methylation-biomarkers-for-the-occurrence-of-lung-adenocarcinoma-from-tcga-data-mining
#2
Xiao-Feng Zhu, Bi-Sheng Zhu, Fei-Ma Wu, Hai-Bo Hu
The development of lung cancer is a combination of multifactor, multistage, and multiple genetic alterations processes. DNA methylation is an important factor. Currently, the study on the genome-scale epigenetic modification for studying the pathogenesis of lung cancer is still lacking. Here, we aimed to identify the epigenetic modifications of lung cancer, thus to provide scientific basis for the personalized medicine, and research of classification screening for lung adenocarcinoma patients. The DNA methylation data, and the corresponding clinical information of lung adenocarcinoma samples were extracted from the Cancer Genome Atlas (TCGA) database...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29666810/the-8-th-tnm-edition-for-lung-cancer-a-critical-analysis
#3
REVIEW
Paul E Van Schil, Ramon Rami-Porta, Hisao Asamura
The 8th edition of the tumor, node and metastasis (TNM) classification provides several new categories and for the first time, some prospective data are included. The T (tumor) descriptor is further subdivided with 1 cm increments for T1 and T2 disease. For metastatic disease (M descriptor) the new M1b category comprises patients with only one metastasis in one distant organ, whereas M1c implies multiple distant metastases in one or several organs. There are no changes regarding the nodal map and N component but new categories are suggested for further analysis, subdividing the N1 and N2 descriptors into involvement of single or multiple lymph node stations...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664358/tailored-management-of-stage-iiia-non-small-cell-lung-cancer-in-the-era-of-the-8th-edition-of-the-tnm-classification-for-lung-cancer
#4
Michael R Mueller
Stage IIIA is a very heterogeneous group encompassing locally advanced disease with T3 and T4 tumors without any nodal involvement and very small T1a primary tumors with unilateral mediastinal lymphatic disease. Tailored management defines interdisciplinary management requiring board decisions, which can sometimes be difficult particularly in stage IIIa non-small-cell lung cancer (NSCLC). Lobectomy still is standard of care even for stage I NSCLC, which increasingly is implemented using minimally invasive surgical technique...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29663705/bronchial-brush-cytology-of-primary-anaplastic-large-cell-lymphoma-of-lung
#5
Meyyappa Devan Rajagopal, Debasis Gochhait, Bheemanathi Hanuman Srinivas, Rajesh Nachiappa Ganesh, Neelaiah Siddaraju, Manju Rajaram
Primary pulmonary lymphoma is defined as clonal lymphoid proliferation affecting one or both lungs in a patient with no extrapulmonary involvement at the time of diagnosis or during the subsequent 3 months. Anaplastic large cell lymphoma (ALCL) is a rare T-cell neoplasm which occurs as two distinct clinical entities-cutaneous and systemic variant. Primary lung involvement is extremely uncommon. It can be classified on the basis of being positive or negative for ALK rearrangement which carries prognostic significance...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29660595/computer-assisted-subtyping-and-prognosis-for-non-small-cell-lung-cancer-patients-with-unresectable-tumor
#6
Maliazurina Saad, Tae-Sun Choi
BACKGROUND: The histological classification or subtyping of non-small cell lung cancer is essential for systematic therapy decisions. Differentiating between the two main subtypes of pulmonary adenocarcinoma and squamous cell carcinoma highlights the considerable differences that exist in the prognosis of patient outcomes. Physicians rely on a pathological analysis to reveal these phenotypic variations that requires invasive methods, such as biopsy and resection sample, but almost 70% of tumors are unresectable at the point of diagnosis...
April 4, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29660202/molecular-biomarkers-for-uterine-leiomyosarcoma-and-endometrial-stromal-sarcoma
#7
REVIEW
Hideaki Tsuyoshi, Yoshio Yoshida
Uterine leiomyosarcoma (u{\hyphen}LMS) and endometrial stromal sarcoma (ESS) are among the most frequent soft tissue sarcomas, which, in adults, lead to fatal lung metastases and have an extremely poor prognosis. Due to their rarity and heterogeneity, there are no suitable biomarkers for diagnosis and prognosis, though some biomarker candidates have appeared. Recently, The Cancer Genome Atlas (TCGA) projects dealing with u{\hyphen}LMS confirmed mutations and deletions in RB1, TP53, and PTEN. In addition, whole{\hyphen}exome sequencing of u{\hyphen}LMS has confirmed and demonstrated frequent alterations in TP53, RB1, α-thalassemia/mental retardation syndrome X-linked (ATRX), and mediator complex subunit 12 (MED12)...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29657152/venous-thromboembolism-in-systemic-sclerosis-prevalence-risk-factors-and-effect-on-survival
#8
Sindhu R Johnson, Nabil Hakami, Zareen Ahmad, Duminda N Wijeysundera
OBJECTIVE: Whether systemic sclerosis (SSc) confers increased risk of venous thromboembolism (VTE) is uncertain. We evaluated the prevalence, risk factors, and effect of VTE on SSc survival. METHODS: A cohort study was conducted of subjects with SSc who fulfilled the American College of Rheumatology/European League Against Rheumatism classification criteria between 1970 and 2017. Deep vein thrombosis was defined as thrombus on extremity ultrasound. Pulmonary embolism was defined as thrombus on thorax computed tomography angiogram...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656753/extraction-of-radiomic-values-from-lung-adenocarcinoma-with-near-pure-subtypes-in-the-international-association-for-the-study-of-lung-cancer-the-american-thoracic-society-the-european-respiratory-society-iaslc-ats-ers-classification
#9
Shun-Mao Yang, Li-Wei Chen, Hao-Jen Wang, Leng-Rong Chen, Kuo-Lung Lor, Yi-Chang Chen, Mong-Wei Lin, Min-Shu Hsieh, Jin-Shing Chen, Yeun-Chung Chang, Chung-Ming Chen
INTRODUCTION: Histological subtypes of lung adenocarcinomas (ADCs) classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) system have been investigated using radiomic approaches. However, the results have had limitations since <80% of invasive lung ADCs were heterogeneous, with two or more subtypes. To reduce the influence of heterogeneity during radiomic analysis, computed tomography (CT) images of lung ADCs with near-pure ADC subtypes were analyzed to extract representative radiomic features of different subtypes...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29651121/classification-of-myositis
#10
REVIEW
Ingrid E Lundberg, Marianne de Visser, Victoria P Werth
The idiopathic inflammatory myopathies (IIMs; also known as myositis) are a heterogeneous group of disorders in which a common feature is chronic inflammation of skeletal muscle, leading to muscle weakness. Other organs are frequently affected in IIMs, such as the skin, joints, lungs, gastrointestinal tract and heart, contributing to morbidity and mortality. Currently, IIMs are most often subclassified into polymyositis, dermatomyositis and inclusion body myositis, but this subclassification has limitations as these subgroups often have overlapping clinical and histopathological features, and outcomes vary within the subgroups; additionally, subgroups without considerable myopathy are not included...
April 12, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29650313/a-novel-feature-extraction-technique-for-pulmonary-sound-analysis-based-on-emd
#11
Ashok Mondal, Poulami Banerjee, Hong Tang
BACKGROUND AND OBJECTIVE: The stethoscope based auscultation technique is a primary diagnostic tool for chest sound analysis. However, the performance of this method is limited due to its dependency on physicians experience, knowledge and also clarity of the signal. To overcome this problem we need an automated computer-aided diagnostic system that will be competent in noisy environment. In this paper, a novel feature extraction technique is introduced for discriminating various pulmonary dysfunctions in an automated way based on pattern recognition algorithms...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29650306/multichannel-lung-sound-analysis-for-asthma-detection
#12
Md Ariful Islam, Irin Bandyopadhyaya, Parthasarathi Bhattacharyya, Goutam Saha
BACKGROUND AND OBJECTIVE: Lung sound signals convey valuable information of the lung status. Auscultation is an effective technique to appreciate the condition of the respiratory system using lung sound signals. The prior works on asthma detection from lung sound signals rely on the presence of wheeze. In this paper, we have classified normal and asthmatic subjects using advanced signal processing of posterior lung sound signals, even in the absence of wheeze. METHODS: We collected lung sounds of 60 subjects (30 normal and 30 asthma) using a novel 4-channel data acquisition system from four different positions over the posterior chest, as suggested by the pulmonologist...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29649507/effects-of-anthraquinones-from-cassia-occidentalis-l-on-ovalbumin-induced-airways-inflammation-in-a-mouse-model-of-allergic-asthma
#13
Wenhao Xu, Meiqun Hu, Qihong Zhang, Jingbo Yu, Weike Su
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia occidentalis Linn. is a traditional ayruvedic edible shrub containing anthraquinones (AQs) as the principle active constituents. In folk medicine, it has a variety of uses including treatment of whooping cough ('pertussis') and inflammatory diseases. Despite these applications, limited data are available to validate the effects of C. occidentalis AQs on airways inflammation in asthma. AIM OF THE STUDY: To explore the anti-inflammatory potential of AQs extracted from C...
April 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29649281/classification-for-long-term-survival-in-oligometastatic-patients-treated-with-ablative-radiotherapy-a-multi-institutional-pooled-analysis
#14
Julian C Hong, Diandra N Ayala-Peacock, Jason Lee, A William Blackstock, Paul Okunieff, Max W Sung, Ralph R Weichselbaum, Johnny Kao, James J Urbanic, Michael T Milano, Steven J Chmura, Joseph K Salama
BACKGROUND: Radiotherapy is increasingly used to treat oligometastatic patients. We sought to identify prognostic criteria in oligometastatic patients undergoing definitive hypofractionated image-guided radiotherapy (HIGRT). METHODS: Exclusively extracranial oligometastatic patients treated with HIGRT were pooled. Characteristics including age, sex, primary tumor type, interval to metastatic diagnosis, number of treated metastases and organs, metastatic site, prior systemic therapy for primary tumor treatment, prior definitive metastasis-directed therapy, and systemic therapy for metastasis associated with overall survival (OS), progression-free survival (PFS), and treated metastasis control (TMC) were assessed by the Cox proportional hazards method...
2018: PloS One
https://www.readbyqxmd.com/read/29626692/global-and-gene-specific-dna-methylation-effects-of-different-asbestos-fibres-on-human-bronchial-epithelial-cells
#15
Deniz Öner, Manosij Ghosh, Matthieu Moisse, Radu Corneliu Duca, Robin Coorens, Jeroen A J Vanoirbeek, Diether Lambrechts, Lode Godderis, Peter H M Hoet
Inhalation exposure to asbestos is associated with lung and pleural diseases in humans and remains a major public health issue worldwide. Human bronchial epithelial cells (16HBE) were exposed to UICC amosite, crocidolite and chrysotile. Cytotoxicity, genotoxicity, global DNA methylation on cytosine residues (using LC-MS/MS) were investigated at different doses (2.5-100 μg/ml). Gene-specific DNA methylation alterations at the whole genome were investigated using a microarray that interrogates >450 thousand CpG sites...
April 4, 2018: Environment International
https://www.readbyqxmd.com/read/29625247/added-value-of-50-gene-panel-sequencing-to-distinguish-multiple-primary-lung-cancers-from-pulmonary-metastases-a-systematic-investigation
#16
Paul Roepman, Alexandra Ten Heuvel, Karen C Scheidel, Tobias Sprong, Danielle A M Heideman, Cees A Seldenrijk, Gerarda J M Herder, J Alain Kummer
Differentiation between multiple primary lung cancers or pulmonary metastases has important implications for staging, prognosis, and treatment strategies. Clinical and immuno-histopathological criteria have been standardized; however, a substantial number of cases remain difficult to classify. Using next-generation sequencing it is now possible to improve classification of multiple lung cancer lesions. This study systematically investigated the value of routine morphological and immunohistochemical characteristics, p53 protein expression, TP53 mutation analysis, and 50-gene panel sequencing on 111 lesions from 50 patients with multiple lung lesions...
April 3, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29625100/national-comparison-of-hospital-performances-in-lung-cancer-surgery-the-role-of-casemix-adjustment
#17
Naomi Beck, Fieke Hoeijmakers, Esmee M van der Willik, David J Heineman, Jerry Braun, Rob A E M Tollenaar, Wilhelmina H Schreurs, Michel W J M Wouters
BACKGROUND: When comparing hospitals on outcome indicators, proper adjustment for casemix (a combination of patient- and disease characteristics) is indispensable. This study examines the need for casemix adjustment in evaluating hospital outcomes for Non-Small Cell Lung Cancer (NSCLC) surgery. METHODS: Data from the Dutch Lung Cancer Audit for Surgery was used to validate factors associated with postoperative 30-day mortality and complicated course with multivariable logistic regression models...
April 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29623248/holistic-classification-of-ct-attenuation-patterns-for-interstitial-lung-diseases-via-deep-convolutional-neural-networks
#18
Mingchen Gao, Ulas Bagci, Le Lu, Aaron Wu, Mario Buty, Hoo-Chang Shin, Holger Roth, Georgios Z Papadakis, Adrien Depeursinge, Ronald M Summers, Ziyue Xu, Daniel J Mollura
Interstitial lung diseases (ILD) involve several abnormal imaging patterns observed in computed tomography (CT) images. Accurate classification of these patterns plays a significant role in precise clinical decision making of the extent and nature of the diseases. Therefore, it is important for developing automated pulmonary computer-aided detection systems. Conventionally, this task relies on experts' manual identification of regions of interest (ROIs) as a prerequisite to diagnose potential diseases. This protocol is time consuming and inhibits fully automatic assessment...
2018: Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization
https://www.readbyqxmd.com/read/29622076/staging-lung-cancer-metastasis
#19
REVIEW
Girish S Shroff, Chitra Viswanathan, Brett W Carter, Marcelo F Benveniste, Mylene T Truong, Bradley S Sabloff
The updated eighth edition of the tumor, node, metastasis (TNM) classification for lung cancer includes revisions to T and M descriptors. In terms of the M descriptor, the classification of intrathoracic metastatic disease as M1a is unchanged from TNM-7. Extrathoracic metastatic disease, which was classified as M1b in TNM-7, is now subdivided into M1b (single metastasis, single organ) and M1c (multiple metastases in one or multiple organs) descriptors. In this article, the rationale for changes in the M descriptors, the utility of preoperative staging with PET/computed tomography, and the treatment options available for patients with oligometastatic disease are discussed...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29622075/staging-lung-cancer-regional-lymph-node-classification
#20
REVIEW
Ahmed H El-Sherief, Charles T Lau, Brett W Carter, Carol C Wu
This article reviews regional lymph node assessment in lung cancer. In the absence of a distant metastasis, the absence or location of lung cancer spread to a regional mediastinal lymph node affects treatment options and prognosis. Regional lymph node maps have been created to standardize assessment of the N descriptor. The International Association for the Study of Lung Cancer lymph node map is used for the standardization of N descriptor assessment. CT, PET/CT with fluorodeoxyglucose, endobronchial ultrasound-guided and/or esophageal ultrasound-guided biopsy, and mediastinoscopy are common modalities used to determine the N descriptor...
May 2018: Radiologic Clinics of North America
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