keyword
MENU ▼
Read by QxMD icon Read
search

Catestatin

keyword
https://www.readbyqxmd.com/read/29432123/catestatin-inhibits-obesity-induced-macrophage-infiltration-and-inflammation-in-the-liver-and-suppresses-hepatic-glucose-production-leading-to-improved-insulin-sensitivity
#1
Wei Ying, Sumana Mahata, Gautam K Bandyopadhyay, Zhenqi Zhou, Joshua Wollam, Jessica Vu, Rafael Mayoral, Nai-Wen Chi, Nicholas J G Webster, Angelo Corti, Sushil K Mahata
The activation of Kupffer cells (KCs) and monocyte-derived recruited macrophages (McMΦs) in the liver contributes to obesity-induced insulin resistance and type 2 diabetes. Mice with diet-induced obesity (DIO mice) treated with chromogranin A peptide catestatin (CST) showed several positive results. These included decreased hepatic/plasma lipids and plasma insulin, diminished expression of gluconeogenic genes, attenuated expression of proinflammatory genes, increased expression of anti-inflammatory genes in McMΦs, and inhibition of the infiltration of McMΦs resulting in improvement of insulin sensitivity...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#2
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/- ) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29195227/catestatin-vasostatin-cortisol-and-visual-analog-scale-scoring-for-stress-assessment-in-healthy-dogs
#3
T Srithunyarat, R Hagman, O V Höglund, M Stridsberg, J Hanson, A S Lagerstedt, A Pettersson
The neuroendocrine glycoprotein chromogranin A is a useful biomarker for stress in humans. Chromogranin A epitopes catestatin and vasostatin can be measured in dogs using radioimmunoassays. The objective of this study was to evaluate catestatin and vasostatin as canine stress biomarkers in a clinical setting. Blood and saliva were collected from 33 healthy dogs that were familiar with sampling procedures and the animal hospital environment (control group) and 30 healthy dogs that were unacquainted (stress group)...
April 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/28981685/role-of-the-neuroendocrine-antimicrobial-peptide-catestatin-in-innate-immunity-and-pain
#4
Zeyu Deng, Changshui Xu
Catestatin (CST) is a neuroendocrine peptide which is derived from the chromogranin A. It has been demonstrated that CST can affect a wide range of processes, such as innate immunity, inflammatory and autoimmune reactions, and several homeostatic regulations. Furthermore, CST is positive against several kinds of bacterial strains at micromolecular range, which shows its antimicrobial activity. Recently, the role of CST in acute and chronic pain has attracted much attention. In this review, we discussed the latest research findings of CST and its role in innate immunity and pain...
November 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28875377/chromogranins-from-discovery-to-current-times
#5
REVIEW
Karen B Helle, Marie-Helene Metz-Boutigue, Maria Carmela Cerra, Tommaso Angelone
The discovery in 1953 of the chromaffin granules as co-storage of catecholamines and ATP was soon followed by identification of a range of uniquely acidic proteins making up the isotonic vesicular storage complex within elements of the diffuse sympathoadrenal system. In the mid-1960s, the enzymatically inactive, major core protein, chromogranin A was shown to be exocytotically discharged from the stimulated adrenal gland in parallel with the co-stored catecholamines and ATP. A prohormone concept was introduced when one of the main storage proteins collectively named granins was identified as the insulin release inhibitory polypeptide pancreastatin...
January 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28871257/reactivation-of-intestinal-inflammation-is-suppressed-by-catestatin-in-a-murine-model-of-colitis-via-m1-macrophages-and-not-the-gut-microbiota
#6
Mohammad F Rabbi, Nour Eissa, Peris M Munyaka, Laëtitia Kermarrec, Omar Elgazzar, Ehsan Khafipour, Charles N Bernstein, Jean Eric Ghia
While there is growing awareness of a relationship between chromogranin-A (CHGA) and susceptibility to inflammatory conditions, the role of human catestatin [(hCTS); CHGA352-67] in the natural history of established inflammatory bowel disease is not known. Recently, using two different experimental models, we demonstrated that hCTS-treated mice develop less severe acute colitis. We have also shown the implication of the macrophages in this effect. The aims of this study were to determine (1) whether hCTS treatment could attenuate the reactivation of inflammation in adult mice with previously established chronic colitis; (2) whether this effect is mediated through macrophages or the gut microbiota...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28618990/biological-roles-of-the-eclectic-chromogranin-a-derived-peptide-catestatin
#7
REVIEW
Teresa Pasqua, Tommaso Angelone, Angela Spena, Maria Carmela Cerra
BACKGROUND: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease. METHODS: Structured search of bibliographic databases for peer-reviewed research literature. RESULTS: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis...
2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28443506/catestatin-a-master-regulator-of-cardiovascular-functions
#8
Sushil K Mahata, Malapaka Kiranmayi, Nitish R Mahapatra
BACKGROUND: Cardiovascular disease (CVD), the most common cause of death globally, accounts for ~30% of all deaths worldwide. Hypertension is a common contributor to morbidity and mortality from CVD. METHODS AND RESULTS: The plasma concentration of chromogranin A (CgA) is elevated in patients with CVD as well as patients with established human essential hypertension and heart failure (HF). In contrast, the plasma level of the CgA-derived peptide catestatin (CST) is diminished in human essential hypertension...
2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28442394/granin-derived-peptides
#9
REVIEW
Josef Troger, Markus Theurl, Rudolf Kirchmair, Teresa Pasqua, Bruno Tota, Tommaso Angelone, Maria C Cerra, Yvonne Nowosielski, Raphaela Mätzler, Jasmin Troger, Jaur R Gayen, Vance Trudeau, Angelo Corti, Karen B Helle
The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980s it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance...
July 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28397784/catestatin-a-novel-predictor-of-left-ventricular-remodeling-after-acute-myocardial-infarction
#10
Dan Zhu, Hong Xie, Xinyu Wang, Ying Liang, Haiyi Yu, Wei Gao
Catestatin was discovered as a potent inhibitor of catecholamine secretion and plays important roles in the cardiovascular system. Our previous study demonstrates a close relationship between catestatin levels and prognosis of ST-elevation myocardial infarction (STEMI). Using the same population, the goal of this study is to investigate the ability of catestatin to predict left ventricular (LV) remodeling in STEMI patients. 72 patients and 30 controls were included. Catestatin was sampled after admission to the emergency room (ER), at day3 (D3), and day7 (D7) after STEMI...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327184/catestatin-vasostatin-cortisol-and-pain-assessments-in-dogs-suffering-from-traumatic-bone-fractures
#11
Thanikul Srithunyarat, Ragnvi Hagman, Odd V Höglund, Mats Stridsberg, Ulf Olsson, Jeanette Hanson, Chalermkwan Nonthakotr, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: Traumatic bone fractures cause moderate to severe pain, which needs to be minimized for optimal recovery and animal welfare, illustrating the need for reliable objective pain biomarkers for use in a clinical setting. The objectives of this study were to investigate catestatin (CST) and vasostatin (VS) concentrations as two new potential biomarkers, and cortisol concentrations, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF), and visual analog scale (VAS) in dogs suffering from traumatic bone fractures before and after morphine administration in comparison with healthy dogs...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28228748/chromogranin-a-regulation-of-obesity-and-peripheral-insulin-sensitivity
#12
REVIEW
Gautam K Bandyopadhyay, Sushil K Mahata
Chromogranin A (CgA) is a prohormone and granulogenic factor in endocrine and neuroendocrine tissues, as well as in neurons, and has a regulated secretory pathway. The intracellular functions of CgA include the initiation and regulation of dense-core granule biogenesis and sequestration of hormones in neuroendocrine cells. This protein is co-stored and co-released with secreted hormones. The extracellular functions of CgA include the generation of bioactive peptides, such as pancreastatin (PST), vasostatin, WE14, catestatin (CST), and serpinin...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28220294/chromogranin-a-regulates-vesicle-storage-and-mitochondrial-dynamics-to-influence-insulin-secretion
#13
Joshua Wollam, Sumana Mahata, Matthew Riopel, Angelina Hernandez-Carretero, Angshuman Biswas, Gautam K Bandyopadhyay, Nai-Wen Chi, Lee E Eiden, Nitish R Mahapatra, Angelo Corti, Nicholas J G Webster, Sushil K Mahata
Chromogranin A (CgA) is a prohormone and a granulogenic factor that regulates secretory pathways in neuroendocrine tissues. In β-cells of the endocrine pancreas, CgA is a major cargo in insulin secretory vesicles. The impact of CgA deficiency on the formation and exocytosis of insulin vesicles is yet to be investigated. In addition, no literature exists on the impact of CgA on mitochondrial function in β-cells. Using three different antibodies, we demonstrate that CgA is processed to vasostatin- and catestatin-containing fragments in pancreatic islet cells...
June 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28209766/glycosylated-chromogranin-a-in-heart-failure-implications-for-processing-and-cardiomyocyte-calcium-homeostasis
#14
Anett Hellebø Ottesen, Cathrine R Carlson, William E Louch, Mai Britt Dahl, Ragnhild A Sandbu, Rune Forstrøm Johansen, Hilde Jarstadmarken, Magnar Bjørås, Arne Didrik Høiseth, Jon Brynildsen, Ivar Sjaastad, Mats Stridsberg, Torbjørn Omland, Geir Christensen, Helge Røsjø
BACKGROUND: Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. METHODS AND RESULTS: CgA processing was characterized in postinfarction HF mice and in patients with acute HF, and the functional role of CST was explored in experimental models. Myocardial biopsies from HF, but not sham-operated mice, demonstrated high molecular weight CgA bands...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28161844/increased-plasma-level-of-catestatin-might-be-associated-with-poor-prognosis-in-hemodialysis-patients
#15
Huaibin Sun, Wanhua Xian, Lina Geng, Engang Li, Zhiguo Peng, Jun Tian
PURPOSE: Cardiac complication is a major cause of death in hemodialysis patients. The aim of the study was to determine the relationship between plasma catestatin level and cardiac death in those people. METHODS: A total of 330 maintenance hemodialysis patients were included. Blood samples were collected. Plasma catestatin level was detected by enzyme-linked immunosorbent assay. Fluid status of each patient was expressed by overhydration to total body weight ratio and daily diuresis...
June 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28049540/catestatin-and-vasostatin-concentrations-in-healthy-dogs
#16
Thanikul Srithunyarat, Ragnvi Hagman, Odd V Höglund, Ulf Olsson, Mats Stridsberg, Supranee Jitpean, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: The neuroendocrine glycoprotein chromogranin A is a useful biomarker in humans for neuroendocrine tumors and stress. Chromogranin A can be measured in both blood and saliva. The objective of this study was to investigate concentrations of and correlation between the chromogranin A epitopes catestatin and vasostatin in healthy dogs accustomed to the sample collection procedures. Blood and saliva samples were collected from 10 research Beagle dogs twice daily for 5 consecutive days, and from 33 privately-owned blood donor dogs in association with 50 different blood donation occasions...
January 3, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28011710/identification-of-novel-loci-affecting-circulating-chromogranins-and-related-peptides
#17
Beben Benyamin, Adam X Maihofer, Andrew J Schork, Bruce A Hamilton, Fangwen Rao, Geert W Schmid-Schönbein, Kuixing Zhang, Manjula Mahata, Mats Stridsberg, Nicholas J Schork, Nilima Biswas, Vivian Y Hook, Zhiyun Wei, Grant W Montgomery, Nicholas G Martin, Caroline M Nievergelt, John B Whitfield, Daniel T O'Connor
Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545 US and 1252 Australian subjects. This identified loci on chromosomes 4q35 and 5q34 affecting catestatin concentration (P = 3.40 × 10-30 for rs4253311 and 1.85 × 10-19 for rs2731672, respectively)...
January 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27887883/nanoprecipitated-catestatin-released-from-pharmacologically-active-microcarriers-pams-exerts-pro-survival-effects-on-msc
#18
C Angotti, M C Venier-Julienne, C Penna, S Femminò, L Sindji, C Paniagua, C N Montero-Menei, P Pagliaro
Catestatin (CST), a fragment of Chromogranin-A, exerts angiogenic, arteriogenic, vasculogenic and cardioprotective effects. CST is a very promising agent for revascularization purposes, in "NOOPTION" patients. However, peptides have a very short half-life after administration and must be conveniently protected. Fibronectin-coated pharmacologically active microcarriers (FN-PAM), are biodegradable and biocompatible polymeric microspheres that can convey mesenchymal stem cell (MSCs) and therapeutic proteins delivered in a prolonged manner...
May 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27815840/application-of-the-co-culture-membrane-system-pointed-to-a-protective-role-of-catestatin-on-hippocampal-plus-hypothalamic-neurons-exposed-to-oxygen-and-glucose-deprivation
#19
Maria Mele, Sabrina Morelli, Gilda Fazzari, Ennio Avolio, Raffaella Alò, Antonella Piscioneri, Loredana De Bartolo, Rosa Maria Facciolo, Marcello Canonaco
Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research goal. Among the many neuronal factors, N-methyl-D-aspartate receptors (NMDAR), orexinergic neuroreceptors (ORXR), and sympatho-inhibitory neuropeptide catestatin (CST) are widely involved with ischemic episodes...
November 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27771336/the-predictive-value-of-plasma-catestatin-for-all-cause-and-cardiac-deaths-in-chronic-heart-failure-patients
#20
Fen Peng, Songyun Chu, Wenhui Ding, Lin Liu, Jing Zhao, Xiaojing Cui, Renxu Li, Jie Wang
Catestatin (CST) is a proteolytic fragment of Chromogranin A with a broad spectrum of activities in the cardiovascular system. The level of plasma CST increases in chronic heart failure patients, but its potential relationship to patient prognosis is unknown. In this study, we measured plasma CST levels in 202 chronic heart failure patients and followed them for a median of 52.5 months. The plasma CST level was higher in patients with all-cause death and cardiac death than in survivors. According to univariate COX regression, higher plasma CST levels predicted increased risk of all-cause and cardiac death...
December 2016: Peptides
keyword
keyword
65191
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"