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Catestatin

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https://www.readbyqxmd.com/read/27887883/nanoprecipitated-catestatin-released-from-pharmacologically-active-microcarriers-pams-exerts-pro-survival-effects-on-msc
#1
C Angotti, M C Venier-Julienne, C Penna, S Femminò, L Sindji, C Paniagua, C N Montero-Menei, P Pagliaro
Catestatin (CST), a fragment of Chromogranin-A, exerts angiogenic, arteriogenic, vasculogenic and cardioprotective effects. CST is a very promising agent for revascularization purposes, in "NO-OPTION" patients. However, peptides have a very short half-life after administration and must be conveniently protected. Fibronectin-coated pharmacologically active microcarriers (FN-PAM), are biodegradable and biocompatible polymeric microspheres that can convey mesenchymal stem cell (MSCs) and therapeutic proteins delivered in a prolonged manner...
November 22, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27815840/application-of-the-co-culture-membrane-system-pointed-to-a-protective-role-of-catestatin-on-hippocampal-plus-hypothalamic-neurons-exposed-to-oxygen-and-glucose-deprivation
#2
Maria Mele, Sabrina Morelli, Gilda Fazzari, Ennio Avolio, Raffaella Alò, Antonella Piscioneri, Loredana De Bartolo, Rosa Maria Facciolo, Marcello Canonaco
Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research goal. Among the many neuronal factors, N-methyl-D-aspartate receptors (NMDAR), orexinergic neuroreceptors (ORXR), and sympatho-inhibitory neuropeptide catestatin (CST) are widely involved with ischemic episodes...
November 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27771336/the-predictive-value-of-plasma-catestatin-for-all-cause-and-cardiac-deaths-in-chronic-heart-failure-patients
#3
Fen Peng, Songyun Chu, Wenhui Ding, Lin Liu, Jing Zhao, Xiaojing Cui, Renxu Li, Jie Wang
Catestatin (CST) is a proteolytic fragment of Chromogranin A with a broad spectrum of activities in the cardiovascular system. The level of plasma CST increases in chronic heart failure patients, but its potential relationship to patient prognosis is unknown. In this study, we measured plasma CST levels in 202 chronic heart failure patients and followed them for a median of 52.5 months. The plasma CST level was higher in patients with all-cause death and cardiac death than in survivors. According to univariate COX regression, higher plasma CST levels predicted increased risk of all-cause and cardiac death...
December 2016: Peptides
https://www.readbyqxmd.com/read/27681934/plasma-catestatin-in-patients-with-acute-coronary-syndrome
#4
Weixian Xu, Haiyi Yu, Hubing Wu, Siheng Li, Baoxia Chen, Wei Gao
OBJECTIVES: To measure plasma catestatin levels in patients with acute coronary syndrome and investigate whether there is an association between catestatin levels and long-term outcome. METHODS: Patients (n = 170) with suspected acute coronary syndrome who underwent emergency coronary angiography were enrolled, including 46 with acute ST-segment elevation myocardial infarction (STEMI), 89 with unstable angina pectoris (UAP), and 35 without coronary artery disease (CAD)...
September 29, 2016: Cardiology
https://www.readbyqxmd.com/read/27484122/catestatin-vasostatin-cortisol-temperature-heart-rate-respiratory-rate-scores-of-the-short-form-of-the-glasgow-composite-measure-pain-scale-and-visual-analog-scale-for-stress-and-pain-behavior-in-dogs-before-and-after-ovariohysterectomy
#5
Thanikul Srithunyarat, Odd V Höglund, Ragnvi Hagman, Ulf Olsson, Mats Stridsberg, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: The stress reaction induced by surgery and associated pain may be detrimental for patient recovery and should be minimized. The neuropeptide chromogranin A (CGA) has shown promise as a sensitive biomarker for stress in humans. Little is known about CGA and its derived peptides, catestatin (CST) and vasostatin (VS), in dogs undergoing surgery. The objectives of this study were to investigate and compare concentrations of CGA epitopes CST and VS, cortisol, body temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF) and visual analog scales (VAS) for stress and pain behavior in dogs before and after ovariohysterectomy...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27415768/potential-applications-of-catestatin-in-cardiovascular-diseases
#6
Yilin Zhao, Dan Zhu
Catestatin (CST) was first named in 1997 for its catecholamine-inhibitory activity. It was discovered as a potent inhibitor of catecholamine secretion and as a regulator of histamine release. Accumulating evidence shows that CST is involved with cardiovascular diseases; however, whether CST is a protective factor for these conditions and the mechanisms by which such actions may be mediated are not well understood. In this article, we review recent basic research and clinical trials in the study of CST and summarize the association of CST with cardiovascular diseases...
August 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27324226/catestatin-gly364ser-variant-alters-systemic-blood-pressure-and-the-risk-for-hypertension-in-human-populations-via-endothelial-nitric-oxide-pathway
#7
Malapaka Kiranmayi, Venkat R Chirasani, Prasanna K R Allu, Lakshmi Subramanian, Elizabeth E Martelli, Bhavani S Sahu, Durairajpandian Vishnuprabu, Rathnakumar Kumaragurubaran, Saurabh Sharma, Dhanasekaran Bodhini, Madhulika Dixit, Arasambattu K Munirajan, Madhu Khullar, Venkatesan Radha, Viswanathan Mohan, Ajit S Mullasari, Sathyamangla V Naga Prasad, Sanjib Senapati, Nitish R Mahapatra
Catestatin (CST), an endogenous antihypertensive/antiadrenergic peptide, is a novel regulator of cardiovascular physiology. Here, we report case-control studies in 2 geographically/ethnically distinct Indian populations (n≈4000) that showed association of the naturally-occurring human CST-Gly364Ser variant with increased risk for hypertension (age-adjusted odds ratios: 1.483; P=0.009 and 2.951; P=0.005). Consistently, 364Ser allele carriers displayed elevated systolic (up to ≈8 mm Hg; P=0.004) and diastolic (up to ≈6 mm Hg; P=0...
August 2016: Hypertension
https://www.readbyqxmd.com/read/27304618/plasma-catestatin-a-useful-biomarker-for-coronary-collateral-development-with-chronic-myocardial-ischemia
#8
Weixian Xu, Haiyi Yu, Weihong Li, Wei Gao, Lijun Guo, Guisong Wang
BACKGROUNDS: Catestatin is an endogenous multifunctional neuroendocrinepeptide. Recently, catestatin was discovered as a novel angiogenic cytokine. The study was to investigate the associations between endogenous catestatin and coronary collateral development among the patients with chronic myocardial ischemia. METHODS: Thirty-eight patients with coronary artery chronic total occlusions (CTO) (CTO group) and 38 patients with normal coronary arteries (normal group) were enrolled in the series...
2016: PloS One
https://www.readbyqxmd.com/read/26875516/catestatin-and-gaba-a-r-related-feeding-habits-rely-on-dopamine-ghrelin-plus-leptin-neuroreceptor-expression-variations
#9
Maria Mele, Giuseppina Iachetta, Raffaella Alò, Ennio Avolio, Gilda Fazzari, Antonio Carelli, Vincenza Laforgia, Marcello Canonaco
Catestatin (CST), an endogenously small sympathoinhibitory peptide is capable of interfering with the major cerebral neuroreceptor-blocking site, i.e. γ-aminobutyric acidA receptor (GABAAR) system especially in limbic brain areas that are involved with feeding behaviors. The GABAARergic-related effects seem to derive from its interaction with other molecular neuroreceptors such as dopaminergic, ghrelin and leptinergic. In this context, the present study aimed to investigate probable feeding responses (eating and drinking) induced by treatment with CST and the GABAAR antagonist bicucullin (BIC) alone or simultaneously (CST+BIC) in the Syrian hibernating hamster (Mesocricetus auratus) model...
April 1, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/26821570/chronic-administration-of-catestatin-improves-autonomic-function-and-exerts-cardioprotective-effects-in-myocardial-infarction-rats
#10
Dandan Wang, Tao Liu, Shaobo Shi, Ran Li, Yingguang Shan, Yan Huang, Dan Hu, Congxin Huang
Catestatin (CST), which is emerging as a novel cardiac modulator, can protect the heart against excessive sympathetic drive in hypertensive cardiomyopathy. The aim of this study is to investigate whether exogenous CST decreases excessive cardiac sympathetic drive and improves autonomic function and exerts cardioprotective effects in myocardial infarction (MI) rats. Rats were divided into a sham group, MI group, and MI plus CST (MI + CST) group. Four weeks later, the autonomic function of the animals was assessed by analyzing heart rate variability (HRV) and measuring plasma catecholamine...
January 27, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26567709/catestatin-attenuates-endoplasmic-reticulum-induced-cell-apoptosis-by-activation-type-2-muscarinic-acetylcholine-receptor-in-cardiac-ischemia-reperfusion
#11
Feng Liao, Yang Zheng, Junyan Cai, Jinghui Fan, Jing Wang, Jichun Yang, Qinghua Cui, Guoheng Xu, Chaoshu Tang, Bin Geng
Catestatin (CST) is a catecholamine secretion inhibiting peptide as non-competitive inhibitor of nicotinic acetylcholine receptor. CST play a protective role in cardiac ischemia/reperfusion (I/R) but the molecular mechanism remains unclear. Cardiomyocytes endogenously produced CST and its expression was reduced after I/R. CST pretreatment decreased apoptosis especially endoplasmic reticulum (ER) stress response during I/R. The protection of CST was confirmed in H9c2 cardiomyoblasts under Anoxia/reoxygenation (A/R)...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26556564/analysis-and-validation-of-traits-associated-with-a-single-nucleotide-polymorphism-gly364ser-in-catestatin-using-humanized-chromogranin-a-mouse-models
#12
Saiful A Mir, Kuixing Zhang, Milos Milic, Yusu Gu, Timo Rieg, Michael Ziegler, Sucheta M Vaingankar
OBJECTIVE: The human prohormone chromogranin A (CHGA), an index member of the granin family is processed to generate catestatin, a peptide that is hypotensive in action and modulates catecholamine release within the sympathoadrenal system. Hypertensive patients with excess sympathetic activity have diminished catestatin. Often the study of physiological consequences of human genetic variation is confounded by elements such as other variations in obligatory linkage disequilibrium with the variant being studied...
January 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26552046/regulation-of-intestinal-sglt1-by-catestatin-in-hyperleptinemic-type-2-diabetic-mice
#13
Jessica A Dominguez Rieg, Venkat R Chirasani, Hermann Koepsell, Sanjib Senapati, Sushil K Mahata, Timo Rieg
The small intestine is the major site for nutrient absorption that is critical in maintenance of euglycemia. Leptin, a key hormone involved in energy homeostasis, directly affects nutrient transport across the intestinal epithelium. Catestatin (CST), a 21-amino acid peptide derived from proprotein chromogranin A, has been shown to modulate leptin signaling. Therefore, we reasoned that leptin and CST could modulate intestinal Na(+)-glucose transporter 1 (SGLT1) expression in the context of obesity and diabetes...
January 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26379222/harnessing-the-multifunctionality-in-nature-a-bioactive-agent-release-system-with-self-antimicrobial-and-immunomodulatory-properties
#14
Hayriye Özçelik, Nihal Engin Vrana, Alexandru Gudima, Vladimir Riabov, Alexei Gratchev, Youssef Haikel, Marie-Hélène Metz-Boutigue, Adele Carradò, Jacques Faerber, Thierry Roland, Harald Klüter, Julia Kzhyshkowska, Pierre Schaaf, Philippe Lavalle
Major problems with biomedical devices in particular implants located in nonsterile environments concern: (i) excessive immune response to the implant, (ii) development of bacterial biofilms, and (iii) yeast and fungi infections. An original multifunctional coating that addresses all these issues concomitantly is developed. A new exponentially growing polyelectrolyte multilayer film based on polyarginine (PAR) and hyaluronic acid (HA) is designed. The films have a strong inhibitory effect on the production of inflammatory cytokines released by human primary macrophage subpopulations...
September 16, 2015: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/26241941/the-no-stimulator-catestatin-improves-the-frank-starling-response-in-normotensive-and-hypertensive-rat-hearts
#15
T Angelone, A M Quintieri, T Pasqua, E Filice, P Cantafio, F Scavello, C Rocca, S K Mahata, A Gattuso, M C Cerra
The myocardial response to mechanical stretch (Frank-Starling law) is an important physiological cardiac determinant. Modulated by many endogenous substances, it is impaired in the presence of cardiovascular pathologies and during senescence. Catestatin (CST:hCgA352-372), a 21-amino-acid derivate of Chromogranin A (CgA), displays hypotensive/vasodilatory properties and counteracts excessive systemic and/or intra-cardiac excitatory stimuli (e.g., catecholamines and endothelin-1). CST, produced also by the myocardium, affects the heart by modulating inotropy, lusitropy and the coronary tone through a Nitric Oxide (NO)-dependent mechanism...
August 1, 2015: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/26211667/a-common-genetic-variant-of-the-chromogranin-a-derived-peptide-catestatin-is-associated-with-atherogenesis-and-hypertension-in-a-japanese-population
#16
Youngju Choi, Masahiro Miura, Yoshio Nakata, Takehito Sugasawa, Sumiko Nissato, Takeshi Otsuki, Jun Sugawara, Motoyuki Iemitsu, Yasushi Kawakami, Hitoshi Shimano, Yoshimi Iijima, Kiyoji Tanaka, Shinya Kuno, Prasanna K R Allu, Nitish R Mahapatra, Seiji Maeda, Kazuhiro Takekoshi
Chromogranin A (CHGA) is a major protein in the secretory granules of chromaffin cells. CHGA also gives rise to cardiovascular/metabolism regulatory peptides, such as catestatin (CST) and pancreastatin (PST). While CST is a potent inhibitor of catecholamine secretion, PST is a potent physiological inhibitor of glucose-induced insulin secretion. Recently, several SNPs were identified in the CST and PST domains of CHGA locus in different populations. Among the discovered SNPs, CST variant allele Ser-364 was associated with blood pressure alteration and PST variant allele Ser-297 was associated with significantly higher plasma glucose level...
2015: Endocrine Journal
https://www.readbyqxmd.com/read/26079001/a-molecular-dynamics-study-of-catestatin-docked-on-nicotinic-acetylcholine-receptors-to-identify-amino-acids-potentially-involved-in-the-binding-of-chromogranin-a-fragments
#17
Sebastian Kraszewski, Dominik Drabik, Marek Langner, Christophe Ramseyer, Sineenat Kembubpha, Sukkid Yasothornsrikul
Catestatin, a cationic and hydrophobic 21-amino acid fragment of chromogranin A, is known to be a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release. Since this receptor is the target of several neuronal and non-neuronal disorder prophylaxes and treatments, this study aims at the elucidation of the binding of human catestatin to the entire nAChR reconstructed in lipid bilayers by means of docking followed by full atomistic molecular dynamics simulations...
July 14, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/25848973/correlation-of-plasma-catestatin-level-and-the-prognosis-of-patients-with-acute-myocardial-infarction
#18
Dan Zhu, Hong Xie, Xinyu Wang, Ying Liang, Haiyi Yu, Wei Gao
Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI...
2015: PloS One
https://www.readbyqxmd.com/read/25774921/catestatin-exerts-direct-protective-effects-on-rat-cardiomyocytes-undergoing-ischemia-reperfusion-by-stimulating-pi3k-akt-gsk3%C3%AE-pathway-and-preserving-mitochondrial-membrane-potential
#19
Eleonora Bassino, Sara Fornero, Maria Pia Gallo, Clara Gallina, Saveria Femminò, Renzo Levi, Bruno Tota, Giuseppe Alloatti
Catestatin (Cst) is a 21-amino acid peptide deriving from Chromogranin A. Cst exerts an overall protective effect against an excessive sympathetic stimulation of cardiovascular system, being able to antagonize catecholamine secretion and to reduce their positive inotropic effect, by stimulating the release of nitric oxide (NO) from endothelial cells. Moreover, Cst reduces ischemia/reperfusion (I/R) injury, improving post-ischemic cardiac function and cardiomyocyte survival. To define the cardioprotective signaling pathways activated by Cst (5 nM) we used isolated adult rat cardiomyocytes undergoing simulated I/R...
2015: PloS One
https://www.readbyqxmd.com/read/25636335/decreased-plasma-chromogranin-a361-372-catestatin-but-not-chromogranin-a17-38-vasostatin-in-female-dogs-with-bacterial-uterine-infection-pyometra
#20
Supranee Jitpean, Mats Stridsberg, Ann Pettersson, Odd V Höglund, Bodil Ström Holst, Ragnvi Hagman
BACKGROUND: Pyometra often induces systemic inflammatory response syndrome (SIRS) and early diagnosis is crucial for survival. Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. A prognostic value of CgA has been found in humans that are critically ill or that have SIRS associated with infection. CgA has not yet been studied in dogs with bacterial infection. The aim of the study was to investigate CgA, measured by Chromogranin A361-372 (Catestatin; Cst) and Chromogranin A17-38 (Vasostatin; VS) in healthy dogs and in dogs with pyometra...
2015: BMC Veterinary Research
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