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Henning Reis, Stefanie Bertram, Leona Pott, Ali Canbay, Anja Gallinat, Hideo Andreas Baba
Hepatocellular Carcinoma (HCC) is a lethal cancer worldwide. Recently, the hippo signaling pathway has been implicated in tumorigenesis of HCC and other malignant tumors. Aim of the study was therefore to evaluate the hippo signaling pathway activity and its clinico-pathological associations and crosstalk in different tumor forming hepatocellular lesions (HCC, hepatocellular adenoma (HCA), focal nodular hyperplasia (FNH) and cirrhosis). A tissue micro array (TMA) from paired human tumorous and non-tumorous (NT) tissue samples of HCC (n = 92), HCA (n = 25), FNH (n = 28) and cirrhosis (n = 28; no NT) was constructed...
June 8, 2016: Pathology Oncology Research: POR
Soo Jeong Nam, Hyun Yang Yeo, Hee Jin Chang, Bo Hyun Kim, Eun Kyung Hong, Joong-Won Park
Purpose: We developed a new method of detecting CTCs in liver cancer patients by constructing cell blocks from peripheral blood cells, including CTCs, followed by multiple immunohistochemical analysis. Materials and Methods: Cell blocks were constructed from the nucleated cell pellets of peripheral blood after removal of red blood cells. The blood cell blocks were obtained from 29 patients with liver cancer, and from healthy donor blood spiked with seven cell lines...
March 30, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Rania Elsayed Wasfy, Aliaa Atef Shams Eldeen
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and thirdly leading cause of cancer-related death worldwide. The estimated risk of hepatocellular carcinoma is 15 to 20 times as high among persons infected with HCV as it is among those who are not infected, with most of the excess risk limited to those with advanced hepatic fibrosis or cirrhosis. Glypican3 (GPC3) plays a key role in relation to signaling with growth factors, regulating the proliferative activity of cancer cells...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Xianglin Mei, Yang Xia, Hironobu Sasano, Hongwen Gao
Yolk sac tumor (YST), also known as endodermal sinus tumor, is a highly malignant germ cell tumor that is extremely rare in the sinonasal region, especially in adults. To the best of our knowledge, only five such cases have been reported till date (four men, one woman). We present a case of sinonasal YST admixed with transitional cell carcinoma in a 58-year-old female. Magnetic resonance imaging revealed a mass in the right ethmoid fissure infiltrating into the posterior and anterior ethmoid sinuses and nasopharynx...
September 2015: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Henning Reis, Carolin Pütter, Dominik A Megger, Thilo Bracht, Frank Weber, Andreas-C Hoffmann, Stefanie Bertram, Jeremias Wohlschläger, Sascha Hagemann, Martin Eisenacher, André Scherag, Jörg F Schlaak, Ali Canbay, Helmut E Meyer, Barbara Sitek, Hideo A Baba
Hepatocellular carcinoma (HCC) is a major lethal cancer worldwide. Despite sophisticated diagnostic algorithms, the differential diagnosis of small liver nodules still is difficult. While imaging techniques have advanced, adjuvant protein-biomarkers as glypican3 (GPC3), glutamine-synthetase (GS) and heat-shock protein 70 (HSP70) have enhanced diagnostic accuracy. The aim was to further detect useful protein-biomarkers of HCC with a structured systematic approach using differential proteome techniques, bring the results to practical application and compare the diagnostic accuracy of the candidates with the established biomarkers...
June 2015: Biochimica et Biophysica Acta
Iman A Abd El Gawad, Ghada I Mossallam, Noha H Radwan, Heba M Elzawahry, Niveen M Elhifnawy
BACKGROUND: Hepatocellular carcinoma (HCC) is usually asymptomatic in the early stage and does not show elevated alpha-feto protein (AFP). AFP shows 60-80% sensitivity in diagnosing HCC. Glypican3 (GPC-3) is an oncofetal protein that is only detected in HCC cells but not in benign liver tissues, while Carcinoembryonic antigen (CEA) is expressed in various neoplasms including HCC. Although, it is not specific for HCC. Prothrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of HCC patients...
June 2014: Journal of the Egyptian National Cancer Institute
Iman Attia Abdelgawad, Ghada Ibrahim Mossallam, Noha Hassan Radwan, Heba Mohammed Elzawahry, Niveen Mostafa Elhifnawy
BACKGROUND: Because of the high prevalence of hepatocellular carcinoma (HCC) in Egypt, new markers with better diagnostic performance than alpha-feto protein (AFP) are needed to help in early diagnosis. The aim of this work was to compare the clinical utility of both serum and mRNA glypican3 (GPC3) as probable diagnostic markers for HCC among Egyptian patients. MATERIALS AND METHODS: A total of 60 subjects, including 40 with HCC, 10 with cirrhosis and 10 normal controls were analyzed for serum GPC3 (sGPC3) by ELISA...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
Mohamed Zaakook, Menar Ayoub, Eman Abu Sinna, Samar El-Sheikh
PURPOSE: Evaluation of the sensitivity and specificity of glypican3 (GPC3) in differentiating hepatocellular carcinoma (HCC) from metastatic carcinomas of the liver in cell block material. PATIENTS AND METHODS: Sixty cell blocks were prepared from liver FNAs performed in the radiodiagnosis department, National Cancer Institute, in the period between August 2011 and May 2012. Cases diagnosed as hepatocellular carcinoma, or metastatic carcinoma were included in the study...
December 2013: Journal of the Egyptian National Cancer Institute
Hye Won Shin, Soo Young Park, Kyoung Bun Lee, Eun Shin, Suk Woo Nam, Jung Young Lee, Ja June Jang
BACKGROUND/AIMS: This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway. METHODS: The global transcript levels in platelet derived growth factor-BB (PDGF-BB)-stimulated hTERT HSCs were analyzed using oligonucleotide microarrays. Oligonucleotide microarrays with 19K human oligo chips were performed to obtain gene expression profiles associated with proliferation in human hTERT HSCs...
December 2009: Korean Journal of Hepatology
Da-Wei Guo, Si-Yang Zhang, Xue-Zhong Hou, Hong-Wei Li, Xiao-Feng Jiang, Wen-Yu Sun, Yun-Tao We, Jian Liang
OBJECTIVE: To transduce the new hepatocellular carcinoma (HCC) specific antigen gene glypican3 (GPC3) into dendritic cells (DCs) and to observe the in vitro cytotoxic effect induced by the genetically modified DCs against the hepatocellular carcinoma cell line (HepG2). METHODS: This study was performed in China Medical University Shenyang, China from September 2007-February 2008. The design of the study was to modify DCs with GPC3 and to be used to activate human T cells and elicit a cell-mediated immune response against HepG2 in vitro...
September 2008: Saudi Medical Journal
Akihiko Taguchi, Masahiro Emoto, Shigeru Okuya, Naofumi Fukuda, Yoshitaka Nakamori, Mutsuko Miyazaki, Sachiko Miyamoto, Katsuya Tanabe, Hiroyuki Aburatani, Yoshitomo Oka, Yukio Tanizawa
Insulin stimulates glucose uptake in fat and muscle primarily by stimulating the translocation of vesicles containing facilitative glucose transporters, GLUT4, from intracellular compartments to the plasma membrane. Although cell surface externalization of GLUT4 is critical for glucose transport, the mechanism regulating cell surface GLUT4 remains unknown. Using a yeast two-hybrid screening system, we have screened GLUT4-binding proteins, and identified a novel glycosyl phosphatidyl inositol (GPI)-linked proteoglycan, Glypican3 (GPC3)...
May 16, 2008: Biochemical and Biophysical Research Communications
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