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Cognative control training

M Dines, R Lamprecht
Fear conditioning leads to long-term fear memory formation and is a model for studying fear-related psychopathologies conditions such as phobias and posttraumatic stress disorder. Long-term fear memory formation is believed to involve alterations of synaptic efficacy mediated by changes in synaptic transmission and morphology in lateral amygdala (LA). EphrinA4 and its cognate Eph receptors are intimately involved in regulating neuronal morphogenesis, synaptic transmission and plasticity. To assess possible roles of ephrinA4 in fear memory formation we designed and used a specific inhibitory ephrinA4 mimetic peptide (pep-ephrinA4) targeted to EphA binding site...
2014: Translational Psychiatry
Kari J Dugger, Taylor Chrisman, Ben Jones, Parker Chastain, Kacie Watson, Kim Estell, Kurt Zinn, Lisa Schwiebert
Studies have indicated increased incidence and severity of allergic asthma due to western lifestyle and increased sedentary activity. Investigations also indicate that exercise reduces the severity of asthma; however, a mechanism of action has not been elucidated. Additional work implicates re-distribution of T helper (Th) cells in mediating alterations of the immune system as a result of moderate aerobic exercise in vivo. We have previously reported that exercise decreases T helper 2 (Th2) responses within the lungs of an ovalbumin (OVA)-sensitized murine allergic asthma model...
November 2013: Brain, Behavior, and Immunity
Claudia Fritsch, Alexander Herrmann, Michael Nothnagel, Karol Szafranski, Klaus Huse, Frank Schumann, Stefan Schreiber, Matthias Platzer, Michael Krawczak, Jochen Hampe, Mario Brosch
So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cells to generate a transcriptome-wide map of TISs in a human monocytic cell line. A neural network was trained on the ribosomal footprints observed at previously annotated AUG translation initiation codons (TICs), and used for the ab initio prediction of TISs in 5062 transcripts with sufficient sequence coverage. Functional interpretation suggested 2994 novel upstream open reading frames (uORFs) in the 5' UTR, 1406 uORFs overlapping with the coding sequence, and 546 N-terminal protein extensions...
November 2012: Genome Research
Tomonori Ogata, Yasuharu Oishi, Kazuhiko Higashida, Mitsuru Higuchi, Isao Muraoka
Skeletal muscle may develop adaptive molecular chaperone enhancements as a potential defense system through repeated daily exercise stimulation. The present study investigated whether prolonged exercise training alters the expression of molecular chaperone proteins for the long term in skeletal muscle. Mature male Wistar rats were subjected for 8 wk to either a single bout of acute intermittent treadmill running (30 m/min, 5 min x 4, 5 degrees grade) or prolonged treadmill running training (15-40 m/min, 5 min x 4, 5-7 degrees grade)...
May 2009: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
T Kamolz, U Baumann, R Pointner
UNLABELLED: The study consists of a prospective randomized controlled clinical trial of patients undergoing laparoscopic cholecystectomy. Besides medical and sociodemographic data, two personality factors--self-efficacy and locus of control--were found to predict postoperative pain. Self-efficacy describes the expectations of a person to successfully execute the behavior required to produce behavioral outcomes. Locus of control, in the extreme case, is a personality factor which is represented by an internal orientation in which the individual believes that rewards are brought about by his own action, versus an external orientation, in which the individual believes that rewards are the result of powerful others or chance factors and fate...
April 20, 1998: Der Schmerz
José M Pizarro, Luis S Haro, Edwin J Barea-Rodriguez
The Morris water maze is a task widely used to investigate cellular and molecular changes associated with spatial learning and memory. This task has both spatial and aversive (swimming related stress) components. It is possible that stress may influence cellular modifications observed after learning the Morris water maze spatial task. Heat shock proteins, also known as stress proteins, are up-regulated in response to thermal stress, trauma, or environmental insults. In the rat hippocampus, psychophysiological stress increases the levels of heat shock protein 70 (HSC70)...
March 2003: Neurobiology of Learning and Memory
M M Jirovec, J Jenkins, M Isenberg, J Baiardi
The urine control theory, a middle range theory substructed from Roy's adaptation model, is presented to explicate the phenomenon of urine control. Urine in the bladder is identified as the focal stimulus, and the impact of the cognator subsystem in relation to urine control is described. The role of contextual stimuli related to mobility and the environment is also described. Relationships between concepts are explained and supported with individual case studies. The case findings are used to exemplify the interrelationships in the model...
July 1999: Nursing Science Quarterly
M A Osinski, M S Pampusch, M P Murtaugh, D R Brown
The heptadecapeptide nociceptin/orphanin FQ is the cognate ligand for the opioid receptor-like orphanin FQ (OFQ) receptor, a member of the G protein-coupled receptor superfamily. The gastrointestinal tract is a major site of opioid action, and preliminary evidence suggests that an OFQ receptor may be expressed in rat small intestine. We addressed the hypothesis that this receptor is expressed in the gastrointestinal tract of the pig, a model for the human digestive system. A 1205-bp cDNA was isolated from porcine forebrain which contained the 370 amino acid open reading frame encoding the OFQ receptor...
January 22, 1999: European Journal of Pharmacology
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