Yuu Okura, Yuri Ikawa-Teranishi, Akihiko Mizoroki, Noriyuki Takahashi, Takashi Tsushima, Machiko Irie, Zulkarnain Harfuddin, Momoko Miura-Okuda, Shunsuke Ito, Genki Nakamura, Hiroaki Takesue, Yui Ozono, Masamichi Nishihara, Kenta Yamada, Siok Wan Gan, Akira Hayasaka, Shinya Ishii, Tetsuya Wakabayashi, Masaru Muraoka, Nishiki Nagaya, Hiroshi Hino, Takayuki Nemoto, Taichi Kuramochi, Takuya Torizawa, Hideaki Shimada, Takehisa Kitazawa, Makoto Okazaki, Junichi Nezu, Ludvig M Sollid, Tomoyuki Igawa
In human celiac disease (CeD) HLA-DQ2.5 presents gluten peptides to antigen-specific CD4+ T cells, thereby instigating immune activation and enteropathy. Targeting HLA-DQ2.5 with neutralizing antibody for treating CeD may be plausible, yet using pan-HLA-DQ antibody risks affecting systemic immunity, while targeting selected gluten peptide:HLA-DQ2.5 complex (pHLA-DQ2.5) may be insufficient. Here we generate a TCR-like, neutralizing antibody (DONQ52) that broadly recognizes more than twenty-five distinct gluten pHLA-DQ2...
December 22, 2023: Nature Communications