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Ptsd antiepileptic

Natalie N Rohde, Christine B Baca, Anne C Van Cott, Karen L Parko, Megan E Amuan, Mary Jo Pugh
OBJECTIVE: We examined patterns of antiepileptic drug (AED) use in a cohort of Iraq/Afghanistan war veterans (IAVs) who were previously identified as having epilepsy. We hypothesized that clinicians would be more likely to prescribe newer AEDs and would select specific AEDs to treat seizures based on patient characteristics including gender and comorbidities. METHODS: From the cohort of IAVs previously identified with epilepsy between fiscal years 2009 and 2010, we selected those who received AEDs from the Veterans Health Administration in FY2010...
May 2015: Epilepsy & Behavior: E&B
Akira Kishimoto, Yurie Goto, Kenji Hashimoto
Post-traumatic stress disorder (PTSD) is a pathological response to trauma characterized by frequent recollections, recurrent nightmares, and flashbacks of the traumatic event(s). To date, the precise mechanisms underlying the development of PTSD remain unknown. Several studies have suggested that antiepileptic drugs, such as gabapentin and lamotrigine, may be effective in the treatment of PTSD symptoms. We report on a 15-year-old Japanese female junior high school student who developed PTSD symptoms following repeated teasing from male classmates...
December 2014: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Sophie A George, Mariana Rodriguez-Santiago, John Riley, Elizabeth Rodriguez, Israel Liberzon
RATIONALE: Post-traumatic stress disorder (PTSD) is a chronic, debilitating disorder. Only two pharmacological agents are approved for PTSD treatment, and they often do not address the full range of symptoms nor are they equally effective in all cases. Animal models of PTSD are critical for understanding the neurobiology involved and for identification of novel therapeutic targets. Using the rodent PTSD model, single prolonged stress (SPS), we have implicated aberrant excitatory neural transmission and glucocorticoid receptor (GR) upregulation in the medial prefrontal cortex (mPFC) and hippocampus (HPC) in fear memory abnormalities associated with PTSD...
January 2015: Psychopharmacology
Christian A Müller, Olga Geisel, Roman Banas, Andreas Heinz
INTRODUCTION: At present, the substances acamprosate, naltrexone and disulfiram are available for pharmacotherapy in alcohol dependence, but clinical studies found only modest effect sizes of these treatment options. AREAS COVERED: This article focuses on current pharmacological treatment approaches for alcohol dependence, which have been evaluated in randomized, placebo-controlled trials (RCTs). EXPERT OPINION: Besides the opioid system modulator nalmefene, which has recently been approved as a medication for the reduction of alcohol consumption, several compounds have been investigated in patients with alcohol dependence using a randomized, placebo-controlled design...
March 2014: Expert Opinion on Pharmacotherapy
Almari Ginory, Michelle Chaney-Catchpole, Julie M Demetree, Laura M Mayol Sabatier, Mathew Nguyen
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity syndrome most commonly associated with antiepileptic agents, allopurinol, and sulfonamides. It is a severe adverse reaction associated with fever, rash, eosinophilia, lymphadenopathy, and internal organ involvement. We present the case of a 17-year-old Caucasian female with bipolar disorder type II and posttraumatic stress disorder treated with lamotrigine for a non-Food and Drug Administration-approved indication that developed DRESS syndrome at an initial dose higher than that recommended...
July 2013: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Dragica Kozarić-Kovačić, Marija Eterović
Lamotrigine is an antiepileptic drug with broad spectrum of actions, also approved for the treatment of bipolar disorder. Growing number of reports document the antiaggressive effect of lamotrigine in various psychiatric diseases. However, there has been only 1 study in the literature investigating the role of lamotrigine in posttraumatic stress disorder (PTSD), but its antiaggressive aspect was not observed. Although aggression is commonly associated with PTSD, there is paucity of data considering its management...
May 2013: Clinical Neuropharmacology
Mohamad Z Koubeissi
Vivid recollection of a particular past memory is a rare ictal phenomenon in temporal lobe epilepsy. When the memory is traumatic, the presentation may mimic post-traumatic stress disorder (PTSD). We report a woman with temporal lobe epilepsy who was misdiagnosed with post-traumatic stress disorder for two years before she had a suspected generalised seizure; video-EEG monitoring confirmed that her episodes were epileptic. Adequate treatment with an antiepileptic medication resulted in total resolution of the episodes...
September 2012: Epileptic Disorders: International Epilepsy Journal with Videotape
Jonathan I Bisson
INTRODUCTION: Post-traumatic stress disorder (PTSD) may affect 10% of women and 5% of men at some stage, and symptoms may persist for several years. Risk factors include major trauma, lack of social support, peritraumatic dissociation, and previous psychiatric history or personality factors. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent PTSD? What are the effects of interventions to treat PTSD? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2009 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review)...
2010: Clinical Evidence
Maria Stamatakos, John V Campo
PURPOSE OF REVIEW: To review and summarize existing literature regarding pharmacological interventions for post-traumatic stress disorder (PTSD) in children and adolescents. A literature search limited to articles focused on the pharmacological treatment of children aged 0-18 years with a history of trauma and/or PTSD was conducted through the National Library of Medicine and PsychInfo, 1967-present, and each citation manually reviewed. RECENT FINDINGS: Pharmacologic trials for pediatric PTSD are limited in scope and number, with one small double-blind, randomized controlled trial of the selective serotonin reuptake inhibitor (SSRI) sertraline...
October 2010: Current Opinion in Pediatrics
Anne C VanCott, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan, Mary Jo Pugh
BACKGROUND: The U.S. Food and Drug Administration (FDA) recently linked antiepileptic drug (AED) exposure to suicide-related behaviors based on meta-analysis of randomized clinical trials. We examined the relationship between suicide-related behaviors and different AEDs in older veterans receiving new AED monotherapy from the Veterans Health Administration (VA), controlling for potential confounders. METHODS: VA and Medicare databases were used to identify veterans 66 years and older, who received a) care from the VA between 1999 and 2004, and b) an incident AED (monotherapy) prescription...
2010: BMC Medicine
David K Chen, Shahram Izadyar
Various psychiatric disorders can contribute to psychogenic nonepileptic events (PNEEs), including posttraumatic stress disorder (PTSD). We hypothesize that among patients with PNEEs and PTSD, the nature of the traumatic experience leading to PTSD has an association with the clinical manifestations of PNEEs. We found that the presence of PTSD, in general, did not demonstrate significant association with any particular PNEE semiology in a veterans population. However, 11 of 12 (91.7%) subjects with PNEEs and specifically combat-related PTSD showed significant predilection for hypomotor or nonmotor PNEEs, as compared to 5 of 12 (41...
February 2010: Epilepsy & Behavior: E&B
Jonathan I Bisson
INTRODUCTION: Post-traumatic stress disorder (PTSD) may affect 10% of women and 5% of men at some stage, and symptoms may persist for several years. Risk factors include major trauma, lack of social support, peritraumatic dissociation, and psychiatric or personality factors. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent; and to treat PTSD? We searched: Medline, Embase, The Cochrane Library and other important databases up to December 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review)...
2007: Clinical Evidence
Joseph Zohar, Michael A Matar, Gal Ifergane, Zeev Kaplan, Hagit Cohen
BACKGROUND: The short- and long-term behavioral effects of a brief course of pregabalin, an antiepileptic structural analogue of alpha-aminobyturic acid with analgesic and anxiolytic effects, were assessed in an animal model of post-traumatic stress disorder (PTSD). METHOD: Two-hundred thirty-three adult male Sprague-Dawley rats were employed. Behavioral responses to traumatic stress exposure (predator urine scent) were assessed immediately after (1 h) and 30 days after treatment with saline or pregabalin (at doses of 30, 100 and 300 mg/kg) in terms of behavior in the elevated plus maze (EPM) and the acoustic startle response (ASR) paradigms...
September 2008: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Heather A Berlin
Post-traumatic stress disorder (PTSD) is a disruptive, chronic, and relatively common disorder that is often difficult to treat. Many patients with PTSD are unresponsive, have only moderate or marginal responses, or have troubling side effects to first-line serotonin reuptake inhibitor treatment. Studies suggest that antiepileptic drugs (AEDs) may be an effective treatment alternative or adjunctive treatment for the symptoms of PTSD. Recent results from case reports and open and controlled studies on the efficacy and tolerability of AEDs in PTSD are reviewed here, and their methodological limitations are discussed when relevant...
August 2007: Current Psychiatry Reports
Marco Mula, Stefano Pini, Giovanni B Cassano
Antiepileptic drugs (AEDs) have been successfully used in the treatment of mood disturbances, leading clinicians and researchers to investigate their use in other psychiatric disorders. This article reviews the literature about the potential efficacy of AEDs in anxiety disorders. An updated MEDLINE search (January 1970 to September 2006) using the terms "panic disorder," "agoraphobia," "posttraumatic stress disorder," "obsessive-compulsive disorder," "generalized anxiety disorder," "social phobia," "phobia," "carbamazepine," "phenobarbital," "phenytoin," "valproate," "lamotrigine," "topiramate," "vigabatrin," "tiagabine," "gabapentin," "levetiracetam," and "pregabalin" showed more than 70 articles and 38 published studies...
June 2007: Journal of Clinical Psychopharmacology
Lori L Davis, Elizabeth C Frazier, Raela B Williford, Jason M Newell
This article reviews the literature on the long-term pharmacological treatment of post-traumatic stress disorder (PTSD). A PUBMED search was conducted; only studies on the effects of long-term (>14-weeks) pharmacological treatment for PTSD in adults or children were considered. Our search identified three randomised, double-blind, placebo-controlled studies (one each for sertraline, fluoxetine and risperidone), four open-label studies (one each for sertraline, paroxetine, nefazodone and valproate), one retrospective case series (clozapine) and one pooled analysis (sertraline)...
2006: CNS Drugs
Luciana D'Alessio, Brenda Giagante, Silvia Oddo, Walter Silva W, Patrícia Solís, Damián Consalvo, Silvia Kochen
PURPOSE: The aim of this study is to describe similarities and differences in epidemiological, psychiatric and semiologic variables between patients with psychogenic none epileptic seizures (PNES) and comorbid epilepsy (mixed PNES), and patients with PNES without comorbid epilepsy (pure PNES). RESULTS: Forty-three patients with PNES diagnosed by Video-EEG were included. Twenty-four had pure PNES, and ninteen mixed PNES. Female population, age, duration of PNES, psychiatric institutionalization, psychopharmacotherapy, dissociative disorders and posttraumatic stress disorder (PTSD), were significantly higher in the pure PNES patients...
July 2006: Seizure: the Journal of the British Epilepsy Association
Paul E Keck, Jeffrey R Strawn, Susan L McElroy
BACKGROUND: Anxiety disorders are among the most commonly co-occurring psychiatric syndromes with bipolar disorder. The presence of co-occurring anxiety disorders has important prognostic and treatment implications. METHOD: Using the PaperChase database augmented by a manual search of the literature, we identified 122 publications that consisted of reports regarding pharmacologic agents used in the treatment of bipolar disorder also assessing the efficacy of these agents in anxiety disorders, treatment studies of patients with comorbid bipolar disorder and specific anxiety disorders, and studies of novel antiepileptic agents in the treatment of anxiety symptoms or disorders...
2006: Journal of Clinical Psychiatry
Taoufik M Alsaadi, Anna Vinter Marquez
Psychogenic nonepileptic seizures are episodes of movement, sensation, or behaviors that are similar to epileptic seizures but do not have a neurologic origin; rather, they are somatic manifestations of psychologic distress. Patients with psychogenic nonepileptic seizures frequently are misdiagnosed and treated for epilepsy. Video-electroencephalography monitoring is preferred for diagnosis. From 5 to 10 percent of outpatient epilepsy patients and 20 to 40 percent of inpatient epilepsy patients have psychogenic nonepileptic seizures...
September 1, 2005: American Family Physician
Barbara A Dworetzky, Andreja Strahonja-Packard, Christopher W Shanahan, Jeanette Paz, Barbara Schauble, Edward B Bromfield
PURPOSE: To describe male patients (pts) with psychogenic nonepileptic seizures (PNESs) followed up in a Veteran's Administration (VA) seizure clinic and to compare them with those with epileptic seizures (ESs) by using clinical, and psychosocial variables. METHODS: Adult male veterans seen between 1997 and 2000 with ESs were compared with those with PNESs with respect to clinical history (head trauma, antiepileptic drug exposure, depression, anxiety, substance abuse, seizure description), documented chronic pain, posttraumatic stress disorder (PTSD), compensation for diagnosis, neurologic examination, and test results including imaging and EEG data...
September 2005: Epilepsia
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