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Hashimotos thyroiditis

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https://www.readbyqxmd.com/read/28742402/association-of-il-10-regulating-micrornas-in-peripheral-blood-mononuclear-cells-with-the-pathogenesis-of-autoimmune-thyroid-disease
#1
Yukina Takuse, Mikio Watanabe, Naoya Inoue, Ritsuko Ozaki, Hiroshi Ohtsu, Minori Saeki, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani
Interleukin (IL)-10 is known to suppress inflammation in autoimmune diseases. IL-10 can be regulated by miRNAs. To elucidate the involvement of miRNAs that regulate IL-10 expression with the pathogenesis of autoimmune thyroid disease (AITD), we examined the expression levels of hsa-miR-27a-3p, hsa-miR-98-5p, hsa-miR-106a-5p, and hsa-miR-223-3p in peripheral blood mononuclear cells (PBMCs) from 43 patients with Graves' disease (GD), 38 patients with Hashimoto's disease (HD), and 21 healthy volunteers. We evaluated the association between the expression levels of four miRNAs and intracellular expression of IL-10 in PBMCs from 11 healthy volunteers...
July 25, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742400/role-of-different-cd40-polymorphisms-in-graves-disease-and-hashimoto-s-thyroiditis
#2
Dongguo Wang, Jiayu Chen, Huanyuan Zhang, Fangfang Zhang, Linjun Yang, Yonghua Mou
Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was to identify the relationship of the polymorphisms of three sites of CD40 with the susceptibility to AITD in the Chinese population. We genotyped three polymorphisms of CD40: C/T -1 SNP, 58038T site of the third exon and C64610G site of the ninth exon in 196 GD cases, 121 HT cases and 122 control subjects...
July 25, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28739190/the-treatment-and-outcome-analysis-of-primary-squamous-cell-carcinoma-of-the-thyroid
#3
Ryuji Yasumatsu, Masanobu Sato, Ryutaro Uchi, Takafumi Nakano, Kazuki Hashimoto, Ryunosuke Kogo, Masahiko Taura, Mioko Matsuo, Torahiko Nakashima, Takashi Nakagawa
OBJECTIVES: Primary squamous cell carcinoma (SCC) of the thyroid is a rare disease. It usually presents with locally advanced disease and has an overall poor prognosis. In this study, we investigated the characteristics and outcomes of patients with SCC of the thyroid, and reported our experience with chemotherapy with lenvatinib in the treatment of SCC of the thyroid. METHODS: The management outcome of 10 patients who had SCC of the thyroid between January 2000 and 2015 at Kyushu University Hospital or associated facilities was reviewed...
July 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28738696/the-role-of-autoantibodies-in-the-syndromes-of-orthostatic-intolerance-a-systematic-review
#4
Mohammed Ruzieh, Lillian Batizy, Osama Dasa, Carson Oostra, Blair Grubb
Orthostatic intolerance is defined as the provocation of symptoms upon standing, commonly caused by neurogenic orthostatic hypotension (OH) and postural tachycardia syndrome (POTS), the etiology for which has not been fully uncovered yet. Many reports have described the occurrence of dysautonomia, orthostatic intolerance and POTS following febrile illness, presumably viral and post-vaccine. Furthermore, patients with dysautonomia have higher rates of autoimmune disorders such as Hashimoto thyroiditis and SLE...
July 24, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28724185/myo-inositol-plus-selenium-supplementation-restores-euthyroid-state-in-hashimoto-s-patients-with-subclinical-hypothyroidism
#5
M Nordio, S Basciani
OBJECTIVE: Clinical evidence suggests that oral supplementation with myo-inositol (MI) and selenium (Se) is useful in the treatment of autoimmune thyroiditis. The purpose of this study was to highlight the positive response of Hashimoto's patients with subclinical hypothyroidism (SH) treated with MI and Se (MI-Se) in restoring a normal thyroid function. PATIENTS AND METHODS: A total of 168 patients with Hashimoto's thyroiditis (HT) having Thyroid Stimulating Hormone (TSH) levels between 3 and 6 µIU/ml were randomized into 2 groups: one receiving MI-Se and the other one Se alone...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724172/favorable-effects-of-myo-inositol-selenomethionine-or-their-combination-on-the-hydrogen-peroxide-induced-oxidative-stress-of-peripheral-mononuclear-cells-from-patients-with-hashimoto-s-thyroiditis-preliminary-in-vitro-studies
#6
S Benvenga, T Vicchio, F Di Bari, R Vita, P Fallahi, S M Ferrari, S Catania, C Costa, A Antonelli
OBJECTIVE: The aim of this study was to assess whether blood mononuclear cells (PBMC) from Hashimoto's thyroiditis (HT) and control women, were protected from in vitro H2O2-induced oxidative stress after addition of antioxidants. PATIENTS AND METHODS: PBMC, from 8 HT women and 3 healthy women (controls), were cultured in the presence of 200 µM H2O2 alone, with subsequent addition of myo-inositol (Myo) (0.25, 0.5, 1.0 µM), selenomethionine (SelMet) (0.25, 0.5, 1...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724056/prevalence-of-pancreatic-autoantibodies-in-non-diabetic-patients-with-autoimmune-thyroid-disease-and-its-relation-to-insulin-secretion-and-glucose-tolerance
#7
Carolina Sallorenzo, Regina Silva, Teresa Kasamatsu, Sérgio Dib
Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD; n = 181) and Hashimoto's thyroiditis (HT; n = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients...
July 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28717394/immunohistochemical-expression-of-er-%C3%AE-and-pr-in-papillary-thyroid-carcinoma
#8
Marwa Mohammed Serag Eldien, Asmaa Gaber Abdou, Tarek Rageh, Eman Abdelrazek, Enas Elkholy
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with multiple risk factors including exposure to ionising radiation. Oestrogens contribute to papillary carcinoma development by promoting cell proliferation and invasion of mutated epithelial follicular cells. The present study aimed to assess ER-α and PR expression in PTC and to correlate their expression with the clinicopathological parameters in this cancer. This study included 62 primary and six metastatic papillary thyroid carcinoma cases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28710237/focal-neurological-presentation-in-hashimoto-s-encephalopathy-mimicking-a-vascular-occlusion-of-the-middle-cerebral-artery
#9
Ahmad Alazzeh, Sarah Jaroudi, Matthew Gooch, Alan N Peiris
Hashimoto's encephalopathy is a rare form of autoimmune encephalopathy. It is likely an underdiagnosed entity especially in the setting of focal neurological defects. We report a case of a 49-year-old man who presented with "strange behavior"of a day's duration. Examination was significant only for lethargy, poor attention span and agitation. Routine labs revealed leucocytosis. Head CT scan was unremarkable. Lumbar puncture showed high white blood cells with lymphocytosis and elevated protein level. The patient was empirically treated for meningitis without improvement...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28706507/epigenetics-and-autoimmune-thyroid-diseases
#10
REVIEW
Fabio Coppedè
Increasing evidence suggests that epigenetic modifications, including changes in DNA methylation, covalent modifications of histone tails, and gene silencing mediated by non-coding RNA molecules, play a substantial role in the pathogenesis of autoimmune disorders and might be seen as the result of environmental insults that trigger these conditions. Studies in cells and tissues of patients with autoimmune thyroid diseases (AITD), and particularly in Graves' disease (GD) and Hashimoto's thyroiditis (HT), are increasingly revealing altered epigenetic marks and resultant deregulation of gene expression levels, but the available data are still limited to be translated into the clinical settings...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28697689/vitamin-d-treatment-in-patients-with-hashimoto-s-thyroiditis-may-decrease-the-development-of-hypothyroidism
#11
Bekir Ucan, Mustafa Sahin, Muyesser Sayki Arslan, Nujen Colak Bozkurt, Muhammed Kizilgul, Askin Güngünes, Erman Cakal, Mustafa Ozbek
The relationship between Hashimoto's thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto's thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto's thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL...
July 12, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28696209/hashimoto-s-thyroiditis-predicts-outcome-in-intrathyroidal-papillary-thyroid-cancer
#12
Vincenzo Marotta, Concetta Sciammarella, Maria Grazia Chiofalo, Claudio Gambardella, Claudio Bellevicine, Marica Grasso, Giovanni Conzo, Giovanni Docimo, Gerardo Botti, Nunzia Simona Losito, Giancarlo Troncone, Maurizio De Palma, Laura Giacomelli, Luciano Pezzullo, Annamaria Al Colao, Antongiulio Faggiano
Hashimoto's thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analyzing all disease stages. Given that HT-related microenvironment involves solely the thyroid, we aimed to assess relationship between HT, as detected through pathological assessment, and outcome in intrathyroidal PTC. This was a multicenter, retrospective, observational study including 301 PTC with no evidence of extrathyroidal disease. Primary study endpoint was the rate of clinical remission...
July 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28694134/hashimoto-s-encephalopathy-and-anti-mog-antibody-encephalitis-50-years-after-lord-brain-s-description
#13
Kerrie-Anne Chen, Fabienne Brilot, Russell C Dale, Antony R Lafferty, Peter Ian Andrews
PURPOSE: To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). RESULTS: A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs...
June 10, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28690889/imbalances-in-t-cell-related-transcription-factors-among-patients-with-hashimoto-s-thyroiditis
#14
Vahid Safdari, Ebrahim Alijani, Maryam Nemati, Abdollah Jafarzadeh
OBJECTIVES: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto's thyroiditis (HT). Differentiation of effector T helper (Th) 1, Th2, Th17 and regulatory T cell (Treg) lymphocytes is regulated by transcription factors, including Th1-specific T box (T-bet), GATA binding protein-3 (GATA3), retinoid-related orphan receptor (ROR)-α and forkhead box P3 (FOXP3). This study aimed to investigate Th1/Th2, Th1/Treg, Th2/Treg and Th17/Treg balances at the level of these transcription factors...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28687736/association-between-braf-v600e-mutation-and-ultrasound-features-in-papillary-thyroid-carcinoma-patients-with-and-without-hashimoto-s-thyroiditis
#15
Qin Zhang, Bo-Ji Liu, Wei-Wei Ren, Ya-Ping He, Xiao-Long Li, Chong-Ke Zhao, Yi-Feng Zhang, Wen-Wen Yue, Jia-Yi Zheng, Hui-Xiong Xu
To assess the association between BRAF V600E mutation and ultrasound (US) features in papillary thyroid carcinoma (PTC) patients with and without Hashimoto's thyroiditis (HT). We retrospectively reviewed the US features and status of BRAF V600E mutation in 438 consecutive patients with surgically confirmed PTCs. The association between BRAF mutation and US features were analyzed. In addition, we conducted subgroup analyses in terms of coexistent HT. The BRAF mutation was found in 86.5% of patients (379 of 438)...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680307/thyroid-function-and-ultrasonography-abnormalities-in-lithium-treated-bipolar-patients-a-cross-sectional-study-with-healthy-controls
#16
Özlem Kuman Tunçel, Fisun Akdeniz, Süha Süreyya Özbek, Gülgün Kavukçu, Gökçen Ünal Kocabaş
INTRODUCTION: Lithium has many effects on thyroid physiology. Although these side effects have been known for a long time, large sample studies of lithium-treated patients using ultrasonography are lacking. The aim of this study is to investigate the detailed thyroid morphologies, hormone levels, and antibodies of lithium-treated patients compared with healthy controls. METHODS: This cross-sectional study involved 84 lithium-treated patients with bipolar disorder and 65 gender and age similar controls who had never been exposed to lithium...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28680002/chromophobe-renal-cell-carcinoma-like-thyroid-carcinoma-a-novel-clinicopathologic-entity-possibly-associated-with-tuberous-sclerosis-complex
#17
Mitsuyoshi Hirokawa, Akira Miyauchi, Minoru Kihara, Takumi Kudo, Yuko Hashimoto, Shinichi Suzuki, Tsutomu Daa, Huy Gia Vuong, Norisato Mitsutake
We report three cases of chromophobe renal cell carcinoma-like thyroid carcinoma as a novel clinicopathologic entity possibly associated with tuberous sclerosis complex. A 15-year-old female, a 19-year-old male, and a 21-year-old male presented with primary thyroid carcinoma. Two of the patients had associated tuberous sclerosis complex. Macroscopically, the carcinomas showed invasive growth. Histologically, the carcinoma cells showed a trabecular pattern with thin vascular stroma, and were characterized by abundant eosinophilic cytoplasm with perinuclear clearing, a prominent cell border, a wrinkled nuclear membrane, and binucleation, which are all features of chromophobe renal cell carcinoma...
July 6, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28679865/a-meta-analysis-of-hashimoto-s-thyroiditis-and-papillary-thyroid-carcinoma-risk
#18
Xingjian Lai, Yu Xia, Bo Zhang, Jianchu Li, Yuxin Jiang
OBJECTIVE: It remains inconclusive whether Hashimoto's thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question. RESULTS: Twenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678751/association-between-cd40-rs1883832-and-immune-related-diseases-susceptibility-a-meta-analysis
#19
Jiaxuan Qin, Jinchun Xing, Rongfu Liu, Bin Chen, Yuedong Chen, Xuan Zhuang
BACKGROUND/OBJECTIVE: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.Methods/main results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678538/what-they-don-t-see
#20
Cody M Clemens
The author is currently living with a chronic autoimmune disease known as Hashimoto's Thyroiditis, which caused his hypothyroidism. Although this disease is most common in middle-aged women, he was diagnosed at age 23. This disease is unique, because it is not entirely visible to others. In this piece, he presents a personal narrative of his diagnosis process and utilizes poetic inquiry to demonstrate to readers what "they," meaning individuals without an invisible chronic autoimmune disease, don't see.
July 5, 2017: Health Communication
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