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Hashimotos thyroiditis

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https://www.readbyqxmd.com/read/28443243/association-between-hashimoto-s-thyroiditis-and-thyroid-cancer-in-64-628-patients
#1
Christina Resende de Paiva, Christian Grønhøj, Ulla Feldt-Rasmussen, Christian von Buchwald
BACKGROUND: The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). METHODS: PubMed, OVID Medline, Google Scholar, and the Cochrane Library were searched from 1955 to 2016...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28441801/-prediction-of-occult-carcinoma-in-contralateral-nodules-based-on-the-ultrasonic-features-of-unilateral-papillary-thyroid-carcinoma
#2
L M Yang, Q Li, B W Zhao, J G Lyu, H S Xu, L L Xu, S Y Li, L Gao, J Zhu
Objective: To investigate the occurrence of occult carcinoma in contralateral lobes based on the ultrasonic features of unilateral papillary thyroid carcinoma. Methods: The study included 202 consecutives cases of unilateral papillary thyroid carcinoma with benign nodules in the contralateral lobe identified by preoperative ultrasound or fine-needle aspiration from June 2014 to December 2015. All patients received total thyroidectomies, and with postoperative pathological examination they were divided into two groups, one including 60 cases with positive occult cancer and another one consisting of 142 cases with negative occult cancer...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28440417/increased-cd19-cd24-cd27-b-regulatory-cells-are-associated-with-insulin-resistance-in-patients-with-type-i-hashimoto-s-thyroiditis
#3
Min Yang, Changji Du, Yinping Wang, Jun Liu
Hashimoto's thyroiditis (HT) is characterized by dysregulated immune responses and is commonly associated with insulin resistance. However, the mechanism of insulin resistance in HT remains to be fully elucidated. The aim of the present study was to investigate the correlation between the percentage of B regulatory lymphocytes (Bregs) and insulin resistance in patients with HT but with normal thyroid function (type I). A total of 59 patients with type I HT and 38 healthy volunteers were enrolled in the study...
April 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440063/micronuclei-and-nuclear-buds-highlighting-overlooked-indicators-of-chromosomal-damage-in-thyroid-aspiration-smears
#4
Tuba Dilay Kokenek-Unal, Ipek Coban
BACKGROUND: We aimed to examine the diagnostic utility of micronuclei (MN) and nuclear buds (NBs) in aspiration smears of the well-differentiated epithelial lesions of thyroid. METHODS: One hundred five cases composed of 34 follicular nodular disease (FND), 31 Hashimoto's thyroiditis (HT), and 40 papillary thyroid carcinoma (PTC) were compiled retrospectively. May- Grünwald Giemsa (MGG) stained smears of each case were selected to count cells with nuclear protrusions (NPs) per 1000 cells...
April 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28439882/prevalence-and-clinical-relevance-of-tsh-receptor-blocking-antibodies-in-autoimmune-thyroid-disease
#5
T Diana, J Krause, P D Olivo, J König, M Kanitz, B Decallonne, G J Kahaly
OBJECTIVE: The prevalence and clinical relevance of TSH-receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated. METHODS: Serum TBAb were measured with a reporter gene bioassay using chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). All samples were measured for TSHR stimulatory Ab (TSAb) and TSHR binding inhibiting immunoglobulins (TBII)...
April 25, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28439272/the-emerging-role-of-epigenetics-in-autoimmune-thyroid-diseases
#6
REVIEW
Bin Wang, Xiaoqing Shao, Ronghua Song, Donghua Xu, Jin-An Zhang
Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves' disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Epigenetics have been considered to exert key roles in integrating those genetic and environmental factors, and epigenetic modifications caused by environmental factors may drive genetically susceptibility individuals to develop AITD...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28436636/-iodine-131-joint-radio-frequency-ablation-treatment-for-child-with-hyperthyroidism-goiter-one-case-report
#7
Yonghua Chen, Li Liang, Yanlan Fang, Chunlin Wang, Linfa Li, Tian'an Jiang
A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8.1 cm×3.2 cm in the left and 8.2 cm×4.8 cm in the right. After iodine 131 combined with radiofrequency ablation (RFA) treatment, throat discomfort and recumbent breathing difficulties disappeared, and B-ultrasonic showed that the size of thyroid reduced to 2...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28435274/hashimoto-encephalopathy-with-high-plasma-monoamine-metabolite-levels-a-case-report
#8
Sho Horikoshi, Itaru Miura, Yasuto Kunii, Satoko Asano, Keiko Kanno-Nozaki, Hirobumi Mashiko, Hirooki Yabe
Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto's thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolites of dopamine and noradrenaline, respectively, are the possible biomarkers of neuropsychiatric diseases. We report a case of Hashimoto encephalopathy, in which we longitudinally measured the plasma levels of monoamine metabolites...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28431875/protein-oxidation-and-autoantibodies-reactivity-against-malondialdehyde-and-hydrogen-peroxide-modified-thyroid-antigens-in-plasma-of-patients-with-graves-disease-and-hashimoto-thyroiditis
#9
Malek Mseddi, Riadh Ben Mansour, Bochra Gargouri, Fatma Mnif, Samir El Ghawi, Boutheina Hammami, Abdelmonem Ghorbel, Mohamed Abid, Saloua Lassoued
The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Carbonyl and thiol groups, and MDA-protein adducts were first assessed among 74 AITD patients and 65 healthy controls...
April 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28428677/hypothyroidism-in-pediatric-population-bosnian-and-herzegovinian-situation
#10
Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
INTRODUCTION: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages. GOAL: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28419663/total-thyroidectomy-for-pressure-symptoms-in-patients-with-hashimoto-s-thyroiditis
#11
Katrina Heggie, Meei Yeung, Simon Grodski, James Lee, Jonathan Serpell
BACKGROUND: Hashimoto's thyroiditis (HT) is rarely on its own the indication for thyroidectomy. However, surgery in patients with HT will be undertaken when there is malignancy and may be required for pressure symptoms. Therefore, this study aimed to investigate the indications for surgery in HT patients. METHODS: The Monash University Endocrine Surgery Database was analysed from 1994 to 2013 for patients with HT. Patients with HT were compared to a similar group of patients with no HT on histopathology...
April 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28413173/25-hydroxyvitamin-d-serum-level-in-hashimoto-s-thyroiditis-but-not-graves-disease-is-relatively-deficient
#12
Wencai Ke, Tiange Sun, Yanan Zhang, Leqi He, Qiang Wu, Jun Liu, Bingbing Zha
Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department...
April 11, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28407273/comorbidity-of-chronic-spontaneous-urticaria-and-autoimmune-thyroid-diseases-a-systematic-review
#13
REVIEW
Pavel Kolkhir, Martin Metz, Sabine Altrichter, Marcus Maurer
Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG anti-thyroid AAbs (strong evidence)...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28403750/improvement-of-the-classification-quality-in-detection-of-hashimoto-s-disease-with-a-combined-classifier-approach
#14
Zbigniew Omiotek
The purpose of the study was to construct an efficient classifier that, along with a given reduced set of discriminant features, could be used as a part of the computer system in automatic identification and classification of ultrasound images of the thyroid gland, which is aimed to detect cases affected by Hashimoto's thyroiditis. A total of 10 supervised learning techniques and a majority vote for the combined classifier were used. Two models were proposed as a result of the classifier's construction. The first one is based on the K-nearest neighbours method (for K = 7)...
April 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28400827/effects-of-vitamin-d-deficiency-treatment-on-metabolic-markers-in-hashimoto-thyroiditis-patients
#15
Parichehr Vahabi Anaraki, Ashraf Aminorroaya, Massoud Amini, Awat Feizi, Bijan Iraj, Azamosadat Tabatabaei
BACKGROUND: The aim of the current trial was to investigate the effect of Vitamin D treatment on metabolic markers in people with Vitamin D deficiency and thyroid autoimmunity. MATERIALS AND METHODS: In this double-blind, randomized, placebo-controlled clinical trial, 65 Vitamin D deficient euthyroid or hypothyroid patients with positive TPO-Ab were enrolled. They randomly allocated into two groups to receive oral Vitamin D3 (50000 IU weekly) and placebo for 12 weeks...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28394968/-autoimmune-encephalitis-induced-by-antibodies-against-gaba-a-receptor
#16
Pablo González R, Lorena Hudson A, Esteban Basáez M, Marcelo Miranda C
Among autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements. A new variant, mediated by antibodies against the GABA-A receptor, was recen-tly described. We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus. The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392654/concurrent-linear-immunoglobulin-a-dermatosis-hashimoto-thyroiditis-and-immunoglobulin-a-nephropathy-in-an-adult
#17
Ji Young Yang, Inwhee Park, Sue Kyung Kim
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28387647/management-of-childhood-thyroid-nodules-surgical-and-endocrinological-experience-in-more-than-one-hundred-cases
#18
Emre Divarcı, Ülgen Celtik, Zafer Dökümcü, Orkan Ergün, Geylani Özok, Samim Özen, Damla Gökşen Şimşek, Şükran Darcan, Nazan Çetingül, Aylin Oral, Yeşim Ertan, Bengü Demirağ, Ahmet Çelik
OBJECTIVE: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children. METHODS: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Detailed ultrasonography and fine needle aspiration biopsy(FNAB) were the corner stones of the diagnostic approach. RESULTS: One hundred-three children(72F,31M) with a mean age of 13...
April 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28382784/the-impact-of-presence-of-hashimoto-s-thyroiditis-on-diagnostic-accuracy-of-ultrasound-guided-fine-needle-aspiration-biopsy-in-subcentimeter-thyroid-nodules-a-retrospective-study-from-fuscc
#19
Lili Gao, Ben Ma, Li Zhou, Yu Wang, Shuwen Yang, Ning Qu, Yi Gao, Qinghai Ji
The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US-FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow-up US/US-FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false-negative rate (FNR), false-positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients...
April 5, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28382505/association-of-established-hypothyroidism-associated-genetic-variants-with-hashimoto-s-thyroiditis
#20
A Barić, L Brčić, S Gračan, V Torlak Lovrić, I Gunjača, M Šimunac, M Brekalo, M Boban, O Polašek, M Barbalić, T Zemunik, A Punda, V Boraska Perica
PURPOSE: Hashimoto's thyroiditis (HT) as a chronic autoimmune disease of the thyroid gland is the most common cause of hypothyroidism. Since HT and hypothyroidism are closely related, the main aim of this study was to explore the association of established hypothyroidism single-nucleotide polymorphisms (SNPs) with HT. METHODS: The case-control dataset included 200 HT cases and 304 controls. Diagnosis of HT cases was based on clinical examination, measurement of thyroid antibodies (TgAb, TPOAb), hormones (TSH and FT4) and ultrasound examination...
April 5, 2017: Journal of Endocrinological Investigation
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