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https://www.readbyqxmd.com/read/27889555/correlation-between-microvascular-dysfunction-and-b-type-natriuretic-peptide-levels-in-non-ischemic-heart-failure-patients-with-cardiac-fibrosis
#1
Kyoko Hirakawa, Megumi Yamamuro, Tomoaki Uemura, Seiji Takashio, Koichi Kaikita, Daisuke Utsunomiya, Mina Nakayama, Eiichiro Yamamoto, Yasuyuki Yamashita, Seiji Hokimoto, Kenichi Tsujita
BACKGROUNDS: The relationship between microvascular dysfunction and plasma B-type natriuretic peptide (BNP) levels remains unclear in heart failure (HF) patients with cardiac fibrosis. METHODS: This study evaluated 55 consecutive non-ischemic HF patients in an effort to determine the relationship between endothelial independent coronary microvascular dysfunction and plasma BNP levels, as well as whether each measure is correlated with myocardial fibrosis. We evaluated plasma BNP levels in patients with stable HF...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27881133/alcohol-and-stroke-the-splitters-win-again
#2
EDITORIAL
Arthur L Klatsky, H Nicole Tran
Study of the relationships of alcohol drinking and risk of stroke can readily become mired in the labyrinthine interactions of drinking categorizations, non-linear associations, disparate cardiovascular conditions, and the heterogeneous types of stroke. This Commentary discusses the recent article by Larsson et al. (BMC Medicine 14:178, 2016). The authors split their material into separate meta-analyses of subarachnoid hemorrhage, intracerebral hemorrhage, and ischemic stroke, finding disparate alcohol-stroke relationships...
November 24, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27856437/quantifying-intracranial-plaque-permeability-with-dynamic-contrast-enhanced-mri-a-pilot-study
#3
P Vakil, A H Elmokadem, F H Syed, C G Cantrell, F H Dehkordi, T J Carroll, S A Ansari
BACKGROUND AND PURPOSE: Intracranial atherosclerotic disease plaque hyperintensity and/or gadolinium contrast enhancement have been studied as imaging biomarkers of acutely symptomatic ischemic presentations using single static MR imaging measurements. However, the value in modeling the dynamics of intracranial plaque permeability has yet to be evaluated. The purpose of this study was to use dynamic contrast-enhanced MR imaging to quantify the contrast permeability of intracranial atherosclerotic disease plaques in symptomatic patients and to compare these parameters against existing markers of plaque volatility using black-blood MR imaging pulse sequences...
November 17, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27785045/buerger-s-disease-providing-integrated-care
#4
REVIEW
Peter Klein-Weigel, Theresa Sophie Volz, Leonora Zange, Jutta Richter
Buerger's disease, also known as thromboangiitis obliterans (TAO), is a segmental inflammatory disease affecting small- and medium-sized vessels, which is strongly associated with tobacco use. Although the etiology is still unknown, recent studies suggest an immunopathogenesis. Diagnosis is based on clinical and angiomorphologic criteria, including age, history of smoking, clinical presentation with distal extremity ischemia, and the absence of other risk factors for atherosclerosis, autoimmune disease, hypercoagulable states, or embolic disease...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27772756/hypertrophic-olivary-degeneration-case-series-and-review-of-literature
#5
Shyam Sabat, Neil Mannering, Amit Agarwal
Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27729300/effectiveness-of-intracranial-percutaneous-trans-luminal-angioplasty-pta-or-stenting-for-atherosclerotic-vertebro-basilar-artery-occlusion-in-acute-phase-of-ischemic-stroke
#6
Daisuke Wajima, Shuta Aketa, Ichiro Nakagawa, Katsuya Masui, Taiji Yonezawa, Tomomi Enami, Fukuko Nishida, Hiroyuki Nakase
OBJECTIVE: Although short-term clinical outcomes after basilar artery stent placement have been reported previously, effectiveness of intracranial stenting for vertebro-basilar artery occlusion in acute phase of ischemic stroke is unclear. METHODS: We clinically investigated 8 patients with intracranial percutaneous trans-luminal angioplasty (PTA) or stenting as our protocol for symptomatic atherosclerotic vertebra-basilar artery occlusion (age range 54-80, mean 69±11 years; 6 male and 2 female) who were admitted to our hospital between August 2013 and December 2015...
October 8, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27668914/evaluation-and-management-of-acute-onset-hemiparesis-in-an-adolescent-with-leukemia
#7
Krishnan N Subrahmanian, Young H Shim, Mona D Shah, Brandon H Tran, Alexandra M Stevens, Andrea T Cruz
Emergency departments (EDs) are alert to the possibility of stroke and the need for early interventions to improve long-term clinical outcomes. However, new-onset hemiparesis in pediatric patients with leukemia may be due to a number of different etiologies, including most common side effects from chemotherapeutic agents. We present a case of a 15-year-old boy with pre-B acute lymphoblastic leukemia on chemotherapy, having recently received a high-dose methotrexate infusion in addition to intrathecal methotrexate therapy, who presented to our ED with acute right-sided hemiparesis...
September 23, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27590357/identification-of-resveratrol-derivative-3-3-4-4-5-5-hexamethoxy-trans-stilbene-as-a-novel-pro-angiogenic-small-molecule-compound
#8
ZhiQiang Chen, Lu Zhang, JingTing Yu, LiangKe Chen, Bo Zhou
The potential to promote neovascularization in ischemic tissues using exogenous agents is an attractive avenue for therapeutics. To identify novel pro-angiogenic small-molecule compound, we screened a series of resveratrol methylated derivatives and identified 3,3',4,4', 5,5'-hexamethoxy-trans-stilbene (3,3',4,4',5,5'-HMS) potently promotes proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro. Furthermore, 3,3',4,4',5,5'-HMS accelerates neo-vessels sprouting of rat aortic rings ex vivo, and neovascularization of chick chorioallantoic membrane (CAM) and mouse matrigel plugs in vivo...
August 31, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27589720/ruscogenin-attenuates-cerebral-ischemia-induced-blood-brain-barrier-dysfunction-by-suppressing-txnip-nlrp3-inflammasome-activation-and-the-mapk-pathway
#9
Guosheng Cao, Nan Jiang, Yang Hu, Yuanyuan Zhang, Guangyun Wang, Mingzhu Yin, Xiaonan Ma, Kecheng Zhou, Jin Qi, Boyang Yu, Junping Kou
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood-brain barrier (BBB) dysfunction after stroke remains unclear. This study aimed to investigate the effects of ruscogenin on BBB dysfunction and the underlying mechanisms in middle cerebral artery occlusion/reperfusion (MCAO/R)-injured mice and oxygen-glucose deprivation/reoxygenation (OGD/R)-injured mouse brain microvascular endothelial cells (bEnd...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27551511/xenon-mediated-neuroprotection-in-response-to-sustained-low-level-excitotoxic-stress
#10
J Lavaur, M Lemaire, J Pype, D Le Nogue, E C Hirsch, P P Michel
Noble gases such as xenon and argon have been reported to provide neuroprotection against acute brain ischemic/anoxic injuries. Herein, we wished to evaluate the protective potential of these two gases under conditions relevant to the pathogenesis of chronic neurodegenerative disorders. For that, we established cultures of neurons typically affected in Alzheimer's disease (AD) pathology, that is, cortical neurons and basal forebrain cholinergic neurons and exposed them to L-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) to generate sustained, low-level excitotoxic stress...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27528047/trans-cinnamaldehyde-protected-pc12-cells-against-oxygen-and-glucose-deprivation-reperfusion-ogd-r-induced-injury-via-anti-apoptosis-and-anti-oxidative-stress
#11
Xue Qi, Ru Zhou, Yue Liu, Jing Wang, Wan-Nian Zhang, Huan-Ran Tan, Yang Niu, Tao Sun, Yu-Xiang Li, Jian-Qiang Yu
Ischemia stroke is the major cause of mortality and permanent neurological disability with little definitive therapeutic options. This cerebral ischemic injury leads to the oxidative stress and eventually cell death. We hypothesized that treatment of this condition with the trans-cinnamaldehyde(TC) could protect cells from ischemic and reperfusion injury. Oxygen and glucose deprivation/reperfusion (OGD/R) was used as an in vitro model of hypoxic ischemic injury in present study. MTT was used to evaluate the protective effects of TC...
October 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27508665/-op-3c-05-characteristics-of-cerebral-hemodynamics-and-carotid-stiffness-in-patients-with-ischemic-leukoaraiosis-and-new-ultrasound-indices-of-ischemic-leukoaraiosis
#12
M Turk, M Zaletel, J Pretnar Oblak
OBJECTIVE: Leukoaraiosis (ILA) is believed to be ischaemic in origin due its association with cerebrovascular risk factors and similar location as lacunar infarctions. Its pathophysiology is not well understood and its diagnosis is still based on magnetic resonance imaging (MRI) as well as exclusion of other causes of white matter hyperintensities (WMH). So far there are no known confirming or screening diagnostic tests of ILA. Ultrasound studies have recently shown increased large artery stiffness, increased cerebrovascular resistance and lower cerebral blood flow in ILA patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27488087/moderate-hypothermia-improves-cardiac-and-vascular-function-in-a-pig-model-of-ischemic-cardiogenic-shock-treated-with-veno-arterial-ecmo
#13
Fabrice Vanhuyse, Nicolas Ducrocq, Huguette Louis, Narimane Al Kattani, Nicolas Laurent, Frédérique Joineau-Groubatch, Aude Falanga, Juan-Pablo Maureira, Antoine Kimmoun, Nicolas Girerd, Nguyen Tran, Bruno Levy
Cardiogenic shock (CS) patients treated with ECMO have severe cardiac failure, associated with ischemia-reperfusion. The use of moderate hypothermia during ischemia-reperfusion syndrome is supported by experimental data. We therefore studied the effects of moderate hypothermia on cardiac and vascular function in pig ischemic CS treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO).Cardiogenic shock was induced in 12 anesthetized pigs by coronary ligation. After one hour of CS, VA-ECMO was initiated and pigs were randomized to normothermia (38°C) or moderate hypothermia (34°C) during 8 hours...
August 2, 2016: Shock
https://www.readbyqxmd.com/read/27465493/upregulation-of-cystathione-%C3%AE-synthase-and-p70s6k-s6-in-neonatal-hypoxic-ischemic-brain-injury
#14
Mirna Lechpammer, Yen P Tran, Pia Wintermark, Veronica Martínez-Cerdeño, Viswanathan V Krishnan, Waseem Ahmed, Robert F Berman, Frances E Jensen, Evgeny Nudler, David Zagzag
Encephalopathy of prematurity (EOP) is a complex form of cerebral injury that occurs in the setting of hypoxia-ischemia (HI) in premature infants. Using a rat model of EOP, we investigated whether neonatal HI of the brain may alter the expression of cystathionine β-synthase (CBS) and the components of the mammalian target of rapamycin (mTOR) signaling. We performed unilateral carotid ligation and induced HI (UCL/HI) in Long-Evans rats at P6 and found increased CBS expression in white matter (i.e., corpus callosum, cingulum bundle and external capsule) as early as 24 hours (P7) post-procedure...
July 28, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27375480/inhibition-of-soluble-epoxide-hydrolase-limits-mitochondrial-damage-and-preserves-function-following-ischemic-injury
#15
Maria K Akhnokh, Feng Hua Yang, Victor Samokhvalov, Kristi L Jamieson, Woo Jung Cho, Cory Wagg, Abhijit Takawale, Xiuhua Wang, Gary D Lopaschuk, Bruce D Hammock, Zamaneh Kassiri, John M Seubert
AIMS: Myocardial ischemia can result in marked mitochondrial damage leading to cardiac dysfunction, as such identifying novel mechanisms to limit mitochondrial injury is important. This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids protects mitochondrial from injury caused by myocardial infarction. METHODS: sEH null and WT littermate mice were subjected to surgical occlusion of the left anterior descending (LAD) artery or sham operation...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27335447/rebuilding-the-damaged-heart-mesenchymal-stem-cells-cell-based-therapy-and-engineered-heart-tissue
#16
REVIEW
Samuel Golpanian, Ariel Wolf, Konstantinos E Hatzistergos, Joshua M Hare
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an array of anti-inflammatory and anti-fibrotic mediators, and very importantly activate resident precursors. These properties form the basis for the strategy of clinical application of cell-based therapeutics for inflammatory and fibrotic conditions. In cardiovascular medicine, administration of autologous or allogeneic MSCs in patients with ischemic and nonischemic cardiomyopathy holds significant promise...
July 2016: Physiological Reviews
https://www.readbyqxmd.com/read/27302077/mismatch-of-low-perfusion-and-high-permeability-predicts-hemorrhagic-transformation-region-in-acute-ischemic-stroke-patients-treated-with-intra-arterial-thrombolysis
#17
Hui Chen, Nan Liu, Ying Li, Max Wintermark, Alan Jackson, Bing Wu, Zihua Su, Fei Chen, Jun Hu, Yongwei Zhang, Guangming Zhu
This study sought to determine whether the permeability related parameter K(trans), derived from computed tomography perfusion (CTP) imaging, can predict hemorrhagic transformation (HT) in patients with acute ischemic stroke who receive intra-arterial thrombolysis. Data from patients meeting the criterion were examined. CTP was performed and K(trans) maps were used to assess the permeability values in HT and non-HT regions. A receiver operating characteristic (ROC) curve was calculated, showing the sensitivity and specificity of K(trans) for predicting HT risk...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27282479/microvesicles-derived-from-alde-low-epcs-support-the-wound-healing%C3%A2-capacity-of-at-mscs
#18
Tran Cam Tu, Toshiharu Yamashita, Toshiki Kato, Masumi Nagano, Nhu Thuy Trinh, Hiromi Hamada, Fujio Sato, Kinuko Ohneda, Mami Matsuo-Takasaki, Osamu Ohneda
Mesenchymal stem cells (MSCs) are defined as multipotent cells that can give rise to various kinds of differentiated mesenchymal cells, and are thus considered to be useful for clinical therapy. However, the big hurdles of MSC therapy are the inability of MSCs to reach the appropriate tissues or sites with high efficiency and engraftment after transplantation. In this study, we investigated how adipose tissue-derived MSCs (AT-MSCs) improve their homing ability after intravenous injection. We previously found that human endothelial progenitor cells with low aldehyde dehydrogenase activity (Alde-Low EPCs) are suitable for the treatment of ischemic tissues...
August 12, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27217892/-tourniquets-a-drama-in-the-infant-about-3-cases
#19
Edgar Ouangré, Moussa Bazongo, Isso Ouédraogo, Maurice Zida, Daouda Ouedraogo, Adama Sanou, Gilbert Patindé Bonkoungou, Rodrigue Namékinsba Doamba, Nayi Zongo, Si Simon Traore
The time limit for the removal of a tourniquet is short; any delay in tourniquet deflation, especially if it exceeds the 3 hour limit, exposes to amputation hazards. Our objective was to report three cases of ischemic limb gangrene, caused by having forgotten to take a tourniquet off after a blood sampling, to inform healthcare professionals about the risk associated with that negligence. We encountered 3 cases of infants (2 three-month-old infants and 1 five-month-old infant), hospitalized in intensive care unit of Yalgado Ouédraogo University Hospital for upper-left limb swelling...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27206877/case-fatality-and-functional-status-three-months-after-first-ever-stroke-in-vietnam
#20
Tran L Pham, Leigh Blizzard, Velandai Srikanth, Amanda G Thrift, Nguyen T K Lien, Nguyen H Thang, Seana L Gall
BACKGROUND: To provide novel information on outcomes after first-ever stroke in Vietnam, case-fatality and functional status were assessed 3months after stroke onset. METHODS: First-ever stroke patients admitted to the stroke unit of a tertiary teaching hospital in Ho Chi Minh City, Vietnam were recruited, examined and interviewed. Functional status was assessed on the modified Rankin Scale (mRS) at admission and again at 3months. RESULT: We recruited 450 consecutive first-ever stroke patients (99...
June 15, 2016: Journal of the Neurological Sciences
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