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https://www.readbyqxmd.com/read/28319836/a-cross-sectional-comparison-of-ethanol-related-cytokine-expression-in-the-hippocampus-of-young-and-aged-fischer-344-rats
#1
Anny Gano, Tamara L Doremus-Fitzwater, Terrence Deak
Our work in Sprague Dawley rats has shown rapid alterations in neuroimmune gene expression (RANGE) in the hippocampus and paraventricular nucleus of the hypothalamus (PVN). These manifest as increased interleukin (IL)-6 and IκBα, and suppressed IL-1β and tumor necrosis factor alpha during acute ethanol intoxication. The present studies tested these effects across the lifespan (young adulthood at 2-3 months; senescence at 18 and 24 months), as well as across strain (Fischer 344) and sex. The hippocampus revealed age-dependent shifts in cytokine expression (IL-6, IL-1β, and monocyte chemoattractant protein 1), but no changes were observed in the PVN at baseline or following ethanol...
March 17, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28319586/short-term-exercise-training-alters-leukocyte-chemokine-receptors-in-obese-adults
#2
Julianne C Barry, Svetlana Simtchouk, Cody Durrer, Mary E Jung, Jonathan P Little
Obesity is characterized by chronic low-grade inflammation driven by activation and tissue infiltration of circulating leukocytes. Although exercise has anti-inflammatory effects, the impact of exercise on mediators of leukocyte migration is unclear. PURPOSE: To determine the impact of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT), in the absence of weight/fat loss, on circulating chemokines and leukocyte chemokine receptors. METHODS: Thirty-seven inactive obese adults were randomized to two weeks (10 sessions) of HIIT or MICT with fasting blood samples collected before and after training...
March 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28317464/molecular-mechanisms-of-pulmonary-response-progression-in-crystalline-silica-exposed-rats
#3
Rajendran Sellamuthu, Christina Umbright, Jenny R Roberts, Shih-Houng Young, Diana Richardson, Walter McKinney, Bean T Chen, Shengqiao Li, Michael Kashon, Pius Joseph
An understanding of the mechanisms underlying diseases is critical for their prevention. Excessive exposure to crystalline silica is a risk factor for silicosis, a potentially fatal pulmonary disease. Male Fischer 344 rats were exposed by inhalation to crystalline silica (15 mg/m(3), six hours/day, five days) and pulmonary response was determined at 44 weeks following termination of silica exposure. Additionally, global gene expression profiling in lungs and BAL cells and bioinformatic analysis of the gene expression data were done to understand the molecular mechanisms underlying the progression of pulmonary response to silica...
March 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28314697/demeanor-of-rivaroxaban-in-activated-inactivated-fxa
#4
Kaname Seki, Yosuke Mizuno, Toku Sakashita, Shintaro Nakano, Jun Tanno, Yasushi Okazaki, Toshihiro Muramatsu, Shigeyuki Nishimura, Takaaki Senbonmatsu
Activated factor X (FXa) plays an important role in thrombin generation and inflammation. Factor X is not converted constitutively to FXa, but only after intrinsic clotting factors are activated and/or cellular injury occurs. Although rivaroxaban is one of direct FXa inhibitors, its function in the inactivated coagulation cascade is unclear. In human umbilical vein endothelial cells that natively express protease-activated receptor-1 and -2, high dose rivaroxaban did not alter gene transcripts including pro-inflammatory genes in DNA microarray...
February 24, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28304248/sustained-release-buprenorphine-improves-postsurgical-clinical-condition-but-does-not-alter-survival-or-cytokine-levels-in-a-murine-model-of-polymicrobial-sepsis
#5
Nicole L Herndon, Sheila Bandyopadhyay, Eldad A Hod, Kevin A Prestia
Cecal ligation and perforation (CLP) is a common technique for studying sepsis in mice. Because of the invasiveness of the procedure and its effects on clinical condition, many animal care and use committees require the use of analgesics with CLP. However, some analgesics have immunomodulatory effects and thus can hinder the overall research outcomes of a project. Here we sought to determine the effects of buprenorphine hydrochloride (Bup HCl) compared with sustained-release buprenorphine (Bup SR) on clinical condition, plasma concentrations of monocyte chemoattractant protein (MCP) 1 and IL6, and overall mortality in a murine CLP model of sepsis...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28302706/acclimatization-of-the-systemic-microcirculation-to-alveolar-hypoxia-is-mediated-by-inos-dependent-increased-nitric-oxide-availability
#6
Alfred J Casillan, Jie Chao, John G Wood, Norberto C Gonzalez
Rats breathing 10% O2 show a rapid and widespread systemic microvascular inflammation that results from nitric oxide (NO) depletion secondary to increased reactive O2 species (ROS) generation. The inflammation eventually resolves and the microcirculation becomes resistant to more severe hypoxia. These experiments were directed to determine the mechanisms underlying this microvascular acclimatization process. Intravital microscopy of the mesentery showed that after three weeks of hypoxia (PB ~380 Torr, inspired PO2 ~ 68-70 Torr) rats showed no evidence of inflammation; however, treatment with the inducible NO synthase (iNOS) inhibitor L-N(6)-(1-Iminoethyl) lysine dihydrochloride (L-NIL) led to ROS generation, leukocyte-endothelial adherence and emigration, and increased vascular permeability...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302561/ameliorative-effect-of-gossypin-against-gentamicin-induced-nephrotoxicity-in-rats
#7
Mohamed Katary, Ahmad Salahuddin
AIM: Gentamicin (GEN) is an aminoglycoside antibiotic employed in treatment of life-threatening gram-negative infections, but one of its major side effects is the induction of nephrotoxicity. Therefore, the aim of this work was to scrutinize the possible protective effect of gossypin against GEN-induced nephrotoxicity. METHOD: Rats were randomly divided into four groups. First group served as a control, second group was injected with gossypin (10mg/kg, orally) for 7days, third group was injected with GEN (80mg/kg, i...
March 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28300760/the-essential-role-of-pin1-via-nf-%C3%AE%C2%BAb-signaling-in-vascular-inflammation-and-atherosclerosis-in-apoe-mice
#8
Ming Liu, Peng Yu, Hong Jiang, Xue Yang, Ji Zhao, Yunzeng Zou, Junbo Ge
Atherosclerosis, as a chronic inflammatory disease, is the major underlying cause of death worldwide. However, the mechanisms that underlie the inflammatory process are not completely understood. Prolyl-isomerase-1 (Pin1), as a unique peptidyl-prolyl isomerase, plays an important role in inflammation and endothelial dysfunction. Herein, we investigate whether Pin1 regulates vascular inflammation and atherosclerosis, and clarify its mechanisms in these processes. ApoE(-/-) mice were randomly given either juglone (0...
March 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28295397/red-blood-cell-transfusions-can-induce-proinflammatory-cytokines-in-preterm-infants
#9
Carlo Dani, Chiara Poggi, Elena Gozzini, Valentina Leonardi, Alice Sereni, Rosanna Abbate, Anna Maria Gori
BACKGROUND: The risk of developing red blood cell (RBC) transfusion-associated necrotizing enterocolitis (TANEC) in preterm infants has recently been emphasized. Our aim was to assess changes in cytokine serum levels after RBC transfusions in a cohort of very preterm infants to evaluate their possible proinflammatory effect. STUDY DESIGN AND METHODS: We carried out a prospective observational study. One transfusion event was studied in infants less than 32 weeks' gestation and more than 7 days old (n = 20) admitted to a tertiary neonatal intensive care unit...
March 11, 2017: Transfusion
https://www.readbyqxmd.com/read/28293857/effect-of-cilostazol-in-treating-diabetes-associated-microvascular-complications
#10
REVIEW
Nicole J Asal, Karolina A Wojciak
PURPOSE: Cilostazol (Pletal), a phosphodiesterase-3 inhibitor, was approved in the United States in 1999 to reduce symptoms of intermittent claudication. Cyclic adenosine monophosphate levels increase from inhibition of phosphodiesterase resulting in anti-platelet, anti-inflammatory, and vasodilatory effects. Diabetes mellitus is a chronic disease that causes endothelial and platelet dysfunction leading to both microvascular and macrovascular complications. This mini-review highlights the emerging evidence suggesting benefits of using cilostazol in treating microvascular complications associated with diabetes mellitus...
March 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28293019/novel-adipokines-methodological-utility-in-human-obesity-research
#11
F Eichelmann, N Rudovich, A F Pfeiffer, M B Schulze, R di Giuseppe, H Boeing, K Aleksandrova
BACKGROUND: Adipokines could pose a link between adiposity, systemic inflammation and metabolic disease risk. However, it is unclear whether representative biomarkers are methodologically suitable for use in human obesity research. METHODS: We assessed the intra-individual reproducibility of selected adipokines in a sample of 207 apparently healthy participants with available biosample collections over 4 month period. Concentrations of the following adipokines were measured at each sampling time point: fatty-acid binding protein-4 (FABP-4), lipocalin-2, monocyte chemoattractant protein 1 (MCP-1), procalcitonin, progranulin, vaspin and visfatin/Nampt...
March 15, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28292183/n-docosahexaenoyl-dopamine-an-endocannabinoid-like-conjugate-of-dopamine-and-the-n-3-fatty-acid-docosahexaenoic-acid-attenuates-lipopolysaccharide-induced-activation-of-microglia-and-macrophages-via-cox-2
#12
Ya Wang, Pierluigi Plastina, Jean-Paul Vincken, Renate Jansen, Michiel Balvers, Jean Paul Ten Klooster, Harry Gruppen, Renger Witkamp, Jocelijn Meijerink
Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties...
March 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28288890/abdominal-aortic-aneurysm-associated-microrna-516a-5p-regulates-expressions-of-methylenetetrahydrofolate-reductase-matrix-metalloproteinase-2-and-tissue-inhibitor-of-matrix-metalloproteinase-1-in-human-abdominal-aortic-vascular-smooth-muscle-cells
#13
Crystal Yin Tung Chan, Bernice Lai Yee Cheuk, Stephen Wing Keung Cheng
OBJECTIVE: MicroRNAs (miRNAs or miRs) have been highlighted to be involved in abdominal aortic aneurysm (AAA) with the emergence of recent miRNA microarray profiling studies. miR-516a-5p has been shown to be significantly overexpressed in vascular smooth muscle cells (VSMCs) from human AAA tissues from our previous microarray study, suggesting its crucial association with AAA. In addition, further bioinformatics analysis predicted methylenetetrahydrofolate reductase (MTHFR), which regulates homocysteine (Hcy) metabolism and is proposed to be a risk gene for AAA formation, to be the down-regulation target of miR-516a-5p...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288138/muc1-c-integrates-pd-l1-induction-with-repression-of-immune-effectors-in-non-small-cell-lung-cancer
#14
A Bouillez, H Rajabi, C Jin, M Samur, A Tagde, M Alam, M Hiraki, T Maeda, X Hu, D Adeegbe, S Kharbanda, K-K Wong, D Kufe
Immunotherapeutic approaches, particularly programmed death 1/programmed death ligand 1 (PD-1/PD-L1) blockade, have improved the treatment of non-small-cell lung cancer (NSCLC), supporting the premise that evasion of immune destruction is of importance for NSCLC progression. However, the signals responsible for upregulation of PD-L1 in NSCLC cells and whether they are integrated with the regulation of other immune-related genes are not known. Mucin 1 (MUC1) is aberrantly overexpressed in NSCLC, activates the nuclear factor-κB (NF-κB) p65ZEB1 pathway and confers a poor prognosis...
March 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28286103/the-vascular-protective-effects-of-anoectochilus-roxburghii-polysaccharose-under-high-glucose-conditions
#15
Zhen-Ling Liu, Jian-Gang Zhang, Qing Liu, Li-Tao Yi, Yu-Meng Li, Ya Li
ETHNOPHARMACOLOGICAL RELEVANCE: Anoectochilus roxburghii has been used as a health food and a herb for treatment diabetes in China for hundreds years. Anoectochilus roxburghii polysaccharose (ARP) is the major active component of the plant. AIM OF THE STUDY: The present study investigated the vascular protection of ARP in vivo and in vitro experiments. MATERIALS AND METHODS: Hypoglycemic activity of ARP was examined in diabetic mice. Moreover, the further vascular protective effects in vitro were investigated in human umbilical vein endothelial cells (HUVECs) stimulated by high glucose (HG, 35mM)...
March 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28284851/clostridium-difficile-derived-membrane-vesicles-induce-the-expression-of-pro-inflammatory-cytokine-genes-and-cytotoxicity-in-colonic-epithelial-cells-in%C3%A2-vitro
#16
Asiimwe Nicholas, Hyejin Jeon, Gati Noble Selasi, Seok Hyeon Na, Hyo Il Kwon, Yoo Jeong Kim, Chi Won Choi, Seung Il Kim, Je Chul Lee
Clostridium difficile is the most common etiological agent of antibiotic-associated diarrhea in hospitalized and non-hospitalized patients. This study investigated the secretion of membrane vesicles (MVs) from C. difficile and determined the expression of pro-inflammatory cytokine genes and cytotoxicity of C. difficile MVs in epithelial cells in vitro. C. difficile ATCC 43255 and two clinical isolates secreted spherical MVs during in vitro culture. Proteomic analysis revealed that MVs of C. difficile ATCC 43255 contained a total of 262 proteins...
March 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28282939/oral-health-status-of-patients-with-lysosomal-storage-diseases-in-poland
#17
Damian Drążewski, Małgorzata Grzymisławska, Katarzyna Korybalska, Natasza Czepulis, Marian Grzymisławski, Janusz Witowski, Anna Surdacka
Patients with lysosomal storage diseases (LSDs) suffer from physical and mental disabilities, which together with poor access to professional care may lead to impaired oral health. This cross-sectional case-control study characterized the status of oral health in patients with LSDs in Poland. Thirty-six children and young adults with various forms of LSDs were examined. The data were compared with those from age- and sex-matched healthy controls. Exemplary cases were presented to highlight typical problems in oral care associated with LSDs...
March 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28275553/enzyme-replacement-therapy-for-farber-disease-proof-of-concept-studies-in-cells-and-mice
#18
Xingxuan He, Shaalee Dworski, Changzhi Zhu, Victor DeAngelis, Alex Solyom, Jeffrey A Medin, Calogera M Simonaro, Edward H Schuchman
A series of studies were carried out in Farber disease (OMIM #228000) cells and mice to evaluate the feasibility of enzyme replacement therapy (ERT) for this disorder. Media from Chinese hamster ovary (CHO) cells overexpressing human recombinant acid ceramidase (rhAC) was used to treat fibroblasts from a Farber disease patient, leading to significantly reduced ceramide. We also found that chondrocytes from Farber disease mice had a markedly abnormal chondrogenic phenotype, and this was corrected by rhAC as well...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28274716/atractylenolide-i-restores-ho-1-expression-and-inhibits-ox-ldl-induced-vsmcs-proliferation-migration-and-inflammatory-responses-in-vitro
#19
Weifeng Li, Wenbing Zhi, Fang Liu, Zehong He, Xiuei Wang, Xiaofeng Niu
Pathogenesis of atherosclerosis is characterized by the proliferation and migration of vascular smooth muscle cells (VSMCs) and inflammatory lesions. The aim of this study is to elucidate the effect of atractylenolide I (AO-I) on smooth muscle cell inflammation, proliferation and migration induced by oxidized modified low density lipoprotein (Ox-LDL). Here, We found that atractylenolide I inhibited Ox-LDL-induced VSMCs proliferation and migration in a dose-dependent manner, and decreased the production of inflammatory cytokines and the expression of monocyte chemoattractant protein-1 (MCP-1) in VSMCs...
March 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28273242/evaluation-of-tgf-%C3%AE-1-and-mcp-1-expression-and-tubulointerstitial-fibrosis-in-children-with-henoch-sch%C3%A3-nlein-purpura-nephritis-and-iga-nephropathy-a-clinical-correlation
#20
Zhao Shuiai, Shen Huijun, Gu Weizhong, Liu Aimin, Mao Jianhua
OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We examined the development of tubulointerstitial fibrosis and its relationship with Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in these patients. METHODS: Renal tissue samples were collected by renal biopsy from 50 children with Henoch-Schönlein purpura nephritis and 50 children with immunoglobulin A nephropathy...
February 1, 2017: Clinics
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