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Peptic ji

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https://www.readbyqxmd.com/read/27883364/determination-of-s-methyl-l-methionine-smm-from-brassicaceae-family-vegetables-and-characterization-of-the-intestinal-transport-of-smm-by-caco-2-cells
#1
Ji-Hoon Song, Hae-Rim Lee, Soon-Mi Shim
The objectives of the current study were to determine S-methyl-L-methionine (SMM) from various Brassicaceae family vegetables by using validated analytical method and to characterize the intestinal transport mechanism of SMM by the Caco-2 cells. The SMM is well known to provide therapeutic activity in peptic ulcers. The amount of SMM from various Brassicaceae family vegetables ranged from 89.08 ± 1.68 μg/g to 535.98 ± 4.85 μg/g of dry weight by using validated ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method...
November 24, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27727075/chronic-obstructive-pulmonary-disease-is-associated-with-increased-recurrent-peptic-ulcer-bleeding-risk
#2
Kuang-Wei Huang, Yi-Chun Kuan, Nai-Fang Chi, Yao-Hsien Huang, Jiing-Chyuan Luo, Li-Nien Chien
BACKGROUND: The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. METHODS: Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002-2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible...
October 7, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27609487/efficacy-of-levofloxacin-based-third-line-therapy-for-the-eradication-of-helicobacter-pylori-in-peptic-ulcer-disease
#3
Joo Hyun Lim, Sang Gyun Kim, Ji Hyun Song, Jae Jin Hwang, Dong Ho Lee, Jae Pil Han, Su Jin Hong, Ji Hyun Kim, Seong Woo Jeon, Gwang Ha Kim, Ki-Nam Shim, Woon Geon Shin, Tae Ho Kim, Sun Moon Kim, Il-Kwon Chung, Hyun-Soo Kim, Heung Up Kim, Joongyub Lee, Jae Gyu Kim
Background/Aims: The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease. Methods: Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance...
September 9, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27211503/accuracy-of-magnetically-controlled-capsule-endoscopy-compared-with-conventional-gastroscopy-in-detection-of%C3%A2-gastric-diseases
#4
Zhuan Liao, Xi Hou, En-Qiang Lin-Hu, Jian-Qiu Sheng, Zhi-Zheng Ge, Bo Jiang, Xiao-Hua Hou, Ji-Yong Liu, Zhen Li, Qi-Yang Huang, Xiao-Jun Zhao, Na Li, Yun-Jie Gao, Yao Zhang, Jie-Qiong Zhou, Xin-Ying Wang, Jun Liu, Xiao-Ping Xie, Cong-Mei Yang, Hua-Lin Liu, Xiao-Tian Sun, Wen-Bin Zou, Zhao-Shen Li
BACKGROUND & AIMS: Diseases of the stomach, including gastric cancer and peptic ulcer, are the most common digestive diseases. It is impossible to visualize the entire stomach with the passive capsule currently used in practice because of the large size of the gastric cavity. A magnetically controlled capsule endoscopy (MCE) system has been designed to explore the stomach. We performed a prospective study to compare the accuracy of detection of gastric focal lesions by MCE vs conventional gastroscopy (the standard method)...
September 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27000074/stereoselective-pharmacodynamics-and-pharmacokinetics-of-proton-pump-inhibitors
#5
Zhi-Cheng Yang, Feng Yu, Yong-Qing Wang, Ji-Fu Wei
Proton pump inhibitors (PPIs) are a group of gastric acid suppressing drugs, that are strong and long-lasting inhibitors of the proton pump (referred to as acid pump antagonists). They work by irreversibly blocking the H+/K+ ATPase. PPIs are used to treat peptic ulcer disease, gastroesophageal reflux disease, nonsteroidal anti-inflammatory drug-induced gastrointestinal lesions, and Zollinger-Ellison syndrome. The structure of PPIs are similar, they all have a similar core with a sulphur atom chiral center combined with different substituent groups...
March 22, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/26970404/pharmacokinetic-and-pharmacodynamic-modeling-analysis-of-intravenous-esomeprazole-in-healthy-volunteers
#6
Dongyang Liu, Hong Yang, Ji Jiang, Péter Nagy, Kai Shen, Jiaming Qian, Pei Hu
Esomeprazole is one of the most commonly used drugs to treat gastroesophageal reflux disease and peptic ulcers, but the quantitative relationships among the pharmacokinetics (PK), pharmacodynamics (PD), and pharmacogenomics (PG) of the drug are not fully understood in special patient populations. A clinical PK/PD/PG study of intravenous (IV) esomeprazole in 5 dosing regimens was conducted in 20 healthy Chinese volunteers, who were categorized into Helicobacter pylori (HP)-negative and HP-positive subgroups...
July 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26828247/analysis-of-risk-factor-and-clinical-characteristics-of-angiodysplasia-presenting-as-upper-gastrointestinal-bleeding
#7
Dae Bum Kim, Woo Chul Chung, Seok Jong Lee, Hea Jung Sung, Seokyung Woo, Hyo Suk Kim, Yeon Oh Jeong, Hyewon Lee, Yeon-Ji Kim
BACKGROUND/AIMS: Angiodysplasia is important in the differential diagnosis of upper gastrointestinal bleeding (UGIB), but the clinical features and outcomes associated with UGIB from angiodysplasia have not been characterized. We aimed to analyze the clinical characteristics and outcomes of angiodysplasia presented as UGIB. METHODS: Between January 2004 and December 2013, a consecutive series of patients admitted with UGIB were retrospectively analyzed. Thirty-five patients with bleeding from angiodysplasia were enrolled...
July 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26464765/association-between-il-17-il-8-and-il-18-expression-in-peripheral-blood-and-helicobacter-pylori-infection-in-mongolian-gerbils
#8
Yan-Rong Zhao, Yan Zhou, Gang Lin, Wei-Jian Hu, Ji-Mei Du
BACKGROUND: Persistent Helicobacter pylori infection confers an increased risk for serious illnesses such as peptic ulcers and gastric cancer. Various cytokines are involved in the regulation of inflammatory immune response in H. pylori-infected gastric mucosa. OBJECTIVES: The current study aimed to obtain evidence regarding the association between IL-17, IL-8 and IL-18 expression in peripheral blood and H. pylori infection in Mongolian gerbils. MATERIALS AND METHODS: Mongolian gerbils were inoculated with H...
August 2015: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/26315480/clopidogrel-inhibits-angiogenesis-of-gastric-ulcer-healing-via-downregulation-of-vascular-endothelial-growth-factor-receptor-2
#9
Jiing-Chyuan Luo, Yen-Ling Peng, Tseng-Shing Chen, Teh-Ia Huo, Ming-Chih Hou, Hui-Chun Huang, Han-Chieh Lin, Fa-Yauh Lee
BACKGROUND/PURPOSE: Although clopidogrel does not cause gastric mucosal injury, it does not prevent peptic ulcer recurrence in high-risk patients. We explored whether clopidogrel delays gastric ulcer healing via inhibiting angiogenesis and to elucidate the possible mechanisms. METHODS: Gastric ulcers were induced in Sprague Dawley rats, and ulcer healing and angiogenesis of ulcer margin were compared between clopidogrel-treated rats and controls. The expressions of the proangiogenic growth factors and their receptors including basic fibroblast growth factor (bFGF), bFGF receptor (FGFR), vascular endothelial growth factor (VEGF), VEGFR1, VEGFR2, platelet-derived growth factor (PDGF)A, PDGFB, PDGFR A, PDGFR B, and phosphorylated form of mitogenic activated protein kinase pathways over the ulcer margin were compared via western blot and reverse transcription polymerase chain reaction...
September 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/26229405/clinical-characteristics-of-helicobacter-pylori-negative-drug-negative-peptic-ulcer-bleeding
#10
COMPARATIVE STUDY
Woo Chul Chung, Eun Jung Jeon, Dae Bum Kim, Hea Jung Sung, Yeon-Ji Kim, Eun Sun Lim, Min-Ah Kim, Jung Hwan Oh
AIM: To investigate the clinical characteristics and outcomes of idiopathic Helicobacter pylori (H. pylori)-negative and drug-negative] peptic ulcer bleeding (PUB). METHODS: A consecutive series of patients who experienced PUB between 2006 and 2012 was retrospectively analyzed. A total of 232 patients were enrolled in this study. The patients were divided into four groups according to the etiologies of PUB: idiopathic, H. pylori-associated, drug-induced and combined (H...
July 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26003554/delayed-bleeding-rate-according-to-the-forrest-classification-in-second-look-endoscopy-after-endoscopic-submucosal-dissection
#11
Shin Na, Ji Yong Ahn, Kee Don Choi, Mi-Young Kim, Jeong Hoon Lee, Kwi-Sook Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim
BACKGROUND AND AIM: Forrest classification is a valid tool to predict rebleeding rate in peptic ulcer, not in post-endoscopic resection ulcer. We evaluated the delayed bleeding rate in Forrest classification II and III lesions when they were not treated in second-look endoscopy. METHODS: Between July 2011 and February 2012, 706 lesions in 656 consecutive patients who underwent second-look endoscopy performed on the second day after endoscopic submucosal dissection (ESD) were prospectively investigated...
October 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25963075/clinical-risk-factors-for-upper-gastrointestinal-bleeding-after-percutaneous-coronary-intervention-a-single-center-study
#12
Ji-Myoung Lee, Seon-Young Park, Jung-Ho Choi, Uh-Jin Kim, Soo-Jung Rew, Jae Yeong Cho, Youngkeun Ahn, Sung-Wook Lim, Chung-Hwan Jun, Chang-Hwan Park, Hyun-Soo Kim, Sung-Kyu Choi, Jong-Sun Rew
BACKGROUND/AIMS: Percutaneous coronary intervention (PCI) is often performed therapeutically, and antithrombotic treatment is required for at least 12 months after stent implantation. However, the development of post-PCI upper gastrointestinal bleeding (UGIB) increases morbidity and mortality. We investigated the incidence and risk factors for UGIB in Korean patients within 1 year after PCI. METHODS: The medical records of 3,541 patients who had undergone PCI between January 2006 and June 2012 were retrospectively reviewed...
January 2016: Gut and Liver
https://www.readbyqxmd.com/read/25644542/risk-factors-associated-with-conversion-of-laparoscopic-simple-closure-in-perforated-duodenal-ulcer
#13
Ji-Hyun Kim, Hyung-Min Chin, You-Jin Bae, Kyong-Hwa Jun
BACKGROUND: Precise patient selection criteria are necessary to guide the surgeon in selecting laparoscopic repair for patients with perforated peptic ulcers. The aims of this study are to report surgical outcomes after surgery for perforated duodenal ulcers and identify risk factors for predicting failure of laparoscopic simple closure for perforated duodenal ulcer. METHODS: In total, 77 patients who underwent laparoscopic simple closure for perforated duodenal ulcers from January 2007 to September 2013 were retrospectively analyzed...
March 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/25642244/prevalence-of-precancerous-conditions-and-gastric-cancer-based-upon-the-national-cancer-screening-program-in-korea-for-7-years-single-center-experience
#14
Ji Hyuk Kang, Yun Jeong Lim, Jung Hyun Kang, Jae Nam Yang, Seung Min Shin, Jae Hyeuk Choi, Jin Ho Lee
Aims. Gastric cancer is the second most prevalent cancer and the third leading cause of cancer-related deaths in Korea. The National Cancer Screening Program (NCSP) has implemented esophagogastroduodenoscopy (EGD) biennially for all Koreans starting in their 40s. This study was conducted to estimate the clinical relevance of NCSP through identifying the prevalence of gastric disease, including cancer. Materials and Methods. Data from 40,821 subjects who received the screening EGD in the single center for 7 years were retrospectively investigated...
2015: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/25640660/a-creative-helicobacter-pylori-diagnosis-scheme-based-on-multiple-genetic-analysis-system-qualification-and-quantitation
#15
COMPARATIVE STUDY
Lifang Zhou, Fuju Zhao, Binjie Hu, Yi Fang, Yingxin Miao, Yiqin Huang, Da'nian Ji, Jinghao Zhang, Lingli Xu, Yanmei Zhang, Zhijun Bao, Hu Zhao
BACKGROUND: Currently, several diagnostic assays for Helicobacter pylori (H. pylori) are available, but each has some limitations. Further, a high-flux quantitative assay is required to assist clinical diagnosis and monitor the effectiveness of therapy and novel vaccine candidates. METHODS: Three hundred and eighty-seven adult patients [nonulcer dyspepsia (NUD) 295, peptic ulcer disease (PUD) 77, gastric cancer (GC) 15] were enrolled for gastrointestinal endoscopies...
October 2015: Helicobacter
https://www.readbyqxmd.com/read/25587522/systemic-classification-for-a-new-diagnostic-approach-to-acute-abdominal-pain-in-children
#16
Ji Hoi Kim, Hyun Sik Kang, Kyung Hee Han, Seung Hyo Kim, Kyung-Sue Shin, Mu Suk Lee, In Ho Jeong, Young Sil Kim, Ki-Soo Kang
PURPOSE: With previous methods based on only age and location, there are many difficulties in identifying the etiology of acute abdominal pain in children. We sought to develop a new systematic classification of acute abdominal pain and to give some helps to physicians encountering difficulties in diagnoses. METHODS: From March 2005 to May 2010, clinical data were collected retrospectively from 442 children hospitalized due to acute abdominal pain with no apparent underlying disease...
December 2014: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/25059927/risk-score-to-predict-gastrointestinal-bleeding-after-acute-ischemic-stroke
#17
RANDOMIZED CONTROLLED TRIAL
Ruijun Ji, Haipeng Shen, Yuesong Pan, Penglian Wang, Gaifen Liu, Yilong Wang, Hao Li, Aneesh B Singhal, Yongjun Wang
BACKGROUND: Gastrointestinal bleeding (GIB) is a common and often serious complication after stroke. Although several risk factors for post-stroke GIB have been identified, no reliable or validated scoring system is currently available to predict GIB after acute stroke in routine clinical practice or clinical trials. In the present study, we aimed to develop and validate a risk model (acute ischemic stroke associated gastrointestinal bleeding score, the AIS-GIB score) to predict in-hospital GIB after acute ischemic stroke...
2014: BMC Gastroenterology
https://www.readbyqxmd.com/read/24953610/difficult-establishment-of-a-chronic-nonsteroidal-anti-inflammatory-drugs-induced-gastric-inflammation-rat-model-due-to-gastric-adaptation-and-small-bowel-damage
#18
Byoung Hwan Lee, Nayoung Kim, Ryoung Hee Nam, Ju Yup Lee, Hye Seung Lee, Chang Hee Lee, Ji Hyun Park, Dong Ho Lee
BACKGROUND/AIMS: The prevalence of peptic ulcer disease has not decreased mainly due to an increase in the use of NSAIDs. This study was conducted in order to determine whether a chronic NSAID-induced gastric inflammation model could be established by repeated administration of NSAID. METHODS: Indomethacin (10 mg/kg) was administered once per week for six weeks in 8- and 26-week rats and animals were sacrificed every week after administration. Gross ulcer index, histologic damage index, myeloperoxidase (MPO) activity, and mucus (glucosamine) levels were measured...
June 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/24932294/misdiagnosed-gastrinoma-a-case-report
#19
Qi-Kai Sun, Wei Wang, Hang-Cheng Zhou, Yang Lv, Ji-Hai Yu, Jin-Liang Ma, Wei-Dong Jia, Ge-Liang Xu
Gastrinoma is most commonly located in the gastrinoma triangle (comprising of the duodenum, pancreas and bile ducts) or in the adjacent lymph nodes. Due to the low mortality rate, it is often misdiagnosed as other diseases with similar clinical characteristics, such as a solid pseudopapillary tumor of the pancreas (SPTP). Therefore, the current study reports a rare case of gastrinoma located in the tail of the pancreas of a female patient under medical examination, who exhibited no clinical symptoms. The tumor, which was located in the body and tail of the pancreas, was successfully resected and the spleen was preserved...
June 2014: Oncology Letters
https://www.readbyqxmd.com/read/24815441/lack-of-association-of-the-mdr1-c3435t-polymorphism-with-susceptibility-to-gastric-cancer-and-peptic-ulcer-a-systemic-review-and-meta-analysis
#20
REVIEW
Dan-Dan Wu, Ji-Xiang Zhang, Jiao Li, Wei-Guo Dong
BACKGROUND: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). MATERIALS AND METHODS: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
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