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https://www.readbyqxmd.com/read/29775783/ocimum-basilicum-mirnome-revisited-a-cross-kingdom-approach
#1
Maulikkumar Patel, Shanaya Patel, Naman Mangukia, Saumya Patel, Archana Mankad, Himanshu Pandya, Rakesh Rawal
O. basilicum is medicinally important herb having inevitable role in human health. However, the mechanism of action is largely unknown. Present study aims to understand the mechanism of regulation of key human target genes that could plausibly modulated by O. basilicum miRNAs in cross kingdom manner using computational and system biology approach. O. basilicum miRNA sequences were retrieved and their corresponding human target genes were identified using psRNA target and interaction analysis of hub nodes. Six O...
May 15, 2018: Genomics
https://www.readbyqxmd.com/read/29775121/a-cohort-study-to-examine-the-use-of-chinese-herbal-medicine-in-combination-with-conventional-therapies-for-patients-with-hepatocellular-carcinoma-in-china
#2
Lingling Sun, Paul Fahey, Xiaoshu Zhu, Weng Ng, Zhuo Ping Chen, Yiwen Qiu, Hezheng Lai, Jietao Lin, Lizhu Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major malignancies associated with high mortality rates. Chinese herbal medicine (CHM) alone, or in combination with conventional therapies (CT), has been widely used for patients with HCC in China. This study aims to explore how integrative therapy (IT) through the combination of CHM and CT affects the survival of patients with intermediate-advanced HCC. METHODS: A retrospective cohort study was performed at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China...
May 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29774137/saudi-anti-human-cancer-plants-database-sacpd-a-collection-of-plants-with-anti-human-cancer-activities
#3
Ateeq Ahmed Al-Zahrani
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD)...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29771635/pathogenesis-based-treatments-in-primary-sjogren-s-syndrome-using-artificial-intelligence-and-advanced-machine-learning-techniques-a-systematic-literature-review
#4
Nathan Foulquier, Pascal Redou, Christophe Le Gal, Bénédicte Rouvière, Jacques-Olivier Pers, Alain Saraux
Big data analysis has become a common way to extract information from complex and large datasets among most scientific domains. This approach is now used to study large cohorts of patients in medicine. This work is a review of publications that have used artificial intelligence and advanced machine learning techniques to study physio pathogenesis-based treatments in pSS. A systematic literature review retrieved all articles reporting on the use of advanced statistical analysis applied to the study of systemic autoimmune diseases (SADs) over the last decade...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29771224/discipline-specific-competency-based-curricula-for-leadership-learning-in-medical-specialty-training
#5
Sandra Turner, Ming-Ka Chan, Judy McKimm, Graham Dickson, Timothy Shaw
Purpose Doctors play a central role in leading improvements to healthcare systems. Leadership knowledge and skills are not inherent, however, and need to be learned. General frameworks for medical leadership guide curriculum development in this area. Explicit discipline-linked competency sets and programmes provide context for learning and likely enhance specialty trainees' capability for leadership at all levels. The aim of this review was to summarise the scholarly literature available around medical specialty-specific competency-based curricula for leadership in the post-graduate training space...
May 8, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29770697/mmpdb-an-open-source-matched-molecular-pair-platform-for-large-multiproperty-data-sets
#6
Andrew Dalke, Jérôme Hert, Christian Kramer
Matched molecular pair analysis (MMPA) enables the automated and systematic compilation of medicinal chemistry rules from compound/property data sets. Here we present mmpdb, an open-source matched molecular pair (MMP) platform to create, compile, store, retrieve, and use MMP rules. mmpdb is suitable for the large data sets typically found in pharmaceutical and agrochemical companies and provides new algorithms for fragment canonicalization and stereochemistry handling. The platform is written in Python and based on the RDKit toolkit...
May 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29770248/hedea-a-python-tool-for-extracting-and-analysing-semi-structured-information-from-medical-records
#7
Anshul Aggarwal, Sunita Garhwal, Ajay Kumar
Objectives: One of the most important functions for a medical practitioner while treating a patient is to study the patient's complete medical history by going through all records, from test results to doctor's notes. With the increasing use of technology in medicine, these records are mostly digital, alleviating the problem of looking through a stack of papers, which are easily misplaced, but some of these are in an unstructured form. Large parts of clinical reports are in written text form and are tedious to use directly without appropriate pre-processing...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29764102/assessment-of-the-effects-of-economic-sanctions-on-iranians-right-to-health-by-using-human-rights-impact-assessment-tool-a-systematic-review
#8
Fatemeh Kokabisaghi
BACKGROUND: Over the years, economic sanctions have contributed to violation of right to health in target countries. Iran has been under comprehensive unilateral economic sanctions by groups of countries (not United Nations [UN]) in recent years. They have been intensified from 2012 because of international community's uncertainty about peaceful purpose of Iran's nuclear program and inadequacy of trust-building actions of this country. This review aimed to identify the humanitarian effects of the sanctions on the right of Iranians to health and the obligations of Iran and international community about it...
January 20, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29763985/induced-pluripotent-stem-cells-ipscs-as-a-new-source-of-bone-in-reconstructive-surgery-a-systematic-review-and-meta-analysis-of-preclinical-studies
#9
REVIEW
Riham Fliefel, Michael Ehrenfeld, Sven Otto
BACKGROUND: It is now well-established that regenerative medicine and stem cell therapy are the most promising approach to obtain full tissue regeneration by using various cell types including stem cells isolated from adult tissues, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Recently, iPSCs have been successfully differentiated into osteoprogenitors to facilitate repair and regeneration of bone defects. Thus, the purpose of this systematic review and meta-analysis is to summarize the articles published that assess the osteogenic potential of iPSCs in-vitro and their ability to heal bone defects in reconstructive surgery...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29763706/exploiting-semantic-patterns-over-biomedical-knowledge-graphs-for-predicting-treatment-and-causative-relations
#10
Gokhan Bakal, Preetham Talari, Elijah V Kakani, Ramakanth Kavuluru
BACKGROUND: Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying different causal relations between biomedical entities is also critical to understand biomedical processes. Generally, natural language processing (NLP) and machine learning are used to predict specific relations between any given pair of entities using the distant supervision approach...
May 12, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29750798/guidelines-for-safe-handling-of-hazardous-drugs-a-systematic-review
#11
Mari A Bernabeu-Martínez, Mateo Ramos Merino, Juan M Santos Gago, Luis M Álvarez Sabucedo, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the scientific literature related to the safe handling of hazardous drugs (HDs). METHOD: Critical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017. RESULTS: In total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39...
2018: PloS One
https://www.readbyqxmd.com/read/29738176/-microdissection-testicular-sperm-extraction-for-patients-with-nonmosaic-klinefelter-syndrome-a-report-of-143-cases
#12
Jia-Ming Mao, Lian-Ming Zhao, Kai Hong, Wen-Hao Tang, De-Feng Liu, Hao-Cheng Lin, Han Wu, Hai-Tao Zhang, Hong-Liang Zhang, Yu-Zhuo Yang, Ya-Peng Wang, Ying Lian, Hui Jiang, Lu-Lin Ma, Jie Qiao
Objective: To investigate the clinical application and outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with nonmosaic Klinefelter syndrome (KS). METHODS: A total of 143 nonmosaic KS patients underwent micro-TESE in the Center of Reproductive Medicine of Peking University Third Hospital between July 2012 and August 2016. We analyzed their clinical and follow-up data and evaluated the outcomes. RESULTS: Spermatozoa were successfully retrieved from the testicular tissue in 44...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29734072/a-dilute-and-shoot-multispectral-integration-approach-towards-nontargeted-component-profiling-of-traditional-herbal-yin-zhi-huang-using-liquid-chromatography-photodiode-array-ion-trap-time-of-flight-characterization
#13
Meiling Wang, Yu Liu, Bin Guo, Lijuan Wei, Hao Teng, Xiaoqing Chen, Ming Ma
Ying-zhi-huang Injection (YZH-I) is a classic intravenous formulation of polyherbal Chinese medicine which has been prescribed to treat severe jaundice and acute hepatitis for nearly 50 years. Despite some published data on its major components in the constituent herbs, the overall chemical profile of the potentially bioactive ingredients in YZH-I formula remains largely unknown. Here we developed a multispectral integration approach towards nontargeted phytochemical profiling of YZH-I by liquid chromatography-ultraviolet diode array detector coupled to ion trap/time-of-flight multistage mass spectrometry (LC-DAD-IT(MSn )/TOF) with fast polarity-switching mode...
April 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29728021/-compatibility-law-of-baizhi-formulae-and-molecular-mechanism-of-core-herbal-pair-baizhi-chuanxiong
#14
Jin Su, Shi-Huan Tang, Fei-Fei Guo, De-Feng Li, Yi Zhang, Hai-Yu Xu, Hong-Jun Yang
By using the traditional Chinese medicine inheritance support system (TCMISS) in this study, the prescription rules of Baizhi formulae were analyzed and the core herbal pair "Baizhi-Chuanxiong" was obtained. Through the systemic analysis of prescription rules of "Baizhi-Chuanxiong" and combined with the pharmacology thinking of "Baizhi-Chuanxiong" in treating headache, the paper was aimed to find out the combination rules containing Baizhi andits molecular mechanisms for treating headaches, and provide the theory basis for further research and reference of Baizhi and its formula...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29725591/the-mu-ta-lig-chemotheca-a-community-populated-molecular-database-for-multi-target-ligands-identification-and-compound-repurposing
#15
Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited for existing compounds by sharing information between researchers who are working on different targets...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29724214/multiple-challenges-of-antibiotic-use-in-a-large-hospital-in-ethiopia-a-ward-specific-study-showing-high-rates-of-hospital-acquired-infections-and-ineffective-prophylaxis
#16
Girma Gutema, Helle Håkonsen, Ephrem Engidawork, Else-Lydia Toverud
BACKGROUND: This project aims to study the use of antibiotics in three clinical wards in the largest tertiary teaching hospital in Ethiopia for a period of 1 year. The specific aims were to assess the prevalence of patients on antibiotics, quantify the antibiotic consumption and identify the main indications of use. METHOD: The material was all the medical charts (n = 2231) retrieved from three clinical wards (internal medicine, gynecology/obstetrics and surgery) in Tikur Anbessa Specialized Hospital (TASH) in Addis Ababa between September 2013 and September 2014...
May 3, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29718389/an-update-on-pug-rest-restful-interface-for-programmatic-access-to-pubchem
#17
Sunghwan Kim, Paul A Thiessen, Tiejun Cheng, Bo Yu, Evan E Bolton
PubChem (https://pubchem.ncbi.nlm.nih.gov) is one of the largest open chemical information resources available. It currently receives millions of unique users per month on average, serving as a key resource for many research fields such as cheminformatics, chemical biology, medicinal chemistry, and drug discovery. PubChem provides multiple programmatic access routes to its data and services. One of them is PUG-REST, a Representational State Transfer (REST)-like web service interface to PubChem. On average, PUG-REST receives more than a million requests per day from tens of thousands of unique users...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29713541/update-on-the-proteomics-of-male-infertility-a-systematic-review
#18
Manesh Kumar Panner Selvam, Ashok Agarwal
Objective: To assess the role of differentially expressed proteins as a resource for potential biomarker identification of infertility, as male infertility is of rising concern in reproductive medicine and evidence pertaining to its aetiology at a molecular level particularly proteomic as spermatozoa lack transcription and translation. Proteomics is considered as a major field in molecular biology to validate the target proteins in a pathophysiological state. Differential expression analysis of sperm proteins in infertile men and bioinformatics analysis offer information about their involvement in biological pathways...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29713462/immigration-analysis-trends-and-outlook-on-the-global-research-activity
#19
Matthias Trost, Eileen M Wanke, Daniela Ohlendorf, Doris Klingelhöfer, Markus Braun, Jan Bauer, David A Groneberg, David Quarcoo, Dörthe Brüggmann
Background: Immigration has a strong impact on the development of health systems, medicine and science worldwide. Therefore, this article provides a descriptive study on the overall research output. Methods: Utilizing the scientific database Web of Science, data research was performed. The gathered bibliometric data was analyzed using the established platform NewQIS, a benchmarking system to visualize research quantity and quality indices. Findings: Between 1900 and 2016 a total of 6763 articles on immigration were retrieved and analyzed...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29710008/-approach-to-evidence-based-medicine-exercises-using-flipped-teaching-introductory-education-for-clinical-practice-for-4th-year-pharmacy-students
#20
Mitsuko Onda, Nobumasa Takagaki
 Osaka University of Pharmaceutical Sciences has included an evidence-based medicine (EBM) exercise in the introductory education for clinical practice for 4th-year pharmacy students since 2015. The purpose of this exercise is to learn the process of practice and basic concepts of EBM, especially to cultivate the practical ability to solve patients' problems and answer their questions. Additionally, in 2016, we have attempted flipped teaching. The students are instructed to review the basic knowledge necessary for active learning in this exercise by watching video teaching materials and to bring reports summarizing the contents on the flipped teaching days...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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