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Tendinopathy

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https://www.readbyqxmd.com/read/28091588/high-molecular-weight-hyaluronic-acid-attenuated-matrix-metalloproteinase-1-and-3-expression-via-cd44-in-tendinopathy
#1
Po-Ting Wu, Li-Chieh Kuo, Fong-Chin Su, Shih-Yao Chen, Tai-I Hsu, Chung-Yi Li, Kuen-Jer Tsai, I-Ming Jou
Evidence indicates that hyaluronic acid (HA) mitigates tendinopathy, but the effect of molecular weight is unclear. We investigated the effects of different concentrations and different molecular weights of HA (350 kDa, 1500 kDa, and 3000 kDa) on matrix metalloproteinase (MMP)-1 and -3 expression in IL-1β-stimulated rat tenocytes, and on their dynamic expression in peritendinous effusion from patients with long head of biceps (LHB) tendinopathy after high-molecular-weight (HMW)-HA treatments. Reverse transcription PCR, real-time PCR, and ELISA were used to determine MMP-1 and -3expression...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090447/quantitative-sodium-magnetic-resonance-imaging-of-cartilage-muscle-and-tendon
#2
REVIEW
Neal K Bangerter, Grayson J Tarbox, Meredith D Taylor, Joshua D Kaggie
Sodium magnetic resonance imaging (MRI), or imaging of the 23Na nucleus, has been under exploration for several decades, and holds promise for potentially revealing additional biochemical information about the health of tissues that cannot currently be obtained from conventional hydrogen (or proton) MRI. This additional information could serve as an important complement to conventional MRI for many applications. However, despite these exciting possibilities, sodium MRI is not yet used routinely in clinical practice, and will likely remain strictly in the domain of exploratory research for the coming decade...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28077355/no-evidence-for-the-use-of-stem-cell-therapy-for-tendon-disorders-a-systematic-review
#3
Haiko I M F L Pas, Maarten H Moen, Hidde J Haisma, Marinus Winters
INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search...
January 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28071602/microgrooved-topographical-surface-directs-tenogenic-lineage-specific-differentiation-of-mouse-tendon-derived-stem-cells
#4
Yuan Shi, Kaili Zhou, Wenjie Zhang, Zhiyong Zhang, Guangdong Zhou, Yilin Cao, Wei Liu
Tendon derived stem cells (TDSCs) are the endogenous cell source for tenocyte turnover and tendon functional maintenance. They are also the important cell source for tendon engineering and regeneration. In addition, TDSCs also play an important role in tendinopathy via their non-tenogenic lineage differentiation. It has been well demonstrated that cell shape could determine mesenchymal stem cell (MSC) lineage differentiation. In this study, a parallel microgrooved polydimethylsiloxane (PDMS) membrane (10 µm groove width and 3 µm depth) was employed to investigate the role of cell elongation via this particular topographic surface in directing murine TDSC (mTDSC) lineage differentiation...
January 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28070627/-tendinopathy-in-rheumatic-diseases
#5
M Henniger, S Rehart
Involvement of tendons and tendon sheaths is frequently found in the most common inflammatory systemic diseases, rheumatoid arthritis and spondyloarthritis. In rheumatoid arthritis tendon manifestations occur as tenosynovitis, with swelling and pain of the tendons mainly on the hands and feet. In spondyloarthritis the involvement of tendons presents as enthesitis with pain and swelling directly at the attachment points of tendons to the bony structures and more commonly in the lower extremities. Pathological alterations of tendons can be normally visualized by sonography and only sometimes with magnetic resonance imaging (MRI) or scintigraphy...
January 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28067582/the-relationship-of-hip-muscle-performance-to-leg-ankle-and-foot-injuries-a-systematic-review
#6
Nili Steinberg, Gali Dar, Martin Dunlop, James Edmund Gaida
OBJECTIVES: Hip control affects movement and muscle firing patterns in the leg, ankle and foot, and may contribute to overuse injuries. Muscle performance can be measured as strength, endurance or muscle activation patterns. Our objective was to systematically review whether hip muscle performance is associated with leg, ankle and foot injuries. DATA SOURCES: A structured and comprehensive search of six medical literature databases was combined with forward and backward citation tracking (AMED, CINAHL, EMBASE, Medline, Scopus and SportDiscus)...
January 9, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28066748/the-use-of-platelet-rich-plasma-to-augment-conservative-and-surgical-treatment-of-hip-and-pelvic-disorders
#7
REVIEW
Matthew J Kraeutler, Tigran Garabekyan, Omer Mei-Dan
BACKGROUND: In recent years, platelet-rich plasma (PRP) has gained popularity within the orthopaedic community as a treatment modality to enhance tissue healing. PURPOSE: This review aims to concisely present the current indications for PRP injections in the treatment of hip and pelvic pathologies and to describe some novel applications for PRP which have not yet been reported in the literature. METHODS: We reviewed the literature on the non-operative and operative indications for PRP in the treatment of hip and pelvic pathologies...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066744/arthroscopic-release-of-iliopsoas-tendon-in-patients-with-femoro-acetabular-impingement-clinical-results-at-mid-term-follow-up
#8
Rodrigo Mardones, Alessio Giai Via, Alexander Tomic, Claudio Rodriguez, Matias Salineros, Marcelo Somarriva
BACKGROUND: The iliopsoas tendon is a recognized cause of extra-articular hip pain, and tenotomy has been described as an effective treatment in patients who do not respond to conservative treatments. Endoscopic release showed higher success rate, lower recurrence, fewer complications compared to open surgery. The aim of the study is to report the results at a mean of 4 years follow-up of a series of patients affected by femoroacetabular impingement (FAI) and an associated iliopsoas tendinopathy, treated with hip arthroscopy and transcapsular tendon release...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066738/ligamentum-teres-tendinopathy-and-tears
#9
REVIEW
Matthew J Kraeutler, Tigran Garabekyan, Cecilia Pascual-Garrido, Omer Mei-Dan
BACKGROUND: The ligamentum teres (LT) consists of two bands that originate on the ischial and pubic sides of the acetabular notch and insert on the fovea capitis of the femoral head. Recent studies have established the LT as an important hip stabilizer in a squatting position, particularly in patients with osseous instability. PURPOSE: This review aims to concisely present the literature on LT tendinopathy and tears in order to guide health care professionals in the appropriate diagnosis and treatment of these disorders...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066732/conservative-management-of-tendinopathies-around-hip
#10
REVIEW
Antonio Frizziero, Filippo Vittadini, Andrea Pignataro, Giuseppe Gasparre, Carlo Biz, Pietro Ruggieri, Stefano Masiero
BACKGROUND: The anatomy of hip is widely complex and several anatomical structures interact and contribute to its functioning. For position and role, hip and the surrounding tendons, which have their insertion around, are overstressed and often overloaded, especially in athletes. This could lead to the developing of several tendinopathies, among which the differential diagnosis is often complicated. Many conservative treatments are used in clinical practice, while actually, no defined conservative protocol is recommended...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28061032/effects-of-platelet-rich-plasma-with-concomitant-use-of-a-corticosteroid-on-tenocytes-from-degenerative-rotator-cuff-tears-in-interleukin-1%C3%AE-induced-tendinopathic-conditions
#11
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sue Shin
BACKGROUND: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28058481/extensor-tendinopathy-of-the-elbow-assessed-with-sonoelastography-histologic-correlation
#12
Andrea S Klauser, Mathias Pamminger, Ethan J Halpern, Mohamed M H Abd Ellah, Bernhard Moriggl, Mihra S Taljanovic, Christian Deml, Judit Sztankay, Guenther Klima, Werner R Jaschke
PURPOSE: To compare agreement between conventional B-mode ultrasound (US) and compression sonoelastography (SEL) of the common extensor tendons of the elbow with histological evaluation. MATERIALS AND METHODS: Twenty-six common extensor tendons were evaluated in 17 cadavers (11 females, median age 85 years and 6 males, median age 80 years). B-mode US was graded into: Grade 1, homogeneous fibrillar pattern; grade 2, hypoechoic areas and/or calcifications <30%; and grade 3 > 30%...
January 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28054125/-tendinopathies-of-the-hip-treatment-recommendations-according-to-evidence-based-medicine
#13
C Macke, C Krettek, S Brand
Tendinopathies of the hip are a differential diagnostic challenge. The spatial proximity of these structures is challenging and many of the structures are located in very deep positions in an individual-specific manner and are covered by other tissues resulting in difficult accessibility for a clinical examination. Furthermore, the definition of the different syndromes is not consistent in the literature, which makes a comparability and assessment difficult. This article demonstrates the most frequent tendinopathies and associated syndromes with their typical clinical presentation, diagnostics and therapy options...
January 4, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28045872/revision-surgery-for-failed-patellar-tendinopathy-exploration
#14
Nicola Maffulli, Alessio Giai Via, Francesco Oliva
Chronic patellar tendinopathy affects athletes, with a higher incidence in high-impact sporting activities. It can seriously impair sports activities. Many patients respond well to conservative treatment, but about 10% of them are refractory to conservative treatment. In these cases, surgery is indicated. Multiple surgical techniques have been reported, including both open and arthroscopic procedures with good results. However, in a small percentage of patients surgery is unsuccessful. This group of patients presents a major challenge, as options are limited...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28038992/functional-and-ultrasonographic-outcomes-after-surgical-fibular-tendon-stabilisation-by-isolated-re-tensioning-of-the-superior-fibular-retinaculum
#15
C Choufani, R Rousseau, A Massein, H Pascal-Mousselard, F Khiami
BACKGROUND: Fibular tendon dislocation is a rare and usually sports-related injury. We report the functional and ultrasonographic outcomes of a simple technique for re-tensioning the superior fibular retinaculum. HYPOTHESIS: Our retinaculum re-tensioning technique is not followed by recurrent fibular tendon dislocation, as demonstrated by ultrasonography. MATERIAL AND METHOD: This single-centre single-surgeon retrospective study included 17 patients who underwent surgery to treat fibular tendon dislocation between January 2008 and December 2013...
December 27, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28028840/pain-duration-is-associated-with-increased-muscle-sympathetic-nerve-activity-in-patients-with-achilles-tendinopathy
#16
J L Jewson, E A Lambert, S Docking, M Storr, G W Lambert, J E Gaida
Tendinopathy is a common condition, which has been linked to surrogate measures of sympathetic nervous system (SNS) activity and insulin resistance. This study aimed to compare in vivo measures of the SNS and insulin resistance between individuals with and without Achilles tendinopathy. This case-control study compared Achilles tendinopathy sufferers to healthy controls. SNS activity was quantified using muscle sympathetic nerve activity (MSNA), while metabolic status was assessed via a modified glucose tolerance test and fasting lipid panel...
December 28, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28012199/who-or-what-controls-tendon
#17
Dianne Little
There are many ways that the tendon phenotype within an individual animal responds to the loading and host environment to which it is subjected, and none occur as an isolated process; rather through integration of mechanotransduction, complex interactions between anabolic and catabolic protein-protein interactions; and through interplay between different RNA species to modulate gene and protein expression. These processes are generally considered to be the integrated response of the tendon organ to the local environment within the host, or 'The Who'...
December 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28005449/clinical-benefits-and-drawbacks-of-local-corticosteroids-injections-in-tendinopathies
#18
Michele Abate, Vincenzo Salini, Cosima Schiavone, Isabel Andia
local glucocorticoids injections are widely administered for the treatment of tendinopathies. positive results have been observed in some tendinopathies but not in others. moreover, worsening of symptoms, and even spontaneous tendon ruptures has been reported. the characteristics of the tendinopathies, the clinical peculiarities of the patient, and the technique used to administer glucocorticoids, can influence the therapeutic response. Areas covered: After reviewing the pertinent literature on the clinical results, basic information, both on the pathogenesis of tendinopathies and the effects of glucocorticoids on tendons, is reported...
December 28, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28004000/utility-of-ultrasonography-in-assessing-the-effectiveness-of-extracorporeal-shock-wave-therapy-in-insertional-achilles-tendinopathy
#19
Yi Cheng, Jian Zhang, Yehua Cai
Introduction. The aim of this study was to investigate the utility of ultrasonography (US) for predicting and assessing the effectiveness of extracorporeal shock wave therapy (ESWT) in insertional Achilles tendinopathy (IAT). Methods. A total of 42 patients with an established diagnosis of chronic IAT were examined by US before ESWT and at 4 weeks and 12 weeks after ESWT. The thickness and cross-sectional area (CSA) of the Achilles tendon, size of calcific plaques, tendon structure score, and neovascularization score were measured at each time point...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28003934/stability-enhancement-using-hyaluronic-acid-gels-for-delivery-of-human-fetal-progenitor-tenocytes
#20
A Grognuz, C Scaletta, A Farron, D P Pioletti, W Raffoul, L A Applegate
Tendon afflictions are very common, and their negative impact is high both at the workplace and in leisure activities. Tendinopathies are increasing in prevalence and can lead to tendon ruptures, where healing is a long process with outcomes that are often disappointing. Human fetal progenitor tenocytes (hFPTs) have been recently tested in vitro as a potential cell source to stimulate tendon regeneration. The aim of the present study was to compare different commercial hyaluronic acid (HA) gels, which could be used to resuspend hFPTs in a formulation that would allow for good delivery of the cells...
December 3, 2016: Cell Medicine
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