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Tendinopathy

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https://www.readbyqxmd.com/read/28901991/dose-dependent-achilles-tendinopathy-in-a-patient-on-aripiprazole
#1
Arash Javanbakht, Victor Ajluni
No abstract text is available yet for this article.
September 10, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28901376/mechanical-loading-modulates-heterotopic-ossification-in-calcific-tendinopathy-through-the-mtorc1-signaling-pathway
#2
Guorong Chen, Huaji Jiang, Xinggui Tian, Jiajun Tang, Xiaochun Bai, Zhongmin Zhang, Liang Wang
Excessive mechanical loading is a major factor affecting heterotopic ossification (HO), which is a major pathological alteration in calcific tendinopathy. However, physical therapies with mechanical loading as the functional element have exhibited promising results in the treatment of calcific tendinopathy. The dual effects that mechanical loading may have on the pathogenesis and rehabilitation of calcified tendinopathy remain unclear. The present study was designed to investigate the effects of mechanical loading on HO in calcific tendinopathy...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899880/effects-of-aging-and-resistance-training-in-rat-tendon-remodeling
#3
Rita C Marqueti, João L Q Durigan, Anderson José S Oliveira, Marcelo Shinyu Mekaro, Vinicius Guzzoni, Andrea A Aro, Edson Rosa Pimentel, Heloisa S Selistre-de-Araujo
In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period...
September 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28889228/intraosseous-migration-of-tendinous-calcifications-two-case-reports
#4
A Marinetti, M Sessa, A Falzone, S W Della Sala
Calcific tendinopathy of the rotator cuff is a common cause of shoulder pain. Inflammation of the rotator cuff tendons may be complicated by adjacent bone erosion and subsequent migration of calcific deposits within the bone resulting in marrow inflammation. Bone marrow involvement is not readily visible using X-ray and ultrasound (US) and further testing is necessary. Magnetic resonance imaging (MRI) is a highly sensitive technique that can detect a focal bone T1 and T2-weighted hypointensity with bone marrow edema-like signal and cortical erosion...
September 9, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28888574/patient-and-disease-specific-factors-associated-with-operative-management-of-de-quervain-tendinopathy
#5
Nikolas H Kazmers, Tiffany C Liu, Joshua A Gordon, David J Bozentka, David R Steinberg, Benjamin L Gray
PURPOSE: It remains unclear which factors, patient- or disease-specific, are associated with electing to undergo operative management for de Quervain tendinopathy. Our null hypothesis was that no patient- or disease-specific factors would be associated with the choice of surgical treatment of de Quervain tendinopathy. METHODS: We performed a retrospective review of consecutive patients diagnosed with de Quervain tendinopathy over 3 years by 1 of 3 fellowship-trained hand surgeons at an urban academic institution...
September 7, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28888475/promoter-methylation-status-of-the-timp2-and-adamts4-genes-and-patellar-tendinopathy
#6
Louis Y El Khoury, Rebecca Rickaby, Tom Samiric, Stuart M Raleigh
OBJECTIVES: Patellar tendinopathy (PT) is a debilitating and prevalent condition that tends to affect those who are physically active or engaged in jumping sports. Although tendinopathies are known to have a genetic basis, the role of DNA methylation as an epigenetic factor and risk determinant for human PT has never been described. We sought to determine whether differences existed between the methylation profiles of both the TIMP2 and ADAMTS4 gene promoter sequences in a cohort of males having undergone surgery for patellar tendinopathy compared to controls...
September 1, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28887458/increased-15-pgdh-expression-leads-to-dysregulated-resolution-responses-in-stromal-cells-from-patients-with-chronic-tendinopathy
#7
Stephanie G Dakin, Lucy Ly, Romain A Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J Carr
The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly induced prostaglandin biosynthesis in diseased compared to healthy tendon cells, and up regulated the formation of several pro-resolving mediators including 15-epi-LXA4 and MaR1. Incubation of IL-1β stimulated healthy tendon cells with 15-epi-LXA4 or MaR1 down-regulated PGE2 and PGD2 production...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883422/effect-of-metabolic-syndrome-on-the-functional-outcome-of-corticosteroid-injection-for-lateral-epicondylitis-retrospective-matched-case-control-study
#8
Young Hak Roh, Minjoon Oh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
Both obesity and diabetes mellitus are well-known risk factors for tendinopathies. We retrospectively compared the efficacy of single corticosteroid injections in treating lateral epicondylitis in patients with and without metabolic syndrome (MetS). Fifty-one patients with lateral epicondylitis and MetS were age- and sex-matched with 51 controls without MetS. Pain severity, Disability of the Arm, Shoulder, and Hand score, and grip strength were assessed at base line and at 6, 12 and 24 weeks post-injection...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28879051/targeting-danger-molecules-in-tendinopathy-the-hmgb1-tlr4-axis
#9
Moeed Akbar, Derek S Gilchrist, Susan M Kitson, Briana Nelis, Lindsay A N Crowe, Emma Garcia-Melchor, James H Reilly, Shauna C Kerr, George A C Murrell, Iain B McInnes, Neal L Millar
OBJECTIVES: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. METHODS: Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing 'early pathology') biopsies were collected from patients undergoing arthroscopic shoulder surgery...
2017: RMD Open
https://www.readbyqxmd.com/read/28875153/three-months-of-progressive-high-load-versus-traditional-low-load-strength-training-among-patients-with-rotator-cuff-tendinopathy-primary-results-from-the-double-blind-randomized-controlled-roctex-trial
#10
Kim Gordon Ingwersen, Steen Lund Jensen, Lilli Sørensen, Hans Ri Jørgensen, Robin Christensen, Karen Søgaard, Birgit Juul-Kristensen
BACKGROUND: Progressive high-load exercise (PHLE) has led to positive clinical results in patients with patellar and Achilles tendinopathy. However, its effects on rotator cuff tendinopathy still need to be investigated. PURPOSE: To assess the clinical effects of PHLE versus low-load exercise (LLE) among patients with rotator cuff tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: Patients with rotator cuff tendinopathy were recruited and randomized to 12 weeks of PHLE or LLE, stratified for concomitant administration of corticosteroid injection...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28860425/marked-expression-of-tnf-receptors-in-human-peritendinous-tissues-including-in-nerve-fascicles-with-axonal-damage-studies-on-tendinopathy-and-tennis-elbow
#11
C Spang, L Renström, H Alfredson, S Forsgren
BACKGROUND: The peritendinous connective tissues can have importance in chronic tendon pain. Recently cytokine TNF-α has been suggested to be involved in tendinopathic processes. It is not known how TNF-α and its receptors TNFR1 and TNFR2 are expressed in peritendinous tissues. METHODS: The objective for this study was to immunohistochemically evaluate the expression patterns of these in the peritendinous tissue located between the plantaris and Achilles tendons and the one located superficially to the extensor origin at the elbow region for patients with tendinopathy/tennis elbow...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860166/effects-of-anti-inflammatory-nsaid-treatment-on-human-tendinopathic-tissue
#12
Katja Maria Heinemeier, Tommy F Øhlenschlæger, Ulla Ramer Mikkelsen, Freja Sønder, Peter Schjerling, Rene Brüggebusch Svensson, Michael Kjaer
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy, but evidence for this treatment is lacking, and little is known regarding effects of NSAIDs on human tendinopathic tendon. This study investigated effects of NSAID treatment (ibuprofen) on human tendinopathic tendon, with changes in gene expression as the primary outcome, and tendon pain, function and blood flow as secondary outcomes. Twenty-six adults (16 male, 10 female) diagnosed with chronic Achilles tendinopathy were randomized to one-week treatment with ibuprofen (600mgx3/day) (n=13) or placebo (n=13) (double-blinded)...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28857901/two-unique-cases-of-ciprofloxacin-associated-avulsion-of-ligament-and-tendon
#13
Jeffrey David Smith, Robert W Irwin, Erin T Wolff
Ciprofloxacin is recognized to have a deleterious relationship with tendons, particularly Achilles tendinopathy, which makes up most case reports. Tendinopathy seems to occur because of induction of collagen-degrading enzymes causing damage and ischemia of the poorly vascularized regions preventing repair. The focus on the relationship of ciprofloxacin and the Achilles tendon leaves patients on fluoroquinolones with non-Achilles tendinopathy symptoms at risk of misdiagnosis. There have not been any documented instances of ligament damage with ciprofloxacin administration in the literature, although ligament and tendon compositions are similar and should have similar susceptibility...
August 25, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28856388/no-beneficial-effect-of-polidocanol-treatment-in-achilles-tendinopathy-a-randomised-controlled-trial
#14
B H Ebbesen, C M Mølgaard, J L Olesen, H E Gregersen, O Simonsen
PURPOSE: Polidocanol injections have been used to treat chronic Achilles tendinopathy in clinical settings, but the few studies published show inconsistent results. The aim of this study was to evaluate the mid-term effect of Polidocanol in patients with chronic Achilles tendinopathy. It was hypothesised that patients treated with Polidocanol would have significant improvements in the outcome measures investigated compared to patients treated with a placebo treatment at mid-term follow-up...
August 30, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28856171/genetic-factors-in-tendon-injury-a-systematic-review-of-the-literature
#15
REVIEW
Natalie H Vaughn, Hayk Stepanyan, Robert A Gallo, Aman Dhawan
BACKGROUND: Tendon injury such as tendinopathy or rupture is common and has multiple etiologies, including both intrinsic and extrinsic factors. The genetic influence on susceptibility to tendon injury is not well understood. PURPOSE: To analyze the published literature regarding genetic factors associated with tendon injury. STUDY DESIGN: Systematic review; Level of evidence, 3. METHODS: A systematic review of published literature was performed in concordance with the Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) guidelines to identify current evidence for genetic predisposition to tendon injury...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28855793/the-use-of-compression-tack-and-flossing-along-with-lacrosse-ball-massage-to-treat-chronic-achilles-tendinopathy-in-an-adolescent-athlete-a-case-report
#16
Jennifer Borda, Mitchell Selhorst
BACKGROUND: Achilles tendinopathy is an overuse injury that often affects individuals engaged in recreational or competitive level activity. Although most patients experience satisfactory results with therapy, a substantial portion fail to respond to traditional treatment. The purpose of this case study is to describe the successful use of compression tack and flossing (CTF) with lacrosse ball massage (LBM) in the treatment of an adolescent athlete with Achilles tendinopathy who had failed to respond to traditional treatment...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28855560/elastin-is-localised-to-the-interfascicular-matrix-of-energy-storing-tendons-and-becomes-increasingly-disorganised-with-ageing
#17
Marta S C Godinho, Chavaunne T Thorpe, Steve E Greenwald, Hazel R C Screen
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding and recoil. With ageing, the IFM becomes stiffer and less fatigue resistant, potentially explaining why older tendons become more injury-prone. Recent data indicates enrichment of elastin within the IFM, but this has yet to be quantified. We hypothesised that elastin is more prevalent in energy storing than positional tendons, and is mainly localised to the IFM...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842745/diagnosis-of-long-head-of-biceps-tendinopathy-in-rotator-cuff-tear-patients-correlation-of-imaging-and-arthroscopy-data
#18
Morgane Rol, Luc Favard, Julien Berhouet
INTRODUCTION: The goal of this prospective study was to assess the reliability of pre-operative cross-sectional imaging for the diagnosis of long head of biceps (LHB) tendinopathy in patients with a rotator cuff tear. METHODS: Cross-sectional imaging with MRI or CT arthrography data from 25 patients operated upon because of a rotator cuff tear between 1 October 2015 and 1 April 2016 was analysed by one experienced orthopaedic surgeon, one experienced radiologist and one orthopaedic resident...
August 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28842108/percutaneous-ultrasonic-tenotomy-for-achilles-tendinopathy-is-a-surgical-procedure-with-similar-complications
#19
Patrick J Sanchez, John F Grady, Amol Saxena
Percutaneous ultrasonic tenotomy is a relatively new treatment option for multiple types of tendinopathy. However, a paucity of high-level data is available on its use for chronic Achilles tendinosis. The present case series details the complications associated with the use of this technique. When considering percutaneous ultrasonic tenotomy, the surgeon should be cognizant that it is a surgical procedure with complications similar to those of other Achilles tendon surgeries.
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28842106/electromagnetic-transduction-therapy-for-achilles-tendinopathy-a-preliminary-report-on-a-new-technology
#20
Ludger Gerdesmeyer, Amol Saxena, Tim Klueter, Norbert Harrasser, Brian Fullem, Andre Krath
A parallel prospective feasibility study was performed on 53 patients with chronic mid-portion Achilles tendinopathy (age 44.7 ± 9.1 years). Of the 53 patients, 28 (active group) were treated using a new electromagnetic (pulsed electromagnetic field) transduction therapy device (Cellactor(®) MT1) and heel cushions. The device produces an electromagnetic field of 80 milliTesla; a total of 8 treatments was performed within 4 weeks in an outpatient setting, without anesthesia, immobilization, or rest. A control group of 25 patients with a similar duration of symptoms was treated with heel cushions only...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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