keyword
https://read.qxmd.com/read/38537073/the-role-of-robotic-assisted-surgery-in-the-management-of-rectal-cancer-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Chenxion Zhang, Hao Tan, Han Xu, Jiaming Ding
BACKGROUND: Rectal cancer poses a significant global health burden. There is a lack of concrete evidence concerning the benefits of robotic-assisted surgery (RAS) for rectal cancer surgery as compared to laparoscopic and open techniques. To address this gap, we conducted a meta-analysis to assess the intraoperative, postoperative, and safety outcomes of robotic surgery in this context. METHODS: MEDLINE, Scopus, and the Cochrane library were searched till May 2023 for randomized and non-randomized studies comparing robotic surgery with either laparoscopic or open approach for rectal cancers...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#2
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#3
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536881/small-intestine-bacterial-overgrowth-is-associated-with-increased-campylobacter-and-epithelial-injury-in-duodenal-biopsies-of-bangladeshi-children
#4
JOURNAL ARTICLE
Shah Mohammad Fahim, Jeffrey R Donowitz, Ekaterina Smirnova, Ning-Juin Jan, Subhasish Das, Mustafa Mahfuz, S M Abdul Gaffar, William A Petri, Chelsea Marie, Tahmeed Ahmed
Small intestine bacterial overgrowth (SIBO) has been associated with enteric inflammation, linear growth stunting, and neurodevelopmental delays in children from low-income countries. Little is known about the histologic changes or epithelial adherent microbiota associated with SIBO. We sought to describe these relationships in a cohort of impoverished Bangladeshi children. Undernourished 12-18-month-old children underwent both glucose hydrogen breath testing for SIBO and duodenoscopy with biopsy. Biopsy samples were subject to both histological scoring and 16s rRNA sequencing...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536871/species-specific-responses-during-seoul-orthohantavirus-infection-in-human-and-rat-lung-microvascular-endothelial-cells
#5
JOURNAL ARTICLE
Danny Noack, Mirjam C G N van den Hout, Carmen W E Embregts, Wilfred F J van IJcken, Marion P G Koopmans, Barry Rockx
Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome (HFRS) in humans worldwide. In rats, SEOV predominantly exists as a persistent infection in the absence of overt clinical signs. Lack of disease in rats is attributed to downregulation of pro-inflammatory and upregulation of regulatory host responses. As lung microvascular endothelial cells (LMECs) represent a primary target of infection in both human and rats, infections in these cells provide a unique opportunity to study the central role of LMECs in the dichotomy between pathogenicity in both species...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536863/reinfection-of-farm-dogs-following-praziquantel-treatment-in-an-endemic-region-of-cystic-echinococcosis-in-southeastern-iran
#6
JOURNAL ARTICLE
Mehdi Borhani, Mohammad Ali Mohammadi, Mahbod Entezami, Mohammad Reza Baneshi, Saeid Nasibi, Joaquin M Prada, Majid Fasihi Harandi
Cystic Echinococcosis (CE) as a prevalent tapeworm infection of human and herbivorous animals worldwide, is caused by accidental ingestion of Echinococcus granulosus eggs excreted from infected dogs. CE is endemic in the Middle East and North Africa, and is considered as an important parasitic zoonosis in Iran. It is transmitted between dogs as the primary definitive host and different livestock species as the intermediate hosts. One of the most important measures for CE control is dog deworming with praziquantel...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536861/predictors-for-participation-in-mass-treatment-and-female-genital-schistosomiasis-re-investigation-and-the-effect-of-praziquantel-treatment-in-south-african-adolescents
#7
JOURNAL ARTICLE
Takalani Girly Nemungadi, Elisabeth Kleppa, Hashini Nilushika Galappaththi-Arachchige, Pavitra Pillay, Svein Gunnar Gundersen, Birgitte Jyding Vennervald, Patricia Doris Ndhlovu, Myra Taylor, Saloshni Naidoo, Eyrun Floerecke Kjetland
OBJECTIVE: Female Genital Schistosomiasis (FGS) causes intravaginal lesions and symptoms that could be mistaken for sexually transmitted diseases or cancer. In adults, FGS lesions [grainy sandy patches (GSP), homogenous yellow patches (HYP), abnormal blood vessels and rubbery papules] are refractory to treatment. The effect of treatment has never been explored in young women; it is unclear if gynaecological investigation will be possible in this young age group (16-23 years). We explored the predictors for accepting anti-schistosomal treatment and/or gynaecological reinvestigation in young women, and the effects of anti-schistosomal mass-treatment (praziquantel) on the clinical manifestations of FGS at an adolescent age...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#8
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536619/acceptability-and-feasibility-of-the-plasma-separation-card-for-an-integrated-model-of-care-for-hbv-and-hcv-screening-among-people-attending-hiv-clinics-in-cameroon-and-uganda
#9
JOURNAL ARTICLE
Camila A Picchio, Aina Nicolàs, Ironne Valdèse Ayemfouo Fofou, Viola Kasone, Magellan Guewo-Fokeng, Claude T Tagny, Teddy Nanyonjo, Hellen Nansumba, Yves Nacel Kouongni, Rita Gaëlle Epse Sezawo Kamdjeu, Emmanuel Seremba, Charles Kouanfack, Isaac Ssewanyana, Richard Njouom, Ariadna Rando Segura, Francisco Rodríguez-Frías, Jean Claude Mbanya, Ponsiano Ocama, Jeffrey V Lazarus
BACKGROUND: Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. METHODS: This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88)...
March 27, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38536525/correction-to-added-diagnostic-value-of-16s-rrna-gene-pan-mycobacterial-pcr-for-nontuberculous-mycobacterial-infections-a-10-year-retrospective-study
#10
Simon Andenmatten, Onya Opota, Jessica Mazza-Stalder, Laurent Nicod, Gilbert Greub, Katia Jaton
No abstract text is available yet for this article.
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536524/clinical-impact-and-cost-consequence-analysis-of-eplex%C3%A2-blood-culture-identification-panels-for-the-rapid-diagnosis-of-bloodstream-infections-a-single-center-randomized-controlled-trial
#11
JOURNAL ARTICLE
Yvan Caspar, A Deves, C Richarme, M Le Marechal, L Ponderand, A-L Mounayar, S Lejeune, J Arata-Bardet, M Gallouche, C Recule, D Maubon, C Garnaud, M Cornet, M Veloso, B Chabani, M Maurin, S David-Tchouda, P Pavese
To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536523/suitability-of-reduced-dose-glucocorticoids-therapy-regimen-for-antibody-associated-vasculitis-patients-with-tb-a-retrospective-study
#12
JOURNAL ARTICLE
Rui Wen, Jingni Xiao, Ning Ding, Yong Zhong, Qiong Yuan, Jiali Li, Qi Wang, Hebin Xie, Jiao Qin
INTENTION: Immunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Due to impaired cellular immunological function and the use of glucocorticoids and immunosuppressants, AAV patients are predisposed to opportunistic infections, including tuberculosis (TB). This retrospective study aims to analyze the clinical characteristics of patients with AAV and TB and explore suitable glucocorticoid regimens for them...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536514/detection-of-anaplasma-spp-and-ehrlichia-spp-in-dogs-from-a-veterinary-teaching-hospital-in-italy-a-retrospective-study-2012-2020
#13
JOURNAL ARTICLE
Veronica Facile, Maria Chiara Sabetti, Andrea Balboni, Lorenza Urbani, Alessandro Tirolo, Martina Magliocca, Francesco Lunetta, Francesco Dondi, Mara Battilani
Anaplasma phagocytophilum, Anaplasma platys and Ehrlichia canis, responsible of diseases in dogs, are tick-borne pathogens with a proven or potential zoonotic role that have shown increasing prevalence worldwide. The aims of this retrospective study were to assess the frequency of Anaplasma spp. and Ehrlichia spp. exposure in dogs tested in a veterinary teaching hospital in Italy over a 9-year period, to compare the performance of the diagnostic tests used, to evaluate correlations with clinical data, and to genetically analyse the identified bacteria...
March 27, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38536442/a-phase-1-double-blinded-placebo-controlled-clinical-trial-to-evaluate-the-safety-and-immunogenicity-of-hev-239-hecolin%C3%A2-vaccine-in-healthy-us-adults
#14
JOURNAL ARTICLE
Carol M Kao, Christina A Rostad, Lauren E Nolan, Etza Peters, Jennifer Kleinhenz, Jacob D Sherman, Ashley Tippett, J Wai Kuo Shih, Inci Yildirim, Vivien Agbakoba, Tatiana Beresnev, Cassandra Ballou, Satoshi Kamidani, Vinit Karmali, Muktha Natrajan, Erin M Scherer, Nadine Rouphael, Evan J Anderson
INTRODUCTION: Establishing the safety and immunogenicity of a hepatitis E virus vaccine in multiple populations could facilitate broader access and prevent maternal and infant mortality. METHODS: We conducted a phase 1, randomized, double-blinded, placebo-controlled (4:1 vaccine: placebo) trial of 30 µg HEV-239 (Hecolin®, Xiamen Innovax Biotech Company Limited, China) administered intramuscularly in healthy US adults aged 18-45 years. Participants were vaccinated on days 1, 29, and 180...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38536197/adamts5-promotes-permeability-of-the-blood-brain-barrier-during-treponema-pallidum-subspecies-pallidum-invading-the-central-nervous-system
#15
JOURNAL ARTICLE
Zuoxi Chen, Fangzhi Du, Ruihua Zhang, Qingyun Wu, Zhiyu Lu, Rui-Li Zhang, Qianqiu Wang
The pathogenesis of neurosyphilis remains unclear. A previous study found a noteworthy up-regulation of a disintegrin and metalloproteinase with thrombospondin type 1 motif 5 (ADAMTS5) gene in human brain microvascular endothelial cells cocultured with Treponema pallidum subspecies pallidum (Tp). To investigate the ADAMTS5 role in Tp invading the central nervous system (CNS), we conducted relevant experiments. Our study revealed that Tp caused an increase in human cortical microvascular endothelial cell/D3 (hCMEC/D3) barrier permeability and significantly enhanced ADAMTS5 expression...
March 27, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38536055/predicting-increased-incidence-of-common-antibiotic-resistant-and-antibiotic-associated-pathogens-using-ensemble-species-distribution-modeling
#16
JOURNAL ARTICLE
Siqi C Brough, Luke Caddell, Raymond J Liou, Advait Patil, Giulio De Leo, Joseph D Forrester
The Centers for Disease Control estimates antibiotic-associated pathogens result in 2.8 million infections and 38,000 deaths annually in the United States. This study applies species distribution modeling to elucidate the impact of environmental determinants of human infectious disease in an era of rapid global change. We modeled methicillin-resistant Staphylococcus aureus and Clostridioides difficile using 31 publicly accessible bioclimatic, healthcare, and sociodemographic variables. Ensemble models were created from 8 unique statistical and machine learning algorithms...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38535973/-pseudomonas-stutzeri-bloodstream-infection-is-a-prevailing-community-onset-disease-with-important-mortality-rates-results-from-a-retrospective-observational-study-in-australia
#17
JOURNAL ARTICLE
Juan P Horcajada, Felicity Edwards, Silvia Fonio, Milagro Montero, Patrick Harris, David L Paterson, Kevin B Laupland
BACKGROUND: The recognition of Pseudomonas stutzer i as a cause of infections in humans has been increasing. However, only case reports and small series of P. stutzeri bloodstream infections have been published. Epidemiological data on these infections are extremely scarce. Our objective was to describe the incidence, epidemiology, antimicrobial resistance rates, and outcomes of P. stutzeri bloodstream infections in a large population-based cohort in Australia. METHODS: Retrospective, laboratory-based surveillance study conducted in Queensland, Australia (population ≈ 5 million) during 2000-2019...
March 27, 2024: Infectious Diseases
https://read.qxmd.com/read/38535510/clinical-characteristics-of-118-pediatric-patients-with-acute-benign-myositis-associated-with-influenza-a-virus-infection
#18
JOURNAL ARTICLE
Shaoqun Jiang, Jieling Li, Jie Cao, Yuexu Ou, Yuanhui Duan, Xiaoming Gan
OBJECTIVE: The objective of this study was to investigate the clinical and laboratory features of acute benign myositis associated with influenza A virus infection in children. METHODS: A retrospective analysis was performed on the clinical data of 118 children with acute benign myositis associated with influenza A virus infection who were admitted to the Children's Hospital of Chongqing Medical University during the epidemic period of influenza A from February 2023 to May 2023...
March 27, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38535424/cardiorespiratory-performance-in-kidney-and-liver-transplant-recipients-the-dilemma-to-combine-lifestyle-and-fitness
#19
JOURNAL ARTICLE
Giovannino Polara, Alessio Montagnoli, Roberto Palazzo, Melissa Orlandi, Gabriele Mascherini, Marco Corsi, Edoardo Falconi, Laura Stefani
It is widely demonstrated that moderate-intensity exercise is associated with improved fitness in non-communicable chronic diseases. However, there are no specific guidelines available for transplant recipients. Body composition is closely linked to exercise capacity, typically estimated by cardiopulmonary testing, but its potential correlation with cardiovascular health outcomes has not been investigated yet. This study aims to evaluate and compare cardiorespiratory performance and body composition in two groups of liver and kidney transplant recipients...
February 29, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535409/a-phase-three-study-of-the-safety-and-immunogenicity-of-a-four-dose-series-of-20-valent-pneumococcal-conjugate-vaccine-in-healthy-infants
#20
JOURNAL ARTICLE
Shelly Senders, Nicola P Klein, Noor Tamimi, Allison Thompson, Gary Baugher, James Trammel, Yahong Peng, Peter Giardina, Ingrid L Scully, Michael Pride, Kimberly J Center, William C Gruber, Daniel A Scott, Wendy Watson
BACKGROUND: The 20-valent pneumococcal conjugate vaccine (PCV20) was developed to extend pneumococcal disease protection beyond 13-valent PCV (PCV13). METHODS: This phase 3, double-blind study conducted in the United States/Puerto Rico evaluated PCV20 safety and immunogenicity. Healthy infants were randomized to receive a 4-dose series of PCV20 or PCV13 at 2, 4, 6 and 12-15 months old. Objectives included demonstrating noninferiority (NI) of PCV20 to PCV13 immunoglobulin G (IgG) geometric mean concentrations after doses 3 and 4 and percentages of participants with predefined IgG concentrations after dose 3, with 7 additional PCV20 serotypes compared with the lowest result among vaccine serotypes in the PCV13 group...
March 26, 2024: Pediatric Infectious Disease Journal
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