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Amikacin nebulised

J P Clancy, L Dupont, M W Konstan, J Billings, S Fustik, C H Goss, J Lymp, P Minic, A L Quittner, R C Rubenstein, K R Young, L Saiman, J L Burns, J R W Govan, B Ramsey, R Gupta
RATIONALE: Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition. OBJECTIVES: To examine the safety and efficacy of 28 days of once-daily Arikace in cystic fibrosis (CF) patients chronically infected with P aeruginosa. METHODS: 105 subjects were evaluated in double-blind, placebo-controlled studies. Subjects were randomised to once-daily Arikace (70, 140, 280 and 560 mg; n=7, 5, 21 and 36 subjects) or placebo (n=36) for 28 days...
September 2013: Thorax
J-C Dubus, S Ravilly
INTRODUCTION: Delivery of drugs by the inhaled route is particularly attractive in cystic fibrosis despite heterogeneous and variable deposition in the lungs. STATE OF THE ART: Proposed therapies include drugs aimed at improving the mucus quality (nebulised hypertonic saline or RhDNase and, in the future, mannitol as a dry powder) or treating chronic colonization and early infection with Pseudomonas aeruginosa (nebulised tobramycine and colistine and, soon, aztreonam lysate, ciprofloxacin and liposomal amikacine)...
October 2008: Revue des Maladies Respiratoires
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