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https://www.readbyqxmd.com/read/29783206/-experimental-evaluation-of-the-therapeutic-potential-of-liposome-mediated-apoe3-gene-transfection-for-cerebral-atherosclerosis
#1
Vadym V Biloshytskyi, Alisa V Pachevska, Alina V Biloshytska, Valerii M Istoshyn, Maryna V Biloshytska, Olha B Shevnia
OBJECTIVE: Introduction: In recent years, a stroke has been the cause of high lethality, long-term and sustained disability, the problem of which is still far from being resolved. The root cause of stroke is atherosclerosis. The aim: Study of neurotrophic and neuroprotective functions of apoE in rat brain tissue in experimental atherosclerosis. PATIENTS AND METHODS: Materials and methods: The study included 60 sexually mature rats. The model of experimental atherosclerosis was created by Anichkov method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783061/enhanced-extinction-of-aversive-memories-in-mice-lacking-sparc-related-protein-containing-immunoglobulin-domains-1-spig1-fstl4
#2
Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Noda
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity related to learning and memory. We previously reported that SPARC-related protein-containing immunoglobulin domains 1 (SPIG1, also known as Follistatin-like protein 4, FSTL4) binds to pro-BDNF and negatively regulates BDNF maturation; however, its neurological functions, particularly in learning and memory, have not yet been elucidated. We herein examined the electrophysiological and behavioral phenotypes of Spig1-knockout (Spig1-KO) mice...
May 18, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29782958/changes-in-behavioural-parameters-oxidative-stress-and-neurotrophins-in-the-brain-of-adult-offspring-induced-to-an-animal-model-of-schizophrenia-the-effects-of-fa-deficient-or-fa-supplemented-diet-during-the-neurodevelopmental-phase
#3
L Canever, T G Freire, G A Mastella, L Damázio, S Gomes, I Fachim, C Michels, G Carvalho, A K Godói, B R Peterle, F F Gava, S Valvassori Sda, J Budni, J Quevedo, A I Zugno
A deficiency of maternal folic acid (FA) can compromise the function and development of the brain, and may produce a susceptibility to diseases such as schizophrenia (SZ) in the later life of offspring. The aim of this study was to evaluate the effects of both FA deficient and FA supplemented diets during gestation and lactation on behavioural parameters, the markers of oxidative stress and neurotrophic factors in adult offspring which had been subjected to an animal model of SZ. Female mother rats (Dam's) were separated into experimental maternal groups, which began receiving a special diet (food) consisting of the AIN-93 diet, a control diet, or an FA deficient diet during the periods of pregnancy and lactation...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29782918/bdnf-haploinsufficiency-exerts-a-transient-and-regionally-different-influence-upon-oligodendroglial-lineage-cells-during-postnatal-development
#4
Madeline Nicholson, Rhiannon J Wood, Jessica L Fletcher, Maarten van den Buuse, Simon S Murray, Junhua Xiao
The Brain-Derived Neurotrophic Factor (BDNF) plays important roles in promoting myelination in the developing central nervous system (CNS), however the influence it exerts on oligodendrocyte development in vivo remain unclear. As BDNF knockout mice die in the perinatal period, we undertook a systematic developmental analysis of oligodendroglial lineage cells within multiple CNS regions of BDNF heterozygous (HET) mice. Our data identify that BDNF heterozygosity results in transient reductions in oligodendroglial lineage cell density and progression that are largely restricted to the optic nerve, whereas the corpus callosum, cerebral cortex, basal forebrain and spinal cord white matter tracts are unaffected...
May 18, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29781786/sitagliptin-rescues-memory-deficits-in-parkinsonian-rats-via-upregulating-bdnf-to-prevent-neuron-and-dendritic-spine-loss
#5
Jing Li, Shuhu Zhang, Chenye Li, Mei Li, Lan Ma
OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disease with high morbidity among adults worldwide that causes tremendous trouble to people's lives. The purpose of this study was to investigate the impact of sitagliptin on PD and its potential mechanism. METHODS: First, the memory of rats in each group was evaluated with the Morris water maze (MWM) test and the passive avoidance test. Then, both brain-derived neurotrophic factor (BDNF) protein and mRNA levels were detected by ELISA and qPCR assays, respectively...
May 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29781158/role-of-brain-derived-neurotrophic-factor-in-the-pathogenesis-of-distention-associated-abdominal-pain-in-bowel-obstruction
#6
Y Fu, Y M Lin, J H Winston, R Radhakrishnan, L-Y M Huang, X Z Shi
BACKGROUND: Previous studies found that visceral sensitivity is increased in bowel obstruction (BO). We hypothesized that mechanical stress-induced expression of BDNF in smooth muscle cells (SMC) of the distended bowel plays a critical role in visceral hypersensitivity in BO by altering voltage-gated K+ channel (Kv ) activity in sensory neurons. METHODS: Partial colon obstruction was maintained in rats for 7 days. Colon-projecting neurons in the dorsal root ganglia (DRG, T13 to L2) were isolated for electrophysiological and gene expression studies...
May 21, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29780293/serial-changes-of-cytokines-in-children-with-cerebral-palsy-who-received-intravenous-granulocyte-colony-stimulating-factor-followed-by-autologous-mobilized-peripheral-blood-mononuclear-cells
#7
Hani Koh, Wee-Jin Rah, Yong-Joo Kim, Jin-Hwa Moon, Mi-Jung Kim, Young-Ho Lee
Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29780164/three-new-cyathane-diterpenes-with-neurotrophic-activity-from-the-liquid-cultures-of-hericium-erinaceus
#8
Yuting Zhang, Li Liu, Li Bao, Yanlong Yang, Ke Ma, Hongwei Liu
Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73...
May 21, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29779176/intranasal-delivery-of-pgdnf-dna-nanoparticles-provides-neuroprotection-in-the-rat-6-hydroxydopamine-model-of-parkinson-s-disease
#9
Amirah E-E Aly, Brendan T Harmon, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Barbara L Waszczak
Glial cell line-derived neurotrophic factor (GDNF) gene therapy could offer a disease-modifying treatment for Parkinson's disease (PD). Here, we report that plasmid DNA nanoparticles (NPs) encoding human GDNF administered intranasally to rats induce transgene expression in the brain and protect dopamine neurons in a model of PD. To first test whether intranasal administration could transfect cells in the brain, rats were sacrificed 1 week after intranasal pGDNF NPs or the naked plasmid. GDNF ELISA revealed significant increases in GDNF expression throughout the brain for both treatments...
May 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29777700/transient-receptor-potential-ankyrin-1-channels-are-involved-in-spontaneous-peptide-hormone-release-from-astrocytes
#10
Mai Takizawa, Kazuki Harada, Kazuaki Nakamura, Takashi Tsuboi
Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+ ]i ) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spontaneous [Ca2+ ]i increase in astrocytes. While several physiological functions of TRPA1-mediated spontaneous Ca2+ signal have been revealed, relation with gliotransmitter release, especially peptide hormone exocytosis is largely unknown...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775986/effects-of-two-training-programs-on-transcriptional-levels-of-neurotrophins-and-glial-cells-population-in-hippocampus-of-experimental-multiple-sclerosis
#11
Maryam Naghibzadeh, Rouhollah Ranjbar, Mohammad Reza Tabandeh, Abdolhamid Habibi
The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775745/analysis-of-neurotrophic-and-antioxidant-factors-related-to-midbrain-dopamine-neuronal-loss-and-brain-inflammation-in-the-cerebrospinal-fluid-of-the-elderly
#12
Angel Martin-de-Pablos, Antonio Córdoba-Fernández, Emilio Fernández-Espejo
Midbrain dopamine neuronal loss and neuroinflammation are two phenomena that are associated with brain senescence. Neurotrophic factor changes and oxidative stress could subserve these phenomena. Aging-related brain changes can be well monitored through the cerebrospinal fluid (CSF). The objective was to analyze neurotrophic and oxidative parameters that could be related to midbrain dopamine neuronal loss or brain inflammation in the CSF of elderly subjects: 1) levels of the dopaminotrophic factors BDNF, GDNF, persephin, and neurturin, 2) levels of the proinflammatory factors TGFβ1 and TGFβ2 ; 3) activity of main antioxidant enzymes (catalases, glutathione-peroxidase, glutathione-reductase, glutathione-S-transferases, peroxirredoxins, and superoxide-dismutases), 4) ferritin content, antioxidant protein which reduces reactive free iron, and 5) antioxidant potential of the cerebrospinal fluid...
May 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#13
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775542/exercise-and-circulating-bdnf-mechanisms-of-release-and-implications-for-the-design-of-exercise-interventions
#14
Jeremy James Walsh, Michael E Tschakovsky
Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism underlying these exercise-induced benefits and is the subject of considerable attention in the exercise-brain health literature...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29775479/acute-intermittent-hypoxia-and-rehabilitative-training-following-cervical-spinal-injury-alters-neuronal-hypoxia-and-plasticity-associated-protein-expression
#15
Atiq Hassan, Breanna M Arnold, Sally Caine, Behzad M Toosi, Valerie M K Verge, Gillian D Muir
One of the most promising approaches to improve recovery after spinal cord injury (SCI) is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH, brief exposures to reduced O2 levels alternating with normal O2 levels) initiates plasticity in respiratory systems and has been shown to improve recovery in respiratory and non-respiratory spinal systems after SCI in experimental animals and humans. Although the mechanism by which AIH elicits its effects after SCI are not well understood, AIH is known to alter protein expression in spinal neurons in uninjured animals...
2018: PloS One
https://www.readbyqxmd.com/read/29774769/serum-mediated-activation-of-bone-marrow-derived-mesenchymal-stem-cells-in-ischemic-stroke-patients-a-novel-preconditioning-method
#16
Gyeong Joon Moon, Yeon Hee Cho, Dong Hee Kim, Ji Hee Sung, Jeong Pyo Son, Sooyoon Kim, Jae Min Cha, Oh Young Bang
Stroke induces complex and dynamic, local and systemic changes including inflammatory reactions, immune responses, and repair and recovery processes. Mesenchymal stem cells (MSCs) have been shown to enhance neurological recovery after stroke. We hypothesized that serum factors play a critical role in the activation of bone marrow (BM) MSCs after stroke such as by increasing proliferation, paracrine effects, and rejuvenation. Human MSCs (hMSCs) were grown in fetal bovine serum (FBS), normal healthy control serum (NS), or stroke patient serum (SS)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29774144/effects-of-passage-and-cryopreservation-on-neurotrophic-factor-secretion-from-choroid-plexus-epithelial-cells
#17
Feng Zhao, Xiao-Yan Ding, Feng Wu, Xiao-Hui Li, Yu-Huan Li, Sheng-Li Huang
The aim of the present study was to evaluate the effects of passage and cryopreservation of choroid plexus epithelial cells on their secretion of neurotrophic factors. Choroid plexus epithelial cells were cryopreserved and thawed following primary culture or passage cultured for up to two passages. The supernatant of primary, first/second passage and cryopreserved-thawed choroid plexus epithelial cells was collected when cells reached 80-90% confluence. ELISA was used to quantify brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF) levels in the cell supernatant...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29773978/effects-of-sevoflurane-exposure-during-mid-pregnancy-on-learning-and-memory-in-offspring-rats-beneficial-effects-of-maternal-exercise
#18
Ziyi Wu, Xingyue Li, Yi Zhang, Dongyi Tong, Lili Wang, Ping Zhao
Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29773102/-over-expression-of-bdnf-inhibits-angiotensin-ii-induced-apoptosis-of-cardiomyocytes-in-sd-rats
#19
Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong Li
Objective To investigate the role and molecular mechanism of brain-derived neurotrophic factor (BDNF) against the process of cardiomyocyte hypertrophy and apoptosis. Methods Cardiomyocyte hypertrophy were estabolished by angiotensin II (Ang II) in neonatal cardiomyocytes in vitro and incomplete ligature of abdominal aorta of SD rats in vivo. BDNF over-expressing recombinant vector pcDNA5-BDNF was transfected into cardiomyocytes by liposomes. Immunofluorescence staining was used to detect the effect of BDNF transfection on the surface area of myocardial cells...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29772442/cognitive-and-hippocampus-biochemical-changes-following-sleep-deprivation-in-the-adult-male-rat
#20
Ebrahim Nabaee, Mahnaz Kesmati, Ali Shahriari, Lotfollah Khajehpour, Mozhgan Torabi
Sleep deprivation (SD) influences physiological processes such as cognitive function. The balance of oxidant and antioxidant markers, neurotrophic factors and magnesium are affected by sleep deprivation but there is no difference between pre and post training sleep deprivation. This study was designed to investigate memory retrieval and biochemical factors such as oxidant and antioxidant enzyme, brain-derived neurotrophic factor (BDNF) and magnesium levels in the hippocampus following pre and post-training sleep deprivation...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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