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Hyperviscosity syndrome

Subina Narang, Panchmi Gupta, Anuj Sharma, Sunandan Sood, Anshu Palta, Shilpa Goyal
Central retinal vein occlusion (CRVO) is a common pathology of the retinal vasculature. Patients with CRVO usually present with a drop in visual acuity. The condition bears no specific therapy; treatment is aimed at the management of potentially blinding complications, of which there are many. With majority of cases being unilateral, bilateral CRVO is usually associated with an underlying systemic illness such as a hyperviscosity syndrome. Here, we present a case of a patient, who presented with a bilateral drop in vision diagnosed as bilateral CRVO on ophthalmic evaluation...
July 2016: Middle East African Journal of Ophthalmology
Suvro Sankha Datta, Somnath Mukherjee, Biplabendu Talukder, Prasun Bhattacharya
Therapeutic plasma exchange (TPE) is a conjunctive modality of treatment along with rituximab to decrease paraproteinemia associated with hyperviscosity. Here we narrate our experience in treating a diagnosed case of Waldenstrom's macroglobulinemia in 70 years old male patient with moderate anemia and severe features of hyperviscosity syndrome by serial TPE and rituximab combined with bortezomib. The patient was relieved of his symptoms after initial two TPE procedures performed on alternative day. However he again developed signs and symptoms of the disease within 6 weeks following second TPE and starting of rituximab (375 mg/m(2) weekly for 4 weeks) therapy with bortezomib...
June 2016: Indian Journal of Hematology & Blood Transfusion
Pawani Sachar, Kumar Rajamani
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially fatal complication of medical ovarian stimulation. Uncommonly, it is associated with thromboembolic complications with venous thrombosis being more common than arterial thromboembolic events. We present a case of cerebral infarction in the setting of severe OHSS secondary to in vitro fertilization treatment with no residual neurological deficits. MATERIALS AND METHODS: We also performed a review of previously published ischemic cerebral infarction and cerebral venous sinus thrombosis (CVST) cases associated with OHSS to evaluate common patterns in presentations, commonly affected central nervous system sites, trends for therapeutic options in these cases, and outcomes...
September 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Jorge J Castillo, Ramon Garcia-Sanz, Evdoxia Hatjiharissi, Robert A Kyle, Xavier Leleu, Mary McMaster, Giampaolo Merlini, Monique C Minnema, Enrica Morra, Roger G Owen, Stephanie Poulain, Marvin J Stone, Constantine Tam, Marzia Varettoni, Meletios A Dimopoulos, Steven P Treon, Efstathios Kastritis
The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop consensus recommendations for the diagnosis and initial evaluation of patients with WM. In this document, we present the results of the deliberations that took place to address these issues...
October 2016: British Journal of Haematology
Christine H Yang, Saurabh Gombar, Clare J Twist, Dita Gratzinger, Carlos O Esquivel, Audrey H Lau
No abstract text is available yet for this article.
May 26, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Daniel Halperin, Simon Hallam, Athar Haroon, Tom Butler, Samir Agrawal
Waldenstrom's macroglobulinaemia is the most commonly reported subtype of lymphoplasmacytic lymphoma (LPL); it is characterised by IgM secretion. Neurological complications are common usually as a result of hyperviscosity. In rare cases, cells can infiltrate the central nervous system; this is known as Bing-Neel syndrome. We report the case of a 57-year-old male with lymphoplasmacytic lymphoma of the IgG-subtype with neurological symptoms and the consequent finding of lymphoplasmacytoid cells in his cerebrospinal fluid as well as deposits on MRI and PET-CT imaging...
2016: Case Reports in Hematology
Christopher J Borgman
Multiple myeloma is a neoplastic plasma-cell disorder resulting from malignant plasma cells in the bone marrow. It can cause a hyperviscosity syndrome secondary to the paraproteinaemia associated with the disease. The increased hyperviscosity can lead to retinal vein occlusions and other ocular problems that may challenge clinicians. In patients with multiple myeloma and hypertension and/or diabetes mellitus, retinal changes appear similar and changes due to one disease or the other may be difficult to determine...
July 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Emanuele Cecchi, Guido Parodi, Serena Fatucchi, Paola Angelotti, Cristina Giglioli, Anna Maria Gori, Brunella Bandinelli, Benedetta Bellandi, Elena Sticchi, Ilaria Romagnuolo, Lucia Mannini, David Antoniucci, Rosanna Abbate
Takotsubo cardiomyopathy (TTC) pathophysiology is still unclear. A transient intracoronary thrombosis dissolved at the time of angiography has been hypothesized. We aimed to evaluate the prevalence of thrombophilic disorders in TTC patients. In 75 TTC women, 75 age- and sex-matched acute coronary syndrome (ACS) patients, both enrolled during the acute phase, and in 75 control subjects, we compared the prevalence of congenital and acquired thrombophilic alterations and the values of clotting and endothelial activation biomarkers...
September 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Daniela Proverbio, Eva Spada, Roberta Perego, Giada Bagnagatti de Giorgi
Serum hyperviscosity syndrome (HVS) was documented in two dogs with canine leishmaniasis (CanL) and seizures as the major clinical complaint. In both cases, laboratory abnormalities included mild non-regenerative anemia, thrombocytopenia, hypoalbuminemia, hyperproteinemia with monoclonal gammopathy, and marked serum hyperviscosity. CanL was diagnosed using cytology in one case and indirect immunofluorescence assay and conventional polymerase chain reaction in the second. Specific therapy with meglumine antimoniate and allopurinol(c) led to short-term remission in both dogs and normalization of serum viscosity...
March 2016: Journal of the American Animal Hospital Association
Gabriela Hernández-Molina, Paola Bermúdez-Bermejo
AIM: Increased serum viscosity is recognized in primary Sjögren's syndrome (pSS); however, a classic hyperviscosity syndrome (HVS) is rare. We compared the clinical and serological profile among three groups of pSS patients: (i) with HVS; (ii) with high serum viscosity (≥ 1.9 cP [centipoises]) but without HVS; and (iii) with normal viscosity (< 1.9 cP). METHODS: We identified four pSS patients with HVS and retrospectively assessed their clinical/serological features...
October 7, 2015: International Journal of Rheumatic Diseases
Ji-Bin Yin, Ying Li, Tiemin Liu, Rui-Tao Wang
BACKGROUND Gallstones are associated with dyslipidemia, metabolic syndrome, hyperinsulinemia, and carotid intima-media thickness, which all are related to hyperviscosity. Therefore, this study aimed to examine the associations between blood viscosity and gallstones. MATERIAL AND METHODS We investigated the associations between blood viscosity and gallstones in a study conducted in middle-aged subjects. RESULTS Among 849 enrolled patients, 421 (49.6%) had gallstone disease. Compared with control subjects, whole-blood viscosity (WBV) levels were increased in patients with gallstones...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
I Lippi, F Perondi, S J Ross, V Marchetti, G Lubas, G Guidi
A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment. These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome...
2015: Open veterinary journal
Yandi Chen, Lifeng An, Guanghua Jin
To study the pathogenesis of hearing loss in chronic myelogenous leukemia (CML). To report one case with CML whose first sign was sudden unilateral hearing loss. Sudden hearing loss in CML was presented with dramatic high white blood cell count in peripheral blood. Some cases of sudden hearing loss in CML may be improved or even cured by leukapheresis and intrathecal chemotherapy. The proposed pathogenesis for deafness in leukemia is due to hyperleukocytosis, hyperviscosity syndrome, leukemic infiltration and the inner ear hemorrhage...
May 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Rithwick Rajagopal, Rajendra S Apte
The presence of retinal vasculopathy in the absence of typical predisposing factors should suggest a possible underlying hematologic abnormality. In such cases, a systemic investigation may reveal a potentially fatal hypercoagulability or hyperviscosity syndrome. Retinal vein occlusion is the most commonly encountered ophthalmic finding in such syndromes; however, abnormalities of the arterial system, the choroid, and the macula are also possible. Visual symptoms may be the only manifestation of the underlying process, making timely diagnosis by the ophthalmologist critical for both treatment and thrombotic prophylaxis...
March 2016: Survey of Ophthalmology
Yoshitaka Kikukawa, Ayako Yamamura-Fujimoto, Shinya Endo, Eiko Miyagawa, Yawara Kawano, Shikiko Ueno, Hiroaki Mitsuya, Hiroyuki Hata, Yutaka Okuno
Waldenström's macroglobulinemia (WM) is a neoplasm of lymphoplasmacytic cells that produces monoclonal IgM protein. Although hyperviscosity syndrome is a common feature of WM, central nervous system (CNS) involvement in WM is rare and is known as Bing-Neel syndrome. A 60-year-old woman was referred to our hospital with bed-bound polyneuropathy, edema, splenomegaly, IgM-λ-type monoclonal protein and CD20-positive lymphocyte infiltration in the bone marrow. She was diagnosed with WM accompanying POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) and was treated with rituximab and thalidomide...
2015: Journal of Clinical and Experimental Hematopathology: JCEH
M B Plotnikov, A S Vasil'ev, O I Aliev, L N Zibareva
Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity. Under conditions of this model of high blood viscosity syndrome in Brattleboro rats, Lychnis chalcedonica L. extract (150 mg/kg) administered intragastrically for 10 days exhibited hemorheological activity by modulating macro- (plasma viscosity, fibrinogen concentration) and microrheological (erythrocyte aggregation and deformability parameters...
September 2015: Bulletin of Experimental Biology and Medicine
Tânia Santos, Susana Machado, Vítor Sousa, Mário Campos
Renal involvement in Waldenström's macroglobulinaemia (WM) is very unusual when compared to multiple myeloma. We report a case of a patient who developed anuric acute kidney injury secondary to cast nephropathy, dependent on high-flux haemodialysis. Complementary study revealed the presence of blood IgM monoclonal gammopathy and a massive bone marrow lymphoplasmacytic infiltration. There were no osteolytic lesions and no clinical signs/symptoms of hyperviscosity syndrome. The diagnosis of WM was established and a dexamethasone plus cyclophosphamide regime was started, in addition to plasmapheresis...
2015: BMJ Case Reports
Dan-dan Pan, Jian-li Gao, Su-hong Chen, Qi-jing Tang, En-wei Zhu, Gui-yuan Lv
OBJECTIVE: To observe the effect of composite factors, like long-term high-salt & fat diet and alcohol abuse on blood viscosity and blood pressure in rats, and compare with a model induced by high molecular dextran, in order to build a chronic hyperviscosity aminal model which is similar to human hyperviscosity in clinic and lay a foundation for efficacy evaluation on traditional Chinese medicines. METHOD: Male SD rats were randomly divided into the normal group, the high molecular dextran (HMD) group and the high salt & fat and alcohol (HSFA) group...
April 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Salvatore Scarpato, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Antonio Brucato, Luca Quartuccio, Maurizio Pietrogrande, Giuseppe Monti, Massimo Galli
Cryoglobulinaemic syndrome (CS) includes clinical signs and symptoms that range from the classic triad of Meltzer and Franklin (purpura, weakness and arthralgias) to multiple organ involvement, and it may be characterised by nociceptive or neuropathic pain. Both types of pain use the same pathways and neurotransmitters, but nociceptive pain has an adaptive system and biological function whereas neuropathic pain does not. Managing CS means dealing with often very different clinical patterns, activity and severity with the aim of preventing irreversible organ damage, reducing pain, improving the patients' quality of life and reducing social costs...
February 2015: Best Practice & Research. Clinical Rheumatology
Krzysztof Woźniak, Elżbieta Urbanowska, Emilian Snarski
Plasmapheresis also known as a therapeutic plasma exchange (TPE) is a procedure of plasma removal with it's ineligible plasma's component. Usually it is a supportive measure used simultaneously with the treatment, but in a few diseases, e.g. in trombotictrombocytopenic purpura (TTP), it is a first-choice treatment. During the plasmapheresis plasma is mostly replaced by 20% solution of albumin or combination of 20% solution of albumin and 0.9% solution of NaCl, however in some diseases fresh frozen plasma (FFP) is used...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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