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https://www.readbyqxmd.com/read/28933536/a-bimetallic-silver-neodymium-theranostic-nanoparticle-with-multimodal-nir-mri-ct-imaging-and-combined-chemo-photothermal-therapy
#1
Sandeep K Mishra, S Kannan
An engineered metallic nanostructure is an excellent candidate for "theranosis" of cancer, having intrinsic properties of multimodal imaging and therapy. Toward this target, the development of silver-neodymium bimetallic nanoparticles (Ag-Nd BNPs) via microwave-assisted polyol synthesis is presented. The resultant Ag-Nd BNPs exhibit good monodispersity with average size of 10 nm, fluorescence in the near-infrared (NIR) region, and magnetic properties. The Ag-Nd BNPs also validate MRI, CT, and NIR trimodal imaging ability and enunciate valuable temperature response upon irradiation under a NIR laser...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933294/biodegradable-black-phosphorus-based-nanomaterials-in-biomedicine-theranostic-applications
#2
Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang, Huiqing Zhong, Zhouyi Guo
Ascribe to the unique two-dimensional planar nanostructure with exceptional physical and chemical properties, black phosphorous (BP) as the emerging inorganic two-dimensional nanomaterial with high biocompatibility and degradability has been becoming one of the most promising materials of great potentials in biomedicine. The exfoliated BP sheets possess ultra-high surface area available for valid bio-conjugation and molecular loading for chemotherapy. Utilizing the intrinsic near-infrared optical absorbance, BP-based photothermal therapy in vivo, photodynamic therapy and biomedical imaging has been realized, achieving unprecedented anti-tumor therapeutic efficacy in animal experiments...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933283/organic-nanotheranostics-for-photoacoustic-imaging-guided-phototherapy
#3
Houjuan Zhu, Chen Xie, Peng Chen, Kanyi Pu
Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as one of the avant-garde strategies for cancer treatment. Photoacoustic (PA) imaging is a new hybrid imaging modality that shows great promise for real-time in vivo monitoring of biological processes with deep tissue penetration and high spatial resolution. To enhance therapeutic efficiency and reduce side effects, it is necessary to explore the combination of cancer therapy and diagnosis. Nanotheranostics composed of PTT/PDT and PA imaging are emerging to provide unprecedented advantages in accelerating cancer theranostics...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28930346/one-pot-solution-synthesis-of-shape-controlled-copper-selenide-nanostructures-and-their-potential-applications-in-photocatalysis-and-photothermal-therapy
#4
Xianwen Wang, Zhaohua Miao, Yan Ma, Huajian Chen, Haisheng Qian, Zhengbao Zha
Developing a facile and reliable method for the fabrication of transition metal chalcogenides is a vital and endless pursuit of scientific and technological disciplines. In this work, we develop a one-pot solution approach to obtain copper selenide nanostructures with different morphologies and crystal structures (Cu2Se nanoparticles, CuSe nanoplates and CuSe2 nanosheets). In comparison to previously reported methods, our method did not use expensive and very toxic raw materials. After detailed studies of reaction conditions, including temperature, reaction time, and feeding amount of surfactants and precursors, we found that the feeding ratio of precursors played a key role in the crystal structures and morphologies of the final products...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28928385/dually-functioned-core-shell-nayf4-er-3-yb-3-nayf4-tm-3-yb-3-nanoparticles-as-nano-calorifiers-and-nano-thermometers-for-advanced-photothermal-therapy
#5
Yanqiu Zhang, Baojiu Chen, Sai Xu, Xiangping Li, Jinsu Zhang, Jiashi Sun, Hui Zheng, Lili Tong, Guozhu Sui, Hua Zhong, Haiping Xia, Ruinian Hua
To realize photothermal therapy (PTT) of cancer/tumor both the photothermal conversion and temperature detection are required. Usually, the temperature detection in PTT needs complicated instruments, and the therapy process is out of temperature control in the present investigations. In this work, we attempt to develop a novel material for achieving both the photothermal conversion and temperature sensing and control at the same time. To this end, a core-shell structure with NaYF4:Er(3+)/Yb(3+) core for temperature detection and NaYF4:Tm(3+)/Yb(3+) shell for photothermal conversion was designed and prepared...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923735/pegylated-magnetic-prussian-blue-nanoparticles-asa-multifunctional-therapeutic-agent-for-combined-targeted-photothermal-ablation-and-ph-triggered-chemotherapy-of-tumour-cells
#6
Peng Xue, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang
Multifunctional nanoagents have become popular and valuable pharmaceuticals for effective cancer treatment. Moreover, there is an increasing tendency to develop therapeutic agents with excellent biocompatibility, high efficiency, specific targeting and combinatorial treatment effects. In this study, we proposed a facile technique to synthesize PEGylated (polyethylene glycol modified) magnetic Prussian blue (PB) nanoparticles with encapsulated doxorubicin (DOX), abbreviated as Fe3O4@PB/PEG/DOX NPs, for combined targeted photothermal ablation and pH-triggered chemotherapy of tumour cells...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28919744/composite-iron-oxide-prussian-blue-nanoparticles-for-magnetically-guided-t1-weighted-magnetic-resonance-imaging-and-photothermal-therapy-of-tumors
#7
Shraddha S Kale, Rachel A Burga, Elizabeth E Sweeney, Zungho Zun, Raymond W Sze, Anthony Tuesca, J Anand Subramony, Rohan Fernandes
Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe3O4@GdPB) as a novel theranostic agent for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28917152/pegylated-thermosensitive-lipid-coated-hollow-gold-nanoshells-for-effective-combinational-chemo-photothermal-therapy-of-pancreatic-cancer
#8
Bijay Kumar Poudel, Biki Gupta, Thiruganesh Ramasamy, Raj Kumar Thapa, Shiva Pathak, Kyung Taek Oh, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Pancreatic cancer has extremely poor prognosis with an 85% mortality rate that results from aggressive and asymptomatic growth, high metastatic potential, and rapid development of resistance to already ineffective chemotherapy. In this study, plasmonic hollow gold nanoshells (GNS) coated with PEGylated thermosensitive lipids were prepared as an efficient platform to ratiometrically co-deliver two drugs, bortezomib and gemcitabine (GNS-L/GB), for combinational chemotherapy and photothermal therapy of pancreatic cancer...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28915497/pegylated-polydopamine-coated-magnetic-nanoparticles-for-combined-targeted-chemotherapy-and-photothermal-ablation-of-tumour-cells
#9
Peng Xue, Lihong Sun, Qian Li, Lei Zhang, Jinhong Guo, Zhigang Xu, Yuejun Kang
The integration of multifunctional therapeutic capabilities into a single nanosystem has attracted much attention for use as an efficient cancer therapy. However, developing biocompatible therapeutic nano-agents with desirable safety, efficiency, targeting, and synergistic effects remains challenging. Herein, we designed a class of multifunctional PEGylated magnetic nanoparticles (NPs) with a core-shell structure and polydopamine (PDA) coating, which were loaded with the anticancer drug doxorubicin (DOX) for simultaneous targeted chemotherapy and photothermal ablation of tumour cells...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28906574/efficacy-and-safety-of-a-novel-picosecond-laser-using-combination-of-1%C3%A2-064-and-595%C3%A2-nm-on-patients-with-melasma-a-prospective-randomized-multicenter-split-face-2-hydroquinone-cream-controlled-clinical-trial
#10
Young-Jun Choi, Jae-Hui Nam, Jung Yup Kim, Joon Hong Min, Kui Young Park, Eun Jung Ko, Beom Joon Kim, Won-Serk Kim
BACKGROUND AND OBJECTIVES: Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone...
September 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28900512/aptavalve-gated-mesoporous-carbon-nanospheres-image-cellular-mucin-and-provide-on-demand-targeted-drug-delivery
#11
Chengyi Li, Min Qian, Shanshan Wang, Huilin Jiang, Yilin Du, Jianxin Wang, Weiyue Lu, Niren Murthy, Rongqin Huang
In this report, we present a mesoporous carbon nanosphere that can target drugs to tumors and image tumor biomarkers. A single-strand DNA (P0 aptamer) aptavalve was capped on the surface of doxorubicin-loaded oxide mesoporous carbon nanospheres (Dox-OMCN-P0) through π-π stacking for real-time imaging-guided on-demand targeting drug delivery. The Dox-OMCN-P0 could not only realize the detection of MUC1 tumor marker with a wide linear range (0.1 - 10.6 μmol/L) and a low detection limit (17.5 nmol) based on different apparatuses, but also achieve in-situ targeting imaging of cellular MUC1 concentration in vitro and in vivo via "off-on" fluorescence biosensing...
2017: Theranostics
https://www.readbyqxmd.com/read/28898464/functionalized-ultrasmall-fluorinated-graphene-with-high-nir-absorbance-for-controlled-delivery-of-mixed-anticancer-drugs
#12
Peiwei Gong, Qiao Zhao, Dujuan Dai, Shumiao Zhang, Zhenzhen Tian, Lu Sun, Jiashuo Ren, Zhe Liu
Fluorinated graphene (FG) possess distinctively novel properties different from graphene and is suitable for many biomedical applications. However, the hydrophobic nature and inert property of FG are limiting its further application as biological materials. Here we show the preparation of nanosized FG (60 nm) that exhibits high NIR absorbance for photothermal therapy. In order to make it stable in physiological solutions, FG is enriched with oxygen and followed by covalent binding with chitosan as a novel pH-responsive nanocarrier...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28895715/a-pompon-like-runps-based-theranostic-nanocarrier-system-with-stable-photoacoustic-imaging-characteristic-for-accurate-tumor-detection-and-efficient-phototherapy-guidance
#13
Gengjia Chen, Meng Xu, Shuang Zhao, Jing Sun, Qianqian Yu, Jie Liu
Even though numerous therapeutic methods exist for cancer treatment, many fail to achieve ideal outcomes or have severe side effects. Here, we describe a theranostic nanocarrier system with improved tumor vasculature detection and tumor margin quantification that increases the accuracy and guidance efficiency of phototherapy. Novel pompon-like RuNPs with superb photothermal properties and high encapsulation efficiency were first synthesized via the polyol reducing method. Based on these RuNPs, we then developed a multifunctional theranostic system, pRu-pNIPAM@RBT, composed of poly(Nisopropylacrylamide) as the thermal-response switch and of [Ru(bpy)2(tip)]2+ as the photosensitizer of PDT and the contrast agent of biomedical imaging...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28894365/photothermal-ablation-of-inflammatory-breast-cancer-tumor-emboli-using-plasmonic-gold-nanostars
#14
Bridget M Crawford, Ronnie L Shammas, Andrew M Fales, David A Brown, Scott T Hollenbeck, Tuan Vo-Dinh, Gayathri R Devi
Inflammatory breast cancer (IBC) is rare, but it is the most aggressive subtype of breast cancer. IBC has a unique presentation of diffuse tumor cell clusters called tumor emboli in the dermis of the chest wall that block lymph vessels causing a painful, erythematous, and edematous breast. Lack of effective therapeutic treatments has caused mortality rates of this cancer to reach 20%-30% in case of women with stage III-IV disease. Plasmonic nanoparticles, via photothermal ablation, are emerging as lead candidates in next-generation cancer treatment for site-specific cell death...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28892614/realization-of-red-plasmon-shifts-up-to-900-nm-by-agpd-tipping-elongated-au-nanocrystals
#15
Xingzhong Zhu, Hang Kuen Yip, Xiaolu Zhuo, Ruibin Jiang, Jianli Chen, Xiao-Ming Zhu, Zhi Yang, Jianfang Wang
The synthesis of metal nanostructures with plasmon wavelengths beyond ~1000 nm is strongly desired, especially for those with small sizes. Herein we report on a AgPd-tipping process on Au nanobipyramids with the resultant red plasmon shifts reaching up to ~900 nm. The large red plasmon shifts are ascribed to the deposition of the metal at the tips of Au nanobipyramids, which is verified by electrodynamic simulations. The method has been successfully applied to Au nanobipyramids and nanorods with different longitudinal dipolar plasmon wavelengths, demonstrating that the plasmon wavelengths of these Au nanocrystals can be extended to the entire near-infrared region...
September 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28892609/molecular-engineering-of-conjugated-polymers-for-biocompatible-organic-nanoparticles-with-highly-efficient-photoacoustic-and-photothermal-performance-in-cancer-theranostics
#16
Bing Guo, Zonghai Sheng, Dehong Hu, Anran Li, Shidang Xu, Purnima Naresh Manghnani, Chengbo Liu, Lin Guo, Hairong Zheng, Bin Liu
Conjugated polymer nanoparticles (CP NPs) are emerging candidates of "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs with highly efficient PA and PTT performance. Herein, by designing CP1, CP2, and CP3 using different electron acceptors (A) and a planar electron donor (D), we demonstrate how the D-A strength affects their absorption, emission, extinction coefficient, and ultimately PA and PTT performance...
September 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28892360/in-vivo-imaging-guided-photothermal-photoacoustic-synergistic-therapy-with-bioorthogonal-metabolic-glycoengineering-activated-tumor-targeting-nanoparticles
#17
Lihua Du, Huan Qin, Teng Ma, Tao Zhang, Da Xing
Developing multifunctional phototheranostics with nanoplatforms offers promising potential for effective eradication of malignant solid tumors. In this study, we develop a multifunctional phototheranostic by combining photothermal therapy (PTT) and photoacoustic therapy (PAT) based on a tumor-targeting nanoagent (DBCO-ZnPc-LP). The nanoagent DBCO-ZnPc-LP was facilely prepared by self-assembling of a single lipophilic near-infrared (NIR) dye zinc(II)-phthalocyanine (ZnPc) with a lipid-poly(ethylene glycol) (LP) and following modified further with dibenzyl cyclootyne (DBCO) for introducing the two-step chemical tumor-targeting strategy based on metabolic glycoengineering and click chemistry...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28890109/nir-light-induced-tumor-phototherapy-using-photo-stable-icg-delivery-system-based-on-inorganic-hybrid
#18
Huijuan Zhang, Xiaoge Zhang, Xing Zhu, Jianjiao Chen, Qianqian Chen, Hongling Zhang, Lin Hou, Zhenzhong Zhang
NIR responsive inorganic hybrid (Ti@GO) was synthesized. It could absorb NIR light and convert it into local hyperthermia and ROS synchronously. Ti@GO was firstly developed as photosensitizer and photothermal agent to realize tumor PTT and PDT. For anti-tumor application, HA was grafted on Ti@GO simultaneously as water solubility improver and tumor targeting moiety. ICG was chose as model drug. Results demonstrated HA-Ti@GO could remarkably improve ICG stability and drug accumulation in 4 T1 cells, to enhance tumor phototherapy efficiency and reduce light-associated side effects...
September 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28887972/dual-targeting-hyaluronic-acid-rgd-mesoporous-silica-coated-gold-nanorods-for-chemo-photothermal-cancer-therapy
#19
Huimin Zhou, Haixing Xu, Xin Li, Yahui Lv, Tian Ma, Shiying Guo, Zhijun Huang, Xiaobing Wang, Peihu Xu
This work reports a multifunctional nanoplatform (GNRs@mSiO2-HA-RGD) by conjugating targeting ligand hyaluronic acid (HA) and RGD with mesoporous silica-coated gold nanorods (GNRs@mSiO2) for dual-targeted chemo-photothermal therapy. Doxorubicin hydrochloride (DOX) was used as the model drug to investigate the drug loading, in vitro drug release profiles and cell evaluation. The nanoplatform has demonstrated a good photothermal effect and excellent drug loading capacity of about 20.16%. It also had pH-enzyme sensitive and NIR-triggered drug release properties...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28883725/gold-nanoparticles-enlighten-the-future-of-cancer-theranostics
#20
REVIEW
Jianfeng Guo, Kamil Rahme, Yan He, Lin-Lin Li, Justin D Holmes, Caitriona M O'Driscoll
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses...
2017: International Journal of Nanomedicine
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