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photothermal therapy

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https://www.readbyqxmd.com/read/28640986/antimonene-quantum-dots-synthesis-and-application-as-near-infrared-photothermal-agents-for-effective-cancer-therapy
#1
Wei Tao, Xiaoyuan Ji, Xiaoding Xu, Mohammad Ariful Islam, Zhongjun Li, Si Chen, Phei Er Saw, Han Zhang, Zameer Bharwani, Zilei Guo, Jinjun Shi, Omid Farokhzad
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28632263/fabrication-of-a-graphene-c60-nanohybrid-via-%C3%AE-cyclodextrin-host-guest-chemistry-for-photodynamic-and-photothermal-therapy
#2
Zhen Hu, Cheng Wang, Feng Zhao, Xirong Xu, Shuhong Wang, Long Yu, Dayu Zhang, Yudong Huang
The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C60 with graphene via host-guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising γ-cyclodextrin (γ-CD) at its surface was assembled via π-π interaction, creating hybrid structures with drug storage and tumor targeting properties. This γ-CD-modified graphene (GO-FA/Py-γ-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-γ-CD/C60 nanohybrid...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28630340/enhancing-t1-magnetic-resonance-imaging-contrast-with-internalized-gadolinium-iii-in-a-multilayer-nanoparticle
#3
Valeria S Marangoni, Oara Neumann, Luke Henderson, Caterina C Kaffes, Hui Zhang, Runmin Zhang, Sandra Bishnoi, Ciceron Ayala-Orozco, Valtencir Zucolotto, James A Bankson, Peter Nordlander, Naomi J Halas
Multifunctional nanoparticles for biomedical applications have shown extraordinary potential as contrast agents in various bioimaging modalities, near-IR photothermal therapy, and for light-triggered therapeutic release processes. Over the past several years, numerous studies have been performed to synthesize and enhance MRI contrast with nanoparticles. However, understanding the MRI enhancement mechanism in a multishell nanoparticle geometry, and controlling its properties, remains a challenge. To systematically examine MRI enhancement in a nanoparticle geometry, we have synthesized MRI-active Au nanomatryoshkas...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629893/a-new-nir-triggered-dox-and-icg-co-delivery-system-for-enhanced-multidrug-resistant-cancer-treatment-through-simultaneous-chemo-photothermal-photodynamic-therapy
#4
Yanna Yu, Zhipeng Zhang, Yun Wang, Hao Zhu, Fangzhou Li, Yuanyuan Shen, Shengrong Guo
It is a great challenge to combat multidrug resistant (MDR) cancer effectively. To address this issue, we developed a new near-infrared (NIR) triggered chemotherapeutic agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG) co-release system by aid of NIR induced photothermal effect of gold nanocages (AuNCs) and temperature sensitive phase-change property of 1-tetradecanol at its melting point of 39°C, which could simultaneously exerted chemo/photothermal/photodynamic treatment on MDR human breast cancer MCF-7/ADR cells...
June 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28629031/near-infrared-persistent-luminescence-phosphors-znga-2-o-4-cr-3-as-an-accurately-tracker-to-photothermal-therapy-in-vivo-for-visual-treatment
#5
Hongbin Chen, Bin Zheng, Chao Liang, Li Zhao, Ying Zhang, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Hanjie Wang, Jin Chang
The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGa2O4:Cr(3+) (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629007/upconverting-and-persistent-luminescent-nanocarriers-for-accurately-imaging-guided-photothermal-therapy
#6
Peiqi Zhao, Wei Ji, Shiyong Zhou, Lihua Qiu, Lanfang Li, Zhengzi Qian, Xianming Liu, Huilai Zhang, Xuchen Cao
The fluorescence-guided photothermal therapy (FPTT) has great potential in cancer treatment. However, the conventional FPTT has to be stimulated by external light, which tends to increase background noise and leads to the inaccurate infrared light irradiation for PTT. In this study, upconverting and persistent luminescent nanocarriers (UPLNs) loaded mesoporous silica nanoparticles (UPLNs@mSiO2) were first designed to solve the problem mentioned above. The UPLNs cores can effectively reduce the short-lived autofluorescence interference by exerting the delay time between signal acquisition and pulsed excitation light...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628998/a-facile-fabrication-of-silk-mos2-hybrids-for-photothermal-therapy
#7
Zhao Li, Yuhong Yang, Jinrong Yao, Zhengzhong Shao, Xin Chen
Photothermal therapy, due to its safety and effectiveness, has attracted tremendous interest in the area of cancer treatment in recent few decades. The emerging of two-dimensional transition metal dichalcogenides has provided this promising therapy with a novel genus of nanomaterials. Herein, we present a facile one-step way to prepare a hybrid of regenerated silk fibroin (RSF) and molybdenum disulfide (MoS2) nanosheets simply by directly adding MoS2 dispersion into RSF aqueous solution to induce the self-assembly of silk protein on the surface of MoS2 flakes...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28626897/ultrastable-near-infrared-conjugated-polymer-nanoparticles-for-dually-photoactive-tumor-inhibition
#8
Tao Yang, Ling Liu, Yibin Deng, Zhengqing Guo, Guobing Zhang, Zhishen Ge, Hengte Ke, Huabing Chen
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low-bandgap donor-acceptor (D-A)-type conjugated-polymer nanoparticles (CP-NPs) are developed to afford a highly efficient singlet-to-triplet transition and photothermal conversion for near-infrared (NIR) light-induced photodynamic (PDT)/photothermal (PTT) treatment. CP-NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28625050/new-insight-into-the-chemical-nature-of-the-plasmonic-nanostructures-synthesized-by-reduction-of-au-iii-with-sulfide-species
#9
Maria Ana Huergo, Lisandro J Giovanetti, Mario Sergio Moreno, Christoph M Maier, Felix G Requejo, Roberto C Salvarezza, Carolina Vericat
We have studied the products of the controversial synthesis of HAuCl4 with Na2S, which include gold nanostructures (Au NSs) that absorb in the near-infrared (NIR) and are highly promising for photothermal therapies and other nanomedical applications. From high resolution transmission electron microscopy, X-ray absorption spectroscopy and small angle X-ray scattering we have found that only metallic gold nanostructures are formed as a result of this synthesis, with no detectable amount of gold sulfide or other oxidized gold species that could account for the NIR absorption...
June 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28624725/multifunctional-polymeric-micelles-loaded-with-doxorubicin-and-poly-dithienyl-diketopyrrolopyrrole-for-near-infrared-light-controlled-chemo-phototherapy-of-cancer-cells
#10
Hui Liu, Kai Wang, Cangjie Yang, Shuo Huang, Mingfeng Wang
Polymeric micelles loaded with multiple therapeutic modalities are important to overcome challenges such as drug resistance and improve the therapeutic efficacy. Here we report a new polymer micellar drug carrier that integrates chemotherapy and photothermal therapy in a single platform. Specifically, a narrow bandgap poly(dithienyl-diketopyrrolopyrrole) (PDPP) polymer was encapsulated together with a model anticancer drug doxorubicin (DOX) in the hydrophobic cores of polymeric micelles formed by Pluronic F127, an amphiphilic poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer...
June 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28621774/mesoporous-polydopamine-nanoparticles-with-co-delivery-function-for-overcoming-multidrug-resistance-via-synergistic-chemo-photothermal-therapy
#11
Yuxin Xing, Jixi Zhang, Feng Chen, Junjie Liu, Kaiyong Cai
Theranostic agents for combined chemo-photothermal therapy have attracted intensive interest in the treatment of multi-drug resistance (MDR) in cancer therapy. However, the development of simple theranostic agents as dual hosts for both heat and a high payload of chemotherapeutic agents remains a big challenge. Herein, mesoporous polydopamine nanoparticles (MPDA) were successfully developed with properties of a high payload of DOX (up to 2000 μg mg(-1)) and the drug efflux inhibitor TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate), as well as strong near-infrared absorption...
June 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28617486/ultra-high-loading-of-sinoporphyrin-sodium-in-ferritin-for-single-wave-motivated-photothermal-and-photodynamic-co-therapy
#12
Chao Huang, Chengchao Chu, Xiaoyong Wang, Huirong Lin, Junqing Wang, Yun Zeng, Wenzhen Zhu, Yi-Xiang J Wang, Gang Liu
In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation...
June 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28616966/magnetic-resonance-imaging-guided-multi-drug-chemotherapy-and-photothermal-synergistic-therapy-with-ph-and-nir-stimulation-release
#13
Jichun Yang, Yang Chen, Yu-Hao Li, Xue-Bo Yin
The combination of multi-drug chemotherapy and photothermal therapy (PTT) enhances cancer therapeutic efficacy. Herein, we develop a simple and smart pH/NIR dual-stimulus-responsive degradable mesoporous CoFe2O4@PDA@ZIF-8 sandwich nanocomposite. Mesoporous CoFe2O4 core acts as T2-weighted magnetic resonance (MR) imaging probe, PTT agent, and loading platform of hydrophilic doxorubicin (DOX). A polydopamine (PDA) layer is used to avoid the premature leakage of DOX before arriving at tumor site, enhance PTT efficiency, and facilitate the integration of ZIF-8 (a kind of metal-organic frameworks)...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28614069/pegylated-lipid-bilayer-wrapped-nano-graphene-oxides-for-synergistic-co-delivery-of-doxorubicin-and-rapamycin-to-prevent-drug-resistance-in-cancers
#14
Raj Kumar Thapa, Jeong Hoon Byeon, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Nano-graphene oxide (nGO) is a carbon allotrope studied for its potential as carrier for chemotherapeutic delivery and its photoablation effects. However, interaction of nGO with blood components and the subsequent toxicities warrant a hybrid system for effective cancer drug delivery. Combination chemotherapy aids in effective cancer treatment and prevention of drug resistance. Therefore, in this study, we attempted to prepare polyethylene glycosylated (PEGylated) lipid bilayer-wrapped nGO co-loaded with doxorubicin (DOX) and rapamycin (RAPA), GOLDR, for the prevention and treatment of resistant cancers...
June 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28613898/enhanced-phototherapy-by-nanoparticle-enzyme-via-generation-and-photolysis-of-hydrogen-peroxide
#15
Kaiwen Chang, Zhihe Liu, Xiaofeng Fang, Haobin Chen, Xiaoju Men, Ye Yuan, Kai Sun, Xuanjun Zhang, Zhen Yuan, Changfeng Wu
Light has been widely used for cancer therapeutics such as photodynamic therapy (PDT) and photothermal therapy (PTT). This paper describes a strategy called enzyme-enhanced phototherapy (EEPT) for cancer treatment. We constructed a nanoparticle platform by covalent conjugation of glucose oxidase (GOx) to small polymer dots (Pdots), which could be persistently immobilized into tumor. While the malignant tumors have high glucose uptake, the GOx efficiently catalyzes the glucose oxidation with simultaneous generation of H2O2...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28611005/bottom-up-synthesis-of-ws2-nanosheets-with-synchronous-surface-modification-for-imaging-guided-tumor-regression
#16
Shige Wang, Jiulong Zhao, Hailun Yang, Chenyao Wu, Fei Hu, Haizhou Chang, Guixiang Li, Dan Ma, Duowu Zou, Mingxian Huang
Two-dimensional transition metal dichalcogenides (TMDs) have been receiving great attention as NIR photothermal transducing agent in tumor photothermal therapy. Keeping in mind the low efficiency of the conventional top-down exfoliation method to produce 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS2 nanosheets, by hydrothermally treating the mixture solution of tetrathiotungstate and PVP...
June 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28605594/rational-design-of-branched-nanoporous-gold-nanoshells-with-enhanced-physico-optical-properties-for-optical-imaging-and-cancer-therapy
#17
Jibin Song, Xiangyu Yang, Zhen Yang, Lisen Lin, Yijing Liu, Zijian Zhou, Zheyu Shen, Guocan Yu, Yunlu Dai, Orit Jacobson, Jeeva Munasinghe, Bryant Yung, Gao-Jun Teng, Xiaoyuan Chen
Reported procedures on the synthesis of gold nanoshells with smooth surfaces have merely demonstrated efficient control of shell thickness and particle size, yet no branch and nanoporous features on the nanoshell have been implemented to date. Herein, we demonstrate the ability to control the roughness and nanoscale porosity of gold nanoshells by using redox-active polymer poly(vinylphenol)-b-(styrene) nanoparticles as reducing agent and template. The porosity and size of the branches on this branched nanoporous gold nanoshell (BAuNSP) material can be facilely adjusted by control of the reaction speed or the reaction time between the redox-active polymer nanoparticles and gold ions (Au(3+))...
June 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28600224/enhancement-of-transdermal-protein-delivery-by-photothermal-effect-of-gold-nanorods-coated-on-polysaccharide-based-hydrogel
#18
Aung Thu Haine, Yuki Koga, Yuta Hashimoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a useful and attractive method for protein therapy and dermal vaccination. However, this delivery method is restricted by the low permeability of the stratum corneum. The purpose of this study was to develop a transdermal delivery system for enhancement of protein permeability into the skin. First, we prepared a transparent gel patch made of polysaccharides with gold nanorods on the gel surface and fluorescein isothiocyanate-modified ovalbumin (FITC-OVA) inside. Next, the gel patch was placed on mouse skin to allow contact with the coated gold nanorods, and irradiated by a continuous-wave laser...
June 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28594019/recent-progress-in-the-biomedical-applications-of-polydopamine-nanostructures
#19
REVIEW
Rahila Batul, Tasnuva Tamanna, Abdul Khaliq, Aimin Yu
Polydopamine is a dark brown-black insoluble biopolymer produced by autoxidation of dopamine. Although its structure and polymerization mechanism have not been fully understood, there has been a rapid growth in the synthesis and applications of polydopamine nanostructures in biomedical fields such as drug delivery, photothermal therapy, bone and tissue engineering, and cell adhesion and patterning, as well as antimicrobial applications. This article is dedicated to reviewing some of the recent polydopamine developments in these biomedical fields...
June 8, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28593987/spaser-as-a-biological-probe
#20
Ekaterina I Galanzha, Robert Weingold, Dmitry A Nedosekin, Mustafa Sarimollaoglu, Jacqueline Nolan, Walter Harrington, Alexander S Kuchyanov, Roman G Parkhomenko, Fumiya Watanabe, Zeid Nima, Alexandru S Biris, Alexander I Plekhanov, Mark I Stockman, Vladimir P Zharov
Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots...
June 8, 2017: Nature Communications
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