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photothermal therapy

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https://www.readbyqxmd.com/read/29344592/ph-responsible-fluorescent-carbon-nanoparticles-for-tumor-selective-theranostics-via-ph-turn-on-off-fluorescence-and-photothermal-effect-in-vivo-and-in-vitro
#1
Eun Bi Kang, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Insik In, Ji Hoon Jeong, Sung Young Park
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable photothermal therapy (PTT) in vivo and in vitro. The fluorescent "off" of FNP-I was activated after reaching the cancer cell environment, where the zwitterionic compartment of FNP lost its hydrophobicity to induce PTT-mediated heat release of IR825 under NIR irradiation in the tumor...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29344312/an-endogenous-vaccine-based-on-fluorophores-and-multivalent-immunoadjuvants-regulates-tumor-micro-environment-for-synergistic-photothermal-and-immunotherapy
#2
Ling Li, Suleixin Yang, Linjiang Song, Yan Zeng, Tao He, Ning Wang, Chuan Yu, Tao Yin, Li Liu, Xiawei Wei, Qinjie Wu, Yuquan Wei, Li Yang, Changyang Gong
Recently, near-infrared (NIR) light-based photothermal therapy (PTT) has been widely applied in cancer treatment. However, in most cases, the tissue penetration depth of NIR light is not sufficient and thus photothermal therapy is unable to completely eradicate deep, seated tumors inevitably leading to recurrence of the tumor. Due to this significant limitation of NIR, improved therapeutic strategies are urgently needed. Methods: We developed an endogenous vaccine based on a novel nanoparticle platform for combinatorial photothermal ablation and immunotherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#3
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29344297/mesoporous-carbon-nanospheres-as-a-multifunctional-carrier-for-cancer-theranostics
#4
Libo Zhou, Ying Jing, Yubin Liu, Zhihe Liu, Duyang Gao, Haobin Chen, Weiye Song, Tao Wang, Xiaofeng Fang, Weiping Qin, Zhen Yuan, Sheng Dai, Zhen-An Qiao, Changfeng Wu
Optical nanomaterials with intense absorption in near-infrared (NIR) region hold great promise for biomedical applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). In this work, we report mesoporous carbon nanospheres (Meso-CNs) with broadband and intense absorption in the UV-Vis-NIR region (300-1400 nm) and explore their potential as a multifunctional platform for photoacoustic imaging and chemo-photothermal therapy. Methods: Meso-CNs were prepared by a "silica-assisted" synthesis strategy and characterized by transmission electron microscope and optical spectroscopy...
2018: Theranostics
https://www.readbyqxmd.com/read/29342359/semiconducting-photothermal-nanoagonist-for-remote-controlled-specific-cancer-therapy
#5
Xu Zhen, Chen Xie, Yuyan Jiang, Xiangzhao Ai, Bengang Xing, Kanyi Pu
Nanomedicines have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cancer cells because of utilization of the therapeutic agents that induce cell apoptosis from inner organelles. We herein report the development of semiconducting photothermal nanoagonists that can remotely and specifically initiate the apoptosis of cancer cells from cell membrane. The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally-responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29341583/tumor-catalytic-photothermal-therapy-with-yolk-shell-gold-carbon-nanozymes
#6
Lei Fan, Xiangdong Xu, Chunhua Zhu, Jie Han, Lizeng Gao, Juqun Xi, Rong Guo
Nanozymes, as a new generation of artificial enzymes, offer great opportunities in biomedical engineering and disease treatment. Synergizing the multiple intrinsic functions of nanozymes can improve their performance in biological systems. Here, we report a novel nanozyme with yolk-shell structure fabricated by combining a single gold nanoparticle core with a porous hollow carbon shell nanospheres (Au@HCNs). Au@HCNs exhibited enzyme-like activities similar to horseradish peroxidase and oxidase under an acidic environment, showing the ability of ROS generation...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29339567/erythrocyte-membrane-coated-gold-nanocages-for-targeted-photothermal-and-chemical-cancer-therapy
#7
Dao-Ming Zhu, Wei Xie, Yu-Sha Xiao, Meng Suo, Ming-Hui Zan, Qing-Quan Liao, Xue-Jia Hu, Li-Ben Chen, Bei Chen, Wen-Tao Wu, Li-Wei Ji, Hui-Ming Huang, Shi-Shang Guo, Xing-Zhong Zhao, Quan-Yan Liu, Wei Liu
Recently, red blood cell (RBC) membrane-coated nanoparticles have attracted much attention because of their excellent immune escapability; meanwhile, gold nanocages (AuNs) have been extensively used for cancer therapy due to their photothermal effect and drug delivery capability. The combination of the RBC membrane coating and AuNs may provide an effective approach for targeted cancer therapy. However, few reports have shown the utilization of combining these two technologies. Here, we design erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy...
January 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29339189/magnetic-nanoparticles-modified-porous-scaffolds-for-bone-regeneration-and-photothermal-therapy-against-tumors
#8
Jia-Wei Lu, Fan Yang, Qin-Fei Ke, Xue-Tao Xie, Ya-Ping Guo
For effectively treating tumor related-bone defects, design and fabrication of multifunctional biomaterials still remain a great challenge. Herein, we firstly fabricated magnetic SrFe12O19 nanoparticles modified-mesoporous bioglass (BG)/chitosan (CS) porous scaffold (MBCS) with excellent bone regeneration and antitumor function. The as-produced magnetic field from MBCS promoted the expression levels of osteogenic-related genes (OCN, COL1, Runx2 and ALP) and the new bone regeneration by activated BMP-2/Smad/Runx2 pathway...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29339061/dose-dependent-photochemical-photothermal-toxicity-of-indocyanine-green-based-therapy-on-three-different-cancer-cell-lines
#9
Mustafa Kemal Ruhi, Ayşe Ak Can, Murat Gülsoy
The Food and Drug Administration-approved Indocyanine Green can be used as a photosensitizer to kill cancer cells selectively. Although indocyanine green is advantageous as a photosensitizer in terms of strong absorption in the near-infrared region, indocyanine green-based cancer treatment is still not approved as a clinical method. Some reasons for this are aggregation at high concentrations, rapid clearance of the photosensitizer from the body, low singlet oxygen quantum yield, and the uncertainty concerning its action mechanism...
January 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29337533/localized-fe-ii-induced-cytotoxic-reactive-oxygen-species-generating-nano-system-for-enhanced-anticancer-therapy
#10
Yuxue Ding, Jiaxun Wan, Zihao Zhang, Fang Wang, Jia Guo, Changchun Wang
The anticancer therapy on basis of reactive oxygen species (ROS)-mediated cellular apoptosis has achieved great progress. However, this kind of theraputic strategy still faces some challenges such as light, photosensitizer and oxygen (O2) dependence. In this article, a ROS-mediated anticancer therapy independent of light, photosensitizer and oxygen was established based on a Fe2+-induced ROS-generating nano-system. First, artemisinin (ART) was loaded in porous magnetic supraparticles (MSP) by a nano-deposition method...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336463/protein-corona-in-drug-delivery-for-multimodal-cancer-therapy-in-vivo
#11
Eugenia Li Ling Yeo, Patricia Soo Ping Thong, Khee Chee Soo, James Chen Yong Kah
The protein corona is inevitably formed on nanoparticles (NPs) when they are introduced in vivo and has been associated with a reduction in targeting yield, immune recognition and rapid blood clearance, leading to poor tumor accumulation. We have recently shown that it is possible to exploit the protein corona for drug delivery by exploiting it for loading and triggering the release of a photosensitizer Chlorin e6 (Ce6) for simultaneous photodynamic (PDT) and photothermal therapy (PTT) in vitro. Here, we extended our previous in vitro studies to evaluate its effectiveness in vivo...
January 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29336170/nanoparticles-for-treatment-of-atherosclerosis-challenges-of-plasmonic-photothermal-therapy-in-translational-studies
#12
Alexander N Kharlamov, Ilya V Zubarev, Ekaterina V Shishkina, Vladimir Ya Shur
No abstract text is available yet for this article.
January 16, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29336140/synthesis-of-cisplatin-iv-prodrug-tethered-cufes2-nanoparticles-in-tumor-targeted-chemotherapy-and-photothermal-therapy
#13
Wubshet Mekonnen Girma, Shin-Hwa Tzing, Po-Jen Tseng, Chih-Ching Huang, Yong-Chien Ling, Jia-Yaw Chang
In this study, for the first time, CuFeS2 nanocrystals were successfully prepared through a facile noninjection-based synthetic strategy, by reacting Cu and Fe precursors with dodecanethiol in a 1-octadecene solvent. This one-pot noninjection strategy features easy handling, large-scale production, and high synthetic reproducibility. Following hyaluronic acid (HA) encapsulation, CuFeS2 nanocrystals coated with HA (CuFeS2@HA) not only readily dispersed in water and showed improved biocompatibility, but also possessed a tumor-specific targeting ability of cancer cells bearing the cluster determinant 44 (CD44) receptors...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29334363/macrophage-membrane-coated-iron-oxide-nanoparticles-for-enhanced-photothermal-tumor-therapy
#14
Qian-Fang Meng, Lang Rao, Minghui Zan, Ming Chen, Guang-Tao Yu, Xiaoyun Wei, Zhuhao Wu, Yue Sun, Shi Shang Guo, Xing-Zhong Zhao, Fu-Bing Wang, Wei Liu
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should own long blood circulation and active cancer targeting. Additionally, they should be innoxious and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting, and light-to-heat conversion capabilities...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29334186/natural-humic-acid-based-phototheranostic-agent
#15
Zhao-Hua Miao, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, Cheng-Yan Xu
Humic acids, a major constituent of natural organic carbon resources, are naturally formed through the microbial biodegradation of animal and plant residues. Due to numerous physiologically active groups (phenol, carboxyl, and quinone), the biomedical applications of humic acid have been already investigated across different cultures for several centuries or even longer. In this work, sodium humate, the sodium salt of humic acid, is explored as phototheranostic agent for light-induced photoacoustic imaging and photothermal therapy based on intrinsic absorption in the near-infrared region...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334184/ph-responsive-peg-doxorubicin-encapsulated-aza-bodipy-nanotheranostic-agent-for-imaging-guided-synergistic-cancer-therapy
#16
Dapeng Chen, Qianyun Tang, Jianhua Zou, Xiaoyan Yang, Wei Huang, Qi Zhang, Jinjun Shao, Xiaochen Dong
Synergistic cancer therapy is of great interest for multiple advantages, such as excellent targeting accuracy, low side effects, and enhanced therapeutic efficiency. Herein, a near-infrared photosensitizer aza-BODIPY (AB) with high singlet oxygen quantum yield (ΦΔ = 82%) is designed and synthesized. With Schiff's base obtained from condensation reaction between doxorubicin (DOX) and polyethylene glycol-benzaldehyde (PEG-CHO) as the polymer matrix, aza-BODIPY is encapsulated to afford hydrophilic nanoparticles (DAB NPs)...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334095/gd3-doped-mose2-nanosheets-used-as-a-theranostic-agent-for-bimodal-imaging-and-highly-efficient-photothermal-cancer-therapy
#17
Jiali Pan, Xufeng Zhu, Xu Chen, Yingyu Zhao, Jie Liu
Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd3+)-doped molybdenum selenide (MoSe2) nanosheets, and then using poly(ethylene glycol) (PEG) modification on the surface, MoSe2(Gd3+)-PEG nanosheets were obtained which had high stability in physiological solutions and showed no obvious toxicity in vivo. It revealed that Gd3+ used as a paramagnetic material for MoSe2(Gd3+)-PEG provided a strong contrast effect in magnetic resonance imaging, furthermore, the MoSe2 showed strong absorption in the near infrared region, and therefore, MoSe2(Gd3+)-PEG could be used as contrast agent for photoacoustic imaging (PAI)...
January 15, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29334090/supramolecular-photosensitizers-rejuvenate-photodynamic-therapy
#18
Xingshu Li, Songyi Lee, Juyoung Yoon
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT) has become a clinically promising approach for the treatment of a wide range of cancers and other diseases. However, the full potential of PDT has not been achieved thus far as a consequence of the lack of optimal photosensitizers (PSs) and/or smart transport/activation strategies. These problems, which unfortunately lie at the core of the PDT paradigm, include the oxygen reliance limits, the effect of PDT on hypoxic tumors, limitations of light penetration, and undesired skin photosensitization induced by "always on" PSs...
January 15, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29333689/2d-black-phosphorus-reinforced-3d-printed-scaffolds-a-stepwise-countermeasure-for-osteosarcoma
#19
Bowen Yang, Junhui Yin, Yu Chen, Shanshan Pan, Heliang Yao, Youshui Gao, Jianlin Shi
With the ever-deeper understanding of nano-bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29328618/highly-crystalline-multicolor-carbon-nanodots-for-dual-modal-imaging-guided-photothermal-therapy-of-glioma
#20
Min Qian, Yilin Du, Shanshan Wang, Chengyi Li, Huiling Jiang, Wei Shi, Jian Chen, Yi Wang, Ernst Wagner, Rongqin Huang
Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system (CNS) presents a great challenge for the current nanomaterial design. Herein, an in-situ solid-state transformation method was developed for the preparation of multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm sized HCCDs containing a highly crystalline carbon nanocore and a hydrophilic surface, which therefore simultaneously provide strong photoacoustic and photothermal performance as well as tunable fluorescence emission...
January 12, 2018: ACS Applied Materials & Interfaces
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