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photothermal therapy

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https://www.readbyqxmd.com/read/28726368/mussel-inspired-polydopamine-coated-lanthanide-nanoparticles-for-nir-ii-ct-dual-imaging-and-photothermal-therapy
#1
Yu Dai, Dongpeng Yang, Danping Yu, Cong Cao, Qiuhong Wang, Songhai Xie, Liang Shen, Wei Feng, Fuyou Li
Nanomedicine has attracted substantial attentions for accurate diagnosis or treatment of carcinoma in recent years. Nd3+ doped lanthanide nanophosphors based near-infrared-II (NIR-II) optical imaging is widely used for deep penetration tissue imaging while X-ray computed tomography (CT) is well-suited for in vivo imaging. Polymer coated lanthanide nanophosphors were increasingly used as both diagnostics and therapies for tumor in vivo. However, the bio-compatibility of nanocomposites and efficiency of tumor ablation should be taken into consideration when construct of a nanotheranostic probe...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28723583/label-free-high-resolution-3-d-imaging-of-gold-nanoparticles-inside-live-cells-using-optical-diffraction-tomography
#2
Doyeon Kim, Nuri Oh, Kyoohyun Kim, SangYun Lee, Chan-Gi Pack, Ji-Ho Park, YongKeun Park
Delivery of gold nanoparticles (GNPs) into live cells has high potentials, ranging from molecular-specific imaging, photodiagnostics, to photothermal therapy. However, studying the long-term dynamics of cells with GNPs using conventional fluorescence techniques suffers from phototoxicity and photobleaching. Here, we present a method for 3-D imaging of GNPs inside live cells exploiting refractive index (RI) as imaging contrast. Employing optical diffraction tomography, 3-D RI tomograms of live cells with GNPs are precisely measured for an extended period with sub-micrometer resolution...
July 16, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28722819/self-targeting-immune-transparent-plasma-protein-coated-nanocomplex-for-noninvasive-photothermal-anticancer-therapy
#3
Fwu-Long Mi, Thierry Burnouf, Shih-Yuan Lu, Yu-Jen Lu, Kun-Ying Lu, Yi-Cheng Ho, Chang-Yi Kuo, Er-Yuan Chuang
Cancer cells exhibit specific physiological differences compared to normal cells. Most surface membranes of cancer cells are characterized by high expression of given protein receptors, such as albumin, transferrin, and growth factors that are also present in the plasma of patients themselves, but are lacking on the surface of normal cells. These distinct features between cancer and normal cells can serve as a niche for developing specific treatment strategies. Near-infrared (NIR)-light-triggered therapy platforms are an interesting novel avenue for use in clinical nanomedicine...
July 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28722543/comparison-of-ovalbumin-and-ovalbumin-epitope-peptide-for-transdermal-delivery-and-vaccination-mediated-by-the-photothermal-effect-of-gold-nanorods
#4
Aung Thu Haine, Yuji Miyamoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a powerful and attractive method for protein therapy and dermal vaccination compared with other administrations. However, this delivery method is restricted by the low permeability of the stratum corneum, a hydrophobic barrier that restricts the entry of hydrophilic molecules such as proteins. In this study, we developed an improved gel patch system carrying ovalbumin and ovalbumin epitope peptide, and then compared their permeability into the skin. First, the gel patch was placed on mouse skin to allow contact with the polymer coated gold nanorods and then irradiated by a continuous-wave laser...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28719022/engineering-the-surface-of-smart-nanocarriers-using-a-ph-thermal-gsh-responsive-polymer-zipper-for-precise-tumor-targeting-therapy-in-vivo
#5
Penghui Zhang, Yan Wang, Jing Lian, Qi Shen, Chen Wang, Bohan Ma, Yuchao Zhang, Tingting Xu, Jianxin Li, Yongping Shao, Feng Xu, Jun-Jie Zhu
Nanocarrier surface chemistry plays a vital role in mediating cell internalization and enhancing delivery efficiency during in vivo chemotherapy. Inspired by the ability of proteins to alter their conformation to mediate functions, a pH-/thermal-/glutathione-responsive polymer zipper consisting of cell-penetrating poly(disulfide)s and thermosensitive polymers bearing guanidinium/phosphate (Gu(+) /pY(-) ) motifs to spatiotemporally tune the surface composition of nanocarriers for precise tumor targeting and efficient drug delivery is developed...
July 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28714303/melittin-containing-hybrid-peptide-hydrogels-for-enhanced-photothermal-therapy-of-glioblastoma
#6
Honglin Jin, Guifang Zhao, Jianli Hu, Quanguang Ren, Kui Yang, Chao Wan, Ai Huang, Pindong Li, Jue-Ping Feng, Jing Chen, Zhenwei Zou
The design of biocompatible and efficacious anticancer biomaterials to achieve relatively low tumor recurrence rates is the main pursuit of cancer photothermal therapy (PTT). RADA 16-I is a synthetic amphiphilic peptide with the sequence RADARADARADARADA that can self-assemble into a peptide nanofiber hydrogel. In this study, we synthesized a novel Melittin-RADA32-Indocyanine green (ICG) hydrogel ("MRI hydrogel"), which contains melittin in the peptide hydrogel backbone and ICG in the hydrogel matrix, for enhanced PTT of glioblastomas...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28712919/an-innovative-mwcnts-dox-tc-nanosystem-for-chemo-photothermal-combination-therapy-of-cancer
#7
Xia Dong, Zhiting Sun, Xiaoxiao Wang, Xigang Leng
Chemotherapy and photothermal therapy can be efficiently integrated to achieve enhanced antitumor efficacy by using carbon nanotubes (CNTs) which are super in delivering drug and converting near infrared radiation (NIR) into heat. We previously developed an innovative TAT-chitosan functionalized MWCNTs (MWCNTs/TC) based drug delivery system for doxorubicin (DOX) and preliminarily investigated its release profile and antitumor effect. In the present study, the application potential of MWCNTs/DOX/TC in chemo-photothermal combination therapy was further explored...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28710483/near-infrared-induced-phase-shifted-icg-fe3o4-loaded-plga-nanoparticles-for-photothermal-tumor-ablation
#8
Chengcheng Niu, Yan Xu, Senbo An, Ming Zhang, Yihe Hu, Long Wang, Qinghai Peng
Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709019/biocompatible-pegylated-bismuth-nanocrystals-all-in-one-theranostic-agent-with-triple-modal-imaging-and-efficient-in%C3%A2-vivo-photothermal-ablation-of-tumors
#9
Zhenglin Li, Jing Liu, Ying Hu, Zhuo Li, Xuelei Fan, Ye Sun, Flemming Besenbacher, Chunying Chen, Miao Yu
Biocompatible single-component theranostic agents integrating multimodal imaging and therapeutic functions (namely, "all-in one" agents) are highly desired for clinical cancer treatments. Herein, PEGylated pure metallic bismuth nanocrystals (Bi-PEG NCs) have been developed to be a competent theranostic agent for in vivo high-performance multimodal bio-imaging and photothermal ablation of tumors. The resultant Bi-PEG NCs show excellent physiological stability, biocompatibility, prolonged blood circulation half-life and preferential tumor accumulation...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28708389/nanostructured-phthalocyanine-assemblies-with-protein-driven-switchable-photoactivities-for-biophotonic-imaging-and-therapy
#10
Xingshu Li, C-Yoon Kim, Seunghyun Lee, Dayoung Lee, Hyung Min Chung, Gyoungmi Kim, Si-Hyun Heo, Chulhong Kim, Ki-Sung Hong, Juyoung Yoon
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible and versatile phthalocyanine building blocks. The nanostructured phthalocyanine assemblies (NanoPcTBs) display intrinsically unique photothermal and photoacoustic properties. Fluorescence and reactive oxygen species (ROS) generation can be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT)...
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#11
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28702600/an-nir-sensitive-layered-supramolecular-nanovehicle-for-combined-dual-modal-imaging-and-synergistic-therapy
#12
Shanyue Guan, Yangziwan Weng, Mengnan Li, Ruizheng Liang, Chenghua Sun, Xiaozhong Qu, Shuyun Zhou
A supramolecular nanovehicle, denoted as ICG-DOX/Gd-LDH, was synthesized by the co-intercalation of indocyanine green (ICG) and doxorubicin hydrochloride (DOX) into a gallery of Gd(3+)-doped-layered double hydroxide (Gd-LDH) such that to achieve a chemo-photothermal synergistic therapeutic agent. The unique structure of Gd-LDH can not only stabilize the photothermal agent ICG to enhance the photothermal efficiency, but also hamper the recombination between electron and holes, leading to the generation of more reactive oxygen species (ROS) under irradiation in the NIR range...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28700898/sub-100nm-long-tumor-retention-sn-38-loaded-photonic-micelles-for-tri-modal-cancer-therapy
#13
Xixiao Yang, Xiangdong Xue, Yan Luo, Tzu-Yin Lin, Hongyong Zhang, Diana Lac, Kai Xiao, Yixuan He, Bei Jia, Kit S Lam, Yuanpei Li
The tumor penetration and accumulation of nanoparticle-based drug delivery systems are highly dependent on the particle size. Nanomedicines in the sub-100nm range have been suggested by previous studies to have superior antitumor efficacy on various solid tumors. SN-38 is a very important and highly potent drug for several cancers including colon cancer. However, due to the ultra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100nm, SN-38-encapsulated nanoparticles without modification of the chemical structure...
July 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28692799/highly-stable-organic-small-molecular-nanoparticles-as-an-advanced-and-biocompatible-phototheranostic-agent-of-tumor-in-living-mice
#14
Ji Qi, Yuan Fang, Ryan T K Kwok, Xiaoyan Zhang, Xianglong Hu, Jacky W Y Lam, Dan Ding, Ben Zhong Tang
Near-infrared (NIR)-absorbing organic small molecules hold great promise as the phototheranostic agents for clinical translation by virtue of their intrinsic advantages such as well-defined chemical structure, high purity, and good reproducibility. However, most of the currently available ones face the challenges in varying degrees in terms of photothermal instability, and photobleaching/reactive oxygen nitrogen species (RONS) inresistance, which indeed impair their practical applications in precise diagnosis and treatment of diseases...
July 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28692135/self-templated-stepwise-synthesis-of-monodispersed-nanoscale-metalation-covalent-organic-polymers-for-in-vivo-bioimaging-and-photothermal-therapy
#15
Yanshu Shi, Xiaoran Deng, Shouxin Bao, Bei Liu, Bin Liu, Ping'an Ma, Ziyong Cheng, Maolin Pang, Jun Lin
Size and shape controlled growth of nanoscale microporous organic polymers (MOPs) is a big challenge scientists confronted with, meanwhile, rendering these materials for in vivo biomedical applications is still scarce. In this study, monodispersed nano metalation covalent organic polymers (MCOP, M = Fe, Gd) with sizes around 120 nm were prepared by a self-templated two-step solution-phase synthesis method. The metal ions (Fe3+) played important roles in miniature the particle size and functionalization of the products during reaction with p-phenylenediamine (Pa), and then the resultant Fe-Pa complex was used as a template for the subsequent formation of MCOP following the Schiff base reaction with 1,3,5-triformylphloroglucinol (Tp)...
July 10, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28689965/ph-and-nir-light-responsive-magnetic-iron-oxide-nanoparticles-for-mitochondria-mediated-apoptotic-cell-death-induced-by-chemo-photothermal-therapy
#16
Yunok Oh, Jae-Young Je, Madhappan Santha Moorthy, Hansoo Seo, Won Ho Cho
Recently, various therapeutic strategies in anticancer drug development are focused to reduce adverse side effects and to enhance the therapeutic efficacy. Mostly, the iron oxide (Fe3O4) nanoparticles have widely been utilized as an efficient drug delivery system towing to their unique properties such as excellent magnetic behavior, considerably low toxicity, easy surface modification and high drug-loading efficacy. In the present study, we synthesized a multifunctional, DMSA coated, water soluble Fe3O4 nanoparticles (Fe3O4@DMSA/DOX) for an effective pH and NIR-light triggered delivery of anticancer drug (DOX) in cancer therapy...
July 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28688985/mussel-inspired-plga-polydopamine-core-shell-nanoparticle-for-light-induced-cancer-thermochemotherapy
#17
Huacheng He, Eleni Markoutsa, Yihong Zhan, Jiajia Zhang, Peisheng Xu
Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature...
July 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28686414/stimuli-responsive-cluster-bomb-for-programmed-tumor-therapy
#18
Qi Lei, Shi-Bo Wang, Jing-Jing Hu, Yi-Xiong Lin, Cheng-Hui Zhu, Lei Rong, Xian-Zheng Zhang
In this paper, mesoporous silica nanoparticle (MSN) loaded with doxorubicin (DOX) and capped with tumor homing/penetrating peptide tLyP-1-modified tungsten disulfide quantum dots (WS2-HP) was designed and applied as a stimuli-responsive "Cluster Bomb" for high-performance tumor suppression. The peptide tLyP-1 on the surface can both facilitate the homing of DOX@MSN-WS2-HP to 4T1 tumor and greatly enhance the penetration of WS2-HP in tumor. The benzoic-imine bonds as the linkers between "bomblets" and "dispenser" are stable under normal physical conditions and quite labile at pH 6...
July 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28686409/structural-characterization-of-bio-functionalized-gold-nanoparticles-by-ultrahigh-resolution-mass-spectrometry
#19
Simone Nicolardi, Yuri E M van der Burgt, Jeroen D C Codée, Manfred Wuhrer, Cornelis H Hokke, Fabrizio Chiodo
Bio-functionalized gold nanoparticles (AuNPs) enable innovative translational research and development in biomedicine. Biomolecules such as peptides, proteins, lipids and carbohydrates can be assembled onto AuNPs to yield nanomaterials with unique properties for applications in imaging, photothermal therapy, vaccination strategies and drug delivery. The characterization of functionalized AuNPs still remains an analytical challenge that normally requires the combination of multiple techniques. Laser desorption/ionization (LDI) and matrix-assisted LDI (MALDI) has been applied successfully in combination with time-of-flight (TOF) mass spectrometry (MS) for the analysis of surface chemistry of AuNPs functionalized with synthetic ligands, however only for ligands with a molecular mass limited to 1000 Da...
July 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28685676/recent-advances-in-superparamagnetic-iron-oxide-based-nanoprobes-as-multifunctional-theranostic-agents-for-breast-cancer-imaging-and-therapy
#20
Jianjun Zheng, Wenzhi Ren, Tianxiang Chen, Jin Yinhua, Aijing Li, Kun Yan, Yijiao Wu, Aiguo Wu
Breast cancer accounts for nearly one in three cancers, and it is the most common cancer diagnosed among women. The death rate of breast cancer is estimated to 14%. Hence, accurate diagnosis in early stage and effective treatment in any stage are critical for the survival of breast cancer. Mammogram has been the most common technique administered to detect breast cancer. However, the radiation dose from mammogram is harmful to patients. Fortunately, magnetic resonance imaging (MRI) can diagnose breast cancer without any radiation dose, and enhanced MRI can make earlier and differential diagnosis...
July 5, 2017: Current Medicinal Chemistry
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