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https://www.readbyqxmd.com/read/28231500/silver-nanoparticle-embedded-graphene-oxide-methotrexate-for-targeted-cancer-treatment
#1
Raj Kumar Thapa, Jae Hee Kim, Jee-Heon Jeong, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Combination therapies are widely investigated cancer treatment modalities. Carbon based systems such as graphene oxide (GO), plasmonic nanoparticles such as silver nanoparticles (AgNPs), and the folate analog, methotrexate (MTX), have been separately studied for their potential anticancer effects. In this study, we combined these systems to develop AgNPs-embedded GO with conjugated MTX (MTX-GO/AgNPs) and studied their folate receptor-targeted anticancer effects. Results revealed successful formation of AgNPs on GO along with MTX conjugation as suggested by UV/visible, TEM, AFM, FTIR, and XRD analysis...
February 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28231079/vaginal-erbium-laser-as-second-generation-thermotherapy-for-the-genitourinary-syndrome-of-menopause-a-pilot-study-in-breast-cancer-survivors
#2
Marco Gambacciani, Marco Levancini
OBJECTIVE: The aim of this study was to evaluate the efficacy and acceptability of a second generation of vaginal laser treatment, the vaginal erbium laser, as a nonablative photothermal therapy for the management of genitourinary syndrome of menopause in postmenopausal breast cancer survivors. METHODS: The study was performed using an erbium laser crystal yttrium-aluminum-garnet (XS Fotona Smooth, Fotona, Ljubljana, Slovenia) with a wavelength of 2,940 nm. Forty-three postmenopausal breast cancer survivors were treated with three laser applications every 30 days...
March 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28228012/investigation-of-thermally-induced-cellular-ablation-and-heat-response-triggered-by-planar-mos2-based-nanocomposite
#3
Shinya Ariyasu, Jing Mu, Xiao Zhang, Ying Huang, Edwin K L Yeow, Hua Zhang, Bengang Xing
In comparison to conventional tumor treatment methods, photothermal therapy (PTT) is one of the innovative therapeutic strategies that employs light to produce the localized heat for targeted ablation of cancer cells. Among various kinds of heat generation nanomaterials, transition metal dichalcogenide nanosheets, especially-molybdenum disulfide (MoS2) have recently been investigated as one of the promising PTT candidates because of their strong absorbance in the near-infrared (NIR) tissue transparency window and excellent photothermal conversion capability...
February 23, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28198587/hexaphyrin-as-a-potential-theranostic-dye-for-photothermal-therapy-and-19f-magnetic-resonance-imaging
#4
Tomohiro Higashino, Hirotaka Nakatsuji, Ryosuke Fukuda, Haruki Okamoto, Hirohiko Imai, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Nikolai Tkachenko, Mitsuru Hashida, Tatsuya Murakami, Hiroshi Imahori
meso-Aryl substituted expanded porphyrins have two potential key features suitable for theranostic agents, excellent absorption in near infrared (NIR) region and possible introduction of multiple fluorine atoms at structurally nearly equivalent positions. Herein, hexaphyrin (hexa) was synthesized using 2,6-bis(trifluoromethyl)-4-formyl benzoate and pyrrole and evaluated as a novel theranostic expanded porphyrin possessing the above key features. Under NIR light illumination hexa showed intense photothermal and weak photodynamic effects, which were most likely due to its low-lying excited states close to a singlet oxygen...
February 15, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28192672/smart-nanostructures-for-cargo-delivery-uncaging-and-activating-by-light
#5
Mahdi Karimi, Parham Sahandi Zangabad, Soodeh Baghaee-Ravari, Mahdi Ghazizadeh, Hamed Mirshekari, Michael R Hamblin
Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, etc. Among drug delivery systems (DDSs), smart nanocarriers that can respond to specific stimuli in their local environment represent a growing field. Nanoplatforms that can be activated by an external application of light, can be used for a wide variety of photo-activated therapies, (especially light-triggered DDSs) relying on photo-isomerization, photo-crosslinking/uncrosslinking, photo-reduction, etc...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#6
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics (Syd)
https://www.readbyqxmd.com/read/28187379/novel-doxorubicin-loaded-pegylated-cuprous-telluride-nanocrystals-for-combined-photothermal-chemo-cancer-treatment
#7
Xianwen Wang, Yan Ma, Huajian Chen, Xiaoyi Wu, Haisheng Qian, Xianzhu Yang, Zhengbao Zha
Recently, combined photothermal-chemo therapy has attracted great attention due to its enhanced anti-tumor efficiency via synergistic effects. Herein, PEGylated cuprous telluride nanocrystals (PEGylated Cu2Te NCs) were developed as novel drug nanocarriers for combined photothermal-chemo treatment of cancer cells. PEGylated Cu2Te NCs were fabricated through a simple two-step process, comprised of hot injection and thin-film hydration. The as-prepared PEGylated Cu2Te NCs (average diameter of 5.21±1.05nm) showed a noticeable photothermal conversion efficiency of 33...
February 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28183070/remotely-controlled-drug-release-based-on-iron-oxide-nanoparticles-for-specific-therapy-of-cancer
#8
Lin Wu, Ling Chen, Fei Liu, Xueyong Qi, Yanru Ge, Song Shen
Chemotherapy has been widely used in clinic and usually causes serious side effects. To improve therapeutic effect, it is really necessary to realize local drug release and specific therapy. In this work, we demonstrate Azo (4,4-azobis (4-cyanovaleric acid))-functionalized multifunctional nanoparticles to realize near-infrared (NIR) laser-responsive drug release and combined chemo-photothermal cancer therapy. Doxorubicin (DOX) was attached to magnetic nanoparticles via a thermal-cleavable Azo linker, which could decompose while the temperature reach ∼43°C...
January 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28181456/dual-plasmonic-gold-nanostars-for-photoacoustic-imaging-and-photothermal-therapy
#9
Vijay Raghavan, Cathal O'Flatharta, Roisin Dwyer, Aedán Breathnach, Haroon Zafar, Peter Dockery, Antony Wheatley, Ivan Keogh, Martin Leahy, Malini Olivo
AIM: To fabricate multimodal nanoconstruct that act as a single node for photoacoustic imaging (PAI) and photothermal therapy (PTT) in the fight against cancer. MATERIALS & METHODS: Dual plasmonic gold nanostars (DPGNS) were chemically synthesized by reducing gold precursor using ascorbic acid and silver ions as shape directing agent. PAI and PTT were performed using commonly available 1064 nm laser source on DPGNS embedded tumor xenografts on mice. RESULTS & CONCLUSION: Photoacoustic amplitude increase with longer wavelength source and with silica coating of DPGNS...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28178904/cit-cus-fe3o4-based-and-enzyme-responsive-magnetic-nanoparticles-for-tumor-chemotherapy-photothermal-and-photodynamic-therapy
#10
Xiali Zhu, Heqing Huang, Yingjie Zhang, Huijuan Zhang, Lin Hou, Zhenzhong Zhang
Safe and efficient drug delivery in a controllable fashion, especially remote and repeatable switch of on-demand drug release, is the subject of widespread attention. A kind of magnetic nanoparticles (DOX-Cit/CuS@Fe3O4-NPs) simultaneously consisted of Cit/CuS@Fe3O4 and doxorubicin (DOX) was presented. The drug release from DOX-Cit/CuS@Fe3O4-NPs could be successfully triggered by the presence of gelatinase, showing great promise for tumor-targeted drug release through an enzymatic degradation mechanism. Compared with free DOX, DOX-Cit/CuS@Fe3O4-NPs could not only specially deliver Cit/CuS@Fe3O4 and DOX into MCF-7 cells, but also could greatly improve the quantity of ROS produced in MCF-7 cells under of 980 nm laser irradiation...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28177224/protein-stabilized-gadolinium-oxide-gold-nanoclusters-hybrid-for-multimodal-imaging-and-drug-delivery
#11
Lu Han, Jun-Mei Xia, Xin Hai, Yang Shu, Xu-Wei Chen, Jian-Hua Wang
A protein-stabilized multifunctional theranostic nanoplatform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3-AuNCs nanohybrid is developed by integrating Gd2O3 nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance and X-ray computed tomography imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen ((1)O2) upon near-infrared laser stimulation at 808 nm...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28169441/hydrogel-microfluidic-co-culture-device-for-photothermal-therapy-and-cancer-migration
#12
Jong Min Lee, Hye In Seo, Jun Hyuk Bae, Bong Geun Chung
We developed the photo-crosslinkable hydrogel microfluidic co-culture device to study photothermal therapy and cancer cell migration. To culture MCF7 human breast carcinoma cells and metastatic U87MG human glioblastoma in the microfluidic device, we used 10 w/v% gelatin methacrylate (GelMA) hydrogels as a semi-permeable physical barrier. We demonstrated the effect of gold nanorod on photothermal therapy of cancer cells in the microfluidic co-culture device. Interestingly, we observed that metastatic U87MG human glioblastoma largely migrated toward vascular endothelial growth factor (VEGF)-treated GelMA hydrogel-embedding microchannels...
February 7, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28165076/zwitterionic-gold-nanorods-low-toxicity-and-high-photothermal-efficacy-for-cancer-therapy
#13
Huangyong Jiang, Dong Chen, Dongbo Guo, Nan Wang, Yue Su, Xin Jin, Gangsheng Tong, Xinyuan Zhu
Novel "zwitterionic" gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)-b-poly(lipoic methacrylate) (pMPC-b-pLA)}. In vitro, they exhibited low dark cytotoxicity and a high therapeutic efficacy to cancer cells. Their blood circulation half-life in vivo (t1/2, ∼10 h) was 20-fold longer than that of CTAB-Au NRs (t1/2, <30 min). After intravenous administration, they accumulated in tumour sites via an enhanced permeability and retention (EPR) effect and enabled destruction of human xenograft tumours in mice after exposure of the tumour location to NIR laser irradiation at 808 nm...
February 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28161572/single-wavelength-light-mediated-synergistic-bimodal-cancer-photoablation-and-amplified-photothermal-performance-by-graphene-gold-nanostar-photosensitizer-theranostics
#14
Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, Yuan Tian, Hong Yang, Shun Li, Yiyao Liu
: Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy (PTT) as well as effective photothermal imaging. The stable and biocompatible GO/AuNS-PEG composite displayed a high photothermal conversion efficiency due to the enhanced optical absorbance of both graphene and gold nanostars in the near-infrared (NIR) range...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28160445/gold-nanoparticle-mediated-photothermal-therapy-applications-and-opportunities-for-multimodal-cancer-treatment
#15
REVIEW
Rachel S Riley, Emily S Day
Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat in response to exogenously applied laser light, has been well documented as an independent strategy for highly selective cancer treatment. Gold-based nanoparticles are the main mediators of PTT because they offer: (1) biocompatibility, (2) small diameters that enable tumor penetration upon systemic delivery, (3) simple gold-thiol bioconjugation chemistry for the attachment of desired molecules, (4) efficient light-to-heat conversion, and (5) the ability to be tuned to absorb near-infrared light, which penetrates tissue more deeply than other wavelengths of light...
February 3, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28159715/dual-function-nanostructured-lipid-carriers-to-deliver-ir780-for-breast-cancer-treatment-anti-metastatic-and-photothermal-anti-tumor-therapy
#16
Huipeng Li, Kaikai Wang, Xue Yang, Yiwen Zhou, Qineng Ping, David Oupicky, Minjie Sun
: Cancer treatments that use a combination of approaches with the ability to affect multiple disease pathways have proven highly effective. The present study reports on CXCR4-targeted nanostructured lipid carriers (NLCs) with a CXCR4 antagonist AMD3100 in the shell (AMD-NLCs). AMD-NLCs loaded with IR780 (IR780-AMD-NLCs) reduced the invasiveness of cancer cells, while simultaneously mediating efficient tumor targeting and photothermal therapeutic outcomes. We present the combined effect of encapsulated IR780 on photothermal therapy and of the AMD3100 coating on tumor targeting, CXCR4 antagonism and inhibition of cancer cell invasion and breast cancer lung metastasis in vitro and in vivo...
January 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28157634/hollow-mesoporous-carbon-as-a-near-infrared-absorbing-carrier-compared-with-mesoporous-carbon-nanoparticles-for-chemo-photothermal-therapy
#17
Xian Li, Yue Yan, Yuanzhe Lin, Jian Jiao, Da Wang, Donghua Di, Ying Zhang, Tongying Jiang, Qinfu Zhao, Siling Wang
In this study, hollow mesoporous carbon nanoparticles (HMCN) and mesoporous carbon nanoparticles (MCN) were used as near-infrared region (NIR) nanomaterials and drug nanocarriers were prepared using different methods. A comparison between HMCN and MCN was performed with regard to the NIR-induced photothermal effect and drug loading efficiency. The results of NIR-induced photothermal effect test demonstrated that HMCN-COOH had a better photothermal conversion efficacy than MCN-COOH. Given the prominent photothermal effect of HMCN-COOH in vitro, the chemotherapeutic drug DOX was chosen as a model drug to further evaluate the drug loading efficiencies and NIR-triggered drug release behaviors of the nanocarriers...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28155952/cuco2s4-nanocrystals-a-new-platform-for-multimodal-imaging-guided-photothermal-therapy
#18
Xiaojuan Huang, Guoying Deng, Lijun Liao, Wenlong Zhang, Guoqiang Guan, Feng Zhou, Zhiyin Xiao, Rujia Zou, Qian Wang, Junqing Hu
Multifunctional nanomaterials open an avenue for the integration of cancer treatment and diagnosis, trending towards the clinical application of nanomedicines in future. Herein, we synthesized biocompatible CuCo2S4 nanocrystals (NCs) via a simple reflux method and unitized them as a new theranostic platform, where an intense near-infrared (NIR) absorption offers the CuCo2S4 NCs a perfect photothermal performance and photoacoustic (PA) imaging ability; the magnetic characteristic of Co allows them to serve as an enhanced magnetic resonance (MR) contrast agent...
February 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28155894/photothermal-therapeutic-application-of-gold-nanorods-porphyrin-trastuzumab-complexes-in-her2-positive-breast-cancer
#19
Xinmei Kang, Ximing Guo, Weiwei An, Xingjian Niu, Suhan Li, Zhaoliang Liu, Yue Yang, Na Wang, Qicheng Jiang, Caichuan Yan, Hui Wang, Qingyuan Zhang
Gold nanorods are effective photothermal agents in diagnosis and treatment of cancer due to their specific near-infrared laser absorption. However, tumor photothermal therapy by nanorods alone is lack of targeting. Here, we described a novel nanocomplex made up of gold nanorods, porphyrin, and trastuzumab, called TGNs and investigated the TGN-mediated photothermal therapy as a potential alternative treatment of targeting HER2-positive breast cancers. By conjugating trastuzumab and porphyrin to the surface of gold nanorods, we have increased the targeting specificity and amplified the detecting effectiveness at the same time...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28152314/liposomal-indocyanine-green-for-enhanced-photothermal-therapy
#20
Hwan-Jun Yoon, Hye-Seong Lee, Ji-Young Lim, Ji Ho Park
In this study, we engineered liposomal indocyanine green (ICG) to maximize its photothermal effects while maintaining the fluorescence intensity. Various liposomal formulations of ICG were prepared by varying the lipid composition and the molar ratio between total lipid and ICG, and their photothermal characteristics were evaluated under near-infrared irradiation. We showed that the ICG dispersity in the liposomal membrane and its physical interaction with phospholipids were the main factors determining the photothermal conversion efficiency...
February 2, 2017: ACS Applied Materials & Interfaces
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