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https://www.readbyqxmd.com/read/29046028/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-throughout-the-life-cycle-in-argentina
#1
Juan Carlos Ivancevich, Hugo Neffen, Mario E Zernotti, Estrella Asayag, Ariel Blua, Alberto Cicerán, Edgardo J Jares, Alberto J Lavrut, Jorge F Máspero, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio W Canonica, Thomas B Casale, Álvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, Jean Bousquet
The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multi-morbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045991/naloxone-counseling-for-harm-reduction-and-patient-engagement
#2
Jonathan K Han, Lucas G Hill, Marianne E Koenig, Niladri Das
BACKGROUND AND OBJECTIVES: The United States is experiencing an epidemic of opioid-related deaths. Naloxone, the drug of choice for reversing acute opioid overdose, is not routinely prescribed for outpatient use. The aims of this project were to improve naloxone awareness, increase naloxone prescribing, and prevent opioid overdoses. METHODS: A naloxone counseling intervention was implemented in three family health centers by an interprofessional team of providers including family medicine physicians, clinical pharmacists, and social workers...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045990/electronic-health-record-impacts-on-family-medicine-teachers-survey-of-third-year-medical-student-clerkship-preceptors-at-an-academic-medical-center
#3
Elizabeth Curry, Tamara K Oser, Sean M Oser
BACKGROUND AND OBJECTIVES: Electronic Health Record (EHR) use in clinical practice has accelerated in recent years. While several aspects of EHR use have been extensively studied, there is little data on EHR impacts on medical student educators, especially those involved in outpatient family medicine. This study evaluated perceived impacts of EHR use on clinician teachers of outpatient family medicine. METHODS: The study used a mixed methods survey of clinicians who teach third-year medical students during the required family and community medicine outpatient clerkship at a Mid-Atlantic medical school...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045986/impact-of-residency-training-redesign-on-residents-clinical-knowledge
#4
Elaine Waller, M Patrice Eiff, Eve Dexter, Jason C B Rinaldo, Miguel Marino, Roger Garvin, Alan B Douglass, Robert Phillips, Larry A Green, Patricia A Carney
BACKGROUND AND OBJECTIVES: The In-training Examination (ITE) is a frequently used method to evaluate family medicine residents' clinical knowledge. We compared family medicine ITE scores among residents who trained in the 14 programs that participated in the Preparing the Personal Physician for Practice (P4) Project to national averages over time, and according to educational innovations. METHODS: The ITE scores of 802 consenting P4 residents who trained in 2007 through 2011 were obtained from the American Board of Family Medicine...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045845/revealing-the-determinants-of-widespread-alternative-splicing-perturbation-in-cancer
#5
Yongsheng Li, Nidhi Sahni, Rita Pancsa, Daniel J McGrail, Juan Xu, Xu Hua, Jasmin Coulombe-Huntington, Michael Ryan, Boranai Tychhon, Dhanistha Sudhakar, Limei Hu, Michael Tyers, Xiaoqian Jiang, Shiaw-Yih Lin, M Madan Babu, Song Yi
It is increasingly appreciated that alternative splicing plays a key role in generating functional specificity and diversity in cancer. However, the mechanisms by which cancer mutations perturb splicing remain unknown. Here, we developed a network-based strategy, DrAS-Net, to investigate more than 2.5 million variants across cancer types and link somatic mutations with cancer-specific splicing events. We identified more than 40,000 driver variant candidates and their 80,000 putative splicing targets deregulated in 33 cancer types and inferred their functional impact...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045715/towards-precision-medicine-in-anca-associated-vasculitis
#6
Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
ANCA-associated vasculitis (AAV) is characterized by inflammation and destruction of small and medium-sized vessels. Current management strategies for AAV have been validated in large groups of patients. However, recent insights indicate that distinct patient subsets may actually exist within AAV, thereby justifying the development of more personalized treatment strategies. In this review, we discuss current evidence for a better classification of AAV based on ANCA type. We describe how thus defined categories of AAV patients may differ in genetic background, clinical presentation, immune pathology, response to treatment and disease outcome...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045276/impact-of-required-versus-self-directed-use-of-virtual-patient-cases-on-clerkship-performance-a-mixed-methods-study
#7
Sarang Kim, Laura R Willett, Wilbur J Pan, Joyce Afran, John A Walker, Judy A Shea
PURPOSE: To explore how students use and benefit from virtual patient cases (VPCs). METHOD: In academic years 2013-2014 and 2014-2015, cohorts of students in pediatrics (Peds), family medicine (FM), and internal medicine (IM) clerkships were allocated to either core required use (CRU) or self-directed use (SU) of MedU VPCs. Outcomes included number and time of case review, student perception of learning from VPCs, National Board of Medical Examiners (NBME) subject examination scores, and summative clinical ratings for medical knowledge and differential diagnoses/problem solving...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#8
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29044980/phenotypic-and-genotypic-profile-of-clinical-and-animal-multi-drug-resistant-salmonella-enterica-isolates-from-mexico
#9
S Aguilar-Montes de Oca, M Talavera-Rojas, E Soriano-Vargas, J Barba-León, J Vázquez-Navarrete, J Acosta-Dibarrat, C Salgado-Miranda
AIMS: The objective of this study was to obtain a phenotypic and genotypic profile of Salmonella enterica including multidrug-resistant isolates from food-producing animals and clinical isolates, as well as their genetic relatedness in two different States of Mexico (Jalisco and State of Mexico). METHODS AND RESULTS: A total of 243 isolates were evaluated in terms of antimicrobial resistance and related genes through a disk diffusion method and PCR respectively; we found sixteen multidrug-resistant isolates, all of them harbouring the blaCMY gene but not qnr genes, these isolates represent less than 10% of the collection...
October 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29044858/pharmacological-and-chemical-features-of-nepeta-l-genus-its-importance-as-a-therapeutic-agent
#10
REVIEW
Ipek Süntar, Seyed Mohammad Nabavi, Davide Barreca, Nicolas Fischer, Thomas Efferth
Medicinal plants have always had great value for the human population due to their valuable constituents and potential bioactivities. The objective of this review is to present an updated overview of an important medicinal plant genus Nepeta L., from the family Lamiaceae, revealing its traditional utilization, biological activity, phytoconstituents, and mechanisms of action. For this purpose, a literature survey was carried out by using SciFinder, ScienceDirect, Scopus, PubMed, and Web of Science followed by a revision of the bibliographies of the related articles...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044721/body-diffusion-weighted-imaging-using-magnetization-prepared-single-shot-fast-spin-echo-and-extended-parallel-imaging-signal-averaging
#11
Eric K Gibbons, Shreyas S Vasanawala, John M Pauly, Adam B Kerr
PURPOSE: This work demonstrates a magnetization prepared diffusion-weighted single-shot fast spin echo (SS-FSE) pulse sequence for the application of body imaging to improve robustness to geometric distortion. This work also proposes a scan averaging technique that is superior to magnitude averaging and is not subject to artifacts due to object phase. THEORY AND METHODS: This single-shot sequence is robust against violation of the Carr-Purcell-Meiboom-Gill (CPMG) condition...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29044690/apparent-diffusion-coefficients-of-the-five-major-metabolites-measured-in-the-human-brain-in-vivo-at-3t
#12
Dinesh K Deelchand, Edward J Auerbach, Małgorzata Marjańska
PURPOSE: To measure the apparent diffusion coefficients (ADC) of five main metabolites in the human brain at 3T with PRESS and STEAM, avoiding measurement biases because of cross-terms. Cross-terms arise from interactions between slice-selection and spoiler gradients in the localized spectroscopy sequence and the diffusion gradients. METHODS: Diffusion-weighted spectra were acquired from the prefrontal cortex in five healthy subjects using STEAM (echo time [TE]/mixing time [TM]/pulse repetition time [TR] = 21...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29044180/evaluating-phenotype-driven-approaches-for-genetic-diagnoses-from-exomes-in-a-clinical-setting
#13
Reuben J Pengelly, Thahmina Alom, Zijian Zhang, David Hunt, Sarah Ennis, Andrew Collins
Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to prioritise variants as potentially causal. Some methods have a clinical focus while others are more research-oriented. With clinical applications in mind we compare results from alternative methods using 21 exomes for which the disease causal variant has been previously established through traditional clinical evaluation...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#14
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29043594/specialty-care-access-network-extension-of-community-healthcare-outcomes-model-program-for-liver-disease-improves-specialty-care-access
#15
Lisa M Glass, Akbar K Waljee, Heather McCurdy, Grace L Su, Anne Sales
BACKGROUND AND AIMS: To improve subspecialty access, VA Ann Arbor Healthcare System (VAAAHS) implemented the first Specialty Care Access Network (SCAN)-Extension of Community Healthcare Outcomes (ECHO) in chronic liver disease. SCAN-ECHO Liver links primary care providers (PCPs) to hepatologists via secure video-teleconferencing. We aim to describe characteristics of participants (PCPs) and patients (clinical question and diagnosis) in SCAN-ECHO Liver. METHODS: This is a prospective study of the VAAAHS SCAN-ECHO Liver (June 10, 2011-March 31, 2015)...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043570/towards-precision-nephrology-the-opportunities-and-challenges-of-genomic-medicine
#16
REVIEW
Jordan G Nestor, Emily E Groopman, Ali G Gharavi
The expansion of genomic medicine is furthering our understanding of many human diseases. This is well illustrated in the field of nephrology, through the characterization, discovery, and growing insight into various renal diseases through use of Next Generation Sequencing (NGS) technologies. This review will provide an overview of the diagnostic opportunities of using genetic testing in the clinical setting by describing notable discoveries regarding inherited forms of renal disease that have advanced the field and by highlighting some of the potential benefits of establishing a molecular diagnosis in a clinical practice...
October 17, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29043096/sex-determination-using-humeral-dimensions-in-a-sample-from-kwazulu-natal-an-osteometric-study
#17
Oluwatosin Olalekan Ogedengbe, Sunday Adelaja Ajayi, Omobola Aderibigbe Komolafe, Aung Khaing Zaw, Edwin Coleridge Stephen Naidu, Onyemaechi Okpara Azu
The morphological characteristics of the humeral bone has been investigated in recent times with studies showing varying degrees of sexual dimorphism. Osteologists and forensic scientists have shown that sex determination methods based on skeletal measurements are population specific, and these population-specific variations are present in many body dimensions. The present study aims to establish sex identification using osteometric standards for the humerus in a contemporary KwaZulu-Natal population. A total of 11 parameters were measured in a sample of n=211 humeri (males, 113; females, 98) from the osteological collection in the Discipline of Clinical Anatomy, Nelson R...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29043095/applied-anatomy-today-s-requirement-for-clinical-medicine-courses
#18
Ahmad Farrokhi, Masoume Soleymaninejad, Mehrdad Ghorbanlou, Ramazan Fallah, Reza Nejatbakhsh
Anatomy as an indispensable part of the medical curricula, offering impeccable knowledge, prepares the students to enter the practical atmosphere. The aim of this study was to evaluate the clinical application of anatomy courses of the medical students in Zanjan University of Medical Sciences. This cross-sectional study was conducted in 2015 with census sampling on all clinical students (trainees and interns). To collect feedback from students, the questionnaire designed by researchers was used. The Likert rating scale of very high, high, medium, low, and very low was considered and scores of 5 (very high) to 1 (very low) were applied...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042823/digital-health-technology-for-use-in-patients-with-serious-mental-illness-a-systematic-review-of-the-literature
#19
REVIEW
Sonal Batra, Ross A Baker, Tao Wang, Felicia Forma, Faith DiBiasi, Timothy Peters-Strickland
BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness. MATERIALS AND METHODS: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29042728/one-stage-full-mouth-disinfection-using-20-propolis-hydroalcoholic-solution-a-clinico-microbiologic-study
#20
Aena Jain Pundir, Anju Vishwanath, Siddharth Pundir, M Swati, Saket Banchhor, Saba Jabee
BACKGROUND: Propolis is a resinous substance produced by honeybees which has many therapeutic properties because of its unique composition. It has been widely used since many years for different medicinal purposes. AIM: The aim of this study was to investigate the effects of one-stage full mouth disinfection (OSFMD) using 20% propolis hydroalcoholic solution in chronic periodontitis patients. MATERIALS AND METHODS: Thirty patients diagnosed with chronic periodontitis and presenting three or more nonadjacent teeth with deep pockets were selected for the study...
July 2017: Contemporary Clinical Dentistry
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