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https://www.readbyqxmd.com/read/29917100/conventional-and-biologic-disease-modifying-anti-rheumatic-drugs-for-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#1
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
Objectives: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare DMARDs with placebo in participants with symptomatic OA. Methods: Databases (Medline, Embase, Allied and Complementary Medicine Database, Web of Science and Cochrane Library), conference abstracts and ClinicalTrials...
June 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29916923/probiotics-and-mucositis
#2
Emanuele Cereda, Marilisa Caraccia, Riccardo Caccialanza
PURPOSE OF REVIEW: To provide an updated perspective on the use of probiotics as adjuvant treatment strategy for patients suffering from or at risk of developing mucositis. RECENT FINDINGS: Studies suggest that oral and intestinal microbiota could be relevant to mucositis development and treatment, but no clear high-risk pattern has been identified and no single probiotic formulation has emerged from human clinical trials for strong recommendation. Promising results from available clinical trials suggest their use in patients with peri-implant mucositis or at risk of anticancer treatment-related oral or intestinal mucositis...
June 18, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29916593/-the-attention-of-istituto-superiore-di-sanit%C3%A3-to-the-sex-gender-differences-in-workers-health-prevention-and-promotion
#3
Anna Ruggieri, Elisabetta Straface, Eugenio Sorrentino
OBJECTIVES: Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. METHODS: This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916588/-gender-medicine-a-interdisciplinary-approach-to-medicine
#4
Giovannella Baggio
OBJECTIVES: From1995 (Beijing Conference) the World Health Organization strongly did call the attention on the need of great attention to women health and on the lack of studies on the differences in medicine between men and women. From the women health attention we arrived to gender medicine that is a transversal dimension of medicine which describes the differences within the same disease of symptoms, clinical evolution, drug therapy as well as prevention between men and women. METHODS: From some real life examples in this article we wish to make it clear that gender medicine is not a separated medical specialty but a dimension which pass through all specialties...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916586/-personalized-medicine-and-medical-malpractice
#5
Santo Davide Ferrara, Guido Viel
OBJECTIVES: The manuscript deals with personalized medicine and medical liability in Europe and Italy, addressing the importance of synergistic collaboration between clinical and medico-legal professionals in order to appropriately investigate medical errors and prevent any future adverse event. METHODS: Following a rapid epidemiological overview of mala praxis in Europe, the manuscript presents and discusses the International Guidelines developed and adopted by the International Academy of Legal Medicine (IALM), which guide the work of the medical experts under both criminal and/or civil law...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916581/-immunological-mechanisms-of-allergic-diseases
#6
Enrico Maggi
OBJECTIVES: In the last decades the knowledge on pathogenetic mechanisms of allergic diseases extraordinarily improved with relevant clinical outputs. From the '90yrs we know that Th2 cells are essential for allergic inflammation, since they produce type 2 cytokines, recognise allergens, induce IgE switch on B cells and recruit mastcells and eosinophils into tissues for maintaining the flogosis. METHODS: Recently a new subset of innate immunity (ILC2) have been shown to amplify the allergic inflammation...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916567/-chronic-diseases-in-neuromotor-rehabilitation-medicine
#7
Antonio Nardone, Elena Paola Ferrari
OBJECTIVES: Chronic diseases are a major problem, whose importance is nowadays raising up. Up to 86% of deaths are directly related to chronic diseases in Europe as they represent large amount of total diseases, with a major impact on global health spending. METHODS: Patients suffering from heterogeneous disabilities (such as Parkinson's disease, stroke, multiple sclerosis, osteoporosis, osteoarthritis) often show an interaction between the main disease and comorbidity and multimorbidity...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916563/-digitalisation-and-clinical-care-pathways-in-rehabilitation-medicine-a-possible-integration-from-the-goal-planning-and-the-rehabilitation-programme-design-to-the-evaluation-of-clinical-outcomes
#8
Anna Giardini, Silvia Traversoni, Claudio Garbelli, Anna Lodigiani
OBJECTIVES: In the light of the growing complexity featuring the contemporary world, a future challenge is represented by the maintenance of the humanization of healthcare, along with the necessity of a high specificity personalized treatment, in a growing emergency of lack of resources. Furthermore, the ongoing digital revolution spreading in every productive sector involves the health-care system as well, playing a crucial role for the goals of the specialized care-related prevention-treatment-rehabilitation approach of the Rehabilitation Medicine...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916432/approach-to-family-assessment-and-intervention
#9
Anand Krishnan, Priyamadhaba Behera, Baridalyne Nongkynrih
Background.: Family studies are an integral part of teaching of community medicine to all undergraduate medical and nursing students. It enhances the understanding of students about social determinants and multifactorial causation of disease. However, there is no standard approach towards it and it is seen as a clinical presentation with some elements of family included. We describe a systematic and comprehensive approach to a family study. Methods.: Based on the existing literature and personal experience, we identified 11 domains under the acronym Family ASSESSMENT-Structure, Socioeconomic, Sickness, Nutritional, Educational, Environmental, Affordability, System (health), Mental, Family influence, Threats...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916428/prophylactic-hydration-to-protect-renal-function-from-intravascular-iodinated-contrast-material
#10
Akshay D Baheti, Bhavin Jankharia
Nijssen EC, Rennenberg RJ, Nelemans PJ, Essers BA, Janssen MM, Vermeeren MA, van Ommen V, Wildberger JE. (Departments of Radiology and Nuclear Medicine, Internal Medicine, Epidemiology, Clinical Epidemiology and Medical Technology Assessment, and Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.) Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): A prospective, randomised, phase 3, controlled, open-label, non-inferiority trial...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916050/opioid-analgesic-drugs-and-serotonin-toxicity-syndrome-mechanisms-animal-models-and-links-to-clinical-effects
#11
REVIEW
Brian A Baldo
Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants...
June 18, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29916013/stem-cells-technology-a-powerful-tool-behind-new-brain-treatments
#12
REVIEW
Lucienne N Duru, Zhenzhen Quan, Talal Jamil Qazi, Hong Qing
Stem cell research has recently become a hot research topic in biomedical research due to the foreseen unlimited potential of stem cells in tissue engineering and regenerative medicine. For many years, medicine has been facing intense challenges, such as an insufficient number of organ donations that is preventing clinicians to fulfill the increasing needs. To try and overcome this regrettable matter, research has been aiming at developing strategies to facilitate the in vitro culture and study of stem cells as a tool for tissue regeneration...
June 18, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29915979/trials-with-patient-reported-outcomes-registered-on-the-australian-new-zealand-clinical-trials-registry-anzctr
#13
Rebecca Mercieca-Bebber, Douglas Williams, Margaret-Ann Tait, Jessica Roydhouse, Lucy Busija, Chindhu Shunmuga Sundaram, Michelle Wilson, Ailsa Langford, Claudia Rutherford, Natasha Roberts, Madeleine King, Elisabeth Vodicka, Beth Devine
AIMS: It is important to understand the number, types and regions of trials that include patient-reported outcomes (PROs) to appreciate how patient experiences have been considered in studies of health and interventions. Twenty-seven percent of trials registered with ClinicalTrials.gov (2007-2013) included PROs; however, a regional breakdown was not provided and no reviews have been conducted of the Australia New Zealand Clinical Trials Registry (ANZCTR). We aimed to identify trials registered with ANZCTR with PRO endpoints and describe their characteristics...
June 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29915939/-clinical-management-of-epistaxis
#14
L Uhler, S Knipping
BACKGROUND: Epistaxis is a symptom with many causes, often multifactorial and a frequent cause of consultation in acute medicine. OBJECTIVES: The goal of this study is to analyse the diagnostics used for and therapy of epistaxis, complications and the predictive benefit of laboratory tests. MATERIALS AND METHODS: In this retrospective clinical analysis reports of 720 patients with epistaxis in the period from January 2005 to December 2015 were evaluated...
June 18, 2018: HNO
https://www.readbyqxmd.com/read/29915907/a-survey-of-application-of-complementary-and-alternative-medicine-in-chinese-patients-with-parkinson-s-disease-a-pilot-study
#15
Xue-Wei Pan, Xiao-Guang Zhang, Xia-Chan Chen, Qi Lu, Ying-Si Hu, Li-Ya Han, Jian-le Zheng, Jie Jin, Guo-Qing Zheng
OBJECTIVE: To investigate the prevalence and spectrum of complementary and alternative medicine (CAM) application and its related-factors in Parkinson's disease (PD) patients in China. METHODS: A structured questionnaire regarding the use of CAMs was administered to PD patients by face-to-face interview. Demographic and social variables, clinical characteristics and treatments, and the related factors of PD were also surveyed. RESULTS: Ninety out of 113 patients (79...
June 18, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29915616/clinical-characteristics-and-type-of-antithrombotic-treatment-in-a-spanish-cohort-of-elderly-patients-with-atrial-fibrillation-according-to-dependency-frailty-and-cognitive-impairment
#16
Jose María Mostaza, Manuel Jesús Romero Jiménez, Fernando José Ruiz Laiglesia, José Antonio Díaz Peromingo, Manuel Beltrán Robles, Ernesto Guevara Sierra, Ana Santander Bilbao, Carmen Suárez
Background: Available data regarding clinical profile and management of elderly patients with atrial fibrillation (AF) according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods: Cross-sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain...
April 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29915593/detection-of-glycan-shedding-in-the-blood-new-class-of-multiple-sclerosis-biomarkers
#17
Brian DellaValle, Alba Manresa-Arraut, Henrik Hasseldam, Allan Stensballe, Jørgen Rungby, Agnete Larsen, Casper Hempel
Introduction: Multiple sclerosis (MS) is a devastating autoimmune disease, afflicting people in the prime of their lives. Presently, after initial clinical presentation, there are no reliable markers for whether a patient will develop MS, or whether their prognosis will be aggressive or relapsing-remitting. Furthermore, many MS patients do not respond to treatment. Thus, markers for diagnosis, prognosis, and treatment-responsiveness are lacking for a disease, where a precision medicine approach would be valuable...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915506/evaluation-of-hepatocyte-derived-microrna-122-for-diagnosis-of-acute-and-chronic-hepatitis-of-dogs
#18
S R Eman, A A Kubesy, T A Baraka, F A Torad, I S Shaymaa, Faten F Mohammed
Aim: This study was performed to evaluate the diagnostic value of hepatocyte-derived microRNA (miRNA)-122 in acute and chronic hepatitis of dogs. Materials and Methods: A total of 26 dogs presented at Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Cairo University, 16 dogs out of 26 showing clinical signs of hepatic insufficiency were subjected to clinical, ultrasonographic, hematobiochemical and ultrasound-guided fine-needle biopsy for cytological and histopathological investigations...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915500/evaluation-of-wet-cupping-therapy-on-the-arterial-and-venous-blood-parameters-in-healthy-arabian-horses
#19
Turke Shawaf, Wael El-Deeb, Jamal Hussen, Mahmoud Hendi, Shahab Al-Bulushi
Aim: Recently, the complementary therapies such as cupping and acupuncture are being used in veterinary medicine. This research was carried out to determine the effects of wet cupping therapy (Hijama) on the hematological and the biochemical parameters in the healthy Arabian horses for the first time. Materials and Methods: In this study, seven clinically healthy Arabian horses were randomly selected. Four points on the animal body were selected to perform the cupping therapy...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915440/waiting-time-in-the-outpatient-clinic-at-a-national-hospital-in-vietnam
#20
Suong Thi Thao Nguyen, Eiko Yamamoto, Mai Thi Ngoc Nguyen, Huy Bao Le, Tetsuyoshi Kariya, Yu Mon Saw, Cong Duc Nguyen, Nobuyuki Hamajima
Vietnam is facing a problem of over-crowding in public hospitals. Long waiting time is a major dissatisfaction for patients. Reducing waiting time benefits not only patients but also hospitals in decreasing overall workload. To identify factors contributing to long waiting time in outpatient clinics, a cross-sectional study was conducted at a national hospital in Vietnam. The time for each process of 7,931 patients who visited the outpatient clinics within Thong Nhat Hospital from 5 to 9 September 2016 was collected from the computerized clinical database...
May 2018: Nagoya Journal of Medical Science
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