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https://www.readbyqxmd.com/read/27926840/calcium-dependent-structural-dynamics-of-a-spin-labeled-ryr-peptide-bound-to-calmodulin
#1
Cheng Her, Jesse E McCaffrey, David D Thomas, Christine B Karim
We have used chemical synthesis, electron paramagnetic resonance (EPR), and circular dichroism to detect and analyze the structural dynamics of a ryanodine receptor (RyR) peptide bound to calmodulin (CaM). The skeletal muscle calcium release channel RyR1 is activated by Ca(2+)-free CaM and inhibited by Ca(2+)-bound CaM. To probe the structural mechanism for this regulation, wild-type RyRp and four spin-labeled derivatives were synthesized, each containing the nitroxide probe 2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid substituted for a single amino acid...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926793/information-seeking-when-problem-solving-perspectives-of-public-health-professionals
#2
Kristine Newman, Maureen Dobbins, Jennifer Yost, Donna Ciliska
OBJECTIVES: Given the many different types of professionals working in public health and their diverse roles, it is likely that their information needs, information-seeking behaviors, and problem-solving abilities differ. Although public health professionals often work in interdisciplinary teams, few studies have explored their information needs and behaviors within the context of teamwork. This study explored the relationship between Canadian public health professionals' perceptions of their problem-solving abilities and their information-seeking behaviors with a specific focus on the use of evidence in practice settings...
December 7, 2016: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/27925868/overlapping-buprenorphine-opioid-and-benzodiazepine-prescriptions-among-veterans-dually-enrolled-in-va-and-medicare-part-d
#3
Walid F Gellad, Xinhua Zhao, Carolyn T Thorpe, Joshua M Thorpe, Florentina E Sileanu, John P Cashy, Maria Mor, Jennifer A Hale, Thomas Radomski, Leslie R M Hausmann, Michael J Fine, Chester B Good
BACKGROUND: Buprenorphine is a key tool in the management of opioid use disorder, but there are growing concerns about abuse, diversion and safety. These concerns are amplified for the Department of Veterans Affairs (VA), whose patients may receive care concurrently from multiple prescribers within and outside VA. To illustrate the extent of this challenge, we examined overlapping prescriptions for buprenorphine, opioids, and benzodiazepines among Veterans dually enrolled in VA and Medicare Part D...
December 7, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27925754/development-of-improved-radiation-drive-environment-for-high-foot-implosions-at-the-national-ignition-facility
#4
D E Hinkel, L F Berzak Hopkins, T Ma, J E Ralph, F Albert, L R Benedetti, P M Celliers, T Döppner, C S Goyon, N Izumi, L C Jarrott, S F Khan, J L Kline, A L Kritcher, G A Kyrala, S R Nagel, A E Pak, P Patel, M D Rosen, J R Rygg, M B Schneider, D P Turnbull, C B Yeamans, D A Callahan, O A Hurricane
Analyses of high foot implosions show that performance is limited by the radiation drive environment, i.e., the hohlraum. Reported here are significant improvements in the radiation environment, which result in an enhancement in implosion performance. Using a longer, larger case-to-capsule ratio hohlraum at lower gas fill density improves the symmetry control of a high foot implosion. Moreover, for the first time, these hohlraums produce reduced levels of hot electrons, generated by laser-plasma interactions, which are at levels comparable to near-vacuum hohlraums, and well within specifications...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925748/role-of-the-%C3%AE-resonance-in-the-population-of-a-four-nucleon-state-in-the-56-fe%C3%A2-54-fe-reaction-at-relativistic-energies
#5
Zs Podolyák, C M Shand, N Lalović, J Gerl, D Rudolph, T Alexander, P Boutachkov, M L Cortés, M Górska, I Kojouharov, N Kurz, C Louchart, E Merchán, C Michelagnoli, R M Pérez-Vidal, S Pietri, D Ralet, M Reese, H Schaffner, Ch Stahl, H Weick, F Ameil, G de Angelis, T Arici, R Carroll, Zs Dombrádi, A Gadea, P Golubev, M Lettmann, C Lizarazo, D Mahboub, H Pai, Z Patel, N Pietralla, P H Regan, L G Sarmiento, O Wieland, E Wilson, B Birkenbach, B Bruyneel, I Burrows, L Charles, E Clément, F C L Crespi, D M Cullen, P Désesquelles, J Eberth, V González, T Habermann, L Harkness-Brennan, H Hess, D S Judson, A Jungclaus, W Korten, M Labiche, A Maj, D Mengoni, D R Napoli, A Pullia, B Quintana, G Rainovski, P Reiter, M D Salsac, E Sanchis, J J Valiente Dóbon
The ^{54}Fe nucleus was populated from a ^{56}Fe beam impinging on a Be target with an energy of E/A=500  MeV. The internal decay via γ-ray emission of the 10^{+} metastable state was observed. As the structure of this isomeric state has to involve at least four unpaired nucleons, it cannot be populated in a simple two-neutron removal reaction from the ^{56}Fe ground state. The isomeric state was produced in the low-momentum (-energy) tail of the parallel momentum (energy) distribution of ^{54}Fe, suggesting that it was populated via the decay of the Δ^{0} resonance into a proton...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925731/late-time-mixing-sensitivity-to-initial-broadband-surface-roughness-in-high-energy-density-shear-layers
#6
K A Flippo, F W Doss, J L Kline, E C Merritt, D Capelli, T Cardenas, B DeVolder, F Fierro, C M Huntington, L Kot, E N Loomis, S A MacLaren, T J Murphy, S R Nagel, T S Perry, R B Randolph, G Rivera, D W Schmidt
Using a large volume high-energy-density fluid shear experiment (8.5  cm^{3}) at the National Ignition Facility, we have demonstrated for the first time the ability to significantly alter the evolution of a supersonic sheared mixing layer by controlling the initial conditions of that layer. By altering the initial surface roughness of the tracer foil, we demonstrate the ability to transition the shear mixing layer from a highly ordered system of coherent structures to a randomly ordered system with a faster growing mix layer, indicative of strong mixing in the layer at a temperature of several tens of electron volts and at near solid density...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925641/simvastatin-exposure-and-rotator-cuff-repair-in-a-rat-model
#7
Matthew E Deren, John R Ehteshami, Joshua S Dines, Mark C Drakos, Steve B Behrens, Stephen Doty, Struan H Coleman
Simvastatin is a common medication prescribed for hypercholesterolemia that accelerates local bone formation. It is unclear whether simvastatin can accelerate healing at the tendon-bone interface after rotator cuff repair. This study was conducted to investigate whether local and systemic administration of simvastatin increased tendon-bone healing of the rotator cuff as detected by maximum load to failure in a controlled animal-based model. Supraspinatus tendon repair was performed on 120 Sprague-Dawley rats...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27925617/what-causes-mating-system-shifts-in-plants-arabidopsis-lyrata-as-a-case-study
#8
B K Mable, J Hagmann, S-T Kim, A Adam, E Kilbride, D Weigel, M Stift
No abstract text is available yet for this article.
December 7, 2016: Heredity
https://www.readbyqxmd.com/read/27925337/complication-rates-of-catheter-ablation-of-atrial-fibrillation-in-patients-aged-%C3%A2-75-years-versus-75-years-results-from-the-german-ablation-registry
#9
J Moser, S Willems, D Andresen, J Brachmann, L Eckardt, E Hoffmann, K H Kuck, T Lewalter, B Schumacher, S G Spitzer, M Hochadel, J Senges, B A Hoffmann
INTRODUCTION: Despite a rising demand for catheter ablation (CA) of atrial fibrillation (AF) in an elderly population, complication and success rates are not fully elucidated. We sought to compare complication rates of CA of AF in patients ≥ 75 versus < 75 years of age. METHODS AND RESULTS: Patients with symptomatic, drug-refractory AF were prospectively enrolled from January 2007 to 2010 in this multicenter study. A total of 4449 patients, group 1 ≥ 75 years and group 2 < 75 years (n = 227, age 77...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27924983/detection-of-the-tuberculosis-antigenic-marker-mannose-capped-lipoarabinomannan-in-pretreated-serum-by-surface-enhanced-raman-scattering
#10
Alexis C Crawford, Lars B Laurentius, Timothy S Mulvihill, Jennifer H Granger, John S Spencer, Delphi Chatterjee, Kimberly E Hanson, Marc D Porter
The ability to detect tuberculosis (TB) continues to be a global health care priority. This paper describes the development and preliminary assessment of the clinical accuracy of a heterogeneous immunoassay that integrates a serum pretreatment process with readout by surface-enhanced Raman scattering (SERS) for the low-level detection of mannose-capped lipoarabinomannan (ManLAM). ManLAM is a major virulence factor in the infectious pathology of Mycobacterium tuberculosis (Mtb) that has been found in the serum and other body fluids of infected patients...
December 7, 2016: Analyst
https://www.readbyqxmd.com/read/27924434/prophylactic-antibiotics-for-percutaneous-endovascular-procedures
#11
REVIEW
N S Greaves, E Katsogridakis, B Faris, D Murray
Percutaneous endovascular techniques are used increasingly in the vascular armamentarium. Commonly performed as day case procedures under local anaesthetic, they are suited to the highly co-morbid vascular patient population. Furthermore, technological advances have resulted in ever improving outcomes for aneurysmal and occlusive disease. Endovascular procedures such as endovascular aneurysm repair or iliac artery stenting are traditionally associated with reduced infectious complications compared to equivalent open techniques...
December 6, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27924052/magnetic-resonance-imaging-and-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage-a-systematic-review-and-meta-analysis
#12
Lisa A van der Kleij, Jill B De Vis, Jean-Marc Olivot, Lionel Calviere, Christophe Cognard, Nicolaas P A Zuithoff, Gabriel J E Rinkel, Jeroen Hendrikse, Mervyn D I Vergouwen
No abstract text is available yet for this article.
December 6, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27923802/xanthohumol-prevents-dna-damage-by-dietary-carcinogens-results-of-a-human-intervention-trial
#13
Christoph Pichler, Franziska Ferk, Halh Al-Serori, Wolfgang Huber, Walter Jäger, Monika Waldherr, Miroslav Mišík, Michael Kundi, Armen Nersesyan, Irene Herbacek, Siegfried Knasmueller
Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. In vitro and animal studies indicated that XN has DNA and cancer protective properties. To find out if it causes DNA protective effects in humans, an intervention trial was conducted in which the participants (n = 22) consumed a XN containing drink (12 mg XN/P/d). We monitored prevention of DNA damage induced by representatives of major groups of dietary carcinogens [i.e., nitrosodimethylamine (NDMA) benzo(a)pyrene (B(a)P) and the heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)]...
December 6, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27923479/immune-cell-infiltration-in-feline-meningioma
#14
R McBride, E A Sloma, H N Erb, A D Miller
Meningioma is the most common primary brain tumour in the cat. Although most of these tumours are considered to be benign based on histological characteristics, little is known regarding microenvironmental changes associated with the tumour. The characterization of the immune-cell infiltrate in human and canine meningiomas has been described; however, there are no data regarding the cat equivalent. Seventeen formalin-fixed, paraffin wax-embedded samples of feline meningioma were evaluated by light microscopy and immunohistochemistry (IHC) for expression of CD3, Pax5, Iba-1, HLA-DR, MAC387, CD163 and Ki67...
December 3, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27923249/thyroid-function-in-human-obesity-underlying-mechanisms
#15
L C Fontenelle, M M Feitosa, J S Severo, T E C Freitas, J B S Morais, F L Torres-Leal, G S Henriques, D do Nascimento Marreiro
Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various hormones are observed in obese patients. In this context, recent research has shown that overweight can influence the function of the thyroid gland, usually leading to increased thyrotropin concentrations and changes in the ratio between the hormones triiodothyronine and thyroxine, though within the normal range. The etiology of these changes is still unclear; however, several mechanisms have been proposed including the adaptive process to increase energy expenditure, hyperleptinemia, changes in the activity of deiodinases, the presence of thyroid hormones resistance, chronic low-grade inflammation, and insulin resistance...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27922933/the-cross-sectional-association-between-vasomotor-symptoms-and-hemostatic-parameter-levels-in-postmenopausal-women
#16
Laura B Harrington, Marc Blondon, Mary Cushman, Andrew M Kaunitz, Jacques E Rossouw, Matthew A Allison, Lisa W Martin, Karen C Johnson, Jan Rosing, Nancy F Woods, Andrea Z LaCroix, Susan R Heckbert, Barbara McKnight, Nicholas L Smith
OBJECTIVE: Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants. METHODS: This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922636/dna-methylation-and-substance-use-risk-a-prospective-genome-wide-study-spanning-gestation-to-adolescence
#17
C A M Cecil, E Walton, R G Smith, E Viding, E J McCrory, C L Relton, M Suderman, J-B Pingault, W McArdle, T R Gaunt, J Mill, E D Barker
Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or a consequence of substance use. Here, we believe we conducted the first genome-wide, longitudinal study to investigate whether DNA methylation patterns in early life prospectively associate with substance use in adolescence. The sample comprised of 244 youth (51% female) from the Avon Longitudinal Study of Parents and Children (ALSPAC), with repeated assessments of DNA methylation (Illumina 450k array; cord blood at birth, whole blood at age 7) and substance use (tobacco, alcohol and cannabis use; age 14-18)...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27922633/variable-telomere-length-across-post-mortem-human-brain-regions-and-specific-reduction-in-the-hippocampus-of-major-depressive-disorder
#18
F Mamdani, B Rollins, L Morgan, R M Myers, J D Barchas, A F Schatzberg, S J Watson, H Akil, S G Potkin, W E Bunney, M P Vawter, P A Sequeira
No abstract text is available yet for this article.
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27922632/a-phenome-wide-examination-of-neural-and-cognitive-function
#19
R A Poldrack, E Congdon, W Triplett, K J Gorgolewski, K H Karlsgodt, J A Mumford, F W Sabb, N B Freimer, E D London, T D Cannon, R M Bilder
This data descriptor outlines a shared neuroimaging dataset from the UCLA Consortium for Neuropsychiatric Phenomics, which focused on understanding the dimensional structure of memory and cognitive control (response inhibition) functions in both healthy individuals (130 subjects) and individuals with neuropsychiatric disorders including schizophrenia (50 subjects), bipolar disorder (49 subjects), and attention deficit/hyperactivity disorder (43 subjects). The dataset includes an extensive set of task-based fMRI assessments, resting fMRI, structural MRI, and high angular resolution diffusion MRI...
December 6, 2016: Scientific Data
https://www.readbyqxmd.com/read/27922578/facet-joint-violation-during-percutaneous-pedicle-screw-placement-a-comparison-of-two-techniques
#20
Oliver Tannous, Ehsan Jazini, Tristan B Weir, Kelley E Banagan, Eugene Y Koh, D Greg Anderson, Daniel E Gelb, Steven C Ludwig
STUDY DESIGN: A comparative study of facet joint violation (FJV) using two percutaneous surgical techniques. OBJECTIVE: To compare the rate of iatrogenic FJV and medial pedicle wall breach between two methods of percutaneous pedicle screw instrumentation in the thoracic and lumbar spine. SUMMARY OF BACKGROUND DATA: Variable iatrogenic damage to the facet joints has been reported to occur with percutaneous pedicle screw techniques, compared with the open approach, which has been associated with adjacent segment disease...
December 2, 2016: Spine
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