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https://www.readbyqxmd.com/read/28103614/enrichment-of-putative-pax8-target-genes-at-serous-epithelial-ovarian-cancer-susceptibility-loci
#1
Siddhartha P Kar, Emily Adler, Jonathan Tyrer, Dennis Hazelett, Hoda Anton-Culver, Elisa V Bandera, Matthias W Beckmann, Andrew Berchuck, Natalia Bogdanova, Louise Brinton, Ralf Butzow, Ian Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Agnieszka Dansonka-Mieszkowska, Jennifer Anne Doherty, Thilo Dörk, Matthias Dürst, Diana Eccles, Peter A Fasching, James Flanagan, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Ellen L Goode, Marc T Goodman, Jacek Gronwald, Florian Heitz, Michelle A T Hildebrandt, Estrid Høgdall, Claus K Høgdall, David G Huntsman, Allan Jensen, Beth Y Karlan, Linda E Kelemen, Lambertus A Kiemeney, Susanne K Kjaer, Jolanta Kupryjanczyk, Diether Lambrechts, Douglas A Levine, Qiyuan Li, Jolanta Lissowska, Karen H Lu, Jan Lubiński, Leon F A G Massuger, Valerie McGuire, Iain McNeish, Usha Menon, Francesmary Modugno, Alvaro N Monteiro, Kirsten B Moysich, Roberta B Ness, Heli Nevanlinna, James Paul, Celeste L Pearce, Tanja Pejovic, Jennifer B Permuth, Catherine Phelan, Malcolm C Pike, Elizabeth M Poole, Susan J Ramus, Harvey A Risch, Mary Anne Rossing, Helga B Salvesen, Joellen M Schildkraut, Thomas A Sellers, Mark Sherman, Nadeem Siddiqui, Weiva Sieh, Honglin Song, Melissa Southey, Kathryn L Terry, Shelley S Tworoger, Christine Walsh, Nicolas Wentzensen, Alice S Whittemore, Anna H Wu, Hannah Yang, Wei Zheng, Argyrios Ziogas, Matthew L Freedman, Simon A Gayther, Paul D P Pharoah, Kate Lawrenson
BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriched for target genes of transcription factors (TFs) critical to somatic tumorigenesis. METHODS: All 615 TF-target sets from the Molecular Signatures Database were evaluated using gene set enrichment analysis (GSEA) and three GWAS for SOC risk: discovery (2196 cases/4396 controls), replication (7035 cases/21 693 controls; independent from discovery), and combined (9627 cases/30 845 controls; including additional individuals)...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103492/a-novel-type-of-gene-interaction-in-d-melanogaster
#2
B F Chadov, E V Chadova, N B Fedorova
The genes interact according to classical mechanisms, namely, complementation, modification, polymery, and epistasis, in the cells and organisms carrying these genes. Here we describe a novel type of gene interaction when the interacting genes reside in parents, whereas the interaction event takes place in their progenies lacking these genes. The conditional mutations in the D. melanogaster male X chromosome caused the "prohibition on producing daughters" in its offspring. The chromosomal rearrangements in chromosomes 2 and 3 of its female partner removed the prohibition...
January 11, 2017: Mutation Research
https://www.readbyqxmd.com/read/28103304/correction-the-fatty-acid-synthase-inhibitor-platensimycin-improves-insulin-resistance-without-inducing-liver-steatosis-in-mice-and-monkeys
#3
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
[This corrects the article DOI: 10.1371/journal.pone.0164133.].
2017: PloS One
https://www.readbyqxmd.com/read/28103018/copper-oxygen-complexes-revisited-structures-spectroscopy-and-reactivity
#4
Courtney E Elwell, Nicole L Gagnon, Benjamin D Neisen, Debanjan Dhar, Andrew D Spaeth, Gereon M Yee, William B Tolman
A longstanding research goal has been to understand the nature and role of copper-oxygen intermediates within copper-containing enzymes and abiological catalysts. Synthetic chemistry has played a pivotal role in highlighting the viability of proposed intermediates and expanding the library of known copper-oxygen cores. In addition to the number of new complexes that have been synthesized since the previous reviews on this topic in this journal (Mirica, L. M.; Ottenwaelder, X.; Stack, T. D. P. Chem. Rev. 2004, 104, 1013-1046 and Lewis, E...
January 19, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28102045/inflammatory-profile-discriminates-clinical-subtypes-in-lrrk2-associated-parkinson-s-disease
#5
K Brockmann, C Schulte, N Schneiderhan-Marra, A Apel, C Pont-Sunyer, D Vilas, J Ruiz-Martinez, M Langkamp, J-C Corvol, F Cormier, T Knorpp, T O Joos, A Bernard, T Gasser, C Marras, B Schüle, J O Aasly, T Foroud, J F Marti-Masso, A Brice, E Tolosa, D Berg, W Maetzler
BACKGROUND AND PURPOSE: The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes. METHODS: An extensive battery of peripheral inflammatory markers was measured in human serum in a multicentre cohort of 142 PDLRRK2 patients from the MJFF LRRK2 Consortium, stratified by three different subtypes as recently proposed for idiopathic Parkinson's disease: diffuse/malignant, intermediate and mainly pure motor...
February 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28101651/eslicarbazepine-acetate-its-effectiveness-as-adjunctive-therapy-in-clinical-trials-and-open-studies
#6
REVIEW
S D Shorvon, E Trinka, B J Steinhoff, M Holtkamp, V Villanueva, J Peltola, E Ben-Menachem
Eslicarbazepine acetate (ESL) is a once-daily antiepileptic drug that is approved as adjunctive therapy in adults with focal-onset seizures. Following oral administration, ESL is rapidly metabolized to its active metabolite, eslicarbazepine, which acts primarily by enhancing slow inactivation of voltage-gated sodium channels. The efficacy and safety/tolerability of ESL in the adjunctive setting were established in a comprehensive Phase III program (n = 1702 randomized patients) and this evidence has been supported by several open studies (n = 864)...
January 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28101605/surviving-sepsis-campaign-international-guidelines-for-management-of-sepsis-and-septic-shock-2016
#7
Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger
OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015...
January 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28101443/national-physical-activity-surveillance-users-of-wearable-activity-monitors-as-a-potential-data-source
#8
John D Omura, Susan A Carlson, Prabasaj Paul, Kathleen B Watson, Janet E Fulton
The objective of this study was to assess usage patterns of wearable activity monitors among US adults and how user characteristics might influence physical activity estimates from this type of sample. We analyzed data on 3367 respondents to the 2015 HealthStyles survey, an annual consumer mail panel survey conducted on a nationwide sample. Approximately 1 in 8 respondents (12.5%) reported currently using a wearable activity monitor. Current use varied by sex, age, and education level. Use increased with physical activity level from 4...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28101431/non-invasive-terahertz-imaging-of-tissue-water-content-for-flap-viability-assessment
#9
Neha Bajwa, Joshua Au, Reza Jarrahy, Shijun Sung, Michael C Fishbein, David Riopelle, Daniel B Ennis, Tara Aghaloo, Maie A St John, Warren S Grundfest, Zachary D Taylor
Accurate and early prediction of tissue viability is the most significant determinant of tissue flap survival in reconstructive surgery. Perturbation in tissue water content (TWC) is a generic component of the tissue response to such surgeries, and, therefore, may be an important diagnostic target for assessing the extent of flap viability in vivo. We have previously shown that reflective terahertz (THz) imaging, a non-ionizing technique, can generate spatially resolved maps of TWC in superficial soft tissues, such as cornea and wounds, on the order of minutes...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101252/identification-of-proteins-from-wild-cardoon-flowers-cynara-cardunculus-l-by-a-proteomic-approach
#10
Amal Ben Amira, Julien Bauwens, Edwin De Pauw, Souhail Besbes, Hamadi Attia, Frédéric Francis, Christophe Blecker
Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for getting reliable results, two different extraction/precipitation methods (trichloroacetic acid and phenol/ammonium acetate) were tested on fresh and lyophilized flowers. After two-dimensional electrophoresis (2D-E) separations, a better protein pattern was obtained after phenol extraction from lyophilized flowers...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101245/apobec3b-expression-in-human-leptomeninges-and-meningiomas
#11
Mahlon D Johnson, Jay E Reeder, Mary O'Connell
Nucleic acid-editing enzymes of the apolipoprotein B mRNA-editing enzyme (APOBEC) family have been associated with somatic mutation in cancer. However, the role of APOBEC catalytic subunit 3B (APOBEC3B) editing in the pathogenesis of base substitutions in meningiomas is unknown. In the present study, the expression of APOBEC3B was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analyses in five fetal and one adult human leptomeninges and 38 meningiomas. Genomic DNA was sequenced using the Illumina Tru-Seq Cancer Panel...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100839/tyrosine-kinase-blocking-collagen-iv-derived-peptide-suppresses-ocular-neovascularization-and-vascular-leakage
#12
Raquel Lima E Silva, Yogita Kanan, Adam C Mirando, Jayoung Kim, Ron B Shmueli, Valeria E Lorenc, Seth D Fortmann, Jason Sciamanna, Niranjan B Pandey, Jordan J Green, Aleksander S Popel, Peter A Campochiaro
Vascular endothelial growth factor (VEGF)-neutralizing proteins provide benefit in several retinal and choroidal vascular diseases, but some patients still experience suboptimal outcomes, and the need for frequent intraocular injections is a barrier to good outcomes. A mimetic peptide derived from collagen IV, AXT107, suppressed subretinal neovascularization (NV) in two mouse models predictive of effects in neovascular age-related macular degeneration (NVAMD) and inhibited retinal NV in a model predictive of effects in ischemic retinopathies...
January 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28100812/problems-with-equating-thermal-preference-with-emotional-fever-and-sentience-comment-on-fish-can-show-emotional-fever-stress-induced-hyperthermia-in-zebrafish-by-rey-et-al-2015
#13
B Key, R Arlinghaus, H I Browman, S J Cooke, I G Cowx, B K Diggles, J D Rose, W Sawynok, A Schwab, A B Skiftesvik, E D Stevens, C A Watson
No abstract text is available yet for this article.
January 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28100782/triphosphate-re-orientation-of-the-incoming-nucleotide-as-a-fidelity-checkpoint-in-viral-rna-dependent-rna-polymerases
#14
Xiaorong Yang, Xinran Liu, Derek M Musser, Ibrahim M Moustafa, Jamie J Arnold, Craig E Cameron, David D Boehr
The nucleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for maintaining functional genetic information, but at the same time for generating sufficient genetic diversity to escape the bottlenecks of the host's anti-viral response. We have previously shown that the structural dynamics of the motif-D loop is closely related to nucleotide discrimination. Previous studies have also suggested that there is a re-orientation of the triphosphate of the incoming nucleotide, which is essential prior to nucleophilic attack from the primer RNA 3'-hydroxyl...
January 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28100766/comparison-of-a-chop-lasp-based-protocol-with-and-without-maintenance-for-canine-multicentric-lymphoma
#15
E M Lautscham, M Kessler, T Ernst, L Willimzig, R Neiger
The recommendation to treat canine lymphoma with a discontinuous protocol is based on small case numbers and mostly historic controls. This study compares duration of first remission (DFR) and overall survival time (ST) with a discontinuous protocol to the same protocol with maintenance phase. 408 dogs were treated with a CHOP-LAsp (C=cyclophosphamide; H=hydroxydaunorubicin; O=Oncovin; P=prednisolone; LAsp=l-asparaginase)-based 28-week induction protocol. In 75 dogs (cohort 1), this was followed by a maintenance phase consisting of vincristine, chlorambucil and actinomycin-D with a total treatment duration of two years...
January 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28100691/registry-in-a-tube-multiplexed-pools-of-retrievable-parts-for-genetic-design-space-exploration
#16
Lauren B A Woodruff, Thomas E Gorochowski, Nicholas Roehner, Tarjei S Mikkelsen, Douglas Densmore, D Benjamin Gordon, Robert Nicol, Christopher A Voigt
No abstract text is available yet for this article.
January 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28100288/childhood-maltreatment-and-eating-disorder-pathology-a-systematic-review-and-dose-response-meta-analysis
#17
M L Molendijk, H W Hoek, T D Brewerton, B M Elzinga
BACKGROUND: Meta-analyses have established a high prevalence of childhood maltreatment (CM) in patients with eating disorders (EDs) relative to the general population. Whether the prevalence of CM in EDs is also high relative to that in other mental disorders has not yet been established through meta-analyses nor to what extent CM affects defining features of EDs, such as number of binge/purge episodes or age at onset. Our aim is to provide meta-analyses on the associations between exposure to CM (i...
January 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28100280/erratum-to-the-whole-genome-sequence-of-the-mediterranean-fruit-fly-ceratitis-capitata-wiedemann-reveals-insights-into-the-biology-and-adaptive-evolution-of-a-highly-invasive-pest-species
#18
Alexie Papanicolaou, Marc F Schetelig, Peter Arensburger, Peter W Atkinson, Joshua B Benoit, Kostas Bourtzis, Pedro Castañera, John P Cavanaugh, Hsu Chao, Christopher Childers, Ingrid Curril, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Markus Friedrich, Giuliano Gasperi, Scott Geib, Georgios Georgakilas, Richard A Gibbs, Sarah D Giers, Ludvik M Gomulski, Miguel González-Guzmán, Ana Guillem-Amat, Yi Han, Artemis G Hatzigeorgiou, Pedro Hernández-Crespo, Daniel S T Hughes, Jeffery W Jones, Dimitra Karagkouni, Panagiota Koskinioti, Sandra L Lee, Anna R Malacrida, Mosè Manni, Kostas Mathiopoulos, Angela Meccariello, Monica Munoz-Torres, Shwetha C Murali, Terence D Murphy, Donna M Muzny, Georg Oberhofer, Félix Ortego, Maria D Paraskevopoulou, Monica Poelchau, Jiaxin Qu, Martin Reczko, Hugh M Robertson, Andrew J Rosendale, Andrew E Rosselot, Giuseppe Saccone, Marco Salvemini, Grazia Savini, Patrick Schreiner, Francesca Scolari, Paolo Siciliano, Sheina B Sim, George Tsiamis, Enric Ureña, Ioannis S Vlachos, John H Werren, Ernst A Wimmer, Kim C Worley, Antigone Zacharopoulou, Stephen Richards, Alfred M Handler
No abstract text is available yet for this article.
January 18, 2017: Genome Biology
https://www.readbyqxmd.com/read/28099988/exercise-based-rehabilitation-programmes-for-pulmonary-hypertension
#19
REVIEW
Norman R Morris, Fiona D Kermeen, Anne E Holland
BACKGROUND: Individuals with pulmonary hypertension (PH) have reduced exercise capacity and quality of life. Despite initial concerns that exercise training may worsen symptoms in this group, several studies have reported improvements in functional capacity and well-being following exercise-based rehabilitation in PH. OBJECTIVES: To assess the efficacy and safety of exercise-based rehabilitation for people with PH. Primary outcomes were exercise capacity, adverse events during the intervention period and health-related quality of life (HRQoL)...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28099688/discerning-the-survival-advantage-among-patients-with-prostate-cancer-who-undergo-radical-prostatectomy-or-radiotherapy-the-limitations-of-cancer-registry-data
#20
Stephen B Williams, Jinhai Huo, Karim Chamie, Marc C Smaldone, Christopher D Kosarek, Justin E Fang, Leslie M Ynalvez, Simon P Kim, Karen E Hoffman, Sharon H Giordano, Brian F Chapin
BACKGROUND: The objective of this study was to compare the overall survival of patients who undergo radical prostatectomy or radiotherapy versus noncancer controls to discern whether there is a survival advantage according to prostate cancer treatment and the impact of selection bias on these results. METHODS: A matched cohort study was performed using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. In total, 34,473 patients ages 66 to 75 years were identified who were without significant comorbidity, were diagnosed with localized prostate cancer, and received treatment treated with surgery or radiotherapy between 2004 and 2011...
January 18, 2017: Cancer
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