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https://www.readbyqxmd.com/read/28544807/effects-of-teriparatide-on-joint-erosions-in-rheumatoid-arthritis-a-randomized-controlled-trial
#1
D H Solomon, J Kay, J Duryea, B Lu, M B Bolster, R A Yood, R Han, S Ball, C Coleman, E Lo, A Wohlfahrt, M Sury, M Yin, Z Yu, A Zak, E M Gravallese
BACKGROUND: Articular erosions correlate with disability in rheumatoid arthritis (RA). Biologic treatments for RA reduce erosion progression, but erosion healing occurs infrequently. The goal of this study was to assess the effects of the anabolic agent teriparatide on joint erosion volume in RA patients treated with a tumor necrosis factor inhibitor (TNFi). METHODS: We conducted a randomized controlled trial in 24 patients with erosive RA, osteopenia, and disease activity controlled on a TNFi for at least three months...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28544494/4-substituted-thieno-2-3-d-pyrimidines-as-potent-antibacterial-agents-rational-design-microwave-assisted-synthesis-biological-evaluation-and-molecular-docking-studies
#2
Rupinder K Gill, Harpreet Singh, Tilak Raj, Anuradha Sharma, Gagandeep Singh, Jitender Bariwal
In an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. Compounds 12b and 13c showed the promising inhibitory potencies against S. aureus, B. subtilis, P. aeruginosa and E. coli with MICs ranging from 2 to 10 μg/ml. Compound 13c was also found to be highly potent against methicillin resistant S...
May 23, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28544398/prediction-of-long-term-clinical-outcome-in-a-diverse-chronic-hepatitis-b-population-role-of-the-page-b-score
#3
Willem P Brouwer, Adriaan J van der Meer, Andre Boonstra, Elisabeth P C Plompen, Suzan D Pas, Robert J de Knegt, Rob A de Man, Fiebo J W Ten Kate, Harry L A Janssen, Bettina E Hansen
BACKGROUND & AIMS: An abundance of non-invasive scores have been associated with fibrosis and hepatocellular carcinoma (HCC) development. We aimed to compare the prognostic ability of these scores in relation to liver histology in chronic hepatitis B (CHB) patients. METHODS: Liver biopsies from treatment-naïve CHB patients at one tertiary care centre were scored by a single hepato-pathologist. Laboratory values at liver biopsy were used to calculate the PAGE-B, REACH-B, GAG-HCC, CU-HCC, and FIB-4 scores...
May 24, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28544327/genetic-variation-at-the-th2-immune-gene-il13-is-associated-with-ige-mediated-paediatric-food-allergy
#4
S E Ashley, H-T T Tan, R Peters, K J Allen, P Vuillermin, S C Dharmage, M L K Tang, J Koplin, A Lowe, A-L Ponsonby, J Molloy, M C Matheson, R Saffery, J A Ellis, D Martino
BACKGROUND: Food allergies pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-old infants. Few food allergy genetic risk variants have yet been identified. The Th2 immune gene IL13 is a highly plausible genetic candidate as it is central to the initiation of IgE class switching in B cells. OBJECTIVE: Here, we sought to investigate whether genetic polymorphisms at IL13 are associated with the development of challenge-proven IgE-mediated food allergy...
April 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28544101/belatacept-combined-with-transient-calcineurin-inhibitor-therapy-prevents-rejection-and-promotes-improved-long-term-renal-allograft-function
#5
A B Adams, J Goldstein, C Garrett, R Zhang, R E Patzer, K A Newell, N A Turgeon, A S Chami, A Guasch, A D Kirk, S O Pastan, T C Pearson, C P Larsen
Belatacept, a T cell costimulation-blocker demonstrated superior renal function, lower cardiovascular risk, and improved graft/patient survival in renal transplant recipients. Despite the potential benefits, adoption of belatacept has been limited in part due to concerns regarding higher rates and grades of acute rejection in clinical trials. Since July 2011 we have utilized belatacept-based immunosuppression regimens in clinical practice. In this retrospective analysis of 745 patients undergoing renal transplantation at our center, we compared patients treated with belatacept (n=535) to a historical cohort receiving a tacrolimus-based protocol (n=205)...
May 23, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28544094/development-and-validation-of-the-patient-physician-relationship-scale-among-patients-with-irritable-bowel-syndrome
#6
J E Kurlander, W D Chey, C B Morris, Y J B Hu, R K Padival, S I Bangdiwala, N J Norton, W F Norton, D A Drossman
BACKGROUND: An effective patient-physician relationship (PPR) is essential to the care of patients with irritable bowel syndrome (IBS). We sought to develop and validate an IBS-specific instrument to measure expectations of the PPR. METHODS: We conducted structured focus groups about PPRs with 12 patients with IBS. Qualitative analysis was used to generate a questionnaire (the Patient-Physician Relationship Scale [PPRS]), which was modified with input from content experts and usability testing...
May 22, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28543092/effect-of-ultrasonic-and-sonic-activation-of-root-canal-sealers-on-the-push-out-bond-strength-and-interfacial-adaptation-to-root-canal-dentine
#7
P E B Wiesse, R D Pereira, Y C T Silva-Sousa, C Estrela, M D Sousa-Neto, J D Pécora
AIM: To evaluate the effect of ultrasonic and sonic activation of two root canal sealers on interfacial adaptation and push-out bond strength (BS) to root canal dentine. METHODOLOGY: The root canals of seventy-eight roots of maxillary canines was prepared with Ni-Ti rotary instruments under irrigation with 2.5% NaOCl and 17% EDTA. Canals were filled by lateral condensation of gutta-percha and AH Plus (n=39) or MTA Fillapex (n=39). Three subgroups (n=13) were formed according to sealer activation: no activation (NA), sonic activation (SA, 20 s) and ultrasonic activation (US, 20 s)...
May 22, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28543042/the-ntcp-inhibitor-myrcludex-b-effects-on-bile-acid-disposition-and-tenofovir-pharmacokinetics
#8
Antje Blank, Annette Eidam, Mathias Haag, Nicolas Hohmann, Jürgen Burhenne, Matthias Schwab, Stan F J van de Graaf, Markus R Meyer, Hans H Maurer, Katrin Meier, Johanna Weiss, Thomas Bruckner, Alexander Alexandrov, Stephan Urban, Gerd Mikus, Walter E Haefeli
Myrcludex B acts as a hepatitis B and D virus entry inhibitor blocking the sodium taurocholate co-transporting polypeptide (SLC10A1). We investigated effects of myrcludex B on plasma bile acid disposition, tenofovir pharmacokinetics, and perpetrator characteristics on cytochrome P450 (CYP) 3A. Twelve healthy volunteers received 300 mg tenofovir disoproxil fumarate orally and 10 mg subcutaneous myrcludex B. Myrcludex B increased total plasma bile acid exposure 18.2-fold without signs of cholestasis. The rise in conjugated bile acids was up to 123-fold (taurocholic acid)...
May 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28542733/the-pathogenesis-of-dermatomyositis
#9
REVIEW
C Thompson, V Piguet, E Choy
This review looks at the many different factors thought to play a role in idiopathic inflammatory myopathies (IIM), concentrating mainly on the dermatomyositis (DM) subtype. Subject areas addressed include looking at the different clinical features of IIM, paying particular attention to the skin manifestations. There is a discussion around investigations needed with their perceived value, followed by a description of the immunohistochemical findings of DM. This review goes on to address other attributing factors such as genetic associations with the different subtypes of IIM, and environmental factors including infections, ultraviolet radiation and vitamin D deficiency and drugs...
May 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28542541/varicella-zoster-virus-glycoprotein-c-increases-chemokine-mediated-leukocyte-migration
#10
Víctor González-Motos, Carina Jürgens, Birgit Ritter, Kai A Kropp, Verónica Durán, Olav Larsen, Anne Binz, Werner J D Ouwendijk, Tihana Lenac Rovis, Stipan Jonjic, Georges M G M Verjans, Beate Sodeik, Thomas Krey, Rudolf Bauerfeind, Thomas F Schulz, Benedikt B Kaufer, Ulrich Kalinke, Amanda E I Proudfoot, Mette M Rosenkilde, Abel Viejo-Borbolla
Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain in adults. Following infection of epithelial cells in the respiratory tract, VZV spreads within the host by hijacking leukocytes, including T cells, in the tonsils and other regional lymph nodes, and modifying their activity. In spite of its importance in pathogenesis, the mechanism of dissemination remains poorly understood...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28542265/ovarian-features-in-white-tailed-deer-odocoileus-virginianus-fawns-and-does
#11
G D A Gastal, A Hamilton, B G Alves, S G S de Tarso, J M Feugang, W J Banz, G A Apgar, C K Nielsen, E L Gastal
The knowledge about ovarian reserve is essential to determine the reproductive potential and to improve the methods of fertility control for overpopulated species, such as white-tailed deer (Odocoileus virginianus). The goal of this study was to evaluate the effect of age on the female reproductive tract of white-tailed deer, focusing on ovarian features. Genital tracts from 8 prepubertal and 10 pubertal females were used to characterize the preantral follicle population and density, morphology, distribution of follicular classes; stromal cell density; and apoptosis in the ovary...
2017: PloS One
https://www.readbyqxmd.com/read/28542031/septic-coronary-embolization-in-a-patient-with-congenitally-corrected-transposition-of-the-great-arteries
#12
Mehdi Rambod, Abraham D Abernethy, Prospero B Gogo, William E Hopkins
No abstract text is available yet for this article.
May 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28541756/genetic-diversity-of-mtdna-d-loop-sequences-in-four-native-chinese-chicken-breeds
#13
H W Guo, C Li, X N Wang, Z J Li, G R Sun, G X Li, X J Liu, X T Kang, R L Han
1. To explore the genetic diversity of Chinese indigenous chicken breeds, a 585 bp fragment of the mitochondrial DNA (mtDNA) region was sequenced in 102 birds from the Xichuan Black-bone chicken, Yunyang Black-bone chicken and Lushi chicken. In addition, 30 mtDNA D-loop sequences of Silkie fowls were downloaded from NCBI. The mtDNA D-loop sequence polymorphism and maternal origin of 4 chicken breeds were analysed in this study. 2. The results showed that a total of 33 mutation sites and 28 haplotypes were detected in the 4 chicken breeds...
May 25, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28541547/relationship-of-genotype-for-hla-b-57-and-ifnl4-with-disease-progression-in-female-hiv-controllers
#14
Mark H Kuniholm, Howard D Strickler, Kathryn Anastos, Ludmila Prokunina-Olsson, Bradley E Aouizerat, Thomas R O'Brien
No abstract text is available yet for this article.
May 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28541326/rapidly-star-forming-galaxies-adjacent-to-quasars-at-redshifts-exceeding-6
#15
R Decarli, F Walter, B P Venemans, E Bañados, F Bertoldi, C Carilli, X Fan, E P Farina, C Mazzucchelli, D Riechers, H-W Rix, M A Strauss, R Wang, Y Yang
The existence of massive (10(11) solar masses) elliptical galaxies by redshift z ≈ 4 (refs 1, 2, 3; when the Universe was 1.5 billion years old) necessitates the presence of galaxies with star-formation rates exceeding 100 solar masses per year at z > 6 (corresponding to an age of the Universe of less than 1 billion years). Surveys have discovered hundreds of galaxies at these early cosmic epochs, but their star-formation rates are more than an order of magnitude lower. The only known galaxies with very high star-formation rates at z > 6 are, with one exception, the host galaxies of quasars, but these galaxies also host accreting supermassive (more than 10(9) solar masses) black holes, which probably affect the properties of the galaxies...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28541130/measuring-functional-connectivity-in-stroke-approaches-and-considerations
#16
Joshua S Siegel, Gordon L Shulman, Maurizio Corbetta
Recent research has demonstrated the importance of global changes to the functional organization of brain network following stroke. Resting functional magnetic resonance imaging (R-fMRI) is a non-invasive tool that enables the measurement of functional connectivity (FC) across the entire brain while placing minimal demands on the subject. For these reasons, it is a uniquely appealing tool for studying the distant effects of stroke. However, R-fMRI studies rely on a number of premises that cannot be assumed without careful validation in the context of stroke...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28541127/screening-of-plants-with-antimicrobial-activity-against-enterobacteria-pseudomonas-spp-and-staphylococcus-spp
#17
Camila Miorelli Girondi, Analu Barros de Oliveira, Jackeline Alves Prado, Cristiane Yumi Koga-Ito, Aline Chiodi Borges, Alberto Carlos Botazzo Delbem, Daniel Freitas Alves Pereira, Marcos José Salvador, Fernanda Lourenção Brighenti
AIM: This study screened plants for antibacterial properties against bacteria of medical importance. MATERIALS & METHODS: 60 extracts were obtained from the leaves of ten plants (Jatropha weddelliana, Attalea phalerata, Buchenavia tomentosa, Croton doctoris, Mouriri elliptica, Mascagnia benthamiana, Senna aculeata, Unonopis guatterioides, Allagoptera leucocalyx and Bactris glaucescens) using different extraction methods: A) Ethanol 70°C/72 h; B) Water/5 min/100°C; C) Water/1 h/55°C; D) Water/72 h; E) Hexane/72 h and F) Ethanol 99°C/72 h...
May 25, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28541058/further-examination-of-the-factor-structure-of-the-male-role-norms-inventory-short-form-mrni-sf-measurement-considerations-for-women-men-of-color-and-gay-men
#18
Ryon C McDermott, Ronald F Levant, Joseph H Hammer, Rosalie J Hall, Daniel K McKelvey, Zachary Jones
Using multigroup structural equation modeling in a large sample of online-survey respondents (N = 6,744), the present study examined the reliability and dimensionality of the Male Role Norms Inventory-Short Form (MRNI-SF), a popular measurement of traditional masculinity ideology (TMI), and also tested measurement invariance between individuals that do and do not fit the White heterosexual male TMI reference group. Results indicated that (a) it is appropriate to model the MRNI-SF using either a bifactor or unidimensional model but not a second-order model, (b) the raw MRNI-SF total score is a suitable measure of the general TMI construct, (c) the raw self-reliance through mechanical skills and negativity toward sexual minorities subscale scores may be appropriate measures of their respective specific factors (akin to subscale factors), and (d) SEM or ipsatizing procedures should be used to model the 5 other specific factors, given the insufficient model-based reliability of their raw subscale scores...
May 25, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28540475/-intestinal-microbiota-in-individualized-therapies
#19
REVIEW
T Witte, D H Pieper, B Heidrich
During recent years, the analysis of the human microbiota has been receiving more and more scientific focus. Deep sequencing analysis enables characterization of microbial communities in different environments without the need of culture-based methods. Hereby, information about microbial communities is increasing enormously. Numerous studies in humans and animal models revealed the important role of the microbiome in emergence and natural course of diseases such as autoimmune diseases and metabolic disorders, e...
May 24, 2017: Der Internist
https://www.readbyqxmd.com/read/28540107/a-prospective-study-of-spectrum-risk-factors-and-immediate-outcome-of-congenital-anomalies-in-bida-north-central-nigeria
#20
Man Adeboye, M B Abdulkadir, O A Adegboye, A O Saka, P D Oladele, D M Oladele, E C Eze, O O Adeyemi, U Abubakar, A Grace, B F Rotimi
BACKGROUND: Congenital disorders are structural, metabolic, behavioral and functional disorders that are present at birth. Their manifestations are protean ranging from mild anomalies to life-threatening conditions. AIM: The objectives of this study were to describe the congenital anomalies in children seen at Federal Medical Center, Bida over a 12 month period, determine possible factors associated with these anomalies; and their short term outcome. SUBJECTS AND METHODS: Children with clinically recognized congenital malformations were recruited consecutively over a 12 month period and socio-demographic, etiologic and other relevant clinical data were obtained...
November 2016: Annals of Medical and Health Sciences Research
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