Zoë C Levine, Aita Sene, Winnie Mkandawire, Awa B Deme, Tolla Ndiaye, Mouhamad Sy, Amy Gaye, Younouss Diedhiou, Amadou M Mbaye, Ibrahima M Ndiaye, Jules Gomis, Médoune Ndiop, Doudou Sene, Marietou Faye Paye, Bronwyn L MacInnis, Stephen F Schaffner, Daniel J Park, Aida S Badiane, Andres Colubri, Mouhamadou Ndiaye, Ngayo Sy, Pardis C Sabeti, Daouda Ndiaye, Katherine J Siddle
The worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To characterize NMFI in Senegal, we collected venous blood and clinical metadata in a cross-sectional study of febrile patients and healthy controls in a low malaria burden area. Using 16S and untargeted sequencing, we detected viral, bacterial, or eukaryotic pathogens in 23% (38/163) of NMFI cases. Bacteria were the most common, with relapsing fever Borrelia and spotted fever Rickettsia found in 15...
January 25, 2024: Nature Communications