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https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#1
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909594/the-influence-of-adolescence-on-parents-perspectives-of-testing-and-discussing-inherited-cancer-predisposition
#2
Corinna L Schultz, Melissa A Alderfer, Robert B Lindell, Zachary McClain, Kristin Zelley, Kim E Nichols, Carol A Ford
Li-Fraumeni syndrome (LFS) is a highly penetrant cancer predisposition syndrome that may present with a first cancer before or during adolescence/young adulthood. Families offered LFS genetic testing for their children can inform our understanding of how the unique developmental context of adolescence influences parental perspectives about genetic testing and discussions of cancer risk. In this study, semi-structured interviews were conducted with 46 parents of children at risk for LFS to capture those perspectives...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909043/strategic-research-funding-a-success-story-for-medical-mycology
#3
Neil A R Gow, Tehmina Amin, Karen McArdle, Alistair J P Brown, Gordon D Brown, Adilia Warris, The Wtsa-Mmfi Consortium
The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology is a unique investment that aimed to bolster capacity, training and research activity throughout the UK. This article summarises the rationale for collective collaboration of multiple institutions to achieve synergies and address a common medical problem.
June 13, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29909014/non-coding-rnas-in-aneurysmal-aortopathy
#4
REVIEW
Joshua M Spin, Daniel Y Li, Lars Maegdefessel, Philip S Tsao
Aortic aneurysms represent a major public health burden, and currently have no medical treatment options. The pathophysiology behind these aneurysms is complex and variable, depending on location and underlying cause, and generally involves progressive dysfunction of all elements of the aortic wall. Changes in smooth muscle behavior, endothelial signaling, extracellular matrix remodeling, and to a variable extent inflammatory signaling and cells, all contribute to the dilation of the aorta, ultimately resulting in high mortality and morbidity events including dissection and rupture...
June 14, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#5
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908857/midlife-contributors-to-socioeconomic-differences-in-frailty-during-later-life-a-prospective-cohort-study
#6
Eric J Brunner, Martin J Shipley, Sara Ahmadi-Abhari, Carlos Valencia Hernandez, Jessica G Abell, Archana Singh-Manoux, Ichiro Kawachi, Mika Kivimaki
BACKGROUND: Health inequalities persist into old age. We aimed to investigate risk factors for socioeconomic differences in frailty that could potentially be modified through policy measures. METHODS: In this multi-wave longitudinal cohort study (Whitehall II study), we assessed participants' socioeconomic status, behavioural and biomedical risk factors, and disease status at age 45-55 years, and frailty (defined according to the Fried phenotype) at baseline and at one or more of three clinic visits about 18 years later (mean age 69 years [SD 5·9])...
June 13, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29908767/a-qualitative-cross-sectional-study-of-positive-and-negative-comments-of-residency-programs-across-9-medical-and-surgical-specialties
#7
Brittany O Dulmage, Lisa Akintilo, Leah J Welty, Matthew M Davis, Maria Colavincenzo, Shuai Xu
IMPORTANCE: Residency applicants often use social media to discuss the positive and negative features of prospective training programs. An examination of the content discussed by applicants could provide guidance for how medical education faculty can better engage with prospective trainees and adapt to meet the educational expectations of a new generation of digital-native physicians. OBJECTIVE: To identify unstructured social media data submitted by residency applicants and categorize positive and negative statements to determine key themes DESIGN: Qualitative analysis of a retrospective cohort SETTING: Publically available data sets PARTICIPANTS: Anonymized medical trainees applying to residency training positions in nine specialties: dermatology, general surgery, internal medicine, obstetrics/gynecology, plastic surgery, otolaryngology, physical medicine and rehabilitation, pediatrics, and radiology from 2007 to 2017...
June 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29908575/russian-traditional-medicine-in-dermatology
#8
Olga Y Olisova, Elena S Snarskaya, Victor V Gladko, Ekaterina P Burova
The use of herbal remedies for various medical issues is becoming increasingly commonplace in all fields of medicine, and dermatology is no exception. This review focuses on traditional dermatologic herbal remedies, commonly used in Russia, as the rich array of 11 different plant zones has resulted in a great variety of medicinal plants. Herbal remedies warrant deeper investigation and research, especially due to their active substance content, which may interfere with or reinforce the effect of modern medications, something that medical professionals should be aware of when prescribing treatments...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29908450/cervical-sympathetic-chain-schwannoma-masquerading-as-a-vagus-nerve-schwannoma-complicated-by-postoperative-horner-s-syndrome-and-facial-pain-a-case-report
#9
Austin T Baker, Tyler J Homewood, Terry R Baker
INTRODUCTION: Cervical Sympathetic Chain Schwannomas (CSCS) of the carotid sheath are rare neoplasms that can be misdiagnosed on imaging. The following case documents a rare incident of a misdiagnosed CSCS with unusual outcomes of permanent Horner's syndrome and facial pain. PRESENTATION OF CASE: A 36-year-old female presented with a slow-growing neck mass. CT and MRI led to a preoperative diagnosis of vagus nerve schwannoma (VNS). However, surgical treatment revealed the mass to be involved with the cervical sympathetic chain rather than the vagus nerve...
June 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29908425/comparable-indicators-of-therapeutic-misconception-between-epilepsy-or-parkinson-s-disease-patients-between-those-with-clinical-trial-experience-and-trial-non-participants
#10
Emmi Reijula, Arja Halkoaho, Anna-Maija Pietilä, Tuomas Selander, Kirsti Martikainen, Reetta Kälviäinen, Tapani Keränen
PURPOSE: Study design, personal persuasions, and experiences can influence willingness to participate in clinical trials (CTs). A study assessed differences between Parkinson's disease (PD) or epilepsy patients having participated in CTs and non-participants in knowledge of and attitudes toward CTs. Also considered were factors in willingness to take part and how CT participants experienced the informed consent process. METHOD: Random samples of members of Finland's PD (n = 2000) and epilepsy (n = 1875) patient organisations were posted a questionnaire on their views about CTs...
June 9, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29908296/sonographically-guided-plantaris-tendon-release-a-cadaveric-validation-study
#11
Jay Smith, Håkan Alfredson, Lorenzo Masci, Jacob L Sellon, Charonn D Woods
BACKGROUND: The plantaris tendon (PT) has been implicated in the pathogenesis of symptoms in a subset of patients with Achilles region pain syndromes and has been traditionally managed via open surgical resection. Although the PT can be visualized on ultrasound, a minimally invasive technique for sonographically guided PT release has not been formally described. OBJECTIVE: To validate a technique to perform sonographically guided PT release in an unembalmed cadaveric model...
June 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29908128/swedish-adaptation-of-the-general-medical-council-s-multisource-feedback-questionnaires-a-qualitative-study
#12
Jan-Eric Olsson, Solvig Ekblad, Bo Christer Bertilson, Eva Toth-Pal
Objectives: to explore potential users' opinions of a translated and culturally adapted Swedish version of the General Medical Council's MultiSource Feedback Questionnaires. Methods: In this qualitative study, we used content analysis on semi-structured interviews from 44 resident doctors, 29 medical colleagues and 28 patients to analyse their opinions of the Swedish adapted version, created through translation and expert review. Transcribed interview data concerning the informants' general thoughts about the tool were coded manually by three independent coders into categories, compiled as themes, and exemplified by citations...
June 15, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29908027/factors-affecting-empathetic-patient-care-behaviour-among-medical-doctors-and-nurses-an-integrative-literature-review
#13
REVIEW
Muntaha Elayyan, Janet Rankin, M W Chaarani
Background: Healthcare professionals' empathic behaviour is an important component of quality health care. Patients' reports suggest that empathy is often lacking. Specific factors that may facilitate or inhibit empathetic behaviour have not been extensively examined. In Qatar, empathy may be affected by a completely multicultural, multilinguistic setting where healthcare professionals and patients interact. Aim: The purpose of this integrative literature review is to provide the latest evidence on factors that influence the demonstration of empathetic behaviour of nurses and physicians toward patients and to draw general conclusions that increase understanding...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29907917/neurologic-consequences-of-preterm-birth
#14
REVIEW
Margie A Ream, Lenora Lehwald
PURPOSE OF REVIEW: Preterm birth is the leading cause of death worldwide in children < 5 years of age; however, technology and advances in medical knowledge are increasing the survival of children born even at the fringes of viability. With increased survival comes increased risk of long-term neurologic impairments. This paper aims to review recent findings related to changes in brain development associated with prematurity and its impact on neurodevelopmental disabilities. RECENT FINDINGS: Advanced imaging techniques, longitudinal follow-up of individuals born extremely preterm into adulthood and improved understanding of risk factors associated with neurologic impairment contribute to recent discoveries...
June 16, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29907635/increasing-rate-of-pulmonary-embolism-diagnosed-in-hospitalized-children-in-the-united-states-from-2001-to-2014
#15
Shannon L Carpenter, Troy Richardson, Matt Hall
Although rare in children, pulmonary embolism (PE) can cause significant morbidity and mortality. Overall rates of venous thromboembolism (VTE) are increasing in hospitalized children. By using the Pediatric Health Information System database, we evaluated incidence, treatment, and outcome of PE in children younger than age 18 years from 2001 to 2014. Demographic characteristics for those admitted with VTE alone and those admitted with PE were compared. Rates of PE by year were compared with the number of hospital and VTE admissions...
June 26, 2018: Blood Advances
https://www.readbyqxmd.com/read/29907557/effective-behavioral-changes-through-a-digital-mhealth-app-exploring-the-impact-of-hedonic-well-being-psychological-empowerment-and-inspiration
#16
Yuting Lin, Carina Tudor-Sfetea, Sarim Siddiqui, Yusuf Sherwani, Maroof Ahmed, Andreas B Eisingerich
BACKGROUND: New mobile health (mHealth) software apps are emerging and are providing the foundation to radically transform the practice and reach of medical research and care. For this study we collaborated with Quit Genius, a cognitive behavioral therapy (CBT) based mHealth app that helps users quit smoking, to explore the effective design of a digital mHealth app; one that delivers important benefits to its users and helps them change their behaviors for a healthier lifestyle. OBJECTIVE: The specific aims of this study were to (1) explore the key role of CBT program progress, (2) examine the gamification design app elements that deliver significant benefits (ie, empowerment, well-being, inspiration) to users, (3) explore the effectiveness of these app elements to help users quit smoking or reduce the number of cigarettes smoked, and (4) identify and describe any potential drivers and hindrances arising from the app design elements...
June 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29907375/fndc5-expression-in-purkinje-neurons-of-adult-male-rats-with-acute-spinal-cord-injury-following-treatment-with-methylprednisolone
#17
Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleimani
Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Recently, the expression of FNDC5 was reported in cerebellar Purkinje cells as a possible neuroprotective agent. In the present study, we considered the expression of FNDC5 in Purkinje cells following SCI with and without MP administration in adult rats with SCI...
May 7, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29907211/comparison-of-dexmedetomidine-versus-propofol-on-hemodynamics-in-surgical-critically-ill-patients
#18
Ya-Fei Chang, Anne Chao, Po-Yuan Shih, Yen-Chun Hsu, Chen-Tse Lee, Yu-Wen Tien, Yu-Chang Yeh, Lee-Wei Chen
BACKGROUND: Sedation with dexmedetomidine and propofol may cause hypotension or bradycardia. This study aimed to compare the effects of dexmedetomidine and propofol on hemodynamics and clinical outcomes in surgical intensive care unit (ICU) patients after major abdominal surgery. MATERIALS AND METHODS: Enrolled patients were randomly allocated to the dexmedetomidine or propofol group. Cardiac index was measured using a continuous noninvasive cardiac output monitor on the basis of chest bioreactance...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907196/sample-size-of-surgical-randomized-controlled-trials-a-lack-of-improvement-over-time
#19
Usama Ahmed Ali, Joren R Ten Hove, Beata M Reiber, Pieter C van der Sluis, Marc G Besselink
BACKGROUND: Interpretation of randomized controlled trials (RCTs) without a significant difference regarding the primary outcome (negative RCTs) is frequently challenging, due to concerns about sample size and thus sufficient statistical power. We aimed to assess the adequacy of sample size and corresponding power of surgical RCTs. METHODS: We previously identified all surgical RCTs available in PubMed in two distinct years a decade apart (1999 and 2009). For all "negative" trials, we estimated whether the sample size of the trial was appropriate to detect a difference in the primary outcome measure...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907115/determinants-of-human-papillomavirus-vaccine-attitudes-an-interview-of-wisconsin-parents
#20
Kathrine L Barnes, Jeffrey J VanWormer, Shannon Stokley, Elizabeth R Vickers, Huong Q McLean, Edward A Belongia, Casper G Bendixsen
BACKGROUND: Parental attitudes play a key role in their decisions to vaccinate adolescents against the human papillomavirus (HPV). Little is known, however, about the formative experiences that shape parents' attitudes about the HPV vaccine. METHODS: We conducted semi-structured interviews with 25 parents of 11-17 year old adolescents in Wisconsin who changed their HPV vaccine attitudes (per prior surveys) over one year. A modified grounded theory approach was then used to generate primary themes of attitudinal determinants...
June 15, 2018: BMC Public Health
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