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https://www.readbyqxmd.com/read/28830124/postmortem-fluid-and-tissue-concentrations-of-thc-11-oh-thc-and-thc-cooh
#1
Sunday R Saenz, Russell J Lewis, Mike K Angier, Jarrad R Wagner
Marijuana is the most commonly abused illicit drug worldwide. Marijuana is used for its euphoric and relaxing properties. However, marijuana use has been shown to result in impaired memory, cognitive skills and psychomotor function. The Federal Aviation Administration's Civil Aerospace Medical Institute conducts toxicological analysis on aviation fatalities. Due to severe trauma associated with aviation accidents, blood is not always available; therefore, the laboratory must rely on specimens other than blood for toxicological analysis in ~30-40% of cases...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830113/big-data-for-infectious-disease-surveillance-and-modeling
#2
Shweta Bansal, Gerardo Chowell, Lone Simonsen, Alessandro Vespignani, Cécile Viboud
We devote a special issue of the Journal of Infectious Diseases to review the recent advances of big data in strengthening disease surveillance, monitoring medical adverse events, informing transmission models, and tracking patient sentiments and mobility. We consider a broad definition of big data for public health, one encompassing patient information gathered from high-volume electronic health records and participatory surveillance systems, as well as mining of digital traces such as social media, Internet searches, and cell-phone logs...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28830078/reproducing-epidemiologic-research-and-ensuring-transparency
#3
Steven S Coughlin
Measures for ensuring that epidemiologic studies are reproducible include making data sets and software available to other researchers so they can verify published findings, conduct alternative analyses of the data, and check for statistical errors or programming errors. Recent developments related to the reproducibility and transparency of epidemiologic studies include the creation of a global platform for sharing data from clinical trials and the anticipated future extension of the global platform to non-clinical trial data...
August 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28830033/quartz-crystal-microbalance-sensing-cell-substrate-adhesion-and-beyond
#4
REVIEW
Jennifer Y Chen, Lynn S Penn, Jun Xi
Cell adhesion is an essential aspect of cellular behavior. Finding innovative methods to probe the adhesion of cells in their native state can greatly advance the understanding of control and regulation of cellular behavior and their impact on human health. The quartz crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool. Its unique capability of monitoring the cell-substrate interaction non-invasively in real time has led to the emergence of its applications in areas that are relevant to fundamental cell biology and medical research...
August 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28829877/effect-of-ganciclovir-on-il-6-levels-among-cytomegalovirus-seropositive-adults-with-critical-illness-a-randomized-clinical-trial
#5
Ajit P Limaye, Renee D Stapleton, Lili Peng, Scott R Gunn, Louise E Kimball, Robert Hyzy, Matthew C Exline, D Clark Files, Peter E Morris, Stephen K Frankel, Mark E Mikkelsen, Duncan Hite, Kyle B Enfield, Jay Steingrub, James O'Brien, Polly E Parsons, Joseph Cuschieri, Richard G Wunderink, David L Hotchkin, Ying Q Chen, Gordon D Rubenfeld, Michael Boeckh
Importance: The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in nonimmunosuppressed adults with critical illness is unknown. Objective: To determine whether ganciclovir prophylaxis reduces plasma interleukin 6 (IL-6) levels in CMV-seropositive adults who are critically ill. Design, Setting, and Participants: Double-blind, placebo-controlled, randomized clinical trial (conducted March 10, 2011-April 29, 2016) with a follow-up of 180 days (November 10, 2016) that included 160 CMV-seropositive adults with either sepsis or trauma and respiratory failure at 14 university intensive care units (ICUs) across the United States...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28829676/content-validation-of-a-home-parenteral-nutrition-patient-reported-outcome-questionnaire
#6
Tracy-Lee Miller, Geoffrey W Greene, Ingrid Lofgren, Mary L Greaney, Marion F Winkler
BACKGROUND: Patient-reported outcome (PRO) instruments collect information from patients about health conditions and disease management, including quality of life (QOL). Clinicians acknowledge patient concerns about QOL but need guidance to assess the nature and severity of individually experienced problems. The Home Parenteral Nutrition (HPN)-Patient-Reported Outcome Questionnaire (PROQ) was developed for use during medical appointments or homecare visits to address this gap. The purpose of this research was to provide evidence that the HPN-PROQ items and scale possess content validity...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28829650/user-acceptance-factors-of-hospital-information-systems-and-related-technologies-systematic-review
#7
Putu Wuri Handayani, Achmad Nizar Hidayanto, Indra Budi
This study reviews the literature on the most important acceptance factors associated with Hospital Information Systems (HIS) and related technologies based on user groups' perspectives (medical staff, hospital management, administrative personnel, patient, medical student, and IT staff), which can assist researchers and hospital management to develop suitable acceptance models to improve the quality of HIS. We conducted searches in online databases with large repositories of academic studies, written in English and fully accessible by the authors...
August 22, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28829534/how-medicaid-expansion-affected-out-of-pocket-health-care-spending-for-low-income-families
#8
Sherry Glied, Ougni Chakraborti, Therese Russo
ISSUE. Prior research shows that low-income residents of states that expanded Medicaid under the Affordable Care Act are less likely to experience financial barriers to health care access, but the impact on out-of-pocket spending has not yet been measured. GOAL. Assess how the Medicaid expansion affected out-of-pocket health care spending for low-income families compared to those in states that did not expand and consider whether effects differed in states that expanded under conventional Medicaid rules vs...
August 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28829532/an-oxymoron-of-long-term-care-sheltering-in-place-during-an-evacuation-a-literature-review-of-the-best-practices-of-evacuation-and-sheltering-in-place-for-long-term-care-facilities
#9
Megan Baxter
BACKGROUND: Long-term care facilities (LTCFs) are defined as residential facilities that are home to elderly patrons who are no longer able to live independently. These facilities require comprehensive emergency planning to provide the best response to the threat of a disaster for their residents. However, LTCFs are often overlooked in disaster planning, leaving them to work independently to create suitable arrangements in the event of a disaster. This article examines the literature on evacuating and compares it to the literature on sheltering-in-place for LTCFs...
May 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28829524/a-comprehensive-clinical-review-of-opioid-induced-allodynia-discussion-of-the-current-evidence-and-clinical-implications
#10
Corey J Hayes, Jacob T Painter
Opioid analgesics are one of the most often prescribed medication classes, and their use has increased dramatically, with the number of prescriptions doubling between 1998 and 2010. Moreover, long-term use of opioids is becoming more prevalent. The complications arising from opioid use have been clearly documented; however, a relatively unknown complication potentially linked to opioid use is allodynia. This article outlines how research on opioid-induced hyperalgesia has led to the discovery of allodynia. Next, this article provides a detailed review of the current literature on allodynia, which includes animal studies, case reports, case series, and randomized controlled trials...
March 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28829331/assessing-saudi-medical-students-learning-approach-using-the-revised-two-factor-study-process-questionnaire
#11
Shaffi Ahamed Shaik, Ahmed Almarzuqi, Rakan Almogheer, Omar Alharbi, Abdulaziz Jalal, Majed Alorainy
Objectives: To assess learning approaches of 1st, 2nd, and 3rd-year medical students by using revised two-factor study process questionnaire, and to assess reliability and validity of the questionnaire. Methods: This cross-sectional study was conducted at the College of Medicine, Riyadh, Saudi Arabia in 2014. The revised two-factor study process questionnaire (R-SPQ-2F) was completed by 610 medical students of both genders, from foundation (first year), central nervous system (second year), medicine and surgery (third year) courses...
August 17, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28829321/designing-of-ground-truth-annotated-dbt-tu-ju-breast-thermogram-database-towards-early-abnormality-prediction
#12
Mrinal Kanti Bhowmik, Usha Rani Gogoi, Gautam Majumdar, Debotosh Bhattacharjee, Dhritiman Datta, Anjan Kumar Ghosh
The advancement of research in a specific area of clinical diagnosis crucially depends on the availability and quality of the radiology and other test related databases accompanied by ground truth and additional necessary medical findings. The paper describes the creation of the Department of Biotechnology-Tripura University-Jadavpur University (DBT-TU-JU) breast thermogram database. The objective of creating the DBT-TU-JU database is to provide a breast thermogram database that is annotated with the ground truth images of the suspicious regions...
August 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28829268/now-is-the-time-for-a-postracial-medicine-biomedical-research-the-national-institutes-of-health-and-the-perpetuation-of-scientific-racism
#13
Javier Perez-Rodriguez, Alejandro de la Fuente
The consideration of racial differences in the biology of disease and treatment options is a hallmark of modern medicine. However, this time-honored medical tradition has no scientific basis, and the premise itself, that is, the existence of biological differences between the commonly known races, is false inasmuch as races are only sociocultural constructions. It is time to rid medical research of the highly damaging exercise of searching for supposed racial differences in the biological manifestations of disease...
September 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28829260/systemic-racism-and-race-categorization-in-u-s-medical-research-and-practice
#14
Joe Feagin
No abstract text is available yet for this article.
September 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28829223/metabolic-syndrome-in-hispanic-youth-results-from-the-hispanic-community-children-s-health-study-study-of-latino-youth
#15
Samantha A Reina, Maria M Llabre, Denise C Vidot, Carmen R Isasi, Krista Perreira, Mercedes Carnethon, Christina M Parrinello, Linda C Gallo, Guadalupe X Ayala, Alan Delamater
BACKGROUND: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth...
August 22, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28829202/effect-of-heat-moisture-exchanger-on-aerosol-drug-delivery-and-airway-resistance-in-simulated-ventilator-dependent-adults-using-jet-and-mesh-nebulizers
#16
Arzu Ari, Truong Dang, Fahad H Al Enazi, Mohammed M Alqahtani, Abdulrahman Alkhathami, Rowaida Qoutah, Ahmad S Almamary, James B Fink
BACKGROUND: Placement of a heat moisture exchanger (HME) between aerosol generator and patient has been associated with greatly reduced drug delivery. The purpose of this study was to evaluate the effect of filtered and nonfiltered HMEs placed between nebulizer and patient on aerosol deposition and airway resistance (Raw) in simulated ventilator-dependent adults. METHODS: An in vitro lung model was developed to simulate a mechanically ventilated adult (Vt 500 mL, RR 15/min, and PEEP 5 cmH2O, using two inspiratory flow rates 40 and 50 L/min) using an intubated adult manikin with an endotracheal tube (8 mmID)...
August 22, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28829170/advanced-mri-techniques-of-the-shoulder-joint-current-applications-in-clinical-practice
#17
Christopher J Gottsegen, Alexander N Merkle, Jenny T Bencardino, Soterios Gyftopoulos
OBJECTIVE: We are fortunate to live in a time when real advances in medicine are happening at an increasingly rapid pace. This is especially true in the field of radiology, and keeping abreast of these advances is one of the main challenges of clinical practice. Traditionally, cutting edge techniques in our field have been researched and validated at major academic medical centers before slowly making their way into the armamentarium of routine clinical practice. However, the improved ability to communicate and disseminate information in our modern age has facilitated more rapid implementation of new techniques to allow us to better serve our patients...
September 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28829011/-we-never-speak-about-death-healthcare-professionals-views-on-palliative-care-for-inpatients-in-tanzania-a-qualitative-study
#18
E Grace Lewis, Lloyd L Oates, Jane Rogathi, Ashanti Duinmaijer, Aisa Shayo, Simon Megiroo, Barthlomew Bakari, Felicity Dewhurst, Richard W Walker, Matt Dewhurst, Sarah Urasa
OBJECTIVE: Little is known about the current views and practices of healthcare professionals (HCPs) in Sub-Saharan Africa (SSA) regarding delivery of hospital palliative care. The present qualitative study explored the views of nursing staff and medical professionals on providing palliative and end-of-life care (EoLC) to hospital inpatients in Tanzania. METHOD: Focus group discussions were conducted with a purposive sample of HCPs working on the medical and pediatric wards of the Kilimanjaro Christian Medical Centre, a tertiary referral hospital in northern Tanzania...
August 22, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28828920/data-quality-in-the-swedish-quality-register-of-gynecologic-cancer-a-swedish-gynecologic-cancer-group-swegcg-study
#19
Per Rosenberg, Preben Kjølhede, Christian Staf, Maria Bjurberg, Christer Borgfeldt, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Erik Holmberg, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Thomas Högberg
AIM: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC). METHOD: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independent validator. The data in the SQRGC and the re-abstracted data were compared...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28828892/new-considerations-in-the-assessment-of-aortic-stenosis
#20
Lucy M Safi, Jonathan J Passeri, Michael H Picard
Calcific aortic stenosis (AS) is one of the most common acquired valvular heart diseases in industrialized nations. It is a slowly progressive disease and with the aging population, the prevalence of AS is expected to increase. Doppler echocardiography is used to classify patients based on severity of stenosis. Research efforts on how to better identify and risk-assess these patients are currently underway using advanced imaging modalities and serum biomarkers. Thus far, medications for AS prevention have been unsuccessful...
August 22, 2017: Future Cardiology
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