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https://www.readbyqxmd.com/read/29668149/-chronic-low-back-pain-from-the-uncertain-medical-diagnosis-to-the-profane-etiologies
#1
Josiane Mbarga, Claude Pichonnaz, Rose-Anna Foley, Céline Ancey
This qualitative research article is based on interviews with 20 participants to a low back pain rehabilitation program in a Swiss hospital. It shows that, in the absence of the obvious cause that can explain pain, patients construct their own interpretations and explanations in order to give meaning to their experience. Their explanatory models mainly include the lifestyle and the physical aspects related to the body function, what leaves little room for the psychosocial component. Their interpretation is consequently discordant with the current medical approach, which considers that chronic low back pain results from bio-psycho-social factors...
April 18, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29668053/commentary-what-heals-and-why-children-s-understanding-of-medical-treatments
#2
Karl S Rosengren, Matthew J Jiang, Charles W Kalish, David Menendez, Iseli G Hernandez
Lockhart and Keil have written an interesting monograph focusing on the development of reasoning about medicine, a relatively underexplored area of research with potentially broad implications with respect to the design of more-effective medical interventions. In a set of 15 studies with well over 2,200 participants, they examine how children and adults combine aspects of biological and psychological reasoning to create working models of medicine. Lockhart and Keil explore developmental changes in reasoning about illness and its treatment using medicines in terms of dualism (e...
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29667641/-on-the-occasion-of-his-180th-birthday-anniversary-of-ivan-ivanovich-neiding
#3
Yu I Pigolkin, Yu V Lomakin, A V Khodulapov
This article is devoted to the life and professional activities of the internationally renowned forensic doctor Ivan Ivanovich Neiding who became widely known in the early youth as the discoverer of the microscopic diagnostic features of the constriction marks formed in association with hanging and strangulation. During more than 22 years (from 1878 till 1900), I.I. Neiding acted as the head of the Department of Forensic medicine at the Moscow University where a large number of investigations on forensic medical ballistics, toxicology, obstetric and gynecological expertise were carried out under his supervision...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667586/drug-drug-interactions-with-aprepitant-in-antiemetic-prophylaxis-for-chemotherapy
#4
R Schoffelen, A G Lankheet, C M L van Herpen, J J M van der Hoeven, I M E Desar, C Kramers
In the current guidelines to prevent hemotherapyinduced nausea and vomiting, multiple antiemetic drugs are administered simultaneously. In patients who receive highly emetogenic chemotherapy, aprepitant, an NK1-receptor antagonist, is combined with ondansetron and dexamethasone. Aprepitant can influence the pharmacokinetics of other drugs, as it is an inhibitor and inducer of CYP3A4. Some anticancer drugs and other co-medication frequently used in cancer patients are CYP3A4 or CYP29C substrates. We give an overview of the metabolism and current data on clinically relevant drug-drug interactions with aprepitant during chemotherapy...
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29667566/us-emergency-medical-services-fellows
#5
Brian Clemency, Christian Martin-Gill, Nicole Rall, Dipesh Patel, Jeffery Myers
IntroductionThe 2015-2016 academic year was the fourth year since the Accreditation Council for Graduate Medical Education (ACGME; Chicago, Illinois USA) accredited Emergency Medical Services (EMS) fellowships, and the first year an in-training examination was given. Soon, ACGME-accredited fellowship education will be the sole path to EMS board certification when the practice pathway closes after 2019. This project aimed to describe the current class of EMS fellows at ACGME-accredited programs and their current educational opportunities to better understand current and future needs in EMS fellowship education...
April 18, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29667554/establishment-of-novel-reporter-cells-stably-maintaining-transcription-factor-driven-human-secreted-alkaline-phosphatase-expression
#6
Riho Kurata, Asuka Kumagai, Xiaofeng Cui, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-Ichi Ozaki, Yoshimasa Tanaka, Tomo Yonezawa
BACKGROUND: Transcriptional regulation is very important and pivotal function in myriad biological responses. Thus, methods to determine transcriptional activity are required in not only basic medical research but also drug discovery. We established novel reporter constructs using human secreted embryonic alkaline phosphatase (SEAP) and Epstein-Barr virus nuclear antigen (EBNA) 1, which can maintain constructs synchronized to host cell replication. METHODS: We established nuclear factor-kappa B (NFkB) or interferon regulatory factor (IRF) driven SEAP expression constructs and then, introduced them into culture cells...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29667552/harvesting-isolation-and-differentiation-of-rat-adipose-derived-stem-cells
#7
Panayiotis D Megaloikonomos, Georgios N Panagopoulos, Myrto Bami, Vasileios G Igoumenou, Leonidas Dimopoulos, Adamantia Milonaki, Maria Kyriakidou, Evanthia Mitsiokapa, Jane Anastassopoulou, Andreas F Mavrogenis
BACKGROUND: Adipose tissue is one of the most attractive source of stem cells because it can be easily harvested and yields a greater stromal cell density. The multi-lineage potential of adipose-derived stem cells (ADSCs) demonstrates their significant impact within the field of tissue engineering, with studies successfully demonstrating the ability to produce a range of tissue types. However, although, a broad spectrum of applications has already been suggested, many important scientific and medical questions remain unanswered before the clinical application of ADSCs in humans...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29667519/an-investigation-of-factors-affecting-the-performance-of-wheelchair-transfers
#8
Giulia Barbareschi, Catherine Holloway
PURPOSE: Being able to transfer in and out of their wheelchair is an important task for wheelchair users that can be affected by a variety of different factors. The aim of this study was to investigate the interplay between personal characteristics, wheelchair users' transferring technique and the other factors that can affect the performance of wheelchair transfers. METHOD: A cross-sectional survey study was designed to recruit wheelchair users, aged 18 or older, performing sitting-pivot or standing-pivot wheelchair transfers, independently or with assistance...
April 18, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29667466/evaluation-of-a-modified-16-item-readiness-for-interprofessional-learning-scale-ripls-exploratory-and-confirmatory-factor-analyses
#9
Tzu-Chieh Yu, Tanisha Jowsey, Marcus Henning
The Readiness for Interprofessional Learning Scale (RIPLS) was developed to assess undergraduate readiness for engaging in interprofessional education (IPE). It has become an accepted and commonly used instrument. To determine utility of a modified 16-item RIPLS instrument, exploratory and confirmatory factor analyses were performed. Data used were collected from a pre- and post-intervention study involving 360 New Zealand undergraduate students from one university. Just over half of the participants were enrolled in medicine (51%) while the remainder were in pharmacy (27%) and nursing (22%)...
April 18, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29667458/sudden-unexpected-death-in-epilepsy-ongoing-challenges-in-finding-mechanisms-and-prevention
#10
Doungporn Ruthirago, Parunyou Julayanont, Amputch Karukote, Mohamed Shehabeldin, Kenneth Nugent
Patients with epilepsy have a significantly higher risk of death than the general population. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of sudden death among patients with epilepsy. Despite on-going research, there are still deficits in our knowledge about the mechanisms, genetic factors, and prevention of SUDEP. Current evidence suggests that cardiac arrhythmias, respiratory dysfunction, and brainstem arousal system dysfunction are the major mechanisms of SUDEP, and animal models support the role of neurotransmitters, especially serotonin and adenosine, in pathophysiology of SUDEP...
April 18, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29667311/how-japanese-nurses-participate-in-decision-making-infants-with-congenital-life-threatening-conditions
#11
Sohei Shitaya, Nobue Nakamura, Naho Sato
BACKGROUND: In Japan, owing to the progress in medical technology, more children with congenital life-threatening conditions survive than ever before. Nurses who care for these children may also influence decision making in difficult situations. AIM: We aimed to describe Japanese nurses' approach toward medical decision making when caring for families of infants with congenital life-threatening conditions. Frequently, these nurses must care for and support parents with ambivalent feelings...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667263/assumptions-made-when-preparing-drug-exposure-data-for-analysis-have-an-impact-on-results-an-unreported-step-in-pharmacoepidemiology-studies
#12
Stephen R Pye, Thérèse Sheppard, Rebecca M Joseph, Mark Lunt, Nadyne Girard, Jennifer S Haas, David W Bates, David L Buckeridge, Tjeerd P van Staa, Robyn Tamblyn, William G Dixon
PURPOSE: Real-world data for observational research commonly require formatting and cleaning prior to analysis. Data preparation steps are rarely reported adequately and are likely to vary between research groups. Variation in methodology could potentially affect study outcomes. This study aimed to develop a framework to define and document drug data preparation and to examine the impact of different assumptions on results. METHODS: An algorithm for processing prescription data was developed and tested using data from the Clinical Practice Research Datalink (CPRD)...
April 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29667168/cognitive-decline-and-older-driver-crash-risk
#13
Laura A Fraade-Blanar, Beth E Ebel, Eric B Larson, Jeanne M Sears, Hilaire J Thompson, Kwun Chuen G Chan, Paul K Crane
OBJECTIVES: To examine automobile crash risk associated with cognition in older drivers without dementia. DESIGN: Retrospective secondary analysis of longitudinal cohort study. SETTING: Our study used data from the Adult Changes in Thought (ACT) Study merged with Washington State crash reports and licensure records. Data were available from 2002 to 2015. PARTICIPANTS: Group Health enrollees from Washington State aged 65 and older with active driver's licenses (N=2,615)...
April 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29667166/disability-differentials-in-educational-attainment-in-england-primary-and-secondary-effects
#14
Stella Chatzitheochari, Lucinda Platt
Childhood disability has been largely overlooked in social stratification and life course research. As a result, we know remarkably little about mechanisms behind well-documented disability differentials in educational outcomes. This study investigates educational transitions of disabled youth using data from the Longitudinal Study of Young People in England. We draw on social stratification literature on primary and secondary effects as well as that on stigma and labelling in order to explain disabled young people's educational outcomes...
April 17, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29667028/a-review-of-commercial-and-medical-grade-physiological-monitoring-devices-for-biofeedback-assisted-quality-of-life-improvement-studies
#15
Pedro Nogueira, Joana Urbano, Luís Paulo Reis, Henrique Lopes Cardoso, Daniel Castro Silva, Ana Paula Rocha, Joaquim Gonçalves, Brígida Mónica Faria
With the rise in wearable technology and "health culture", we are seeing an increasing interest and affordances in studying how to not only prolong life expectancy but also in how to improve individuals' quality of life. On the one hand, this attempts to give meaning to the increasing life expectancy, as living above a certain threshold of pain and lack of autonomy or mobility is both degrading and unfair. On the other hand, it lowers the cost of continuous care, as individuals with high quality of life indexes tend to have lower hospital readmissions or secondary complications, not to mention higher physical and mental health...
April 17, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29666814/digital-chest-tomosynthesis-the-2017-updated-review-of-an-emerging-application
#16
REVIEW
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666617/perspectives-of-phage-eukaryotic-cell-interactions-to-control-epstein-barr-virus-infections
#17
Andrzej Górski, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives for the future. Furthermore, a leading scientific journal pointed to the recent progress in research on phage interactions with eukaryotic cells (especially cells of the immune system) and potential implications of their results for our broader understanding of the role of phages - not only as "bacteria eaters" - but also as an important part of our body defense protecting against external and internal pathogenic invaders (as suggested previously)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666578/individual-experiences-in-four-cancer-patients-following-psilocybin-assisted-psychotherapy
#18
Tara C Malone, Sarah E Mennenga, Jeffrey Guss, Samantha K Podrebarac, Lindsey T Owens, Anthony P Bossis, Alexander B Belser, Gabrielle Agin-Liebes, Michael P Bogenschutz, Stephen Ross
A growing body of evidence shows that existential and spiritual well-being in cancer patients is associated with better medical outcomes, improved quality of life, and serves as a buffer against depression, hopelessness, and desire for hastened death. Historical and recent research suggests a role for psilocybin-assisted psychotherapy in treating cancer-related anxiety and depression. A double-blind controlled trial was performed, where 29 patients with cancer-related anxiety and depression were randomly assigned to treatment with single-dose psilocybin (0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29666252/mechanisms-of-sampling-interstitial-fluid-from-skin-using-a-microneedle-patch
#19
Pradnya P Samant, Mark R Prausnitz
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical interest, sampling of ISF for clinical applications has made limited impact due to a lack of simple, clinically useful techniques that collect more than nanoliter volumes of ISF. This study describes experimental and theoretical analysis of ISF transport from skin using microneedle (MN) patches and demonstrates collection of >1 µL of ISF within 20 min in pig cadaver skin and living human subjects using an optimized system...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666137/the-french-prospective-multisite-registry-on-sudden-unexpected-infant-death-omin-rationale-and-study-protocol
#20
Karine Levieux, Hugues Patural, Inge Harrewijn, Elisabeth Briand Huchet, Sophie de Visme, Géraldine Gallot, Martin Chalumeau, Christèle Gras Le Guen, Matthieu Hanf
INTRODUCTION: Even after 'back-to-sleep' campaigns, sudden unexpected infant death (SUID) continues to be the leading cause of death for infants 1 month to 1 year old in developed countries, with devastating social, psychological and legal implications for families. To sustainably tackle this problem and decrease the number of SUIDs, a French SUID registry was initiated in 2015 to (1) inform prevention with standardised data, (2) understand the mechanisms leading to SUID and the contribution of the already known or newly suggested risk factors and (3) gather a multidisciplinary group of experts to coordinate and develop innovative and urgent research in the SUID area...
April 17, 2018: BMJ Open
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