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https://www.readbyqxmd.com/read/29475098/xq-1h-protects-against-ischemic-stroke-by-regulating-microglia-polarization-through-ppar%C3%AE-pathway-in-mice
#1
Rui Liu, Junjian Diao, Shucheng He, Binbin Li, Yuxiang Fei, Yunman Li, Weirong Fang
Cerebral ischemic and reperfusion injury often accompany with inflammation, and lead to severe neuronal damage, which further result in neurological disorders and memory disorders. In this study, we researched XQ-1H, a novel derivative of ginkgolide B, protecting against ischemic stroke in mice through regulation of microglia polarization. Middle cerebral artery occlusion (MCAO)/reperfusion in mice is applied to mimic ischemic stroke in vivo. Immediately after MCAO, mice are intragastric administrated with different dose (31 or 62 mg/kg) of XQ-1H for one or continuative three days...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474887/genome-writing-current-progress-and-related-applications
#2
Yueqiang Wang, Yue Shen, Ying Gu, Shida Zhu, Ye Yin
The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field...
February 20, 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#3
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474293/predicting-pain-levels-following-vaginal-reconstructive-surgery-who-is-at-highest-risk
#4
Abigail Shatkin-Margolis, Catrina C Crisp, Christopher Morrison, Rachel N Pauls
OBJECTIVES: An ability to anticipate individuals at increased risk of postoperative pain would improve coordination of care and patient satisfaction. We sought to describe predictive factors of postoperative pain following vaginal reconstructive surgery. METHODS: This institutional review board-approved, retrospective study used previously collected data from research performed at 1 center from 2009 to 2015. Eligible trials enrolled subjects undergoing vaginal reconstructive surgery for pelvic organ prolapse...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29474280/the-effect-of-oral-phenazopyridine-on-perioperative-voiding-after-midurethral-slings-epiphany-study
#5
Omar Felipe Dueñas-Garcia, Tania Sierra, Danielle Taylor, Katherine Leung, Cynthia D Hall, Michael K Flynn
OBJECTIVE: To determine the effect of preoperative oral phenazopyridine on postoperative voiding dysfunction in women undergoing a retropubic midurethral sling. METHODS: A single-institution randomized clinical trial was performed from September 2015 to March 2017, comparing 200 mg of oral phenazopyridine versus no phenazopyridine in patients undergoing a retropubic midurethral sling under general anesthesia with no concomitant procedures. A power calculation indicated that we required at least 40 subjects per arm...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29474272/an-update-in-the-initial-management-of-paediatric-status-epilepticus
#6
Ben Lawton, Tessa Davis, Henry Goldstein, Andrew Tagg
PURPOSE OF REVIEW: Over the last 2 years, algorithms for the optimal management of status epilepticus have changed, as the medical community has recognized the need to terminate seizures in status in a timely manner. Recent research has evaluated the different choices of benzodiazepine and has given consideration to second-line treatment options. RECENT FINDINGS: There has been a move to examine alternatives to phenytoin (such as levetiracetam and lacosamide) as second-line agents...
February 22, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29474212/a-different-perspective-anesthesia-for-extreme-premature-infants-is-there-an-age-limitation-or-how-low-should-we-go
#7
Per-Arne Lönnqvist
PURPOSE OF REVIEW: To put in perspective, the various challenges that faces pediatric anesthesiologists because of the recently lowered limits with regards to the viability of a fetus. Both medical and ethical considerations will be highlighted. RECENT FINDINGS: Issues related to: who should anesthetize these tiny babies; can we provide adequate and legal monitoring during the anesthetic; does these immature babies need hypnosis and amnesia and the moral/ethical implications associated with being involved with care of doubtful long-term outcome are reviewed...
February 22, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29474173/possibility-of-database-research-as-a-means-of-pharmacovigilance-in-japan-based-on-a-comparison-with-sertraline-postmarketing-surveillance
#8
Yoko Hirano, Yuko Asami, Kazuhiko Kuribayashi, Shigeru Kitazaki, Yuji Yamamoto, Yoko Fujimoto
BACKGROUND: Many pharmacoepidemiologic studies using large-scale databases have recently been utilized to evaluate the safety and effectiveness of drugs in Western countries. In Japan, however, conventional methodology has been applied to postmarketing surveillance (PMS) to collect safety and effectiveness information on new drugs to meet regulatory requirements. Conventional PMS entails enormous costs and resources despite being an uncontrolled observational study method. This study is aimed at examining the possibility of database research as a more efficient pharmacovigilance approach by comparing a health care claims database and PMS with regard to the characteristics and safety profiles of sertraline-prescribed patients...
June 20, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29473942/graphical-instructions-for-administration-and-scoring-the-mini-cog-results-of-a-randomized-clinical-trial
#9
Edlira Tam, Benjamin T Gandesbery, Laura Young, Soo Borson, Eiran Z Gorodeski
OBJECTIVES: To develop a novel set of graphical Mini-Cog instructions designed to aid clinicians previously untrained on the Mini-Cog in accurate administration and scoring and to determine whether use of these graphical instructions improved the speed and accuracy of deployment of this tool. DESIGN: Randomized clinical trial. SETTING: Testing was conducted in a simulated environment with a mock patient. PARTICIPANTS: Registered nurses working in inpatient or outpatient settings at a large academic medical center who had no prior exposure to or training with the Mini-Cog (N=92)...
February 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29473941/targeted-geriatric-assessment-for-fast-paced-healthcare-settings-development-validity-and-reliability
#10
Márlon J R Aliberti, Daniel Apolinario, Claudia K Suemoto, Juliana A Melo, Sileno Q Fortes-Filho, Marcos D Saraiva, Carolina B Trindade, Kenneth E Covinsky, Wilson Jacob-Filho
OBJECTIVES: To develop and examine the validity and reliability of a targeted geriatric assessment (TaGA) for busy healthcare settings. DESIGN: The TaGA was developed through the consensus of experts (Delphi technique), and we investigated its construct validity and reliability in a cross-sectional study. SETTING: Geriatric day hospital specializing in acute care in Brazil. PARTICIPANTS: Older adults (N = 534) aged 79...
February 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29473880/assessment-and-treatment-of-pediatric-sleep-problems-knowledge-skills-attitudes-and-practices-in-a-group-of-community-child-psychiatrists
#11
Ali Anwar, Michael D Yingling, Alicia Zhang, Ujjwal Ramtekkar, Ginger E Nicol
As part of a university-based quality improvement project, we aimed to evaluate child psychiatrists' knowledge, skills, attitudes, and practices regarding assessment and treatment of pediatric sleep problems. We developed a nine-question survey of knowledge, skills, attitudes, and practices regarding assessing for and treating sleep complaints in pediatric patients, and administered this survey to child psychiatrists in training and in practice in the state of Missouri. Respondents reported sleep hygiene as the first-line treatment strategy, followed by the use of supplements or over-the-counter remedies...
February 23, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29473531/diabetic-complications-and-insight-into-antidiabetic-potentialities-of-ethno-medicinal-plants-a-review
#12
Muhammad Bilal, Muhammad Sarfaraz Iqbal, Syed Bilal Shah, Tahir Rasheed, Hafiz M N Iqbal
BACKGROUND: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world. OBJECTIVE: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473524/pharmacogenetics-of-glucagon-like-peptide-1-agonists-for-the-treatment-of-type-2-diabetes-mellitus
#13
Spyridon Karras, Eleni Rapti, Theocharis Koufakis, Angeliki Kyriazou, Dimitrios Goulis, Kalliopi Kotsa
BACKGROUND: Pharmacogenetics is a promising area of medical research, providing methods to identify the appropriate pharmaceutical agent and dosing for each unique patient. Glucagon-like peptide-1 (GLP-1) agonists are a novel therapeutic choice used in the treatment of type 2 diabetes mellitus (T2DM), demonstrating efficacy regarding glycemic control and weight loss. Therapeutic response to GLP-1 agonist treatment is a complex biophenomenon, dependent on a plethora of modifiable (diet, exercise, adherence) and non-modifiable (genetic individual variants, ethnic characteristics) parameters...
February 21, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29473483/patient-perceptions-of-text-messaging-to-improve-antiretroviral-therapy-adherence-a-qualitative-study-of-patients-in-a-ryan-white-clinic
#14
Elizabeth Sherman, Kevin Alan Clauson, Shara Elrod, Paula Eckardt, Fadi Alkhateeb, Robin Jacobs
Evidence on the use of short message service (SMS) to improve medication adherence in people living with HIV (PLHIV) is mounting, yet qualitative research on patient perceptions regarding SMS content and utility for HIV/AIDS remains nascent. To explore the experience of receiving medication reminders via SMS among PLHIV, 45 uninsured and underinsured PLHIV nested within the intervention arm of a larger study received daily, 1-way SMS adherence reminders. Qualitative data were collected by face-to-face, structured interview and were analyzed using conventional content analysis methods...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29473392/-objective-over-recent-years-therapeutic-patient-education-has-become-part-of-dental-medicine-management-of-early-childhood-caries-known-to-be-a-very-common-chronic-disease-has-evolved-to-include-an-educational-dimension-the-objective-of-this-study-was-to-identify
#15
Thomas Marquillier, Thomas Trentesaux, Rémi Gagnayre
OBJECTIVE: Over recent years, therapeutic patient education has become part of dental medicine. Management of early childhood caries, known to be a very common chronic disease, has evolved to include an educational dimension. The objective of this study was to identify the levers and barriers to the development of formalized therapeutic education programmes and alternatives. METHODS: A comprehensive exploratory qualitative study was conducted between November 2015 and June 2016 on a targeted sample of 15 people aware of the problem of TPE in dentistry...
January 30, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29473371/-research-progress-of-fire-needling-for-chronic-gastritis
#16
Jingyi Zhao, Haiying Cheng, Yang Ding
To explore the efficacy and mechanism of fire needling for chronic gastritis, "fire needling" and "chronic gastritis" were selected as keywords to collect literature in PubMed, CNKI database and WanFang database. The clinical and experiment literature regarding fire needling for chronic gastritis was analyzed to make a comprehensive discussion on the efficacy and action mechanism of fire needling for chronic gastritis. The results indicated the efficacy of fire needling for chronic gastritis was superior to that of medication or filiform needle...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29473367/-the-relationship-between-acupuncture-moxibustion-theory-of-dou-hanqing-and-neo-confucianism
#17
Baojin Li, Longxiang Huang
For the construction factors of acupuncture-moxibustion theory of DOU Hanqing , a doctor in Jin-Yuan Dynasty, we studied his life, acupuncture-moxibustion theory and culture background in the History of Medicine and Philosophy of Science & Technology. It was found that the major source of DOU Hanqing ' s Confucianism was the CHENG - ZHU Neo-Confucianism. The data show that Neo-Confucianism played an important role in the enrichment of his human nature, spirit, moral cultivation and political talent, making him a scholar in the Jin - Yuan dynasty, also shaping his medical ethics, medical skill and acupuncture-moxibustion theory...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29473300/review-article-managing-medical-emergencies-in-rural-australia-a-systematic-review-of-the-training-needs
#18
REVIEW
Tarsh Pandit, Robin Ray, Sabe Sabesan
The aim of the study was to determine the training needs of doctors managing emergencies in rural and remote Australia. A systematic review of Australian articles was performed using MEDLINE (OVID) and INFORMIT online databases from 1990 to 2016. The search terms included 'Rural Health', 'Emergency Medicine', 'Emergency Medical Services', 'Education, Medical, Continuing' and 'Family Practice'. Only peer-reviewed articles, available in full-text that focussed on the training needs of rural doctors were reviewed...
February 22, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29473279/autism-spectrum-disorder-and-genetic-testing-parental-perceptions-and-decision-making
#19
Alyson E Hanish, Marlene Z Cohen, Lois J Starr
PURPOSE: Advances in genomic technology and research have led to genetic testing being recognized as an essential component of the etiological workup for children with autism spectrum disorder (ASD). Chromosomal microarray analysis (CMA) is a first-tier diagnostic test for patients with ASD, as recommended by the American College of Medical Genetics and other professional societies. An accurate underlying medical diagnosis for ASD has many potential benefits, including appropriate medical management, detailed therapeutic recommendations, and accurate recurrence risk...
February 23, 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29473273/systematic-review-of-strategies-to-increase-access-to-health-services-among-children-over-five-in-low-and-middle-income-countries
#20
REVIEW
Tess Bright, Lambert Felix, Hannah Kuper, Sarah Polack
BACKGROUND: The populations of many low and middle-income countries (LMIC) are young. Despite progress made towards achieving Universal Health Coverage and remarkable health gains, evidence suggests that many children in LMIC are still not accessing needed health care services. Delayed or lack of access to health services can lead to a worsening of health, and can in turn negatively impact a child's ability to attend school, and future employment opportunities. METHODS: We conducted a systematic review to assess the effectiveness of interventions aimed at increasing access to health services for children over five years in LMIC settings...
February 23, 2018: Tropical Medicine & International Health: TM & IH
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