keyword
https://read.qxmd.com/read/38445529/maternal-gbs-vaccination-for-preventing-group-b-streptococcus-disease-in-newborns-a-mini-review-of-current-evidence
#21
REVIEW
Emmanuel Kokori, Gbolahan Olatunji, Rosemary Komolafe, Ikponmwosa Jude Ogieuhi, Babajide Oyebiyi, Irene Ajayi, Ifeanyichukwu Muogbo, Bonaventure Ukoaka, Owolabi Samuel, Nicholas Aderinto
Group B streptococcus (GBS) poses a significant threat to neonates, leading to morbidity and mortality. Intrapartum antibiotics, although effective, have limitations, prompting the exploration of maternal vaccination. This study reviews the current evidence for maternal GBS vaccination in the prevention of early-onset GBS disease in newborns. A search on Google Scholar, PubMed, and Scopus identified studies assessing the impact of maternal GBS vaccination on early-onset GBS disease. Inclusion criteria comprised English-language clinical trials or observational studies...
March 6, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38441465/comparison-of-the-simplexa-gbs-direct-and-aries-gbs-assays-for-the-detection-of-s-agalactiae-in-broth-enriched-swab-specimens
#22
JOURNAL ARTICLE
Lavannya Sabharwal, Matthew L Faron, Blake W Buchan
We conducted a comparative evaluation of the FDA-cleared Simplexa GBS Direct and ARIES GBS molecular assays for the detection of Streptococcus agalactiae (Group B Streptococcus , GBS) in 386 prospectively collected, broth-enriched vaginal/rectal swab specimens. The sensitivity of each test was 96.2% and specificity was ≥98.7% when compared to a combined direct and enriched culture method using chromogenic culture medium. A total of four specimens were called positive by both molecular assays but negative by culture, likely representing specimens with a low burden of GBS in these specimens...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38436256/re-framing-the-importance-of-group-b-streptococcus-as-a-gut-resident-pathobiont
#23
REVIEW
Joie Ling, Andrew J Hryckowian
Streptococcus agalactiae (Group B Streptococcus , GBS) is a Gram-positive bacterial species that causes disease in humans across the lifespan. While antibiotics are used to mitigate GBS infections, it is evident that antibiotics disrupt human microbiomes (which can predispose people to other diseases later in life), and antibiotic resistance in GBS is on the rise. Taken together, these unintended negative impacts of antibiotics highlight the need for precision approaches for minimizing GBS disease. One possible approach involves selectively depleting GBS in its commensal niches before it can cause disease at other body sites or be transmitted to at-risk individuals...
March 4, 2024: Infection and Immunity
https://read.qxmd.com/read/38431823/relation-of-streptococcus-pyogenes-tonsillitis-isolate-to-antimicrobial-agents-and-its-infection-treatment
#24
JOURNAL ARTICLE
Daryna B Pylypiv, Boris M Sharga, Olexandr A Rishko, Vitalii Leshak, Elena Karbovanets
We reported the case of tonsillitis treatment in a 17-years-old boy with use of chemical non-antibiotic preparations, plant derived products and antibiotic benzathine phenoxymethylpenicillin. The antimicrobial agents for treatment were selected on the basis of their activity against a disease agent, the group A β-hemolytic strain Streptococcus pyogenes BS1 isolated from a patient. The bacterium was susceptible in vitro to β-lactams, with largest zones conditioned by penicillin G and benzathine phenoxymethylpenicillin discs, to fluoroquinolones and to cephems, with exception of cefazolin...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38431802/healthcare-associated-infections-after-neurosurgical-procedures-in-ukraine-a-multicentre-study-2020-2022
#25
JOURNAL ARTICLE
Aidyn G Salmanov, Dmytro V Shchehlov, Maryna Mamonova, Ihor M Bortnik, Nadiia B Chabanovych, Yaroslav E Kudelskyi, Daria Chekhunova
OBJECTIVE: Aim: To investigate the epidemiology, microbiology, and risk factors for healthcare-associated infections (HAIs) after a neurosurgical procedure in Ukraine. PATIENTS AND METHODS: Materials and Methods: Prospective multicentre surveillance was conducted from January 2020 to December 2022 in 10 regional hospitals of Ukraine. Definitions of HAIs were adapted from the Centers for Disease Control and Prevention's National Healthcare Safety Network. RESULTS: Results: Of 8,623 neurosurgical patients, 1,579 (18...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38427206/preadmission-course-and-management-of-severe-pediatric-group-a-streptococcal-infections-during-the-2022-2023-outbreak-a-single-center-experience
#26
JOURNAL ARTICLE
Nina Schöbi, Andrea Duppenthaler, Matthias Horn, Andreas Bartenstein, Kristina Keitel, Matthias V Kopp, Philipp Agyeman, Christoph Aebi
PURPOSE: The massive increase of infections with Group A Streptococcus (GAS) in 2022-2023 coincided in Switzerland with a change of the recommendations for the management of GAS pharyngitis. Therefore, the objective of the present study was to investigate whether the clinical manifestations and management before hospitalization for GAS infection differed in 2022-2023 compared with 2013-2022. METHODS: Retrospective study of GAS infections requiring hospitalization in patients below 16 years...
March 1, 2024: Infection
https://read.qxmd.com/read/38401454/predicting-hosts-and-cross-species-transmission-of-streptococcus-agalactiae-by-interpretable-machine-learning
#27
JOURNAL ARTICLE
Yunxiao Ren, Carmen Li, Dulmini Nanayakkara Sapugahawatte, Chendi Zhu, Sebastian Spänig, Dorota Jamrozy, Julian Rothen, Claudia A Daubenberger, Stephen D Bentley, Margaret Ip, Dominik Heider
BACKGROUND: Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), exhibits a broad host range, manifesting as both a beneficial commensal and an opportunistic pathogen across various species. In humans, it poses significant risks, causing neonatal sepsis and meningitis, along with severe infections in adults. Additionally, it impacts livestock by inducing mastitis in bovines and contributing to epidemic mortality in fish populations. Despite its wide host spectrum, the mechanisms enabling GBS to adapt to specific hosts remain inadequately elucidated...
February 20, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38400107/robust-immune-response-and-protection-against-lethal-pneumococcal-challenge-with-a-recombinant-bcg-pspa-pdt-prime-boost-scheme-administered-to-neonatal-mice
#28
JOURNAL ARTICLE
Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite
Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes, leading to serotype replacement. Furthermore, the current vaccines do not protect neonates. Therefore, several protein-based pneumococcal vaccines have been studied over the last few decades. Our group established a recombinant BCG expressing rPspA-PdT as a prime/rPspA-PdT boost strategy, which protected adult mice against lethal intranasal pneumococcal challenge...
January 25, 2024: Vaccines
https://read.qxmd.com/read/38399818/antimicrobial-resistance-profile-of-group-b-streptococci-colonization-in-a-sample-population-of-pregnant-women-from-romania
#29
JOURNAL ARTICLE
Aida Petca, Florica Șandru, Silvius Negoiță, Mihai Cristian Dumitrașcu, Daiana Anne-Marie Dimcea, Tiberiu Nedelcu, Claudia Mehedințu, Marinela Magdalena Filipov, Răzvan-Cosmin Petca
Group B Streptococcus (GBS) represents one of the leading causes of life-threatening invasive disease in pregnant women and neonates. Rates of GBS colonization vary by region, but studies on maternal GBS status are limited in Romania. This study aims to identify the prevalence of colonization with GBS and whether the obstetrical characteristics are statistically associated with the study group's antimicrobial susceptibility patterns of tested GBS strains. This observational study was conducted between 1 May and 31 December 2021 at The Department of Obstetrics and Gynecology at Elias University Emergency Hospital (EUEH) in Bucharest, Romania...
February 19, 2024: Microorganisms
https://read.qxmd.com/read/38388987/the-effect-of-nano-silver-fluoride-self-assembling-peptide-and-sodium-fluoride-varnish-on-salivary-cariogenic-bacteria-a-randomized-controlled-clinical-trial
#30
JOURNAL ARTICLE
Sara M Atteya, Hala A Amer, Susan M Saleh, Yara Safwat
OBJECTIVES: To compare the antibacterial effect of Nanosilver Fluoride varnish (NSF) varnish, P11-4 and Sodium Fluoride (NaF) varnish against salivary Streptococcus mutans (S. mutans) and Lactobacilli. METHODS: 66 patients aged 10-24 years old were randomly assigned to receive single application of NSF, P11-4 or NaF varnish. Baseline unstimulated saliva samples were collected before the agents were applied and S.mutans and Lactobacilli colony forming units (CFU) were counted...
February 23, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38387705/the-associations-between-invasive-group-a-streptococcal-disease-and-infection-with-influenza-varicella-or-hepatitis-c-viruses-a-data-linkage-study-victoria-australia
#31
JOURNAL ARTICLE
Jessie J Goldsmith, Christy Vu, Ziheng Zhu, Jennifer MacLachlan, Tilda N Thomson, Patricia Therese Campbell, Katherine B Gibney
Background Invasive group A streptococcal disease (iGAS) causes significant disability and death. Reported associations between iGAS incidence and influenza, varicella and chronic hepatitis C (HCV) have not been well quantified, and these studies have been susceptible to bias. Methods We used individual-level linked data of iGAS cases from Victoria, Australia (2007-2017) to assess associations between these viral infections and iGAS. A self-controlled case series method was used to estimate the relative incidence of iGAS following an influenza or varicella infection, while the relative incidence of iGAS amongst HCV cases, and HCV cases who inject drugs, was estimated using population-level data and a negative binomial regression model...
February 20, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38387704/analytical-performances-of-a-point-of-care-loop-mediated-isothermal-amplification-lamp-assay-to-detect-group-b-streptococcus-in-intrapartum-pregnant-women-living-in-the-democratic-republic-of-the-congo
#32
JOURNAL ARTICLE
Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent Bélec
INTRODUCTION: Group B Streptococcus (GBS) is the leading infectious cause of stillbirth, and neonatal morbidity and mortality in sub-Saharan Africa. METHODS: Vaginal and rectovaginal swab samples were obtained from 274 intrapartum pregnant women in Democratic Republic of the Congo, to be analysed for GBS DNA detection, in parallel by the point-of-care BIOSYNEX AMPLIFLASH® GBS assay (Biosynex SA, Illkirch-Graffenstaden, France), and by reference quantitative PCR (qPCR)...
February 20, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38387185/cholesterol-as-an-inbuilt-immunoadjuvant-for-a-lipopeptide-vaccine-against-group-a-streptococcus-infection
#33
JOURNAL ARTICLE
Nedaa Alharbi, Ahmed O Shalash, Prashamsa Koirala, Jennifer C Boer, Waleed M Hussein, Zeinab G Khalil, Robert J Capon, Magdalena Plebanski, Istvan Toth, Mariusz Skwarczynski
Peptide-based vaccines can trigger highly specific immune responses, although peptides alone are usually unable to confer strong humoral or cellular immunity. Consequently, peptide antigens are administered with immunostimulatory adjuvants, but only a few are safe and effective for human use. To overcome this obstacle, herein a peptide antigen was lipidated to effectively anchor it to liposomes and emulsion. A peptide antigen B cell epitope from Group A Streptococcus M protein was conjugated to a universal T helper epitope, the pan DR-biding epitope (PADRE), alongside a lipidic moiety cholesterol...
February 18, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38380354/evaluation-of-brushing-efficiency-in-reducing-oral-microbiota-in-mechanically-ventilated-patients-admitted-to-an-intensive-care-unit
#34
JOURNAL ARTICLE
Thainah Bruna Santos Zambrano, Ximena Sayonara Guillén Vivas, Caísa Batista Santos, Viviane de Fátima Mestre, Naga Raju Maddela, Lucia Elena Galarza Santana, Ricardo Sergio Couto de Almeida
BACKGROUND: Patients admitted to the Intensive Care Unit (ICU) are at greater risk of developing nosocomial infections due to their investigations, treatment and changes in the immune system. One of the most prevalent nosocomial infections is respiratory tract infection, such as hospital acquired pneumonia and ventilator-associated pneumonia (VAP). The bacteria commonly found in the oral cavity in the hospital environment are Streptococcus viridians , Staphylococcus aureus , Pseudomonas aeruginosa , Enterococcus spp...
March 2024: Infection prevention in practice
https://read.qxmd.com/read/38370326/urinary-tract-infection-and-progression-to-pyelonephritis-group-b-streptococcus-versus-e-coli
#35
JOURNAL ARTICLE
Sarika Sachdeva, Heather A Rosett, Madison K Krischak, Kristin E Weaver, R Phillips Heine, Anna E Denoble, Sarah K Dotters-Katz
Objective  Group B Streptococcus (GBS) colonization of the lower urinary tract in pregnancy is associated with severe infections such as chorioamnionitis, endometritis, and pyelonephritis. The objective of this study was to compare rates of progression to pyelonephritis between GBS and Escherichia coli lower urinary tract infections (LUTIs), as well as compare infectious and obstetric morbidity secondary to these pathogens. Study Design  Retrospective cohort of pregnant women with LUTIs (asymptomatic bacteria or acute cystitis [AC]) from a single health system between July 2013 and May 2019...
January 2024: American Journal of Perinatology Reports
https://read.qxmd.com/read/38368916/risk-of-immune-related-diseases-in-childhood-after-intrapartum-antibiotic-exposure
#36
JOURNAL ARTICLE
Sofia Ainonen, Eveliina Ronkainen, Mikael Hakkola, Tytti Pokka, Minna Honkila, Marika Paalanne, Eero Kajantie, Niko Paalanne, Terhi S Ruuska
BACKGROUND: Intrapartum antibiotic prophylaxis is effective in preventing early-onset group B streptococcal disease in newborn infants, but it influences gut microbiota development. Gut microbiota composition is in turn associated with immune-related diseases in childhood. OBJECTIVE: We hypothesized that intrapartum antibiotic exposure is associated with immune-related diseases in childhood. STUDY DESIGN: We conducted a population-based cohort study of vaginally delivered children...
February 16, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38368118/re-n-acetylation-of-group-b-streptococcus-type-ia-capsular-polysaccharide-improves-the-immunogenicity-of-glycoconjugate-vaccines
#37
JOURNAL ARTICLE
Jiaming Bei, Jianrong Wu, Jia Liu
The capsular polysaccharides (CPS) of Group B Streptococcus play a crucial role as virulence determinants and are potential candidates for antigenic components in vaccine formulations. Alkaline treatments are commonly used to extract polysaccharides owing to their efficiency and cost-effectiveness; however, they may induce the removal of N-acetyl groups from CPS. This study involved re-N-acetylation of CPS Ia to improve its biological functionality. The structural modifications and enhanced antigenicity of CPS Ia were observed after re-N-acetylation...
April 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38366099/macrolide-and-lincosamide-resistance-of-streptococcus-agalactiae-in-pregnant-women-in-poland
#38
JOURNAL ARTICLE
Dorota Kamińska, Magdalena Ratajczak, Dorota M Nowak-Malczewska, Justyna A Karolak, Marek Kwaśniewski, Anna Szumala-Kakol, Jolanta Dlugaszewska, Marzena Gajecka
Knowing about the antibiotic resistance, serotypes, and virulence-associated genes of Group B Streptococcus for epidemiological and vaccine development is very important. We have determined antimicrobial susceptibility patterns, serotype, and virulence profiles. The antibiotic susceptibility was assessed for a total of 421 Streptococcus agalactiae strains, isolated from pregnant women and neonates. Then, 89 erythromycin and/or clindamycin-resistant strains (82 isolates obtained from pregnant women and seven isolates derived from neonates) were assessed in detail...
February 16, 2024: Scientific Reports
https://read.qxmd.com/read/38360357/antibiotics-to-eradicate-streptococcus-pyogenes-pharyngeal-carriage-in-asymptomatic-children-and-adults-a-systematic-review
#39
REVIEW
Te-Yu Hung, Linny K Phuong, Anneke Grobler, Steven Y C Tong, Pippin Freeth, Asika Pelenda, Katherine B Gibney, Andrew C Steer
UNLABELLED: Streptococcus pyogenes (S. pyogenes) is a Gram-positive bacteria which causes a spectrum of diseases ranging from asymptomatic infection to life-threatening sepsis. Studies report up to 2000 times greater risk of invasive S. pyogenes disease in close contacts of index cases within 30-days of symptom onset. Despite this, there is variability in the management of asymptomatic carriage of S. pyogenes and those at risk of secondary cases of invasive S. pyogenes infection. OBJECTIVE: Our systematic review assessed the efficacy of different antibiotic regimens used for eradication of S...
February 13, 2024: Journal of Infection
https://read.qxmd.com/read/38351491/maternal-and-neonatal-group-b-streptococcus-colonisation-a-systematic-review-and-the-meta-analysis-of-matched-pair-studies
#40
REVIEW
Kai Wei Lee, Sook Fan Yap, Sudaxshina Murdan, Zurina Zainudin, Habibah Abdul Hamid, Mohsen Emamjomeh, Mohd Nasir Mohd Desa, Narcisse Mary Sither Joseph, Mohammad Noor Azmai Amal, Syafinaz Amin-Nordin
AIM: To determine the prevalence of group B Streptococcus (GBS) carriage among parturient women and neonates, and the relative risk of vertical transmission, the relative risk of early and late-onset GBS and the pooled incidence of early-late-onset GBS infection. METHODS: A systematic search of relevant cohort studies from three electronic databases to identify all relevant studies published up to 7 November 2022. The review was conducted in accordance with PRISMA guidelines...
February 13, 2024: Acta Paediatrica
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