Sean W McRae, Michael Cleary, Daniel DeRoche, Francisco M Martinez, Ying Xia, Peter Caravan, Eric M Gale, John A Ronald, Timothy J Scholl
Five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance imaging (MRI). The Mn(II) complexes are synthesized in three steps, each from the commercially available trans -1,2-diaminocyclohexane- N , N , N ', N '-tetraacetic acid (CDTA) chelator, with T 1 -relaxivity of complexes ranging between 2.3 and 3.0 mM-1 s-1 in phosphate buffered saline at an applied field strength of 3.0 T. Pharmacokinetics were assessed in female BALB/c mice by acquiring T 1 -weighted images dynamically for 70 min after agent administration and determining contrast enhancement and washout in various organs...
May 9, 2023: Journal of Medicinal Chemistry