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https://www.readbyqxmd.com/read/29220602/an-observational-study-of-treatment-seeking-users-of-natural-opiates-from-india
#1
Arpit Parmar, Vaibhav Patil, Siddharth Sarkar, Ravindra Rao
BACKGROUND: The type of opioid used influences the severity and complications experienced. Natural opiates (opium and poppy husk) use is a socio-culturally accepted phenomenon reported in India. However, studies on their profile, quality of life, and addiction severity are limited. OBJECTIVES: The objective of this cross-sectional, observational study was to assess the socio-demographic profile, clinical profile, addiction severity, and quality of life of treatment-seeking natural opiate users...
December 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29200559/a-comparative-study-of-factors-associated-with-relapse-in-alcohol-dependence-and-opioid-dependence
#2
Maithili Kadam, Ankita Sinha, Swateja Nimkar, Yusuf Matcheswalla, Avinash De Sousa
Background: Alcohol and opiates are among the most addictive substances posing significant public health problems due to the biopsychosocial impact that they have on individuals. Research shows that majority of abstinent alcohol and/or opioid dependence subjects relapse within 1 year. It has also been estimated that 26-36 million people worldwide abuse opiates, with exceptionally high-relapse rates. The purpose of this study was to compare the sociodemographic factors and correlates relapse in alcohol dependence and opioid dependence...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198562/disease-burden-and-costs-from-excess-alcohol-consumption-obesity-and-viral-hepatitis-fourth-report-of-the-lancet-standing-commission-on-liver-disease-in-the-uk
#3
REVIEW
Roger Williams, Graeme Alexander, Iain Armstrong, Alastair Baker, Neeraj Bhala, Ginny Camps-Walsh, Matthew E Cramp, Simon de Lusignan, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, Graham Foster, Ian Gilmore, Mark Hudson, Deirdre Kelly, Andrew Langford, Neil McDougall, Petra Meier, Kieran Moriarty, Philip Newsome, John O'Grady, Rachel Pryke, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Alison Taylor, Jeremy Thompson, Douglas Thorburn, Julia Verne, John Wass, Andrew Yeoman
This report contains new and follow-up metric data relating to the eight main recommendations of the Lancet Standing Commission on Liver Disease in the UK, which aim to reduce the unacceptable harmful consequences of excess alcohol consumption, obesity, and viral hepatitis. For alcohol, we provide data on alcohol dependence, damage to families, and the documented increase in alcohol consumption since removal of the above-inflation alcohol duty escalator. Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost...
November 28, 2017: Lancet
https://www.readbyqxmd.com/read/29185250/management-of-hepatitis-c-in-decentralised-versus-centralised-drug-substitution-programmes-and-minimally-invasive-point-of-care-tests-to-close-gaps-in-the-hcv-cascade
#4
Andrea Bregenzer, Anna Conen, Jürg Knuchel, Andrée Friedl, Franz Eigenmann, Martin Näf, Peter Ackle, Martin Roth, Christoph Andreas Fux
BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29172826/testing-nursing-sensitive-outcomes-in-out-patient-drug-addicts-with-nursing-role-effectiveness-model
#5
Paulo Rosário Carvalho Seabra, José Joaqui Penedos Amendoeira, Luis Octávio Sá
Our aim was to identify factors that contribute to a better outcome in drug users and to understand the effectiveness of nursing interventions, by applying "Nursing Role Effectiveness Model" (NREM). It's a correlational, cross-sectional study with 180 drug users in a methadone program, randomly selected from three community services. We identified that treatment time, lower co-morbidities, less poly-drug use, family support and being employed contribute to a better quality of life, better mental health, less substance addiction consequences and more satisfaction with nursing care (p < 0...
November 27, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29149893/association-between-severity-of-illicit-drug-dependence-and-quality-of-life-in-a-psychosocial-care-center-in-brazil-cross-sectional-study
#6
Selva Rios Campêlo, Maria Alves Barbosa, Danilo Rocha Dias, Camila Cardoso Caixeta, Cláudio Rodrigues Leles, Celmo Celeno Porto
BACKGROUND: Quality of life must be one of the main purposes for the treatment of drug users, requiring a better understanding of the association between the quality of life and the severity of dependency. This study aimed to investigate the correlation between severity of substance use in various areas of human functioning and quality of life of illicit drug users in a psychosocial care center for alcohol and drugs. METHODS: This cross-sectional study included 60 participants - illicit drug users - treated at a psychosocial care center for alcohol and drugs...
November 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29148565/tobacco-cessation-interventions-for-young-people
#7
REVIEW
Thomas R Fanshawe, William Halliwell, Nicola Lindson, Paul Aveyard, Jonathan Livingstone-Banks, Jamie Hartmann-Boyce
BACKGROUND: Most tobacco control programmes for adolescents are based around prevention of uptake, but teenage smoking is still common. It is unclear if interventions that are effective for adults can also help adolescents to quit. This is the update of a Cochrane Review first published in 2006. OBJECTIVES: To evaluate the effectiveness of strategies that help young people to stop smoking tobacco. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group's Specialized Register in June 2017...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#8
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29077093/why-do-bcl-2-inhibitors-work-and-where-should-we-use-them-in-the-clinic
#9
REVIEW
Joan Montero, Antony Letai
Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via standard molecular biology techniques. We discuss BCL-2 family regulation and how to determine cells' readiness for apoptosis and anti-apoptotic dependence. Cancer cells often adopt anti-apoptotic defense mechanisms in response to oncogenic stress or anti-cancer therapy. However, by determining their anti-apoptotic addiction, we can use novel BH3 mimetics to overwhelm this apoptotic blockade...
October 27, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29066940/intranasal-naloxone-and-related-strategies-for-opioid-overdose-intervention-by-nonmedical-personnel-a-review
#10
REVIEW
Christa R Lewis, Hoa T Vo, Marc Fishman
Deaths due to prescription and illicit opioid overdose have been rising at an alarming rate, particularly in the USA. Although naloxone injection is a safe and effective treatment for opioid overdose, it is frequently unavailable in a timely manner due to legal and practical restrictions on its use by laypeople. As a result, an effort spanning decades has resulted in the development of strategies to make naloxone available for layperson or "take-home" use. This has included the development of naloxone formulations that are easier to administer for nonmedical users, such as intranasal and autoinjector intramuscular delivery systems, efforts to distribute naloxone to potentially high-impact categories of nonmedical users, as well as efforts to reduce regulatory barriers to more widespread distribution and use...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/29056150/substance-p-and-the-neurokinin-1-receptor-the-new-crf
#11
Jesse R Schank, Markus Heilig
Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and sequenced 40 years later, SP has been extensively studied. Early studies identified a role for SP and the NK1R in contraction of intestinal smooth muscle, central pain processing, and neurogenic inflammation. An FDA-approved NK1R antagonist, aprepitant, is used clinically for the treatment of chemotherapy-induced nausea, as the NK1R influences the activity of the brain stem emesis centers...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29054291/neuroscience-informed-psychoeducation-for-addiction-medicine-a-neurocognitive-perspective
#12
Hamed Ekhtiari, Tara Rezapour, Robin L Aupperle, Martin P Paulus
Psychoeducation (PE) is defined as an intervention with systematic, structured, and didactic knowledge transfer for an illness and its treatment, integrating emotional and motivational aspects to enable patients to cope with the illness and to improve its treatment adherence and efficacy. PE is considered an important component of treatment in both medical and psychiatric disorders, especially for mental health disorders associated with lack of insight, such as alcohol and substance use disorders (ASUDs). New advancements in neuroscience have shed light on how various aspects of ASUDs may relate to neural processes...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29053117/-autoaggressive-characteristics-of-married-couples-where-husbands-suffer-from-alcohol-dependence
#13
A V Merinov
AIM: To study autoaggressive characteristics of spouses in families of men with alcohol dependence. MATERIAL AND METHODS: One hundred and twenty-five families, where a husband suffers from alcohol dependence, have been investigated. Suicidal and non-suicidal patterns of autoaggressive behavior as well as their predictors have been studied. The control group consisted of 62 families, where husbands were not alcohol dependent. RESULTS AND CONCLUSION: It has been found that men with alcohol dependence tend to realize anivital programs through suicidal behavior and risky-victim behavioral modes...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29049118/risk-factors-for-opioid-use-disorder-and-overdose
#14
REVIEW
Lynn R Webster
Opioid analgesics are recognized as a legitimate medical therapy for selected patients with severe chronic pain that does not respond to other therapies. However, opioids are associated with risks for patients and society that include misuse, abuse, diversion, addiction, and overdose deaths. Therapeutic success depends on proper candidate selection, assessment before administering opioid therapy, and close monitoring throughout the course of treatment. Risk assessment and prevention include knowledge of patient factors that may contribute to misuse, abuse, addiction, suicide, and respiratory depression...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28982757/another-case-for-diet-restriction-tap73-expressing-medulloblastomas-are-stunted-by-glutamine-withdrawal
#15
REVIEW
Marco Napoli, Elsa R Flores
Medulloblastomas are among the most common malignant brain cancers in the pediatric population and consist of at least four distinct subgroups with unique molecular and genetic features and clinical outcomes. In this issue of Genes & Development, Niklison-Chirou and colleagues (pp. 1738-1753) identify the p53 family member and p73 isoform TAp73 as a crucial factor causing glutamine addiction in aggressive medulloblastomas. Their findings pave the way for the use of glutamine restriction as an adjuvant treatment for TAp73-expressing medulloblastomas...
September 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28960173/family-behavior-therapy-for-alcohol-and-drug-problems-in-later-life
#16
Christopher P Plant, Jason M Holland
Alcohol and drug use problems among older individuals are a growing public health concern. However, few treatments have been developed for this population, despite an emerging body of literature suggesting that older substance users are more likely to benefit from interventions tailored to meet their specific needs. In particular, older adults with a history of substance abuse have expressed a preference for treatments that focus on financial problems, physical health, and mobility issues, and make attempts to prescriptively involve supportive others in treatment...
June 30, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28957338/-i-think-my-body-has-become-addicted-to-those-tablets-chronic-heart-failure-patients-understanding-of-and-beliefs-about-their-illness-and-its-treatment-a-qualitative-longitudinal-study-from-uganda
#17
Elizabeth Namukwaya, Scott A Murray, Julia Downing, Mhoira Leng, Liz Grant
BACKGROUND: Patients with heart failure in Uganda present for health care with advanced structural heart disease, have repeated hospitalizations and poorly controlled disease symptoms. The reasons for these are unclear. Literature from other settings shows that patients' understanding of their illness and their beliefs influence their health related behaviour. The study aimed to explore the beliefs of patients with heart failure, their understanding of their illness and its treatment, and how this influenced their health related behaviour to inform future health education programs, information and palliative care services...
2017: PloS One
https://www.readbyqxmd.com/read/28952977/to-improve-substance-use-disorder-prevention-treatment-and-recovery-engage-the-family
#18
Alicia S Ventura, Sarah M Bagley
: Approximately 21 million people in the United States have a substance use disorder (SUD); the number of family members impacted by a loved one's SUD is exponentially greater. Affected family members of individuals with SUDs are at high risk for developing chronic medical and psychiatric health conditions, are high utilizers of the health care system, and have high health care expenditures. Family members play a central role in the lives of many individuals with SUDs; information given to family members can have a significant impact on persons with addiction and therefore the SUD treatment that an individual might receive...
August 4, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#19
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28891662/increase-and-decrease-of-other-substance-use-during-recovery-from-cannabis-use-disorders
#20
David C Hodgins, Hyoun S Kim, Jonathan N Stea
Little is known about whether recovery from one addiction is associated with increased or decreased risk of subsequent other addictions. This study explored self-reported increases and decreases in other substance use among individuals who have recovered from cannabis use disorder. Media recruitment was used to obtain a sample of 119 individuals with lifetime but not past year cannabis use disorder (30% female). The median length of recovery was 5.0 years. Results showed that both increase and decrease in the use of other substances is very common in recovery from cannabis use...
September 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
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