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https://www.readbyqxmd.com/read/28982757/another-case-for-diet-restriction-tap73-expressing-medulloblastomas-are-stunted-by-glutamine-withdrawal
#1
REVIEW
Marco Napoli, Elsa R Flores
Medulloblastomas are among the most common malignant brain cancers in the pediatric population and consist of at least four distinct subgroups with unique molecular and genetic features and clinical outcomes. In this issue of Genes & Development, Niklison-Chirou and colleagues (pp. 1738-1753) identify the p53 family member and p73 isoform TAp73 as a crucial factor causing glutamine addiction in aggressive medulloblastomas. Their findings pave the way for the use of glutamine restriction as an adjuvant treatment for TAp73-expressing medulloblastomas...
September 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28960173/family-behavior-therapy-for-alcohol-and-drug-problems-in-later-life
#2
Christopher P Plant, Jason M Holland
Alcohol and drug use problems among older individuals are a growing public health concern. However, few treatments have been developed for this population, despite an emerging body of literature suggesting that older substance users are more likely to benefit from interventions tailored to meet their specific needs. In particular, older adults with a history of substance abuse have expressed a preference for treatments that focus on financial problems, physical health, and mobility issues, and make attempts to prescriptively involve supportive others in treatment...
June 30, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28957338/-i-think-my-body-has-become-addicted-to-those-tablets-chronic-heart-failure-patients-understanding-of-and-beliefs-about-their-illness-and-its-treatment-a-qualitative-longitudinal-study-from-uganda
#3
Elizabeth Namukwaya, Scott A Murray, Julia Downing, Mhoira Leng, Liz Grant
BACKGROUND: Patients with heart failure in Uganda present for health care with advanced structural heart disease, have repeated hospitalizations and poorly controlled disease symptoms. The reasons for these are unclear. Literature from other settings shows that patients' understanding of their illness and their beliefs influence their health related behaviour. The study aimed to explore the beliefs of patients with heart failure, their understanding of their illness and its treatment, and how this influenced their health related behaviour to inform future health education programs, information and palliative care services...
2017: PloS One
https://www.readbyqxmd.com/read/28952977/to-improve-substance-use-disorder-prevention-treatment-and-recovery-engage-the-family
#4
Alicia S Ventura, Sarah M Bagley
: Approximately 21 million people in the United States have a substance use disorder (SUD); the number of family members impacted by a loved one's SUD is exponentially greater. Affected family members of individuals with SUDs are at high risk for developing chronic medical and psychiatric health conditions, are high utilizers of the health care system, and have high health care expenditures. Family members play a central role in the lives of many individuals with SUDs; information given to family members can have a significant impact on persons with addiction and therefore the SUD treatment that an individual might receive...
August 4, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#5
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28891662/increase-and-decrease-of-other-substance-use-during-recovery-from-cannabis-use-disorders
#6
David C Hodgins, Hyoun S Kim, Jonathan N Stea
Little is known about whether recovery from one addiction is associated with increased or decreased risk of subsequent other addictions. This study explored self-reported increases and decreases in other substance use among individuals who have recovered from cannabis use disorder. Media recruitment was used to obtain a sample of 119 individuals with lifetime but not past year cannabis use disorder (30% female). The median length of recovery was 5.0 years. Results showed that both increase and decrease in the use of other substances is very common in recovery from cannabis use...
September 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28890714/gut-microbiota-analysis-in-rats-with-methamphetamine-induced-conditioned-place-preference
#7
Tingting Ning, Xiaokang Gong, Lingling Xie, Baomiao Ma
Methamphetamine abuse is a major public health crisis. Because accumulating evidence supports the hypothesis that the gut microbiota plays an important role in central nervous system (CNS) function, and research on the roles of the microbiome in CNS disorders holds conceivable promise for developing novel therapeutic avenues for treating CNS disorders, we sought to determine whether administration of methamphetamine leads to alterations in the intestinal microbiota. In this study, the gut microbiota profiles of rats with methamphetamine-induced conditioned place preference (CPP) were analyzed through 16S rRNA gene sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28876377/crack-cocaine-users-have-less-family-cohesion-than-alcohol-users
#8
Nino C Marchi, Juliana N Scherer, Mayra P Pachado, Luciano S Guimarães, Gerson Siegmund, Melina N de Castro, Silvia Halpern, Daniela Benzano, Maria L Formigoni, Marcelo Cruz, Flavio Pechansky, Felix H Kessler
Objective: Many studies correlate characteristics of family functioning and the development of drug addiction. This study sought to evaluate and compare the family environment styles of two groups of psychoactive substance users: 1) alcohol-only users and 2) crack-cocaine users. Methods: Three hundred and sixty-four users of alcohol, crack-cocaine, and other drugs, recruited from research centers in four Brazilian capitals participated in this study. Subjects were evaluated through the Family Environment Scale and the Addiction Severity Index, 6th version (ASI-6)...
August 30, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28869211/clinicians-views-on-therapeutic-outcomes-of-systemic-interventions-and-on-the-ability-of-the-eq-5d-to-capture-these-outcomes
#9
Saskia J Schawo, Werner B F Brouwer, Leona Hakkaart
BACKGROUND: Systemic interventions focus on improvements of interactions between clients and their environments, and are increasingly used to treat adolescents with problems of substance use and delinquency. Clients' progress may include broad and non-medical effects. When performing economic evaluations of these interventions, the common outcome of costs per quality adjusted life year (cost/QALY) may not capture all of these effects. AIMS OF THE STUDY: The current study is an explorative study...
September 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28867062/home-based-delivery-of-xr-ntx-in-youth-with-opioid-addiction
#10
Hoa T Vo, Rachael Burgower, Ilya Rozenberg, Marc Fishman
Early experience with relapse prevention medications in the treatment of opioid addiction in youth has been positive, but barriers to effectiveness and broader adoption have included problems with adherence and retention, and lack of evidence or consensus about implementation. In particular there is relatively little known about either the effectiveness of extended release naltrexone (XR-NTX) in youth, or optimal models of care for its delivery. The purpose of this study is to report on a pilot initiative to improve the effectiveness of XR-NTX by delivering doses at home with assertive outreach to patients enrolled in a community treatment outpatient program...
August 31, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28792293/the-opioid-epidemic-challenges-of-sustained-remission
#11
Nitin Chopra, Lauren H Marasa
Opioid use disorder is a growing epidemic, with an alarming number of associated deaths. In 2014, in the United States, 18,893 lethal overdoses were related to prescription opioids and 10,574 due to heroin. Despite the growing number of treatment options for substance use disorders, which are chronic, relapsing-remitting conditions, relapse rates remain as high as 91%. In the United States, 7.5 million children reside with at least one patient who abuses drugs or alcohol. Mothers are twice as likely to lose custody of their children...
March 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28780380/the-association-between-parental-history-and-delay-discounting-among-individuals-in-recovery-from-addiction
#12
Liqa N Athamneh, Jeffrey S Stein, Amanda J Quisenberry, Derek Pope, Warren K Bickel
BACKGROUND: Family history of addiction is a risk factor for substance use disorders. Delay discounting (DD) is associated with the risk of substance use and dependence, and is predictive of the likelihood of successful abstinence and treatment outcomes; thus, we investigated the extent to which having parents with addiction (parental history of addiction) and number of addicted parents affect DD among individuals in recovery from addiction. METHODS: Data from 177 individuals in recovery from addiction from The International Quit and Recovery Registry (IQRR), an ongoing online data collection program that aims to understand addiction and how people succeed in recovery, were included in the analysis...
October 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28767537/addressing-stigma-in-medication-treatment-of-adolescents-with-opioid-use-disorder
#13
Sarah M Bagley, Scott E Hadland, Brittany L Carney, Richard Saitz
: In September 2016, the American Academic of Pediatrics released a policy statement that adolescents with opioid use disorder should be offered pharmacotherapy with buprenorphine/naloxone, methadone, or naltrexone. In our clinical practice, however, we have encountered the perception among patients, families, and clinicians alike that medications should be used as a last resort. That we should wait until things get worse is a discarded approach. As addiction specialists, it is imperative that we prevent and identify risky use and use disorders, then intervene early and offer timely, evidence-based treatment...
August 1, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28757154/the-central-serotonin2b-receptor-as-a-new-pharmacological-target-for-the-treatment-of-dopamine-related-neuropsychiatric-disorders-rationale-and-current-status-of-research
#14
REVIEW
Céline Devroye, Adeline Cathala, Pier Vincenzo Piazza, Umberto Spampinato
The serotonin2B receptor (5-HT2BR), which was first cloned and characterized in the rat stomach fundus, is the most recent addition to the 5-HT2R family. While its involvement in the regulation of gastrointestinal, vascular, pulmonary and cardiac physiology has been widely investigated, its functional role within the central nervous system (CNS) has received much less attention. Nevertheless, when considering the data available in the literature with regards to the regulatory control exerted by the central 5-HT2BR on dopamine (DA) and serotonin (5-HT) neuron activity, a very interesting picture emerges and highlights the key role of these receptors for future therapeutic strategies of DA-related neuropsychiatric disorders...
July 27, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28755776/the-mental-health-parity-and-addiction-equity-act-evaluation-study-impact-on-specialty-behavioral-healthcare-utilization-and-spending-among-enrollees-with-substance-use-disorders
#15
Sarah Friedman, Haiyong Xu, Jessica M Harwood, Francisca Azocar, Brian Hurley, Susan L Ettner
BACKGROUND: The federal Mental Health Parity and Addiction Equity Act (MHPAEA) sought to eliminate historical disparities between behavioral health and medical health insurance benefits among the commercially insured. This study determines whether MHPAEA was associated with increased BH expenditures and utilization among a population with substance use disorder (SUD) diagnoses. METHODS: Claims and eligibility data from 5,987,776 enrollees, 2008-2013, were obtained from a national, commercial, managed behavioral health organization...
September 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28720620/in-this-issue-opiates-tobacco-social-determinants-of-health-social-accountability-for-non-profit-hospitals-more-on-pcmh-and-clinical-topics
#16
EDITORIAL
Marjorie A Bowman, Anne Victoria Neale, Dean A Seehusen
This issue contains several articles about the factors contributing to the complex and deadly interplay between social determinants of health, pain, mental illness, and addictive substances such as opioids and tobacco. One article clearly is a call to action: more than half of opioid prescriptions in the United States are given to patients with mental health problems. Two articles report work on the next steps for social determinants of health in health care settings. Social accountability based on community health needs assessments required of community hospitals should lead to the creation of more family medicine residency positions...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28694276/denial-the-greatest-barrier-to-the-opioid-epidemic
#17
Nicole Gastala
"Why can't you be like my old doctor?" This essay explores my experiences as a new family physician in a rural town endemic with liberal opioid prescribing practices and opioid addiction. I detail my inner turmoil while overcoming resistance to change, the influence of these experiences on my professional growth, and my decision to offer medication-assisted treatment.
July 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28687441/de-escalation-of-treatment-in-her2-positive-breast-cancer-determinants-of-response-and-mechanisms-of-resistance
#18
Jamunarani Veeraraghavan, Carmine De Angelis, Jorge S Reis-Filho, Tomás Pascual, Aleix Prat, Mothaffar F Rimawi, C Kent Osborne, Rachel Schiff
Overexpression and/or gene amplification of HER2, a crucial member of the HER family of four receptors, occur in about 15-20% of breast cancers and define an aggressive subtype of the disease. Activated HER homo and heterodimers govern a complex and redundant downstream signaling network that regulates cell survival and metastasis. Despite treatment with effective HER2-targeted therapies, many HER2-positive tumors fail to respond, or initially respond but eventually develop resistance. One of the upfront reasons for this treatment failure is failure to accurately select the tumors that are truly dependent on HER2 for survival and so would benefit the most from HER2-targeted therapy...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28678934/-clinical-and-social-vulnerabilities-in-crack-users-according-to-housing-status-a-multicenter-study-in-six-brazilian-state-capitals
#19
MULTICENTER STUDY
Silvia Chwartzmann Halpern, Juliana Nichterwitz Scherer, Vinicius Roglio, Sibele Faller, Anne Sordi, Felipe Ornell, Carla Dalbosco, Flavio Pechansky, Félix Kessler, Lísia von Diemen
The study had the goal to evaluate psychoactive substance use severity, violence, physical and emotional health of crack users who seeks specialized treatment in Psychosocial Care Centers for Alcohol and Drugs (CAPSad) concerning housing status. This is a multicenter cross-sectional study in six Brazilian capitals with 564 crack users categorized into two groups (1) users who have been homeless sometime in life (n = 266) and (2) individuals who have never lived on streets (n = 298). To assess the substance use severity and the characteristics of the individuals, the Addiction Severity Index, 6th version (ASI-6) was used...
July 3, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28651618/relationships-between-received-and-perceived-social-support-and-health-related-quality-of-life-among-patients-receiving-methadone-maintenance-treatment-in-mainland-china
#20
Kaina Zhou, Hengxin Li, Xiaoli Wei, Juan Yin, Peifeng Liang, Hongmei Zhang, Lingling Kou, Mengmeng Hao, Lijuan You, Xiaomei Li, Guihua Zhuang
BACKGROUND: Social support has been considered one of the most important factors of health-related quality of life (HRQoL) evaluations among different populations; however, few studies have explored the relationships of both received and perceived social support to HRQoL among patients undergoing methadone maintenance treatment (MMT). Thus, the purpose of this cross-sectional study was to clarify these relationships. METHODS: Participants were patients admitted at the two largest privately and publicly funded MMT clinics in Xi'an...
June 26, 2017: Substance Abuse Treatment, Prevention, and Policy
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