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https://www.readbyqxmd.com/read/28090374/neurophysiological-measures-and-alcohol-use-disorder-aud-hypothesizing-links-between-clinical-severity-index-and-molecular-neurobiological-patterns
#1
Mario Vitali, Carmen Napolitano, Marlene Oscar Berman, Simona Flamminii Minuto, Gemma Battagliese, Maria Luisa Attilia, Eric R Braverman, Marina Romeo, Kenneth Blum, Mauro Ceccanti
BACKGROUND: In 1987, Cloninger proposed a clinical description and classification of different personality traits genetically defined and independent from each other. Moreover, he elaborated a specific test the TCI to investigate these traits/states. The study of craving in Alcohol Use Disorder (AUD) assumed a greater significance, since ever more data seems to suggest a direct correlation between high levels of craving and a higher risk of relapse in alcoholics. Thus, our study aim is to explore the possible correlations among TCI linked molecular neurobiological pattern (s), craving and alcohol addiction severity measures in a sample of Italian alcoholics...
April 2016: Journal of Addiction Research & Therapy
https://www.readbyqxmd.com/read/28078986/cultivating-a-trauma-awareness-culture-in-the-addictions
#2
Evdokia Missouridou
BACKGROUND: Research evidence points to the high prevalence of trauma exposure and post traumatic stress among addicted individuals, their families and the professionals responsible for their treatment. OBJECTIVE: The purpose of this review is to enhance understanding of the continuing effects of trauma and its impact on the lives of people with addiction problems as well as on the professionals who strive to provide support and care for them. METHOD: Review of twenty eight articles on traumatic experiences in individuals and families facing addiction problems as well as on traumatic stress in addiction professionals...
January 10, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28072453/post-treatment-low-risk-drinking-as-a-predictor-of-future-drinking-and-problem-outcomes-among-individuals-with-alcohol-use-disorders-a-9-year-follow-up
#3
Andrea H Kline-Simon, Raye Z Litten, Constance M Weisner, Daniel E Falk
BACKGROUND: Treatment for alcohol use disorders has traditionally been abstinence-oriented, but new research and regulatory guidelines suggest that low-risk drinking may also be an acceptable treatment outcome. However, little is known about long-term outcomes for patients who become low-risk drinkers post-treatment. This study explores a post-treatment low-risk drinking outcome as a predictor of future drinking and psychosocial outcomes over 9 years. METHODS: Study participants were adults with alcohol use disorders at treatment entry who received follow-up interviews 6 months post-treatment intake (N=1061) in two large randomized studies conducted at Kaiser Permanente Northern California, a large private, nonprofit, integrated health system...
January 10, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28051841/a-review-of-a-national-training-initiative-to-increase-provider-use-of-mat-to-address-the-opioid-epidemic
#4
REVIEW
Frances R Levin, Adam Bisaga, Maria A Sullivan, Arthur Robin Williams, Kathryn Cates-Wessel
BACKGROUND AND OBJECTIVES: The Providers' Clinical Support System for Medication Assisted Treatment (PCSS-MAT) initiative focuses on training and mentoring health professionals in the treatment of opioid use disorders (OUD) using pharmacological strategies. Led by the American Academy of Addiction Psychiatry (AAAP), PCSS-MAT is a consortium representing four of the five national professional organizations authorized by DATA 2,000-AAAP, American Osteopathic Academy of Addiction Medicine, American Psychiatric Association, and American Society of Addiction Medicine...
December 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/28051839/social-context-and-perspectives-of-non-medical-prescription-opioid-use-among-young-adults-in-rhode-island-a-qualitative-study
#5
Jesse L Yedinak, Elizabeth N Kinnard, Scott E Hadland, Traci C Green, Melissa A Clark, Brandon D L Marshall
BACKGROUND AND OBJECTIVES: This pilot study examined the context of nonmedical prescription opioid (NMPO) use and related risk behaviors among young adults in Rhode Island, a New England region with markedly high prevalence of NMPO use and overdose mortality. METHODS: We conducted semi-structured interviews (n = 13) with young adults (18-29 year-olds) who reported current or recent NMPO use. We also conducted focus groups (two groups, n = 14 total) with professional service providers recruited from service organizations...
December 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/28026980/addiction-related-stigma-and-discrimination-a-qualitative-study-in-treatment-centers-in-mexico-city
#6
Jazmín Mora-Ríos, Miriam Ortega-Ortega, Maria Elena Medina-Mora
: Social rejection of drug use is greater than that directed at other psychiatric conditions, like depression and anxiety, which may lead to social exclusion of substance users and prevent them from seeking and receiving treatment. OBJECTIVE: The objective of this study is to investigate the stigma and discrimination related to addiction in treatment centers in Mexico City. METHODS: Data are from a broad mixed methods study. The present study is a qualitative analysis of 35 in-depth interviews of drug users, family members, and providers, using guidelines for the exploration of experiences of stigma and discrimination related to substance abuse...
December 27, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27997065/depression-and-severity-of-substance-dependence-among-heroin-dependent-patients-with-adhd-symptoms
#7
Yin-To Liao, Chi-Yen Chen, Mei-Hing Ng, Kuo-You Huang, Wen-Chuan Shao, Tsang-Yaw Lin, Vincent Chin-Hung Chen, Michael Gossop
BACKGROUND AND OBJECTIVES: Comorbid attention deficit hyperactivity disorder (ADHD) symptoms are highly prevalent among heroin-dependent patients. We aim to investigate differences in dependence severity, depression, and quality of life between heroin-dependent patients with and without ADHD-screened positive. METHODS: Heroin-dependent participants (n = 447) entering methadone maintenance treatment were divided into ADHD-screened positive (ADHD-P) and ADHD-screened negative (ADHD-N) groups according to scores of Adult ADHD Self-Report Scale (ASRS)...
January 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/27993335/the-oregon-model-of-behavior-family-therapy-from-intervention-design-to-promoting-large-scale-system-change
#8
Thomas Dishion, Marion Forgatch, Patricia Chamberlain, William E Pelham
This paper reviews the evolution of the Oregon model of family behavior therapy over the past four decades. Inspired by basic research on family interaction and innovation in behavior change theory, a set of intervention strategies were developed that were effective for reducing multiple forms of problem behavior in children (e.g., Patterson, Chamberlain, & Reid, 1982). Over the ensuing decades, the behavior family therapy principles were applied and adapted to promote children's adjustment to address family formation and adaptation (Family Check-Up model), family disruption and maladaptation (Parent Management Training-Oregon model), and family attenuation and dissolution (Treatment Foster Care-Oregon model)...
November 2016: Behavior Therapy
https://www.readbyqxmd.com/read/27976434/cultural-competence-in-the-treatment-of-addictions-theory-practice-and-evidence
#9
Sally M Gainsbury
Culturally and linguistically diverse (CALD) populations often have high rates of addictive disorders, but lower rates of treatment seeking and completion than the mainstream population. A significant barrier to treatment is the lack of culturally relevant and appropriate treatment. A literature review was conducted to identify relevant literature related to cultural competence in mental health services delivery and specifically treatment for addictive disorders. Several theoretical models of cultural competence in therapy have been developed, but the lack of rigorous research limits the empirical evidence available...
December 15, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27943032/subtyping-non-treatment-seeking-problem-gamblers-using-the-pathways-model
#10
Miea Moon, Jamey J Lister, Aleks Milosevic, David M Ledgerwood
This study examined whether distinct subgroups could be identified among a sample of non-treatment-seeking problem and pathological/disordered gamblers (PG) using Blaszczynski and Nower's (Addiction 97:487-499, 2002) pathways model (N = 150, 50% female). We examined coping motives for gambling, childhood trauma, boredom proneness, risk-taking, impulsivity, attention-deficit/hyperactivity disorder (ADHD), and antisocial personality disorder as defining variables in a hierarchical cluster analysis to identify subgroups...
December 10, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27929303/correction-to-campos-melady-et-al-2016
#11
(no author information available yet)
Reports an error in "The Effect of Therapists' Adherence and Competence in Delivering the Adolescent Community Reinforcement Approach on Client Outcomes" by Marita Campos-Melady, Jane Ellen Smith, Robert J. Meyers, Susan H. Godley and Mark D. Godley (Psychology of Addictive Behaviors, Advanced Online Publication, Oct 13, 2016, np). In the original article, the disclosed interest for Mark D. Godley in the author note is misrepresented. The accurate representation is that the organization employing Mark D. Godley, Chestnut Health Systems, receives fees for A-CRA training...
December 8, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27925076/experience-and-coping-strategies-in-relatives-of-addicts
#12
Ana Lucia de Moraes Horta, Celina Daspett, Julia Horta Tabosa do Egito, Rosa Maria Stefanini de Macedo
Objective: to understand the experience and coping strategies in relatives of drug addicts. Method: a study was developed with 87 relatives of addicts, registered in two Basic Health Units. The focus group was used as the study method, and content analysis was applied. Results: four categories were chosen: perception of relatives about the drug addiction of their family members; feelings and attitudes related to being a relative of an addict; difficulties found in the process; and, coping strategies...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27920355/initiation-of-addiction-treatment-and-access-to-services-young-adults-accounts-of-their-help-seeking-experiences
#13
Vincent Wagner, Karine Bertrand, Jorge Flores-Aranda, Didier Acier, Natacha Brunelle, Michel Landry, Serge Brochu
Substance addiction in young adults is particularly problematic. Yet, much remain at stake in understanding the specifics of this population's access to services. The objective of this study is to explore young adults' initiation of substance misuse treatment. Our study sample was composed of 35 individuals aged 18 to 30 with problematic psychoactive substance use who have been identified in criminal courts, hospital emergency departments, and Health and Social Services Centers in Québec (Canada). A thematic analysis was performed on the 62 semi-structured interviews conducted with participants...
December 4, 2016: Qualitative Health Research
https://www.readbyqxmd.com/read/27899120/violence-narratives-of-mexican-women-treated-in-mutual-aid-residential-centers-for-addiction-treatment
#14
Ignacio Lozano-Verduzco, Martha Romero-Mendoza, Rodrigo Marín-Navarrete
BACKGROUND: Violence against women is a social and public health issue in Mexico. The aim of this article is to explore violence among an understudied group of women, who attended Mutual-Aid Residential Centers for Addiction Treatment and experienced stigma both as women and addicts. These centers are particular kind of addiction treatment services that stem from 12-step philosophy, but that have been found to manipulate said philosophy and exercise extreme forms of psychological and physical violence...
November 30, 2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/27897471/use-of-risk-mitigation-practices-by-family-nurse-practitioners-prescribing-opioids-for-the-management-of-chronic-non-malignant-pain
#15
Sahil Chaudhary, Peggy Compton
BACKGROUND: Ongoing opioid analgesic use in patients suffering from chronic non-malignant pain (CNMP) has been associated with the development of opioid misuse, abuse, addiction, and overdose. To prevent these adverse outcomes, it is important that family nurse practitioners (FNPs) implement recommended risk mitigation practices (RMPs) when treating CNMP patients with opioids. METHODS: A national sample of 856 FNPs was invited to answer an online survey about their utilization of opioids and RMPs in treating CNMP...
November 29, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27875549/the-synthetic-%C3%AE-nitrostyrene-derivative-cyt-rx20-inhibits-esophageal-tumor-growth-and-metastasis-via-pi3k-akt-and-stat3-pathways
#16
Wen-Chin Chiu, Yi-Chen Lee, Yu-Han Su, Yen-Yun Wang, Chun-Hao Tsai, Yi-An Hou, Chie-Hong Wang, Ying-Fong Huang, Chih-Jen Huang, Shah-Hwa Chou, Pei-Wen Hsieh, Shyng-Shiou F Yuan
The β-nitrostyrene family have been implicated for anti-cancer property. However, the pharmacological role of β-nitrostyrene in esophageal cancer remain unclear. Here, a β-nitrostyrene derivative, CYT-Rx20, was synthesized and assessed for its anti-cancer activities and underlying mechanism in esophageal cancer. CYT-Rx20 induced cytotoxicity in esophageal cancer cells by promoting apoptosis through activation of caspase cascade and poly(ADP-ribose) polymerase (PARP) cleavage. Besides, CYT-Rx20 inhibited esophageal cancer cell migration and invasion by regulating the expression of epithelial to mesenchymal transition (EMT) markers...
2016: PloS One
https://www.readbyqxmd.com/read/27855325/-not-human-dead-already-perceptions-and-experiences-of-drug-related-stigma-among-opioid-using-young-adults-from-the-former-soviet-union-living-in-the-u-s
#17
Alana Gunn, Honoria Guarino
BACKGROUND: Young people from the former Soviet Union (FSU) in the U.S. are engaging in opioid and injection drug use (IDU) in substantial numbers, paralleling nationwide trends. Yet opioid-using FSU immigrants face distinctive acculturation challenges, including perceived stigmatisation as drug users within their immigrant communities, which may exacerbate the negative health and psychosocial consequences of such use. METHODS: This qualitative study draws on semi-structured interviews with 26 FSU immigrant young adults (ages 18-29) living in New York City who reported opioid use in the past month and/or were currently in treatment for opioid use disorder...
December 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27846878/perceived-coercion-to-enter-treatment-among-involuntarily-and-voluntarily-admitted-patients-with-substance-use-disorders
#18
Anne Opsal, Øistein Kristensen, John Kåre Vederhus, Thomas Clausen
BACKGROUND: Perceived coercion is a sense of pressure related to the experience of being referred to treatment. The sense of pressure arises from the patient's internal perception of coercion. The sources of coercion may be the legal system, the family, the health system, or self-criticism (internal sources). Here, we studied patients diagnosed with substance use disorders that were involuntarily admitted to hospital, pursuant to a social services act. We sought to determine whether these patients perceived coercion differently than patients that were admitted voluntarily...
November 15, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27830625/substance-misuse
#19
(no author information available yet)
This literature review concerned the end of life care needs of patients with drug and alcohol addiction, particularly in the UK, and to identify existing good practice guidance. Three themes emerged: » The need to improve recognition of substance misuse in patients receiving palliative care, and to meet the challenges palliative care teams face when caring for patients who have current or past opiate, benzodiazepine or alcohol addictions. » A lack of UK literature addressing the end of life care needs of patients with drug and alcohol addiction...
November 10, 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27822137/axitinib-has-antiangiogenic-and-antitumorigenic-activity-in-myxoid-liposarcoma
#20
Lauren T Kerr, Jacqueline F Donoghue, Alexander L Wilding, Terrance G Johns
Myxoid liposarcoma is a rare form of soft-tissue sarcoma. Although most patients initially respond well to treatment, approximately 21% relapse, highlighting the need for alternative treatments. To identify novel treatment regimens and gain a better understanding of myxoid liposarcoma tumor biology, we screened various candidate and approved targeted therapeutics and chemotherapeutics against myxoid liposarcoma cell lines. Therapeutics that target angiogenesis showed antitumor activity. The small molecule inhibitor axitinib, which targets angiogenesis by inhibiting the VEGFR and PDGFR families and c-Kit, inhibited cell cycle progression and induced apoptosis in vitro, as well as having significant antitumor activity against MLS 1765 myxoid liposarcoma xenografts in mice...
2016: Sarcoma
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