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https://www.readbyqxmd.com/read/28333381/protective-actions-of-h2s-in-acute-myocardial-infarction-and-heart-failure
#1
Erminia Donnarumma, Rishi K Trivedi, David J Lefer
Hydrogen sulfide (H2S) was identified as the third gasotransmitter in 1996 following the discoveries of the biological importance of nitric oxide and carbon monoxide. Although H2S has long been considered a highly toxic gas, the discovery of its presence and enzymatic production in mammalian tissues supports a critical role for this physiological signaling molecule. H2S is synthesized endogenously by three enzymes: cystathionine β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase. H2S plays a pivotal role in the regulation of cardiovascular function as H2S has been shown to modulate: vasodilation, angiogenesis, inflammation, oxidative stress, and apoptosis...
March 16, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28333142/hydrogen-sulfide-promotes-autophagy-of-hepatocellular-carcinoma-cells-through-the-pi3k-akt-mtor-signaling-pathway
#2
Shanshan S Wang, Yuhan H Chen, Ning Chen, Lijun J Wang, Dexi X Chen, Honglei L Weng, Steven Dooley, Huiguo G Ding
Hydrogen sulfide (H2S), in its gaseous form, plays an important role in tumor carcinogenesis. This study investigated the effects of H2S on the cell biological functions of hepatocellular carcinoma (HCC). HCC cell lines, HepG2 and HLE, were treated with NaHS, a donor of H2S, and rapamycin, a classic autophagy inducer, for different lengths of time. Western blotting, immunofluorescence, transmission electron microscopy (TEM), scratch assay, CCK-8 and flow cytometric analysis were carried out to examine the effects of H2S on HCC autophagy, cell behavior and PI3K/Akt/mTOR signaling...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28331192/pd-zno-nanorods-based-sensor-for-highly-selective-detection-of-extremely-low-concentration-hydrogen
#3
Mohit Kumar, Vijendra Singh Bhati, Sapana Ranwa, Jitendra Singh, Mahesh Kumar
We report highly hydrogen selective Pd contacted ZnO nanorods based sensor detecting low concentration even at low operating temperature of 50 °C. The sensor performance was investigated for various gases such as H2, CH4, H2S and CO2 at different operating temperatures from 50 °C to 175 °C for various gas concentrations ranging from 7 ppm to 10,000 ppm (1%). The sensor is highly efficient as it detects hydrogen even at low concentration of ~7 ppm and at operating temperature of 50 °C. The sensor's minimum limit of detection and relative response at 175 °C were found 7 ppm with ~38...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330299/detection-of-antimicrobial-traits-in-fluorescent-pseudomonads-and-molecular-characterization-of-an-antibiotic-pyoluteorin
#4
J U Vinay, M K Naik, R Rangeshwaran, G Chennappa, Sohel S Shaikh, R Z Sayyed
Thirty isolates of fluorescent pseudomonads were obtained from rhizosphere of different crops in Raichur, India. The fluorescent pseudomonad strains were characterized in vitro for biochemical traits, antimicrobial traits, and pyoluteorin antibiotic production. All the isolates that showed fluorescent pigment production under UV light were rod shaped, Gram negative, positive for oxidase, catalase and citrate utilization tests, and negative for indole test. Out of 30 isolates, 07 isolates were positive for HCN production, 15 isolates were positive for H2S production, and all the isolates were positive for siderophore production...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330194/exploited-application-of-sulfate-reducing-bacteria-for-concomitant-treatment-of-metallic-and-non-metallic-wastes-a-mini-review
#5
REVIEW
Ali Hussain, Ali Hasan, Arshad Javid, Javed Iqbal Qazi
A variety of multidimensional anthropogenic activities, especially of industrial level, are contaminating our aquatic and terrestrial environments with a variety of metallic and non-metallic pollutants. The metallic and non-metallic pollutants addressed specifically in this review are heavy metals and various compound forms of sulfates, respectively. Direct and indirect deleterious effects of the both types of pollutants to all forms of life are well-known. The treatment of such pollutants is therefore much necessary before their final discharge into the environment...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330142/an-overview-of-physico-chemical-mechanisms-of-biogas-production-by-microbial-communities-a-step-towards-sustainable-waste-management
#6
REVIEW
Ramansu Goswami, Pritam Chattopadhyay, Arunima Shome, Sambhu Nath Banerjee, Amit Kumar Chakraborty, Anil K Mathew, Shibani Chaudhury
Biogas is a combination of methane, CO2, nitrogen, H2S and traces of few other gases. Almost any organic waste can be biologically transformed into biogas and other energy-rich organic compounds through the process of anaerobic digestion (AD) and thus helping in sustainable waste management. Although microbes are involved in each step of AD, knowledge about those microbial consortia is limited due to the lack of phylogenetic and metabolic data of predominantly unculturable microorganisms. However, culture-independent methods like PCR-based ribotyping has been successfully employed to get information about the microbial consortia involved in AD...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323482/constraints-on-the-early-terrestrial-surface-uv-environment-relevant-to-prebiotic-chemistry
#7
Sukrit Ranjan, Dimitar D Sasselov
The UV environment is a key boundary condition to abiogenesis. However, considerable uncertainty exists as to planetary conditions and hence surface UV at abiogenesis. Here, we present two-stream multilayer clear-sky calculations of the UV surface radiance on Earth at 3.9 Ga to constrain the UV surface fluence as a function of albedo, solar zenith angle (SZA), and atmospheric composition. Variation in albedo and latitude (through SZA) can affect maximum photoreaction rates by a factor of >10.4; for the same atmosphere, photoreactions can proceed an order of magnitude faster at the equator of a snowball Earth than at the poles of a warmer world...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28323252/layer-controlled-precise-fabrication-of-ultrathin-mos2-films-by-atomic-layer-deposition
#8
Lei Liu, Yazhou Huang, Jingjie Sha, Yunfei Chen
Monolayer and/or atomically thin transition metal dichalcogenides cover a wide range of two-dimensional (2-D) materials, whose fascinating semiconducting and optical properties have made them being promising candidate materials for optoelectronic device. Controllable growth of these materials is critical for their device applications. By using MoCl5 and H2S as precursors, monolayer and ultrathin molybdenum disulfide (MoS2) films with controlled lamellar structure have been directly built layer by layer on SiO2 substrates without followed high-temperature annealing...
March 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28322929/exogenous-h2s-prevents-high-glucose-induced-damage-to-osteoblasts-through-regulation-of-katp-channels
#9
Yuanyuan Liu, Jianyong Liu, Xin Li, Fantao Wang, Xin Xu, Chunling Wang
Association between diabetes and osteoporosis has been extensively investigated. However, whether the effects of H2S on osteoblast function under high glucose (HG) condition relate to ATP-sensitive potassium (KATP) channels is unclear. To investigate the effects of H2S on the proliferation, apoptosis, and mineralization of osteoblasts under HG condition, and to observe whether H2S exert this effect through the KATP channels. Primary osteoblasts (POBs) were obtained from the calvaria of Sprague-Dawley rats. Cells were pre-treated with 400 μmol/L NaHS (a H2S donor), and/or 0...
March 16, 2017: Biochimie
https://www.readbyqxmd.com/read/28322600/renal-mitochondrial-response-to-low-temperature-in-non-hibernating-and-hibernating-species
#10
George J Dugbartey, Maarten C Hardenberg, Wendelinde F Kok, Ate Boerema, Hannah V Carey, James Staples, Robert H Henning, Hjalmar Bouma
SIGNIFICANCE: Therapeutic hypothermia is commonly applied to limit ischemic injury in organ transplantation, during cardiac and brain surgery and after cardiopulmonary resuscitation. In these procedures, the kidneys are particularly at risk for ischemia/reperfusion injury (IRI), likely due to their high rate of metabolism. Although hypothermia mitigates ischemic kidney injury, it is not a panacea. Residual mitochondrial failure is thought to be a key event triggering loss of cellular homeostasis, and potentially cell death...
March 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28322298/h2s-regulates-endothelial-nitric-oxide-synthase-protein-stability-by-promoting-microrna-455-3p-expression
#11
Xing-Hui Li, Wen-Long Xue, Ming-Jie Wang, Yu Zhou, Cai-Cai Zhang, Chen Sun, Lei Zhu, Kun Liang, Ying Chen, Bei-Bei Tao, Bo Tan, Bo Yu, Yi-Chun Zhu
The aims of the present study are to determine whether hydrogen sulfide (H2S) is involved in the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, and to identify the role of microRNA-455-3p (miR-455-3p) during those processes. In cultured human umbilical vein endothelial cells (HUVECs), the expression of miR-455-3p, eNOS protein and the NO production was detected after administration with 50 μM NaHS. The results indicated that H2S could augment the expression of miR-455-3p and eNOS protein, leading to the increase of NO level...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321823/cardiovascular-disease-and-resuscitated-septic-shock-lead-to-the-downregulation-of-the-h2s-producing-enzyme-cystathionine-%C3%AE-lyase-in-the-porcine-coronary-artery
#12
Tamara Merz, Tatjana Stenzel, Benedikt Nußbaum, Martin Wepler, Csaba Szabo, Rui Wang, Peter Radermacher, Oscar McCook
BACKGROUND: Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovascular pathologies. Nevertheless, equivocal data are available on both the expression and function of these enzymes in coronary arteries (CA). We recently reported that atherosclerotic pigs subjected to sepsis developed impaired cardiac function, which coincided with decreased myocardial CSE expression and increased nitrotyrosine formation...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28320864/assessment-of-h2s-in-vivo-using-the-newly-developed-mitochondria-targeted-mass-spectrometry-probe-mitoa
#13
Sabine Arndt, Carlos D Baeza-Garza, Angela Logan, Tiziana Rosa, Rudolf Wedmann, Tracy A Prime, Jack L Martin, Kourosh Saeb-Parsy, Thomas Krieg, Milos R Filipovic, Richard C Hartley, Michael P Murphy
Hydrogen sulfide (H2S) is produced endogenously in vivo and has multiple effects on signaling pathways and cell function. Mitochondria can be both an H2S source and sink, and many of the biological effects of H2S relate to its interactions with mitochondria. However, the significance of mitochondrial H2S is uncertain, in part due to the difficulty of assessing changes in its concentration in vivo. While a number of fluorescent H2S probes have been developed these are best suited to cells in culture and cannot be used in vivo...
March 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28319759/removal-of-hydrogen-sulfide-generated-during-anaerobic-treatment-of-sulfate-laden-wastewater-using-biochar-evaluation-of-efficiency-and-mechanisms
#14
Jarupat Kanjanarong, Balendu S Giri, Deb P Jaisi, Fernanda R Oliveira, Piyarat Boonsawang, Sumate Chaiprapat, R S Singh, Avula Balakrishna, Samir Kumar Khanal
Removal of hydrogen sulfide (H2S) from biogas was investigated in a biochar column integrated with a bench-scale continuous-stirred tank reactor (CSTR) treating sulfate-laden wastewater. Synthetic wastewater containing sulfate concentrations of 200-2000mg SO4(2-)/L was used as substrate, and the CSTR was operated at an organic loading rate of 1.5g chemical oxygen demand (COD)/L·day and a hydraulic retention time (HRT) of 20days. The biochar was able to remove about 98.0 (±1.2)% of H2S for the ranges of concentrations from 105-1020ppmv, especially at high moisture content (80-85%)...
March 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319129/changes-in-salivary-microbiota-increase-volatile-sulfur-compounds-production-in-healthy-male-subjects-with-academic-related-chronic-stress
#15
Bruno Dias Nani, Patricia Oliveira de Lima, Fernanda Klein Marcondes, Francisco Carlos Groppo, Gustavo Sattolo Rolim, Antonio Bento Alves de Moraes, Karina Cogo-Müller, Michelle Franz-Montan
OBJECTIVE: To investigate the associations among salivary bacteria, oral emanations of volatile sulfur compounds, and academic-related chronic stress in healthy male subjects. MATERIALS AND METHODS: Seventy-eight healthy male undergraduate dental students were classified as stressed or not by evaluation of burnout, a syndrome attributed to academic-related chronic stress. This evaluation was carried out using the Maslach Burnout Inventory-Student Survey questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28318752/cystathionine-gamma-lyase-deficient-mice-are-protected-against-the-development-of-multiorgan-failure-and-exhibit-reduced-inflammatory-response-during-burn
#16
Akbar Ahmad, Nadiya Druzhyna, Csaba Szabo
Considering the role of H2S in critical illness, the aim of this study was to compare the outcome of burn in wild-type mice and in mice deficient in CSE, one of the principal mammalian H2S-generating enzymes. Animals were subjected to scald burn. Outcome variables included indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. Plasma levels of H2S significantly increased in response to burn in wild-type mice, but remained unchanged in CSE(-/-) mice. Expression of the three H2S-producing enzymes (CSE, CBS and 3-MST) in the lung and liver, and the capacity of tissue homogenates to produce H2S, however, was not affected by burn...
March 15, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28315482/modes-of-antibacterial-action-of-curcumin-under-dark-and-light-conditions-a-toxicoproteomics-approach
#17
Ilya Shlar, Samir Droby, Victor Rodov
Curcumin is a potent natural food-grade antimicrobial compound. Exposure to light further enhances its antimicrobial capacity. Proteomic methods were used in this study for investigating the mechanistic aspects of the antibacterial curcumin effects in the dark and upon illumination. Escherichia coli cells exposed to water-dispersible curcumin-methyl-β-cyclodextrin inclusion complex under dark and light conditions were compared with the non-treated cells kept under the same illumination regimes. Curcumin treatment in the dark evoked adaptive responses aimed at mitigation of oxidative stress, DNA protection, proteostasis, modulation of redox state via changing NADH level, and gasotransmitter (H2S and NH3) biosynthesis...
March 14, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28314724/impact-of-seasonal-hypoxia-on-activity-and-community-structure-of-chemolithoautotrophic-bacteria-in-a-coastal-sediment
#18
Yvonne A Lipsewers, Diana Vasquez-Cardenas, Dorina Seitaj, Regina Schauer, Silvia Hidalgo Martinez, Jaap S Sinninghe Damsté, Filip J R Meysman, Laura Villanueva, Henricus T S Boschker
Seasonal hypoxia in coastal systems drastically changes the availability of electron acceptors in bottom water, which alters the sedimentary reoxidation of reduced compounds. However, the effect of seasonal hypoxia on the chemolithoautotrophic community that catalyze these reoxidation reactions, is rarely studied. Here we examine the changes in activity and structure of the sedimentary chemolithoautotrophic bacterial community of a seasonally hypoxic saline basin under oxic (spring) and hypoxic (summer) conditions...
March 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28304172/ab-initio-studies-on-the-clathrate-hydrates-of-some-nitrogen-and-sulfur-containing-gases
#19
Ningru Sun, Zewen Li, Nianxiang Qiu, Xiaohui Yu, Xuran Zhang, Yanjun Li, Longbin Yang, Kan Luo, Qing Huang, Shiyu Du
Ab initio calculations are performed to investigate the host-guest interactions and multiple occupancies of some sulfur- (H2S, CS2) and nitrogen-containing (N2, NO, and NH3) molecules in dodecahedral, tetrakaidecahedral, and hexakaidecahedral water cages in this work. Five functionals in the framework of density functional theory are compared, and the M06-2X method appears to be the best to predict the binding energies as well as the geometries. Results show that N2 and NO molecules are more stable in the 5(12)6(4) cage, while NH3 and H2S prefer to stabilize in the 5(12)6(2) cage...
March 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28303169/diallyl-trisulfide-suppresses-oxidative-stress-induced-activation-of-hepatic-stellate-cells-through-production-of-hydrogen-sulfide
#20
Feng Zhang, Huanhuan Jin, Li Wu, Jiangjuan Shao, Xiaojing Zhu, Anping Chen, Shizhong Zheng
Accumulating data reveal that garlic has beneficial effects against chronic liver disease. We previously reported that diallyl trisulfide (DATS), the primary organosulfur compound in garlic, reduced fibrosis and attenuated oxidative stress in rat fibrotic liver. The present study was aimed at elucidating the underlying mechanisms. The primary rat hepatic stellate cells (HSCs) were cultured and stimulated with hydrogen peroxide (H2O2) for inducing HSC activation under oxidative stress. We examined the effects of DATS on the profibrogenic properties and oxidative stress in H2O2-treated HSCs...
2017: Oxidative Medicine and Cellular Longevity
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