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https://www.readbyqxmd.com/read/29340437/a-novel-lysosome-targeted-fluorogenic-probe-based-on-5-triazole-quinoline-for-the-rapid-detection-of-hydrogen-sulfide-in-living-cells
#1
Yandong Dou, Xiaoxu Gu, Shasha Ying, Shen Zhu, Shian Yu, Wei Shen, Qing Zhu
A fluorogenic probe based on the novel fluorophore 5-triazole-quinoline was developed for the detection of hydrogen sulfide, an endogenous signaling molecule associated with the development of various diseases. The lysosome-targeted probe Lyso-HS was synthesized via C-H direct azidation from 8-aminoquinoline; it was able to detect H2S in 1 min and exhibited excellent turn-on ability with 95-fold fluorescence enhancement based on a new fluorochrome. The high quenching efficiency was further verified using time-dependent density functional theory (TDDFT)...
January 17, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29338840/hydrogen-sulfide-provides-intestinal-protection-during-a-murine-model-of-experimental-necrotizing-enterocolitis
#2
Natalie A Drucker, Amanda R Jensen, Michael Ferkowicz, Troy A Markel
BACKGROUND: Necrotizing enterocolitis (NEC) continues to be a morbid surgical condition among preterm infants. Novel therapies for this condition are desperately needed. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has been found to have beneficial properties. We therefore hypothesized that intraperitoneal injection of various H2S donors would improve clinical outcomes, increase intestinal perfusion, and reduce intestinal injury in an experimental mouse model of necrotizing enterocolitis...
December 24, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29337193/il-1%C3%AE-augments-h2s-induced-increase-in-intracellular-ca2-through-polysulfides-generated-from-h2s-no-interaction
#3
Ayako Ujike, Tomoki Kuraishi, Soichiro Yamaguchi, Ryota Eguchi, Taisuke Kitano, Jumpei Kamise, Shigeo Ito, Ken-Ichi Otsuguro
H2S has excitatory and inhibitory effects on Ca2+ signals via transient receptor potential ankyrin 1 (TRPA1) and ATP-sensitive K+ channels, respectively. H2S converts intracellularly to polysulfides, which are more potent agonists for TRPA1 than H2S. Under inflammatory conditions, changes in the expression and activity of these H2S target channels and/or the conversion of H2S to polysulfides may modulate H2S effects. Effects of proinflammatory cytokines on H2S-induced Ca2+ signals and polysulfide production in RIN14B cells were examined using fluorescence imaging with fura-2 and SSP4, respectively...
January 11, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29331374/alternative-pathway-of-h2s-and-polysulfides-production-from-sulfurated-catalytic-cysteine-of-reaction-intermediates-of-3-mercaptopyruvate-sulfurtransferase
#4
Noriyuki Nagahara, Shin Koike, Takashi Nirasawa, Hideo Kimura, Yuki Ogasawara
It has been known that hydrogen sulfide and/or polysulfides are produced from a (poly)sulfurated sulfur-acceptor substrate of 3-mercaptopyruvate sulfurtransferase (MST) via thioredoxin (Trx) reduction in vitro. In this study, we used thiosulfate as the donor substrate and the catalytic reaction was terminated on the formation of a persulfide or polysulfides. We can present alternative pathway of production of hydrogen sulfide and/or polysulfides from (poly)sulfurated catalytic-site cysteine of reaction intermediates of MST via Trx reduction...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330066/regulation-of-vascular-tone-homeostasis-by-no-and-h2s-implications-in-hypertension
#5
REVIEW
Sevda Gheibi, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi
Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the vasculature and contribute to the regulation of vascular tone. NO and H2S are synthesized in both vascular smooth muscle and endothelial cells; NO functions primarily through the sGC/cGMP pathway, and H2S mainly through activation of the ATP-dependent potassium channels; both leading to relaxation of vascular smooth muscle cells. A deficit in the NO/H2S homeostasis is involved in the pathogenesis of various cardiovascular diseases, especially hypertension...
January 9, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29328062/cyanobacterial-photosynthesis-under-sulfidic-conditions-insights-from-the-isolate-leptolyngbya-sp-strain-hensonii
#6
Trinity L Hamilton, Judith M Klatt, Dirk de Beer, Jennifer L Macalady
We report the isolation of a pinnacle-forming cyanobacterium isolated from a microbial mat covering the sediment surface at Little Salt Spring-a flooded sinkhole in Florida with a perennially microoxic and sulfidic water column. The draft genome of the isolate encodes all of the enzymatic machinery necessary for both oxygenic and anoxygenic photosynthesis, as well as genes for methylating hopanoids at the C-2 position. The physiological response of the isolate to H2S is complex: (i) no induction time is necessary for anoxygenic photosynthesis; (ii) rates of anoxygenic photosynthesis are regulated by both H2S and irradiance; (iii) O2 production is inhibited by H2S concentrations as low as 1 μM and the recovery rate of oxygenic photosynthesis is dependent on irradiance; (iv) under the optimal light conditions for oxygenic photosynthesis, rates of anoxygenic photosynthesis are nearly double those of oxygenic photosynthesis...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29326065/hydrogen-sulfide-supplement-attenuates-the-apoptosis-of-retinal-ganglion-cells-in-experimental-glaucoma
#7
Shouyue Huang, Ping Huang, Zhongjing Lin, Xiaohong Liu, Xing Xu, Lei Guo, Xi Shen, Changwei Li, Yisheng Zhong
Glaucoma is a group of neurodegenerative eye diseases characterized by progressive impairment of visual function due to loss of retinal ganglion cells (RGC). As hydrogen sulfide (H2S) was reported to play a role in the process of glaucomatous neuropathy and improve RGC survival in experimental glaucoma, the authors aimed to investigate the anti-apoptosis effect of H2S supplement in a rat glaucoma model, and further tried to explore the involved factors in the neuroprotection. A chronic ocular hypertension (COH) rat model induced by intracameral injection of cross-linking hydrogel was employed to simulate glaucoma and 288 rats were subjected to experimental procedures in the present study...
January 8, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29325692/ontogenetic-and-temperature-dependent-changes-in-tolerance-to-hypoxia-and-hydrogen-sulfide-during-the-early-life-stages-of-the-manila-clam-ruditapes-philippinarum
#8
Keita Kodama, Mitsuyasu Waku, Ryota Sone, Dai Miyawaki, Toshiro Ishida, Tetsuji Akatsuka, Toshihiro Horiguchi
Wind-induced upwelling of hypoxic waters containing hydrogen sulfide (H2S) sometimes causes mass mortalities of aquatic organisms inhabiting coastal areas, including the hypoxia-tolerant Manila clam Ruditapes philippinarum. We examined the tolerance of Manila clam to H2S under controlled laboratory conditions. Larvae and juveniles obtained by artificial fertilization or from a wild population were exposed to normoxic or to hypoxic water with or without un-ionized H2S (concentrations, 0.2-52.2 mg/L). Twenty-four-hour exposure experiments revealed ontogenetic changes in the clam's tolerance to H2S exposure: tolerance was enhanced from the larval stages to juveniles just after settlement but was attenuated as juveniles grew...
January 2, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29320370/the-spatial-separation-of-electrons-and-holes-for-enhancing-semiconductor-s-gas-sensing-property-zno-znsno3-nanorod-arrays-prepared-by-a-hetero-epitaxial-growth
#9
Ying Wang, Peng Gao, Linna Sha, Yurong Yang, Lei Yang, Jianjiao Zhang, Yujin Chen, Milin Zhang
The construction of semiconductor composites is known a powerful method to realize the spatial separation of electrons and holes in them, which can result in more electrons or holes and further realize more oxygen ions (O2- and O-) (one of the most critical factor for their gas-sensing properties) dispersing on the surface of semiconductor gas sensor. In this work, using one-dimensional ZnO/ZnSnO3 nanoarrays as an example, which are prepared through a hetero-epitaxial growing process to construct a chemically boned interface, the above strategy for better semiconductor gas-sensing preperty has been realized...
January 10, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29319417/control-of-h2s-generation-in-simultaneous-removal-of-no-and-so2-by-rotating-drum-biofilter-coupled-with-feii-edta
#10
Jun Chen, Bingbin Li, Ji Zheng, Jianmeng Chen
Simultaneous removal of SO2 and NO from flue gas can be biologically achieved by the rotating drum biofilter with FeII(EDTA) as a solvent. One issue related with this process is the generation of H2S. To control its generation, the pathways of H2S formation was investigated, and the parametric tests were conducted. The addition of FeII(EDTA) (10 mM) increased the removal efficiency of NO and SO2, while the S2- concentration decreased from 81 mM to 3.5 mM. The parametric tests showed that the high NO concentration favored the SO2 removal and significantly inhibited the H2S generation...
January 10, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29319082/%C3%AF-holes-and-%C3%AF-lumps-direct-the-lewis-basic-and-acidic-interactions-of-noble-metal-nanoparticles-introducing-regium-bonds
#11
Joakim Halldin Stenlid, Adam Johannes Johansson, Tore Brinck
Using local DFT-based probes for electrostatic as well as charge transfer/polarization interactions, we are able to characterize Lewis basic and acidic sites on copper, silver and gold nanoparticles. The predictions obtained using the DFT-probes are compared to the interaction energies of the electron donating (CO, H2O, NH3 and H2S) and the electron accepting (BH3, BF3, HCl [H-down] and Na+) compounds. The probes include the local electron attachment energy [E(r)], the average local ionization energy [Ī(r)], and the electrostatic potential [V(r)] and are evaluated on isodensity surfaces located at distances corresponding to typical interaction distances...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29318511/midazolam-efficacy-against-acute-hydrogen-sulfide-induced-mortality-and-neurotoxicity
#12
Poojya Anantharam, Dong-Suk Kim, Elizabeth M Whitley, Belinda Mahama, Paula Imerman, Piyush Padhi, Wilson K Rumbeiha
Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while survivors may develop neurological sequelae. Currently, there is no suitable antidote for treatment of acute H2S-induced neurotoxicity. Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in treating acute H2S intoxication...
January 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29317494/hydrogen-sulfide-inhibits-kir2-and-kir3-channels-by-decreasing-sensitivity-to-the-phospholipid-pip2
#13
Junghoon Ha, Yu Xu, Takeharu Kawano, Tyler Hendon, Lia Baki, Sumanta Garai, Andreas Papapetropoulos, Ganesh Thakur, Leigh D Plant, Diomedes E Logothetis
Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain and other peripheral tissues. Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. The gasotransmitter carbon monoxide has been shown to regulate Kir channel activity by altering channel-PIP2 interactions.  Here, we tested in two cellular models the effects and mechanism of action of another gasotransmitter, hydrogen sulfide (H2S), thought to play a key role in cellular responses under ischemic conditions...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29316804/renal-protective-effect-of-hydrogen-sulfide-in-cisplatin-induced-nephrotoxicity
#14
Xu Cao, Siping Xiong, Yebo Zhou, Zhi-Yuan Wu, Lei Ding, Yike Zhu, Mark Wood, Matthew Whiteman, Philip K Moore, Jin-Song Bian
AIMS: Cisplatin is a major therapeutic drug for solid tumors, but can cause severe nephrotoxicity. However, the role and therapeutic potential of hydrogen sulfide (H2S), an endogenous gaso-transmitter, in cisplatin-induced nephrotoxicity remains to be defined. RESULTS: Cisplatin led to the impairment of H2S production in vitro and in vivo by downregulating the expression level of cystathionine γ-lyase (CSE), which may contribute to the subsequent renal proximal tubule (RPT) cell death and thereby renal toxicity...
January 9, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29316454/realizing-highly-chemoselective-detection-of-h2s-in%C3%A2-vitro-and-in%C3%A2-vivo-with-fluorescent-probes-inside-core-shell-silica-nanoparticles
#15
Feiyi Wang, Ge Xu, Xianfeng Gu, Zhijun Wang, Zhiqiang Wang, Ben Shi, Cuifen Lu, Xueqing Gong, Chunchang Zhao
Hydrogen sulfide (H2S) is an appealing signaling molecule that plays fundamental roles in health and disease. However, H2S-mediated selective chemical transformations for the construction of imaging probes are limited, retarding the interrogation of H2S-related biological processes. Here, we present an alternative approach for engineering a new generation of efficient probes with a nonchemoselective moiety as a building block. To demonstrate our design concept, we developed a sulfoxide-functionalized BODIPY that exhibited a substantial redshift in its absorption and emission spectra upon reduction with H2S...
January 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29315060/comparative-study-on-the-removal-efficiency-of-hydrogen-sulfide-h2s-using-three-different-packings
#16
Shihua Pu, Zuohua Liu, Feiyun Yang, Dingbiao Long, Wen Liu, Hao Wang, Kaipei Huang, Xiu Huang
To improve the removal efficiency on hydrogen sulfide (H2S), a biofilter was developed and was made of PVC pipes. The effects of three different packings (i.e., packing A, packing B, and packing C), containing different proportions of activated carbon, sawdust, wormcast, perlite, and pig manure compost, based on different biofilter parameters on H2S removal efficiency were investigated. With the extension of running time, the H2S removal rate of packing A reached up to 90.12%, that of packing B reached a peak at 92...
January 9, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29310239/an-ortho-aldehyde-modified-probe-to-image-thiols-in-living-cells-with-enhanced-selectivity
#17
Panfei Xing, Yuchen Shi, Qiu Li, Yanxian Feng, Lei Dong, Chunming Wang
Developing fluorescent probes to image thiols in the living system may provide powerful tools to study the functions of thiol-containing biological molecules. In this study, we report the design and evaluation of a novel turn-on fluorescent probe NQNO for selective detection of thiols in living cells. By introducing an ortho-aldehyde group to NNO, a conventional compound representing a class of thiol-imaging strategy, we obtained NQNO with enhanced selectivity for thiols over the major interferent hydrogen sulfide (H2S)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29302632/engineered-lys-6-tagged-recombinant-sulfide-reactive-hemoglobin-i-for-covalent-immobilization-at-multiwalled-carbon-nanotubes
#18
Ramonita Díaz-Ayala, Lisa Torres-González, Ruth Pietri, Carlos R Cabrera, Juan López-Garriga
The recombinant HbI was fused with a poly-Lys tag ((Lys)6-tagged rHbI) for specific-site covalent immobilization on two carbon nanotube transducer surfaces, i.e., powder and vertically aligned carbon nanotubes. The immobilization was achieved by following two steps: (1) generation of amine-reactive ester from the carboxylic acid groups of the surfaces and (2) coupling these groups with the amine groups of the Lys-tag. We analyzed the immobilization process using different conditions and techniques to differentiate protein covalent attachment from physical adsorption...
December 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29298893/allosteric-control-of-human-cystathionine-beta-synthase-activity-by-a-redox-active-disulfide-bond
#19
Weining Niu, Jun Wang, Jing Qian, Mengying Wang, Ping Wu, Fei Chen, Shasha Yan
Cystathionine β-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of the three major enzymes involved in the biogenesis of H2S. CBS is a complex protein with a modular three-domain architecture, the central domain of which contains a C272XXC275 motif whose function has yet to be determined. In the present study, we demonstrated that the CXXC motif exists in oxidized and reduced states in the recombinant enzyme by mass spectroscopic analysis and a thiol labeling assay...
January 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29297161/proteolytic-extracts-of-three-bromeliaceae-species-as-eco-compatible-tools-for-leather-industry
#20
María Eugenia Errasti, Néstor Oscar Caffini, Laura María Isabel López
Most tanneries use high proportions of Na2S and CaO during the dehairing step, resulting in effluents of high alkalinity and large amounts of suspended solid, besides the risk of liberating the toxic H2S. Solid waste rich in protein is another environmental problem of tanneries. Enzymes are an interesting technological tool for industry due to their biodegradability, nontoxic nature, and nonpolluting effluent generation. In the leather industry, proteases have been chosen as a promising eco-friendly alternative to Na2S/CaO dehairing...
January 2, 2018: Environmental Science and Pollution Research International
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