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https://www.readbyqxmd.com/read/28927767/gem-dithioacetylated-indole-derivatives-as-novel-antileishmanial-agents
#1
Sharad Porwal, Suman Gupta, Prem M S Chauhan
In this communication we report a serendipitously discovered hybrid molecule 1, combining fragment of 3 (an in vivo active antileishmanial molecule) with H2S donor moiety (known for bimodal behavior of cytoprotection and apoptosis), as antileishmanial agent. Compound 1 suppresses 99.82% parasitemia of L. donovani infected macrophages at 12.5μg/ml without even deforming them (CC50>100μg/ml). This compound appears cytotoxic for intracellular amastigotes while cytoprotective to host macrophages. The concept can be utilized to develop high therapeutic index NCE (New Chemical Entities) for other macrophage mediated diseases like tuberculosis and cancer...
September 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28923859/upregulation-of-cystathionine-%C3%AE-synthase-in-colonic-epithelia-reprograms-metabolism-and-promotes-carcinogenesis
#2
Ches'Nique M Phillips, John Zatarain, Michael E Nicholls, Craig Porter, Steve G Widen, Ketan Thanki, Paul Johnson, Muhammad U Jawad, Mary Pat Moyer, James W Randall, Judith L Hellmich, Manjit Maskey, Suimin Qiu, Thomas Wood, Nadiya Druzhyna, Bartosz Szczesny, Katalin Modis, Csaba Szabo, Celia Chao, Mark R Hellmich
The transsulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mechanisms. However, it is unknown whether the CBS/H2S axis plays a role in colorectal carcinogenesis. Here, we report upregulation of CBS in human biopsies of precancerous adenomatous polyps and show that forced upregulation of CBS in an adenoma-like colonic epithelial cell line is sufficient to induce metabolic and gene expression profiles characteristic of colorectal cancer cells...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28920997/rapid-and-highly-sensitive-detection-of-extracellular-and-intracellular-h2s-by-an-azide-functionalized-al-iii-based-metal-organic-framework
#3
Soutick Nandi, Helge Reinsch, Sooram Banesh, Norbert Stock, Vishal Trivedi, Shyam Biswas
A new, azide-functionalized Al(iii)-based metal-organic framework (MOF) denoted as CAU-10-N3 (1, CAU = Christian-Albrechts-University) and consisting of the 5-azido-isophthalic acid (H2IPA-N3) ligand was employed as a reaction-based fluorescent turn-on probe for the detection of H2S. The activated compound (1') showed fast, selective and highly sensitive sensing properties for extracellular H2S in HEPES buffer (10 mM, pH = 7.4). The material retained its high selectivity even in the presence of possibly competing biological species...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28918294/potassium-channels-modulate-the-action-but-not-the-synthesis-of-hydrogen-sulfide-in-rat-corpus-cavernosum
#4
H Abd Elmoneim, F Sharabi, M Mohy El Din, L Louedec, X Norel, A Senbel
AIM: Hydrogen sulfide (H2S) is a newly-introduced gasotransmitter in penile tissues. However, its exact mechanism of action in mediating penile erection is not fully elucidated. The major aim of this study was to examine the role of different K(+) channels in mediating the responses to H2S in the corpus cavernosum. MAIN METHODS: Tension studies using isolated rat corpus cavernosum strips were conducted. Endogenous H2S production was measured using polarographic technique...
September 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28918293/insight-into-the-h2s-selective-catalytic-oxidation-performance-on-well-mixed-ce-containing-rare-earth-catalysts-derived-from-mgalce-layered-double-hydroxides
#5
Fenglian Zhang, Xin Zhang, Zhengping Hao, Guoxia Jiang, Hongling Yang, Siqiu Qu
A series of well-mixed Ce-containing MgAlCe rare earth catalysts derived from layered double hydroxides were synthesized and tested for H2S selective catalytic oxidation. Particularly, no chemisorption O-vacancies but intrinsic defect sites were present on catalyst surface. Significantly, the catalysts exhibited excellent catalytic activity, reasonable durability, and outstanding sulfur selectivity (100%) at relatively low temperatures. Furthermore, the catalyst followed a step-wise mechanism, and the catalyst deactivation was due mainly to the slower oxidation rate of Ce(3+) to Ce(4+) by O2 as compared to the reduction rate of Ce(4+) to Ce(3+) by H2S...
September 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28915037/reactivity-of-a-fes-surface-under-room-temperature-exposure-to-nitrogen-and-h2s
#6
Miguel Angel Angel Niño, Eduardo Flores, Carlos Sanchez, Juan M Rojo
The reactivity of an iron monosulfide surface exposed at room temperature to molecular nitrogen and hydrogen sulfide has been investigated using X-ray photoemission spectroscopy (XPS) and thermal desorption spectroscopy (TDS). We have observed adsorption of nitrogen at room temperature that depends on the surface nanostructure and on the electronic state of nitrogen. The subsequent reaction of this adsorbed nitrogen with hydrogen sulfide results in depletion of the nitrogen surface content which can be interpreted in terms of ammonia formation...
September 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28915008/h2s-activated-drug-release-from-protein-cages
#7
Weijian Chen, Yajie Zhang, Xiao Li, Hong Chen, Jian Sun, Fude Feng
We took advantage of gasotransmitter H2S as a chemical reaction-based trigger for controlled release of doxorubicin which is pre-coordinated by copper ions and enclosed in horse spleen apoferritin. The nanocomposite is stable at physiological pH and temperature before H2S activation. The drug release strategy avoids disassembly of protein shells and is controllable by the strong affinity of sulfide with copper ions. The in vitro cytotoxicity assay indicates the antitumor effect of doxorubicin toward tumor cells could be achievable by H2S activation...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28912045/sulfate-reducing-bacteria-stimulate-gut-immune-responses-and-contribute-to-inflammation-in-experimental-colitis
#8
Vanessa Ribeiro Figliuolo, Liliane Martins Dos Santos, Alessandra Abalo, Hayandra Nanini, Angela Santos, Nilda M Brittes, Claudio Bernardazzi, Heitor Siffert Pereira de Souza, Leda Quercia Vieira, Robson Coutinho-Silva, Claudia Mara Lara Melo Coutinho
The intestinal microbiota is critical for mammalian immune system development and homeostasis. Sulfate-reducing bacteria (SRB) are part of the normal gut microbiota, but their increased levels may contribute to colitis development, likely in association with hydrogen sulfide (H2S) production. Here, we investigated the effects of SRB in the gut immune response in germ-free mice, and in experimental colitis. After 7days of colonization with Desulfovibrio indonesiensis or with a human SRB consortium (from patients with colitis), germ-free mice exhibited alterations in the colonic architecture, with increased cell infiltration in the lamina propria...
September 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28910651/inhibitory-effects-of-acidic-ph-and-confounding-effects-of-moisture-content-on-methane-biofiltration
#9
Sonya Barzgar, Joseph Patrick Hettiaratchi, Lauretta Pearse, Sunil Kumar
This study focussed on evaluating the effect of hydrogen sulfide (H2S) on biological oxidation of waste methane (CH4) gas in compost biofilters, Batch experiments were conducted to determine the dependency of maximum methane oxidation rate (Vmax) on two main factors; pH and moisture content, as well as their interaction effects. The maximum Vmax was observed at a pH of 7.2 with decreasing Vmax values observed with decreasing pH, irrespective of moisture content. Flow-through columns operated at a pH of 4.5 oxidized CH4 at a flux rate of 53g/m(2)/d compared to 146g/m(2)/d in columns operated at neutral pH...
September 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28910647/impact-of-a-high-ammonia-ammonium-ph-system-on-methane-producing-archaea-and-sulfate-reducing-bacteria-in-mesophilic-anaerobic-digestion
#10
Xiaohu Dai, Chongliang Hu, Dong Zhang, Lingling Dai, Nina Duan
A novel strategy for acclimation to ammonia stress was implemented by stimulating a high ammonia-ammonium-pH environment in a high-solid anaerobic digestion (AD) system in this study. Three semi-continuously stirred anaerobic reactors performed well over the whole study period under mesophilic conditions, especially in experimental group (R-2) when accommodated from acclimation period which the maximum total ammonia nitrogen (TAN) and free ammonia nitrogen (FAN) increased to 4921 and 2996mg/L, respectively...
September 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28910105/modeling-oil-shale-pyrolysis-high-temperature-unimolecular-decomposition-pathways-for-thiophene
#11
AnGayle K Vasiliou, Hui Hu, Thomas W Cowell, Jared C Whitman, Jessica Porterfield, Carol A Parish
The thermal decomposition mechanism of thiophene has been investigated both experimentally and theoretically. Thermal decomposition experiments were done using a 1 mm x 3 cm pulsed silicon carbide microtubular reactor, Unlike previous studies these experiments were able to identify the initial thiophene decomposition products. Thiophene was entrained in either Ar, Ne or He carrier gas, passed through a heated (300-1700 K) SiC microtubular reactor (roughly ≤100 μs residence time), and exited into a vacuum chamber...
September 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28901845/a-review-of-patents-on-therapeutic-potential-and-delivery-of-hydrogen-sulfide
#12
Richa Verma, Yumna Akhtar, Somnath Singh
Hydrogen sulfide (H2S) is a colorless gas with a characteristic smell of rotten eggs. Once only thought of as a toxic gas, evidence now shows that H2S plays major roles in pathological and physiological activities. These roles are being utilized to treat diseases and disorders ranging from hypertension, inflammation, edema, cardiovascular issues, chronic pain, cancer, and many more. Challenges facing the use of H2S currently involve achieving the optimum therapeutic concentrations, synthesizing chemically and physiologically stable donors, and developing clinically appropriate delivery systems...
September 11, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28900398/role-of-hydrogen-sulfide-in-retinal-diseases
#13
REVIEW
Jiantong Du, Hongfang Jin, Liu Yang
As the third gasotransmitter, hydrogen sulfide (H2S) plays a crucial role in the physiology and pathophysiology of many systems in the body, such as the nervous, cardiovascular, respiratory, and gastrointestinal systems. The mechanisms for its effects, including inhibiting ischemic injury, reducing oxidative stress damage, regulating apoptosis, and reducing the inflammation reaction in different systems, have not been fully understood. Recently, H2S and its endogenous synthesis pathway were found in the mammalian retina...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28887562/metformin-improves-endothelial-function-and-reduces-blood-pressure-in-diabetic-spontaneously-hypertensive-rats-independent-from-glycemia-control-comparison-to-vildagliptin
#14
Mahdi Hamidi Shishavan, Robert H Henning, Azuwerus van Buiten, Maaike Goris, Leo E Deelman, Hendrik Buikema
Metformin confers vascular benefits beyond glycemia control, possibly via pleiotropic effects on endothelial function. In type-1-diabetes-mellitus (T1DM-)patients metformin improved flow-mediated dilation but also increased prostaglandin(PG)-F2α, a known endothelial-contracting factor. To explain this paradoxical finding we hypothesized that metformin increased endothelial-vasodilator mediators (e.g. NO and EDHF) to an even larger extent. Spontaneously-hypertensive-rats (SHR) display impaired endothelium-dependent relaxation (EDR) involving contractile PGs...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883608/gyy4137-a-hydrogen-sulfide-donor-modulates-mir194-dependent-collagen-realignment-in-diabetic-kidney
#15
A M Sashi Papu John, Sourav Kundu, Sathnur Pushpakumar, Maura Fordham, Gregory Weber, Manas Mukhopadhyay, Utpal Sen
The relationship between hydrogen sulfide (H2S), microRNAs (miRs), matrix metalloproteinases (MMPs) and poly-ADP-ribose-polymerase-1 (PARP-1) in diabetic kidney remodeling remains mostly obscured. We aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes renal fibrosis in diabetes kidney, and whether H2S ameliorates fibrosis. Wild type, diabetic Akita mice as well as mouse glomerular endothelial cells (MGECs) were used as experimental models, and GYY4137 as H2S donor. In diabetic mice, plasma H2S levels were decreased while ROS and expression of its modulator (ROMO1) were increased...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880555/modulating-the-proton-affinity-of-silanol-and-siloxane-derivatives-by-tetrel-bonds
#16
Carlos Martín-Fernández, M Merced Montero-Campillo, Ibon Alkorta, José Elguero
The proton affinity (PA) on the oxygen atom in silanol and siloxane derivatives is enhanced by the formation of tetrel bonds with small Lewis bases [B···R3SiOH, B···R3SiOSiR3, B···R3SiOSiR3···B; B = H2O, CO, NH3, HCN, H2S; R = H, Me], as shown by MP2/jul-cc-pVTZ calculations. The complexed systems become more basic than ether and other carbon-related compounds, and even more basic than pyridine in some specific cases, reaching values up to 959.4 kJ/mol (H3N···H3SiOSiH3···NH3 complex). Changes on PAs are directly related to very large binding energies for the protonated species...
September 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28879572/diligustilide-releases-h2s-and-stabilizes-s-nitrosothiols-in-ethanol-induced-lesions-on-rat-gastric-mucosa
#17
Josué Arturo Velázquez-Moyado, José Luis Balderas-López, Elizabeth Arlen Pineda-Peña, Brenda Lorena Sánchez-Ortiz, José Carlos Tavares-Carvalho, Andrés Navarrete
(Z,Z')-Diligustilide (DLG) or levistolide A is a dimeric phthalide isolated from Ligusticum porteri (Osha), the roots of which are used in the traditional treatment of many diseases including gastric aches. However, its action has not been completely elucidated. We analyzed the contributions of hydrogen sulfide and S-nitrosothiols to the action of DLG. Animals were pretreated with freshly formed in vitro nitrosothiol using Na2S and sodium nitroprusside to elucidate participation in the action of DLG. We also evaluated the production of H2S in vivo and in real time on the stomach via a specific electrode introduced into the stomachs of anaesthetized animals pretreated with DLG...
September 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28877979/fatty-acids-promote-fatty-liver-disease-via-the-dysregulation-of-3-mercaptopyruvate-sulfurtransferase-hydrogen-sulfide-pathway
#18
Meng Li, Chengfu Xu, Junping Shi, Jiexia Ding, Xingyong Wan, Dahua Chen, Jianguo Gao, Chunxiao Li, Jie Zhang, Yiming Lin, Zhenhua Tu, Xiaoni Kong, Youming Li, Chaohui Yu
OBJECTIVE: Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading to non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the underlying mechanisms by which FFA contributes to the pathogenesis of NAFLD via the regulation of 3-mercaptopyruvate sulfurtransferase (MPST), a key enzyme that regulates endogenous hydrogen sulfide (H2S) biosynthesis. DESIGN: Hepatic MPST expression was evaluated in mice and patients with NAFLD...
September 6, 2017: Gut
https://www.readbyqxmd.com/read/28876901/flexible-graphene-based-wearable-gas-and-chemical-sensors
#19
Eric Singh, M Meyyappan, Hari S Nalwa
Wearable electronics is expected to be one of the most active research areas in the next decade, therefore, nanomaterials possessing high carrier mobility, optical transparency, mechanical robustness and flexibility, light-weight, and environmental stability will be in immense demand. Graphene is one of the nanomaterials that fulfill all these requirements, along with other inherently unique properties and convenience to fabricate into different morphological nanostructures, from atomically thin single layers to nanoribbons...
September 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28874874/3-mercaptopyruvate-sulfurtransferase-produces-potential-redox-regulators-cysteine-and-glutathione-persulfide-cys-ssh-and-gssh-together-with-signaling-molecules-h2s2-h2s3-and-h2s
#20
Yuka Kimura, Shin Koike, Norihiro Shibuya, David Lefer, Yuki Ogasawara, Hideo Kimura
Cysteine-persulfide (Cys-SSH) is a cysteine whose sulfhydryl group is covalently bound to sulfur (sulfane sulfur). Cys-SSH and its glutathione (GSH) counterpart (GSSH) have been recognized as redox regulators, some of which were previously ascribed to cysteine and GSH. However, the production of Cys-SSH and GSSH is not well understood. Here, we show that 3-mercaptopyruvate sulfurtransferase (3MST) produces Cys-SSH and GSSH together with the potential signaling molecules hydrogen per- and tri-sulfide (H2S2 and H2S3)...
September 5, 2017: Scientific Reports
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