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Xu Cao, Lei Ding, Zhi-Zhong Xie, Yong Yang, Matthew Whiteman, Philip K Moore, Jin-Song Bian
Hydrogen sulfide (H2S) has been recognized as the third gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). In the past decade, numerous studies have demonstrated an active role of H2S in the context of cancer biology. The three H2S producing enzymes namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3MST) have been found highly expressed in numerous types of cancer. Moreover, inhibition of CBS has shown anti-tumor activity particularly in colon cancer, ovarian cancer and breast cancer, whereas the consequence of CSE or 3MST inhibition remains largely unexplored in cancer cells...
May 23, 2018: Antioxidants & Redox Signaling
Jun-Hwe Cha, Dong-Ha Kim, Seon-Jin Choi, Won-Tae Koo, Il-Doo Kim
Lead(II) acetate (Pb(Ac)2) reacts with hydrogen sulfide to form colored brownish precipitates of lead sulfide. Thus far, in order to detect leakage of H2S gas in industrial sectors, Pb(Ac)2 has been used as an indicator in the form of test papers with a detection limit only as low as 5 ppm. Diagnosis of halitosis by exhaled breath needs sensors able to detect down to 1 ppm of H2S gas. In this work, high surface area and porous Pb(Ac)2 anchored nanofibers (NFs) that overcome limitations of conventional Pb(Ac)2 based H2S sensor are successfully achieved...
May 23, 2018: Analytical Chemistry
Xiaoyun Jiao, Yongsheng Xiao, Yong Li, Muwen Liang, Xilei Xie, Xu Wang, Bo Tang
Drug-induced liver injury (DILI) has aroused wide concern. Finding new markers or indicators as well as detoxification molecules for DILI are of great significance and good application prospect, which can help develop effective preclinical screening methodology and corresponding treatment protocols. Herein, in this paper, DILI caused by antidepressant drugs of duloxetine and fluoxetine and its remission were evaluated by a two-photon fluorescent probe, RPC-1, through discriminating and imaging HClO and H2S simultaneously...
May 21, 2018: Analytical Chemistry
J Vázquez, V Sindelar
Hydrogen sulfide (H2S) has become an important target for research due to its physiological properties as well as its potential applications in medicine. In this work, supramolecular binding of sulfide (S2-) and hydrosulfide (HS-) anions in water is presented for the first time. Bambusurils were used to slow down the release of these anions in water.
May 21, 2018: Chemical Communications: Chem Comm
Qing Kuang, Ning Xue, Jing Chen, Ziyan Shen, Xiaomeng Cui, Yi Fang, Xiaoqiang Ding
BACKGROUND: Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. METHODS: A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control...
May 18, 2018: American Journal of Nephrology
Dong-Ha Kim, Ji-Soo Jang, Won-Tae Koo, Seon-Jin Choi, Hee-Jin Cho, Min-Hyeok Kim, Sang-Joon Kim, Il-Doo Kim
Herein, we incorporated dual bio-templates, i.e., cellulose nanocrystals (CNC) and apoferritin into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of WO3 nanotube by utilizing self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2...
May 15, 2018: ACS Sensors
Yuxi Zhao, Jeong-Gyu Song, Gyeong Hee Ryu, Kyung Yong Ko, Whang Je Woo, Youngjun Kim, Donghyun Kim, Jun Hyung Lim, Sunhee Lee, Zonghoon Lee, Jusang Park, Hyungjun Kim
The efficient synthesis of two-dimensional molybdenum disulfide (2D MoS2) at low temperatures is essential for use in flexible devices. In this study, 2D MoS2 was grown directly at a low temperature of 200 °C on both hard (SiO2) and soft substrates (polyimide (PI)) using chemical vapor deposition (CVD) with Mo(CO)6 and H2S. We investigated the effect of the growth temperature and Mo concentration on the layered growth by Raman spectroscopy and microscopy. 2D MoS2 was grown by using low Mo concentration at a low temperature...
May 8, 2018: Nanoscale
Aaron P Landry, David P Ballou, Ruma Banerjee
The mitochondrial sulfide oxidation pathway prevents the toxic accumulation of hydrogen sulfide (H2S), a signaling molecule that is maintained at low steady-state concentrations. Sulfide quinone oxidoreductase (SQR), an inner mitochondrial membrane-anchored protein, catalyzes the first and committing step in this pathway, oxidizing H2S to persulfide. The catalytic cycle comprises sulfide addition to the active site cysteine disulfide in SQR followed by sulfur transfer to a small molecule acceptor, while a pair of electrons moves from sulfide, to FAD, to coenzyme Q...
May 1, 2018: ACS Chemical Biology
Jiangchuan Shen, Brenna J C Walsh, Ana Lidia Flores-Mireles, Hui Peng, Yifan Zhang, Yixiang Zhang, Jonathan C Trinidad, Scott J Hultgren, David P Giedroc
Recent studies of hydrogen sulfide (H2S) signaling implicate low molecular weight (LMW) thiol persulfides and other reactive sulfur species (RSS) as signaling effectors. Here, we show that a CstR protein from the human pathogen Enterococcus faecalis ( E. faecalis), previously identified in Staphylococcus aureus ( S. aureus), is an RSS-sensing repressor that transcriptionally regulates a cst-like operon in response to both exogenous sulfide stress and Angeli's salt, a precursor of nitroxyl (HNO). E. faecalis CstR reacts with coenzyme A persulfide (CoASSH) to form interprotomer disulfide and trisulfide bridges between C32 and C61' which negatively regulate DNA binding to a consensus CstR DNA operator...
April 30, 2018: ACS Chemical Biology
Ao Ji, Yichong Fan, Wei Ren, Shen Zhang, Huiwang Ai
Hydrogen sulfide (H2S) is an important gasotransmitter. Although a large number of fluorescent probes for cellular H2S have been reported, only a few can detect H2S in mitochondria, a cellular organelle connecting H2S with mitochondrial function and metabolic pathways. We hereby describe a novel near-infrared fluorescent probe, nimazide, by introducing sulfonyl azide to the core structure of a QSY-21 dark quencher. Nimazide responded quickly to H2S, resulting in robust fluorescence turn-off changes. This conversion displayed high specificity and fast kinetics...
April 27, 2018: ACS Sensors
Yu Zhao, Andrea K Steiger, Michael D Pluth
Hydrogen sulfide (H2S) is an important biomolecule, and controllable H2S donors are needed to investigate H2S biological functions. Here we utilize cysteine-mediated addition/cyclization chemistry to unmask an acrylate-functionalized thiocarbamate and release carbonyl sulfide (COS), which is quickly converted to H2S by carbonic anhydrase (CA).
April 27, 2018: Chemical Communications: Chem Comm
Ling-Ling Qian, Xiao-Yu Liu, Qiang Chai, Ru-Xing Wang
BACKGROUND: A growing number of studies have indicated that hydrogen sulfide (H2S) affects the development of diabetes and its complications, but the specific mechanism is not completely clear. OBJECTIVE: To summarize the effects and recent molecular mechanisms of H2S in various diabetic complications. METHODS: Articles regarding the role of H2S channels in diabetic complications and relevant mechanisms were selected. Relevant articles published from 2006 to present were selected from PubMed...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Zhonghui Chen, Chaoqun Chen, Huawei Huang, Fang Luo, Longhua Guo, Lan Zhang, Zhenyu Lin, Guonan Chen
Hydrogen sulfide (H2S) is important for normal neural functions, which involves in protecting neurons from oxidative stress and neuronal transmission modulation in brain. The detection of H2S is significant for revealing its role in the diagnosis of various disease. In this study, a novel multicolor colorimetric assay based on the etching of gold nanorods (Au NRs) is proposed to evaluate H2S level with the naked eye. This measurement relies on the catalytic oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) via horseradish peroxidase (HRP) to produce TMB2+, which could etch the Au NRs quickly and accompany with a distinct color change...
April 26, 2018: Analytical Chemistry
Lijun Xi, Nenghu Qiao, Dejian Liu, Jing Li, Jingjing Zhang, Jianguo Liu
Two bacterial strains were isolated from coal mine water in China. Isolates were facultatively anaerobic, Gram-stain-negative, rod-shaped, motile by means of a single polar flagellum, and they did not produce bacteriochlorophyll α. Cells grew in tryptic soy broth with 0-5.5 % (w/v) NaCl, at 4-55 °C and pH 3.5-10.5. Isolates were positive for catalase, oxidase, urease, Voges-Proskauer test, gelatin hydrolysis and H2S production. Analysis of 16S rRNA gene sequences indicated that the closest relatives of strains Q4...
April 25, 2018: International Journal of Systematic and Evolutionary Microbiology
Guo Qin Wei, Hui Cao, Yu Gang Sun, Bo Deng, Wei Wei Zhang, Hong Qiang Yang
The root architecture, leaf reactive oxygen species and photosynthetic characteristics of potted Malus hupehensis seedlings were investigated after 10 days of waterlogging under five concentrations of hydrogen sulfide (H2S) donor sodium hydrosulfide (NaSH, 0, 0.02, 0.05, 0.1, 0.2 mmol·L-1 ) and NaSH with scavenger hypotaurine (HT). The results showed that the root length, root surface area, root volume, root diameter, root top number, fractal dimension, first lateral roots and root activity all increased, the leaf superoxide anion (O2- · ) accumulation and hydrogen pero-xide (H2O2) content both decreased, the leaf Pn , Tr , gs , WUE and CUE all raised, the plant height and biomass both increased when the 0...
October 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Bedabyas Behera, Puspendu Kumar Das
Blue shifting H-bonded (C-D···O) complexes between CDCl3 and CH3HCO, (CH3)2CO, C2H5(CH3)CO and red shifting H-bonded (C-D···S) complexes between CDCl3 with (CH3)2S, (C2H5)2S have been identified by FTIR spectroscopy in gas phase at room temperature. With increasing partial pressure of the components, a new band appears in the C-D stretching region of the vibrational spectra. The intensity of this band goes down with increase in temperature at constant pressure which provides the basis for identification of the H-bonded bands in the spectrum...
April 23, 2018: Journal of Physical Chemistry. A
Tianbing Ren, Wang Xu, Qianling Zhang, Xingxing Zhang, Siyu Wen, Haibo Yi, Lin Yuan, Xiaobing Zhang
Two-photon imaging is an emerging tool for biomedical research and clinical diagnostics. Electron donor-acceptor (D-A) type molecules are the most widely employed two-photon scaffolds. However, current D-A type fluorophores suffer from solvatochromic quenching in aqueous biological samples. To address this issue, we devised a novel class of D-A type GFP chromophore analogues that form hydrogen bond network in water to improve the two-photon efficiency. Our design results in TPC dyes with 0.80 quantum yield and large two-photon cross section (210 GM) in water...
April 23, 2018: Angewandte Chemie
Swetlana Gautam, Soniya Rani, Gaurav Kaithwas
The present study was designed to evaluate the effects of Phenidone (Dual inhibitor of COX-2 and 5-LOX, DuCLOX-2/5) on various aspects of cancer chemoprevention against MNU induced mammary gland carcinoma. MNU treated rat showed altered heart rate variability (HRV), increased alveolar bud count, differentiation score, up regulated inflammatory enzyme markers (COX, LOX, NO and H2S) and distorted oxidative stress markers (TBARs, protein carbonyl, SOD, catalase and GSH). The mammary gland surface architecture was studied using carmine staining and H&E staining...
April 18, 2018: Toxicology and Applied Pharmacology
Qing Gao, Suying Xu, Chang Guo, Yueguang Chen, Leyu Wang
Metal organic frameworks (MOFs) containing metal nanoclusters (NCs) display great potentials, but the fabrication faces challenges because of the serious agglomeration of NCs during the MOF growth. We report a crystalline ion triggered growth strategy for embedding AuNCs in ZIF-8. As control, when the encapsulation was triggered with other metal ions (e.g. Ca2+, Pb2+, Cd2+, Na+, Fe3+, Cu2+ and Ni2+), the AuNCs failed to be encapsulated. The quantum yields and lifetime of AuNCs were greatly enhanced after embedding in ZIF-8...
April 20, 2018: ACS Applied Materials & Interfaces
Anders Bodin, Ann-Louise Nygård Christoffersen, Christian Fink Elkjær, Michael Brorson, Jakob Kibsgaard, Stig Helveg, Ib Chorkendorff
Nanoparticle engineering for catalytic applications requires both a synthesis technique for production of well-defined nanoparticles as well as measurements of their catalytic performance. In this paper, we present a new approach to rationally engineering highly active Ni-Mo-S nanoparticle catalysts for hydrodesulfurization (HDS), i.e. removal of sulfur from fossil fuels. Nanoparticle catalysts are synthesized by sputtering of a Mo75Ni25 metal target in a reactive atmosphere of Ar and H2S, followed by gas aggregation of the sputtered material into nanoparticles...
April 17, 2018: Nano Letters
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