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https://www.readbyqxmd.com/read/29045658/exendin-4-a-glucagon-like-peptide-1-receptor-agonist-attenuates-breast-cancer-growth-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#1
Chikayo Iwaya, Takashi Nomiyama, Shiho Komatsu, Takako Kawanami, Yoko Tsutsumi, Yuriko Hamaguchi, Tsuyoshi Horikawa, Yasuteru Yoshinaga, Shinichi Yamashita, Tomoko Tanaka, Yuichi Terawaki, Makito Tanabe, Kazuki Nabeshima, Akinori Iwasaki, Toshihiko Yanase
Incretin therapies have received significant attention because of their tissue-protective effects, which extend beyond those associated with glycemic control. Cancer is a primary cause of death in patients with diabetes mellitus. We previously reported anti-prostate cancer effects of the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist exendin-4 (Ex-4). Breast cancer is one of the most common cancers in female patients with type 2 diabetes mellitus and obesity. Thus, we examined whether GLP-1 action could attenuate breast cancer...
October 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29045584/oxytocin-fails-to-recruit-serotonergic-neurotransmission-in-the-autistic-brain
#2
Arthur Lefevre, Raphaëlle Mottolese, Jérôme Redouté, Nicolas Costes, Didier Le Bars, Marie-Maude Geoffray, Marion Leboyer, Angela Sirigu
Oxytocin (OT), a neuropeptide involved in affiliation has been shown to enhance social skills in patients with autism spectrum disorders (ASD). Nevertheless, OT improvements seem ephemeral. Animal research has demonstrated OT action on serotonin (5-HT), an interaction that we also found in the healthy human brain. Whether such synaptic interplay also occurs in ASD patients is unknown. To address this issue, we mapped the effects of intranasal OT on 5-HT in 18 patients with ASD and 24 healthy controls (HC) in a double blind, placebo controlled, within subject PET-scan experiment...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045562/attenuation-of-high-frequency-30-200%C3%A2-hz-thalamocortical-eeg-rhythms-as-correlate-of-anaesthetic-action-evidence-from-dexmedetomidine
#3
G Plourde, F Arseneau
Background: Gamma (30-80 Hz) and high-gamma (80-200 Hz) thalamocortical EEG rhythms are involved in conscious processes and are attenuated by isoflurane and propofol. To explore the hypothesis that this attenuation is a correlate of anaesthetic action, we characterized the effect dexmedetomidine, a selective adrenergic α-2 agonist with lesser hypnotic potency, on these rhythms. Methods: We recorded local field potentials from barrel cortex and ventroposteromedial thalamic nucleus in ten previously instrumented rats to measure spectral power (30-50 Hz, 51-75 Hz, 76-125 Hz, 126-200 Hz bands) during baseline, at four dexmedetomidine plasma concentrations obtained by i...
October 16, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29045524/combined-irradiation-and-targeted-therapy-or-immune-checkpoint-blockade-in-brain-metastases-toxicities-and-efficacy
#4
A V Tallet, F Dhermain, E Le Rhun, G Noël, Y M Kirova
Background: Targeted therapies (TT) and immune checkpoint inhibitors (ICI) are currently modifying the landscape of metastatic cancer management and are increasingly used over the course of many cancers treatment. They allow long-term survival with controlled extra-cerebral disease, contributing to the increasing incidence of brain metastases (BMs). Radiation therapy remains the cornerstone of BMs treatment (either whole brain irradiation or stereotactic radiosurgery), and investigating the safety profile of radiation therapy combined with TT or ICI is of high interest...
August 2, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045350/donor-human-milk-and-fortifier-use-in-united-states-level-2-3-and-4-neonatal-care-hospitals
#5
Maryanne Tigchelaar Perrin
OBJECTIVE: In 2011 the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of this study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facilities in 2015 and to identify factors associated with non-use. METHODS: Data from the 2015 Maternity Practices in Infant Nutrition and Care survey, conducted by the Center for Disease Control and Prevention, was analyzed for questions about feeding practices within neonatal hospitals...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29044996/lifestyle-habitat-and-farmers-risk-of-exposure-to-tick-bites-in-an-endemic-area-of-tick-borne-diseases-in-hungary
#6
S Li, L Juhász-Horváth, A Trájer, L Pintér, M D A Rounsevell, P A Harrison
Controlling tick bites on farmers is important to the management of tick-borne diseases and occupational health risks in agriculture. Based on an extensive household survey conducted between June and August 2015 with 219 farmers from western Hungary where tick-borne diseases are endemic, we analysed the pattern of farmers' self-reported contacts with ticks and investigated the potential interactions between farmers, landscape and the risk of exposure to tick bites. We developed a lifestyle typology based on farmers' socioeconomic profiles, farming objectives and time use patterns, and a habitat typology describing different configurations of tick habitats and agricultural areas in place of farming...
October 17, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29044826/implementation-and-evaluation-of-the-victorian-suicide-register
#7
Georgina Sutherland, Allison Milner, Jeremy Dwyer, Lyndal Bugeja, Alan Woodward, Jo Robinson, Jane Pirkis
OBJECTIVE: The Victorian Suicide Register (VSR) is a state-based suicide surveillance system that contains detailed information on people who die by suicide and the circumstances surrounding their death. In this paper, we provide an overview of the VSR and then describe the evaluation, which used the Centres for Disease Control and Prevention guidelines for surveillance system evaluation as a framework. METHODS: The evaluation drew on three data sources to assess whether the VSR: i) embodies the attributes of a good public health surveillance system; and ii) can be used to inform community-based suicide prevention efforts...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29044813/activated-mesenchymal-stem-cell-administration-inhibits-chronic-alcohol-drinking-and-suppresses-relapse-like-drinking-in-high-alcohol-drinker-rats
#8
Fernando Ezquer, María Elena Quintanilla, Paola Morales, Marcelo Ezquer, Carolyne Lespay-Rebolledo, Mario Herrera-Marschitz, Yedy Israel
Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells (hMSCs), known for their anti-inflammatory action, on chronic ethanol intake and relapse-like ethanol intake in a post-deprivation condition. Rats were allowed 12-17 weeks of chronic voluntary ethanol (10% and 20% v/v) intake, after which a single dose of activated hMSCs (5 × 10(5) ) was injected into a brain lateral ventricle...
October 18, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29044801/differential-physiological-responses-to-central-leptin-overexpression-in-male-and-female-rats
#9
Isabelle Côté, Sara M Green, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Brains of females are more sensitive to the acute catabolic actions of leptin. However, sex differences in the long-term physiological responses to central leptin receptor modulation are unknown. To this end, we centrally delivered a viral vector to overexpress leptin (Leptin), a neutral leptin receptor antagonist (Leptin-Antagonist), or a green fluorescence protein (Control). We examined chronic changes in body weight and composition in male and female rats. Females displayed greater and sustained responses to Leptin whereas males rapidly lost physiological effects and developed leptin resistance confirmed by lower acute leptin-mediated phosphorylation of STAT3 (P-STAT3)...
October 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29044370/the-ecology-and-epidemiology-of-ross-river-and-murray-valley-encephalitis-viruses-in-western-australia-examples-of-one-health-in-action
#10
John S Mackenzie, Michael D A Lindsay, David W Smith, Allison Imrie
Arboviruses are maintained and transmitted through an alternating biological cycle in arthropods and vertebrates, with largely incidental disease in humans and animals. As such, they provide excellent examples of One Health, as their health impact is inextricably linked to their vertebrate hosts, their arthropod vectors and the environment. Prevention and control requires a comprehensive understanding of these interactions, and how they may be effectively and safely modified. This review concentrates on human disease due to Ross River and Murray Valley encephalitis viruses, the two major arboviral pathogens in Australia...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29043662/stryphnodendron-adstringens-barbatim%C3%A3-o-leaf-fraction-chemical-characterization-antioxidant-activity-and-cytotoxicity-towards-human-breast-cancer-cell-lines
#11
A P L Sabino, L M S Eustáquio, A C F Miranda, C Biojone, T N Mariosa, Cibele Marli Cação Paiva Gouvêa
We evaluated the chemical composition, antioxidant activity, and antitumor potential of a fraction that was isolated from Stryphnodendron adstringens (barbatimão) leaf aqueous extract. Fraction is composed by gallic acid, procyanidin dimer B1, and (-)-epicatechin-3-O-gallate and it exhibits antioxidant and cytotoxic activities. Fraction was cytotoxic against two human breast cancer cell lines, ER (+) and MCF-7 and the triple-negative, MDA-MB-435. The sulforhodamine B assay showed that, as compared to normal control cells, the fraction significantly (P < 0...
October 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29043388/isolation-and-potential-biocementation-of-calcite-precipitation-inducing-bacteria-from-colombian-buildings
#12
Sandra M Montaño-Salazar, Juan Lizarazo-Marriaga, Pedro F B Brandão
Microbiological induced calcium carbonate or calcite precipitation (MICP) has become a highly researched issue due to its multiple applications in the construction industry, being a promising alternative with a great biotechnological importance. In this work, potential calcite precipitation inducing bacteria were isolated from mortar and concrete samples of different buildings at the National University of Colombia. Eighteen crystal-precipitating strains were recovered in Urea-CaCl2 solid medium. The 16S rRNA gene sequencing identified isolates as Arthrobacter, Psychrobacillus and Rhodococcus genera...
October 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29043342/antihypertensive-effects-of-tartary-buckwheat-flavonoids-by-improvement-of-vascular-insulin-sensitivity-in-spontaneously-hypertensive-rats
#13
Zuoxu Hou, Yuanyuan Hu, Xingbin Yang, Wensheng Chen
Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. The present study investigated whether chronic treatment with purified Tartary buckwheat flavonoids fraction (TBF) prevents the development of hypertension via improving vascular insulin sensitivity and reducing oxidative stress. Six-week-old male spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) control rats were subjected to different dosages of TBF for 8 weeks. Blood pressure, mesenteric arteriolar vasorelaxation, superoxide anion (O2(-)) generation, NAD(P)H oxidase activity, and insulin-stimulated Akt/endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production were determined...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29042937/inflammation-and-airway-remodeling-of-the-lung-in-guinea-pigs-with-allergic-rhinitis
#14
Zu-Yao Chen, Shou-Hong Zhou, Qiao-Feng Zhou, Hong-Bo Tang
Allergic rhinitis (AR) and asthma belong to the category of type I allergic diseases, whose pathological features are airway remodeling of the lung and allergic inflammation. The aim of the present study was to evaluate inflammation and remodeling of lung tissue in a guinea pig model of AR in order to confirm consistent pathological changes of upper and lower airways in AR. Male guinea pigs were randomly divided into an experimental and a control group (n=10 in each). The AR model was established by sensitization through intraperitoneal injection of ovalbumin for three weeks and bilateral nasal local excitation for twelve weeks...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042449/peptide-yy-mediates-the-satiety-effects-of-diets-enriched-with-whey-protein-fractions-in-male-rats
#15
Rizaldy C Zapata, Arashdeep Singh, Prasanth K Chelikani
Dairy proteins-whey protein, in particular-are satiating and often recommended for weight control; however, little is known about the mechanisms by which whey protein and its components promote satiety and weight loss. We used diet-induced obese rats to determine whether the hypophagic effects of diets that are enriched with whey and its fractions, lactalbumin and lactoferrin, are mediated by the gut hormone, peptide YY (PYY). We demonstrate that high protein diets that contain whey, lactalbumin, and lactoferrin decreased food intake and body weight with a concurrent increase in PYY mRNA abundance in the colon and/or plasma PYY concentrations...
October 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29042316/concurrent-repeated-exposure-to-3-4-methylenedioxypyrovalerone-and-cocaine-produce-locomotor-sensitization-with-minimal-effects-on-brain-monoamines
#16
REVIEW
Robert J Kohler, Shane A Perrine, Lisa E Baker
Synthetic cathinones, known as "bath salts" on the illicit drug market, pose a significant public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency and efficacy. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one the following four treatments, administered once daily for seven days: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV +5 mg/kg cocaine, or saline...
October 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29042191/roadmap-to-achieve-25-hypertension-control-in-africa-by-2025
#17
Anastase Dzudie, Brian Rayner, Dike Ojji, Aletta E Schutte, Marc Twagirumukiza, Albertino Damasceno, Seringe Abdou Ba, Abdoul Kane, Euloge Kramoh, Jean Baptiste Anzouan Kacou, Basden Onwubere, Ruth Cornick, Karen Sliwa, Benedict Anisiuba, Ana Olga Mocumbi, Elijah Ogola, Mohamed Awad, George Nel, Harun Otieno, Ali Ibrahim Toure, Samuel Kingue, Andre Pascal Kengne, Pablo Perel, Alma Adler, Neil Poulter, Bongani Mayosi
BACKGROUND: The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority action to reduce heart disease and stroke on the continent. OBJECTIVES: The aim of this PASCAR roadmap on hypertension was to develop practical guidance on how to implement strategies that translate existing knowledge into effective action and improve detection, treatment and control of hypertension and cardiovascular health in sub-Saharan Africa (SSA) by the year 2025...
October 14, 2017: Global Heart
https://www.readbyqxmd.com/read/29041860/maternal-behavior-of-the-mouse-dam-toward-pups-implications-for-maternal-separation-model-of-early-life-stress
#18
Rodrigo Orso, Luis Eduardo Wearick-Silva, Kerstin Camile Creutzberg, Anderson Centeno-Silva, Laura Glusman Roithmann, Rafaelly Pazzin, Saulo Gantes Tractenberg, Fernando Benetti, Rodrigo Grassi-Oliveira
Maternal care is essential for an adequate pup development, as well as for the health of the dam. Exposure to stress in early stages of life can disrupt this dam-pup relationship promoting altered neurobiological and behavioral phenotypes. However, there is a lack of consensus regarding the effects of daily maternal separation (MS) on the pattern of maternal behavior. The aim of this study is to compare the patterns of maternal behavior between mice exposed to MS and controls. BALB/c mice were subjected to MS for a period of 180 min/day from postnatal day 2-7 (n = 17) or designated to be standard animal facility reared (AFR) controls (n = 19)...
October 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29040810/photothermal-nanoparticle-initiation-enables-radical-polymerization-and-yields-unique-uniform-microfibers-with-broad-spectrum-light
#19
Rachel C Steinhardt, Timothy Steeves, Brooke Marjorie Wallace, Brittany Moser, Dmitry A Fishman, Aaron P Esser-Kahn
Photothermal processes are utilized across a variety of fields, from separations to medicine, and are an area of active research. Herein, the action of a solar simulator upon carbon black nanoparticles is shown to result in photothermally-initiated chain-growth polymerization of methyl acrylate, butyl acrylate, and methyl methacrylate initiated by benzoyl peroxide. Using methyl acrylate as the model system, products from this reaction are shown to be apparently indistinguishable on the molecular level, but result in unique microstructures relative to the thermal controls...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29040739/papaya-cpein3a-and-cpnac2-cooperatively-regulate-carotenoid-biosynthesis-related-genes-cppds2-4-cplcy-e-and-cpchy-b-during-fruit-ripening
#20
Chang-Chun Fu, Yan-Chao Han, Jian-Fei Kuang, Jian-Ye Chen, Wang-Jin Lu
Papaya is an important tropical fruit with a rich source of carotenoids. The ripening of papaya is a physiological and metabolic process with remarkable changes including carotenoids accumulation, which depends primarily on the action of ethylene. Ethylene response is mediated by a transcriptional cascade involving the transcription factor families of EIN3/EILs and ERFs. Although ERF members have been reported to control carotenoids production in Arabidopsis and tomato, whether EIN3/EILs are also involved in carotenoid biosynthesis during fruit ripening remains unclear...
October 12, 2017: Plant & Cell Physiology
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