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https://www.readbyqxmd.com/read/27911071/severe-brain-injury-in-massachusetts-assessing-the-continuum-of-care
#1
Laura Lorenz, Gabrielle Katz
Acquired brain injury (ABI) is a major public health problem in Massachusetts (Hackman et al, 2014) and includes traumatic brain injury (TBI), stroke, ABI-related infectious diseases, metabolic disorders affecting the central nervous system (brain and spinal cord), and brain tumor. Advances in emergency medical care and neurosurgery mean that more people are surviving severe traumatic brain injury (Trexler et al, 2014). Yet many patients with severe TBI in particular, are not receiving inpatient services after initial treatment (Hackman et al, 2014; CDC, 2014) or later that are known to be effective (Malec & Kean, 2015; Lewis & Horn, 2015; BI Commission, 2011; Kolakowsky-Hayner et al, 2000; Interviews)...
December 10, 2015: Issue Brief
https://www.readbyqxmd.com/read/27907968/palliative-care-practice-in-neurocritical-care
#2
Andrea K Knies, David Y Hwang
Many neurocritically ill patients and their families have high amounts of palliative care needs. Multiple professional societies relevant to neurocritical care have released consensus statements on meeting palliative care needs in neuroscience intensive care units. In this review, the authors discuss the ongoing debate regarding what model of palliative care delivery is optimal, focus on the process of shared decision making during goals-of-care discussions, and briefly comment on transitions from intensive care to comfort care...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27903717/deciphering-decision-making-variation-in-animal-models-of-effort-and-uncertainty-based-choice-reveals-distinct-neural-circuitries-underlying-core-cognitive-processes
#3
Catharine A Winstanley, Stan B Floresco
Maladaptive decision-making is increasingly recognized to play a significant role in numerous psychiatric disorders, such that therapeutics capable of ameliorating core impairments in judgment may be beneficial in a range of patient populations. The field of "decision neuroscience" is therefore in its ascendancy, with researchers from diverse fields bringing their expertise to bear on this complex and fascinating problem. In addition to the advances in neuroimaging and computational neuroscience that contribute enormously to this area, an increase in the complexity and sophistication of behavioral paradigms designed for nonhuman laboratory animals has also had a significant impact on researchers' ability to test the causal nature of hypotheses pertaining to the neural circuitry underlying the choice process...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27891018/legal-challenges-in-neurological-practice
#4
REVIEW
Sita Jayalakshmi, Sudhindra Vooturi
Clinical neuroscience has made tremendous advances over the last century. Neurology as a discipline is still considered challenging and at times risky due to the natural history and progressive course of few of the neurological diseases. Encouragingly, the patient and their caregivers are now increasingly willing to be actively involved in making decisions. The patients' relationship with the doctor is a reflection of the society. A society that is orienting itself toward "rating" and "feedback" has made this doctor-patient relationship, a consumer-service provider relationship...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27875379/the-decision-neuroscience-perspective-on-suicidal-behavior-evidence-and-hypotheses
#5
Alexandre Y Dombrovski, Michael N Hallquist
PURPOSE OF REVIEW: Suicide attempts are usually regretted by people who survive them. Furthermore, addiction and gambling are over-represented among people who attempt or die by suicide, raising the question whether their decision-making is impaired. Advances in decision neuroscience have enabled us to investigate decision processes in suicidal people and to elucidate putative neural substrates of disadvantageous decision-making. RECENT FINDINGS: Early studies have linked attempted suicide to poor performance on gambling tasks...
January 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/27873290/aims-and-structure-of-the-german-research-consortium-bipolife-for-the-study-of-bipolar-disorder
#6
REVIEW
Philipp S Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer
BACKGROUND: Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27864918/how-prior-preferences-determine-decision-making-frames-and-biases-in-the-human-brain
#7
Alizée Lopez-Persem, Philippe Domenech, Mathias Pessiglione
Understanding how option values are compared when making a choice is a key objective for decision neuroscience. In natural situations, agents may have a priori on their preferences that create default policies and shape the neural comparison process. We asked participants to make choices between items belonging to different categories (e.g., jazz vs. rock music). Behavioral data confirmed that the items taken from the preferred category were chosen more often and more rapidly, which qualified them as default options...
November 19, 2016: ELife
https://www.readbyqxmd.com/read/27810002/korea-brain-initiative-integration-and-control-of-brain-functions
#8
Sung-Jin Jeong, Haejin Lee, Eun-Mi Hur, Youngshik Choe, Ja Wook Koo, Jong-Cheol Rah, Kea Joo Lee, Hyun-Ho Lim, Woong Sun, Cheil Moon, Kyungjin Kim
This article introduces the history and the long-term goals of the Korea Brain Initiative, which is centered on deciphering the brain functions and mechanisms that mediate the integration and control of brain functions that underlie decision-making. The goal of this initiative is the mapping of a functional connectome with searchable, multi-dimensional, and information-integrated features. The project also includes the development of novel technologies and neuro-tools for integrated brain mapping. Beyond the scientific goals this grand endeavor will ultimately have socioeconomic ramifications that not only facilitate global collaboration in the neuroscience community, but also develop various brain science-related industrial and medical innovations...
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27793597/impact-of-general-cognition-and-executive-function-deficits-on-addiction-treatment-outcomes-systematic-review-and-discussion-of-neurocognitive-pathways
#9
REVIEW
Sara Domínguez-Salas, Carmen Díaz-Batanero, Oscar Martin Lozano-Rojas, Antonio Verdejo-García
This systematic review aims to examine growing evidence linking cognitive-executive functions with addiction treatment outcomes, and to discuss significant cognitive predictors drawing upon addiction neuroscience theory. We conducted a systematic search to identify studies using measures of general cognition and executive functions in patients with substance use disorders for the purpose of predicting two treatment outcomes: therapeutic adherence and relapse. Forty-six studies were selected, and sample characteristics, timing of assessments, and cognitive measures were analyzed...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27791054/human-amygdala-engagement-moderated-by-early-life-stress-exposure-is-a-biobehavioral-target-for-predicting-recovery-on-antidepressants
#10
Andrea N Goldstein-Piekarski, Mayuresh S Korgaonkar, Erin Green, Trisha Suppes, Alan F Schatzberg, Trevor Hastie, Charles B Nemeroff, Leanne M Williams
Amygdala circuitry and early life stress (ELS) are both strongly and independently implicated in the neurobiology of depression. Importantly, animal models have revealed that the contribution of ELS to the development and maintenance of depression is likely a consequence of structural and physiological changes in amygdala circuitry in response to stress hormones. Despite these mechanistic foundations, amygdala engagement and ELS have not been investigated as biobehavioral targets for predicting functional remission in translational human studies of depression...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779910/decoding-dynamic-brain-patterns-from-evoked-responses-a-tutorial-on-multivariate-pattern-analysis-applied-to-time-series-neuroimaging-data
#11
Tijl Grootswagers, Susan G Wardle, Thomas A Carlson
Multivariate pattern analysis (MVPA) or brain decoding methods have become standard practice in analyzing fMRI data. Although decoding methods have been extensively applied in brain-computer interfaces, these methods have only recently been applied to time series neuroimaging data such as MEG and EEG to address experimental questions in cognitive neuroscience. In a tutorial style review, we describe a broad set of options to inform future time series decoding studies from a cognitive neuroscience perspective...
October 25, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27773570/reversed-procrastination-by-focal-disruption-of-medial-frontal-cortex
#12
Ashwani Jha, Beate Diehl, Catherine Scott, Andrew W McEvoy, Parashkev Nachev
An enduring puzzle in the neuroscience of voluntary action is the origin of the remarkably wide dispersion of the reaction time distribution, an interval far greater than is explained by synaptic or signal transductive noise [1, 2]. That we are able to change our planned actions-a key criterion of volition [3]-so close to the time of their onset implies decision-making must reach deep into the execution of action itself [4-6]. It has been influentially suggested the reaction time distribution therefore reflects deliberate neural procrastination [7], giving alternative response tendencies sufficient time for fair competition in pursuing a decision threshold that determines which one is behaviorally manifest: a race model, where action selection and execution are closely interrelated [8-11]...
November 7, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27746229/interpretable-deep-neural-networks-for-single-trial-eeg-classification
#13
Irene Sturm, Sebastian Lapuschkin, Wojciech Samek, Klaus-Robert Müller
BACKGROUND: In cognitive neuroscience the potential of deep neural networks (DNNs) for solving complex classification tasks is yet to be fully exploited. The most limiting factor is that DNNs as notorious 'black boxes' do not provide insight into neurophysiological phenomena underlying a decision. Layer-wise relevance propagation (LRP) has been introduced as a novel method to explain individual network decisions. NEW METHOD: We propose the application of DNNs with LRP for the first time for EEG data analysis...
December 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27687119/learning-reward-and-decision-making
#14
John P O'Doherty, Jeffrey Cockburn, Wolfgang M Pauli
In this review, we summarize findings supporting the existence of multiple behavioral strategies for controlling reward-related behavior, including a dichotomy between the goal-directed or model-based system and the habitual or model-free system in the domain of instrumental conditioning and a similar dichotomy in the realm of Pavlovian conditioning. We evaluate evidence from neuroscience supporting the existence of at least partly distinct neuronal substrates contributing to the key computations necessary for the function of these different control systems...
September 28, 2016: Annual Review of Psychology
https://www.readbyqxmd.com/read/27683896/genetically-encoded-voltage-indicators-opportunities-and-challenges
#15
Helen H Yang, François St-Pierre
UNLABELLED: A longstanding goal in neuroscience is to understand how spatiotemporal patterns of neuronal electrical activity underlie brain function, from sensory representations to decision making. An emerging technology for monitoring electrical dynamics, voltage imaging using genetically encoded voltage indicators (GEVIs), couples the power of genetics with the advantages of light. Here, we review the properties that determine indicator performance and applicability, discussing both recent progress and technical limitations...
September 28, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27623167/a-html5-open-source-tool-to-conduct-studies-based-on-libet-s-clock-paradigm
#16
Pablo Garaizar, Carmelo P Cubillas, Helena Matute
Libet's clock is a well-known procedure in experiments in psychology and neuroscience. Examples of its use include experiments exploring the subjective sense of agency, action-effect binding, and subjective timing of conscious decisions and perceptions. However, the technical details of the apparatus used to conduct these types of experiments are complex, and are rarely explained in sufficient detail as to guarantee an exact replication of the procedure. With this in mind, we developed Labclock Web, a web tool designed to conduct online and offline experiments using Libet's clock...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27620269/effects-of-mental-health-and-neuroscience-evidence-on-juror-perceptions-of-a-criminal-defendant-the-moderating-role-of-political-orientation
#17
Elyse N Mowle, John F Edens, John W Clark, Karolina Sörman
Several recent studies have examined the effects of mental health and neuroscientific evidence on attitudes toward criminal defendants, suggesting that these factors may influence juror decision-making in meaningful ways. Few studies to date have manipulated both of these variables while also considering theoretically important individual difference variables (e.g., political orientation). Using a criminal case simulation, this study manipulated the presence of evidence concerning mental disorders (psychopathy and schizophrenia) and increasing levels of neuroscientific detail regarding a defendant's brain injury, and examined verdicts and sentencing recommendations in over 400 persons attending jury duty...
September 13, 2016: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/27592151/neural-signatures-of-social-conformity-a-coordinate-based-activation-likelihood-estimation-meta-analysis-of-functional-brain-imaging-studies
#18
REVIEW
Haiyan Wu, Yi Luo, Chunliang Feng
People often align their behaviors with group opinions, known as social conformity. Many neuroscience studies have explored the neuropsychological mechanisms underlying social conformity. Here we employed a coordinate-based meta-analysis on neuroimaging studies of social conformity with the purpose to reveal the convergence of the underlying neural architecture. We identified a convergence of reported activation foci in regions associated with normative decision-making, including ventral striatum (VS), dorsal posterior medial frontal cortex (dorsal pMFC), and anterior insula (AI)...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27582346/anticipatory-scene-representation-in-preschool-children-s-recall-and-recognition-memory
#19
Erica Kreindel, Helene Intraub
Behavioral and neuroscience research on boundary extension (false memory beyond the edges of a view of a scene) has provided new insights into the constructive nature of scene representation, and motivates questions about development. Early research with children (as young as 6-7 years) was consistent with boundary extension, but relied on an analysis of spatial errors in drawings which are open to alternative explanations (e.g. drawing ability). Experiment 1 replicated and extended prior drawing results with 4-5-year-olds and adults...
September 1, 2016: Developmental Science
https://www.readbyqxmd.com/read/27581461/intention-modulates-the-effect-of-punishment-threat-in-norm-enforcement-via-the-lateral-orbitofrontal-cortex
#20
Yuan Zhang, Hongbo Yu, Yunlu Yin, Xiaolin Zhou
UNLABELLED: Although economic theories suggest that punishment threat is crucial for maintaining social norms, counterexamples are noted in which punishment threat hinders norm compliance. Such discrepancy may arise from the intention behind the threat: unintentionally introduced punishment threat facilitates, whereas intentionally introduced punishment threat hinders, norm compliance. Here, we combined a dictator game and fMRI to investigate how intention modulates the effect of punishment threat on norm compliance and the neural substrates of this modulation...
August 31, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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