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Infralimbic

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https://www.readbyqxmd.com/read/28749471/pre-synaptic-trkb-in-basolateral-amygdala-neurons-mediates-bdnf-signaling-transmission-in-memory-extinction
#1
Yuan Li, Dongdong Wang, Yang Li, Hongxia Chu, Lining Zhang, Ming Hou, Xingyu Jiang, Zheyu Chen, Bo Su, Tao Sun
Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde axonal transport of TrkB through the direct binding of its coiled-coil domain 1 (CC1) with TrkB. Here, we constructed a fluorescent CC1 and enhanced green fluorescent protein (EGFP) fused protein, CC1-EGFP, and found that CC1-EGFP could specifically interrupt TrkB anterograde axonal transport and its localization at the pre-synaptic site...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28736518/behavioral-effects-of-systemic-infralimbic-and-prelimbic-injections-of-a-serotonin-5-ht2a-antagonist-in-carioca-high-and-low-conditioned-freezing-rats
#2
Laura A León, Vitor Castro-Gomes, Santiago Zárate-Guerrero, Karen Corredor, Antonio P Mello Cruz, Marcus L Brandão, Fernando P Cardenas, J Landeira-Fernandez
The role of serotonin (5-hydroxytryptamine [5-HT]) and 5-HT2A receptors in anxiety has been extensively studied, mostly without considering individual differences in trait anxiety. Our laboratory developed two lines of animals that are bred for high and low freezing responses to contextual cues that are previously associated with footshock (Carioca High-conditioned Freezing [CHF] and Carioca Low-conditioned Freezing [CLF]). The present study investigated whether ketanserin, a preferential 5-HT2A receptor blocker, exerts distinct anxiety-like profiles in these two lines of animals...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28728677/dynamically-timed-stimulation-of-corticolimbic-circuitry-activates-a-stress-compensatory-pathway
#3
David Carlson, Lisa K David, Neil M Gallagher, Mai-Anh T Vu, Matthew Shirley, Rainbo Hultman, Joyce Wang, Caley Burrus, Colleen A McClung, Sunil Kumar, Lawrence Carin, Stephen D Mague, Kafui Dzirasa
BACKGROUND: The prefrontal cortex plays a critical role in regulating emotional behaviors, and dysfunction of prefrontal cortex-dependent networks has been broadly implicated in mediating stress-induced behavioral disorders including major depressive disorder. METHODS: Here we acquired multicircuit in vivo activity from eight cortical and limbic brain regions as mice were subjected to the tail suspension test (TST) and an open field test. We used a linear decoder to determine whether cellular responses across each of the cortical and limbic areas signal movement during the TST and open field test...
June 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28720520/neural-systems-mediating-the-inhibition-of-cocaine-seeking-behaviors
#4
REVIEW
Victória A Ewald, Ryan T LaLumiere
Over the past decades, research has targeted the neurobiology regulating cocaine-seeking behaviors, largely in the hopes of identifying potential targets for the treatment of cocaine addiction. Although much of this work has focused on those systems driving cocaine seeking, recently, studies examining the inhibition of cocaine-related behaviors have made significant progress in uncovering the neural systems that attenuate cocaine seeking. Such systems include the infralimbic cortex, nucleus accumbens shell, and hypothalamus...
July 15, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28714715/the-development-of-perineuronal-nets-around-parvalbumin-gabaergic-neurons-in-the-medial-prefrontal-cortex-and-basolateral-amygdala-of-rats
#5
Kathryn D Baker, Arielle R Gray, Rick Richardson
Perineuronal nets (PNNs) are extracellular matrix structures that preferentially surround mature GABAergic neurons that express the calcium-binding protein parvalbumin (PV). It has been suggested that aberrant PNN formation in humans may contribute to psychological disorders, many of which emerge during childhood and adolescence. The present experiment investigated the normative developmental trajectory of PNN formation in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) in juvenile (P24), adolescent (P35-36), and adult (∼P70) rats...
August 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28706238/freezing-response-independent-facilitation-of-fear-extinction-memory-in-the-prefrontal-cortex
#6
Jiso Hong, Daesoo Kim
The infralimbic cortex (IL) is known to facilitate the formation of extinction memory through reciprocal interactions with the amygdala, which produces fear responses such as freezing. Thus, whether presynaptic input from the amygdala and post-synaptic output of IL neurons are functionally dissociated in extinction memory formation remains unclear. Here, we demonstrated that photostimulation of IL inputs from BLA did not change freezing responses to conditioned stimuli (CS) during training, but did facilitate extinction memory, measured as a reduction in freezing responses to the CS 1 day later...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694754/using-curcumin-to-prevent-structural-and-behavioral-changes-of-medial-prefrontal-cortex-induced-by-sleep-deprivation-in-rats
#7
Ali Noorafshan, Fatemeh Karimi, Saied Karbalay-Doust, Ali Mohammad Kamali
Sleep Deprivation (SD) is known to result in a range of neurological consequences in chronically-afflicted subjects. Curcumin, a natural substance, has neuroprotective properties. This study aimed to evaluate the effects of curcumin on the medial Prefrontal Cortex (mPFC) of SD rats. Male rats were arbitrarily assigned to nine groups, including control, curcumin (100 mg/kg/day), olive oil, SD, SD+curcumin, SD+olive oil, grid, grid+curcumin, and grid+olive oil groups. SD was induced by a multiplatform box containing water...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28691248/adolescent-alcohol-exposure-decreases-frontostriatal-resting-state-functional-connectivity-in-adulthood
#8
Margaret A Broadwater, Sung-Ho Lee, Yang Yu, Hongtu Zhu, Fulton T Crews, Donita L Robinson, Yen-Yu Ian Shih
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with emergence of adult executive function and top-down inhibitory control over behavior. Alcohol exposure during this critical period of brain maturation may affect development of PFC and frontolimbic connectivity. Adult rats exposed to adolescent intermittent ethanol (AIE; 5 g/kg ethanol, 25 percent v/v in water, intragastrically, 2-day-on, 2-day-off, postnatal day 25-54) or water control underwent resting-state functional MRI to test the hypothesis that AIE induces persistent changes in frontolimbic functional connectivity under baseline and acute alcohol conditions (2 g/kg ethanol or saline, intraperitoneally administered during scanning)...
July 9, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28687229/the-phosphodiesterase-10a-selective-inhibitor-tak-063-induces-c-fos-expression-in-both-direct-and-indirect-pathway-medium-spiny-neurons-and-sub-regions-of-the-medial-prefrontal-cortex-in-rats
#9
Atsushi Nakatani, Sayuri Nakamura, Haruhide Kimura
TAK-063, a selective phosphodiesterase 10A (PDE10A) inhibitor, produces potent antipsychotic-like and pro-cognitive effects in rodents via balanced activation of striatal direct and indirect pathway medium spiny neurons (MSNs). Brain activity modulation by TAK-063 has been characterized using pharmacological magnetic resonance imaging and electroencephalography in animals, revealing modulation of activity in the prefrontal cortex (PFC) where there is little or no PDE10A expression. To understand the specific brain regions and cells affected by TAK-063 in rats, we assessed neural activation in the striatal complex and PFC using immunofluorescence staining to measure c-Fos expression...
July 4, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28685757/social-learning-requires-plasticity-enhanced-by-fluoxetine-through-prefrontal-bdnf-trkb-signaling-to-limit-aggression-induced-by-post-weaning-social-isolation
#10
Éva Mikics, Ramon Guirado, Juzoh Umemori, Máté Tóth, László Biró, Christina Miskolczi, Diána Balázsfi, Dóra Zelena, Eero Castrén, József Haller, Nina N Karpova
Escalated or abnormal aggression induced by early adverse experiences is a growing issue of social concern and urges the development of effective treatment strategies. Here we report that synergistic interactions between psychosocial and biological factors specifically ameliorate escalated aggression induced by early adverse experiences. Rats reared in isolation from weaning until early adulthood showed abnormal forms of aggression and social deficits that were temporarily ameliorated by re-socialization, but aggression again escalated in a novel environment...
July 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28678402/inhibitory-modulation-of-medial-prefrontal-cortical-activation-on-lateral-orbitofrontal-cortex-amygdala-information-flow
#11
Chun-Hui Chang, Ta-Wen Ho
KEY POINTS: The basolateral complex of the amygdala (BLA) receives input from the lateral orbitofrontal cortex (lOFC) for cue-outcome contingencies and the medial prefrontal cortex (mPFC) for emotion control. Here we examined how the mPFC modulates lOFC-BLA information flow. We found that the majority of BLA neurons responsive to lOFC stimulation were also responsive to mPFC stimulation. Activation of the mPFC exerted an inhibitory modulation of the lOFC-BLA pathway, which was reversed with intra-amygdala blockade of GABAergic receptors...
July 5, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28675393/erbb4-signaling-in-the-prelimbic-cortex-regulates-fear-expression
#12
Y-H Chen, Y-J Lan, S-R Zhang, W-P Li, Z-Y Luo, S Lin, J-P Zhuang, X-W Li, S-J Li, J-M Yang, T-M Gao
Many psychiatric diseases such as post-traumatic stress disorder (PTSD) are characterized by abnormal processing of emotional stimuli particularly fear. The medial prefrontal cortex (mPFC) is critically involved in fear expression. However, the molecular mechanisms underlying this process are largely unknown. Neuregulin-1 (NRG1) reportedly regulates pyramidal neuronal activity via ErbB4 receptors, which are abundant in parvalbumin (PV)-expressing interneurons in the PFC. In this study, we aimed to determine how NRG1/ErbB4 signaling in the mPFC modulates fear expression and found that tone-cued fear conditioning increased NRG1 expression in the mPFC...
July 4, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28665166/mild-traumatic-brain-injury-reduces-spine-density-of-projection-neurons-in-the-medial-prefrontal-cortex-and-impairs-extinction-of-contextual-fear-memory
#13
Jing Zhao, Jonathan C Huynh, Michael J Hylin, John OMalley, Alec I Perez, Anthony N Moore, Pramod K Dash
Epidemiology studies have found that a comorbidity exists between traumatic brain injury (TBI) and stress-related disorders. However, the anatomical and cellular bases for this association is poorly understood. An inability to extinguish the memory of a traumatic event lies at the core of many stress-related disorders. Experimental studies have shown that the medial prefrontal cortex (mPFC), especially the infralimbic (IL) cortex, is required for extinction and for storing the memory of extinction. The output from the central nucleus of amygdala projects to lateral hypothalamus, paraventricular nucleus and central grey to regulate heart rate, stress hormone release and freezing behavior, respectively...
June 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28659792/the-serotonin-receptor-6-antagonist-idalopirdine-and-acetylcholinesterase-inhibitor-donepezil-have-synergistic-effects-on-brain-activity-a-functional-mri-study-in-the-awake-rat
#14
Craig F Ferris, Praveen Kulkarni, Jason R Yee, Mark Nedelman, Inge E M de Jong
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination with the AChEI donepezil on brain activity using BOLD (Blood Oxygen Level Dependent) functional magnetic resonance imaging (fMRI) in the awake rat...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28655609/oxytocin-in-the-medial-prefrontal-cortex-attenuates-anxiety-anatomical-and-receptor-specificity-and-mechanism-of-action
#15
Sara Sabihi, Shirley M Dong, Skyler D Maurer, Caitlin Post, Benedetta Leuner
Numerous studies in animals and humans have established that oxytocin (OT) reduces anxiety. In rats, the prelimbic (PL) subregion of the medial prefrontal cortex (mPFC) is among the brain areas implicated in the anxiolytic actions of OT. However, questions remain about the anatomical and receptor specificity of OT and its mechanism of action. Here we assessed whether the regulation of anxiety by mPFC OT is restricted to the PL subregion and evaluated whether oxytocin receptor (OTR) activation is required for OT to have an anxiolytic effect...
June 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28649993/kappa-opioid-receptor-activation-in-dopamine-neurons-disrupts-behavioral-inhibition
#16
Antony D Abraham, Harrison M Fontaine, Allisa J Song, Mackenzie M Andrews, Madison A Baird, Brigitte L Kieffer, Benjamin B Land, Charles Chavkin
The dynorphin/kappa opioid receptor (KOR) system has been previously implicated in the regulation of cognition, but the neural circuitry and molecular mechanisms underlying KOR-mediated cognitive disruption are unknown. Here, we used an operational test of cognition involving timing and behavioral inhibition and found that systemic KOR activation impairs performance of male and female C57BL/6 mice in the differential reinforcement of low response rates (DRL) task. Systemic KOR antagonism also blocked stress-induced disruptions of DRL performance...
June 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28648458/peripheral-nerve-injury-induces-a-transitory-microglial-reaction-in-the-rat-infralimbic-cortex
#17
Paul Chu Sin Chung, Tania Panigada, Romain Cardis, Isabelle Decosterd, Romain-Daniel Gosselin
Undeniable evidence shows that microglia in the spinal cord undergo marked reactions following peripheral injuries. However, only rare studies have investigated the possible short and long term microglial reaction in brain regions following peripheral nerve injury and its interspecies specificities. In the present study we examined microglia in subdivisions of the prefrontal cortex in mice and rats, 7days and 42days after spared nerve injury (SNI) of the sciatic nerve. We show that a bilateral increase of microglial density takes place in the infralimbic cortex in rats 7days post-injury (sham vs...
June 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28648456/brain-derived-neurotrophic-factor-in-the-infralimbic-cortex-alleviates-inflammatory-pain
#18
Lupeng Yue, Long-Yu Ma, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
In chronic pain, it has been reported that the medial prefrontal cortex (mPFC) takes important regulatory roles, and may change functionally and morphologically in result of chronic pain. Brain-derived neurotrophic factor (BDNF) is well known as a critical modulator of neuronal excitability and synaptic transmission in the central nervous system. The aim of the present study is to investigate the role of BDNF in the infralimbic cortex and the prelimbic cortex of the mPFC in complete Freund's adjuvant (CFA)-induced inflammatory pain...
June 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28647594/chronic-mild-stress-impairs-latent-inhibition-and-induces-region-specific-neural-activation-in-chl1-deficient-mice-a-mouse-model-of-schizophrenia
#19
Mona Buhusi, Daniel Obray, Bret Guercio, Mitchell J Bartlett, Catalin V Buhusi
Schizophrenia is a neurodevelopmental disorder characterized by abnormal processing of information and attentional deficits. Schizophrenia has a high genetic component but is precipitated by environmental factors, as proposed by the 'two-hit' theory of schizophrenia. Here we compared latent inhibition as a measure of learning and attention, in CHL1-deficient mice, an animal model of schizophrenia, and their wild-type littermates, under no-stress and chronic mild stress conditions. All unstressed mice as well as the stressed wild-type mice showed latent inhibition...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28647452/differential-roles-of-the-infralimbic-and-prelimbic-areas-of-the-prefrontal-cortex-in-reconsolidation-of-a-traumatic-memory
#20
Natali Levin, Milly Kritman, Mouna Maroun, Irit Akirav
Studies about reconsolidation of conditioned fear memories have shown that pharmacological manipulation at memory reactivation can attenuate or enhance the subsequent expression of the conditioned fear response. Here we examined the effects of a single injection of the mTOR inhibitor rapamycin (Rap) into the infralimbic (IL) and prelimbic (PL) areas [which compose the ventromedial prefrontal cortex (PFC)] on reconsolidation and extinction of a traumatic fear memory. We found opposite effects of Rap infused into the PL and IL on reconsolidation and extinction: intra-PL Rap and systemic Rap impaired reconsolidation and facilitated extinction whereas intra-IL Rap enhanced reconsolidation and impaired extinction...
June 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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