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Infralimbic

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https://www.readbyqxmd.com/read/29341883/title-brain-region-specific-molecular-responses-to-maternal-separation-and-social-defeat-stress-in-mice
#1
Benjamin D Sachs, Ha L Tran, Emily Folse, Marc G Caron
The association between stress and mental illness has been well documented, but the molecular consequences of repeated exposure to stress have not been completely identified. The present study sought to elucidate the combinatorial effects of early life maternal separation stress and adult social defeat stress on alterations in signal transduction and gene expression that have been previously implicated in susceptibility to psychosocial stress. Molecular analyses were performed in the prelimbic/infralimbic cortex, amygdala, and nucleus accumbens, three brain regions that have been suggested to play critical roles in determining stress responses...
January 13, 2018: Neuroscience
https://www.readbyqxmd.com/read/29329984/infralimbic-dopamine-d2-receptors-mediate-glucocorticoid-induced-facilitation-of-auditory-fear-memory-extinction-in-rats
#2
Masoumeh Dadkhah, Payman Raise Abdullahi, Ali Rashidy-Pour, Hamid Reza Sameni, Abbas Ali Vafaei
The infralimbic (IL) cortex of the medial prefrontal cortex plays an important role in the extinction of fear memory. Also, it has been showed that both brain glucocorticoid and dopamine receptors are involved in many processes such as fear extinction that drive learning and memory; however, the interaction of these receptors in the IL cortex remains unclear. We examined a putative interaction between the effects of glucocorticoid and dopamine receptors stimulation in the IL cortex on fear memory extinction in an auditory fear conditioning paradigm in male rats...
January 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29317519/%C3%AE-arrestin-biased-%C3%AE-adrenergic-signaling-promotes-extinction-learning-of-cocaine-reward-memory
#3
Bing Huang, Youxing Li, Deqin Cheng, Guanhong He, Xing Liu, Lan Ma
Extinction learning of cocaine-associated contextual cues can help prevent cocaine addicts from relapsing. Pharmacological manipulation of β-adrenergic receptor (β-AR) during extinction learning is being developed as a potential strategy to treat drug addiction. We demonstrated that the extinction learning of cocaine-associated memory was mediated by β-arrestin2-biased but not heterotrimeric guanine nucleotide-binding protein (G protein)-dependent β-adrenergic signaling. We found that administration of the nonbiased β-AR antagonist propranolol, but not the G protein-biased β-AR antagonist carvedilol, blocked extinction learning of cocaine-conditioned place preference and the associated ERK activation in the infralimbic prefrontal cortex...
January 9, 2018: Science Signaling
https://www.readbyqxmd.com/read/29317484/chemogenetic-excitation-of-accumbens-projecting-infralimbic-cortical-neurons-blocks-toluene-induced-conditioned-place-preference
#4
Wesley N Wayman, John J Woodward
Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our lab has previously shown that, in male rats, an acute binge-like exposure to toluene vapor that mimics human solvent abuse modifies the intrinsic excitability of medial prefrontal cortex (mPFC) pyramidal neurons projecting to the nucleus accumbens (NAc). These changes showed region (infralimbic; IL vs. prelimbic; PRL), layer (shallow; 2/3 vs. deep; 5/6), target (core vs...
January 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29316846/acute-stress-evokes-sexually-dimorphic-stressor-specific-patterns-of-neural-activation-across-multiple-limbic-brain-regions-in-adult-rats
#5
Ankit Sood, Karina Chaudhari, Vidita A Vaidya
Stress enhances the risk for psychiatric disorders such as anxiety and depression. Stress responses vary across sex and may underlie the heightened vulnerability to psychopathology in females. Here, we examined the influence of acute immobilization stress (AIS) and a two-day short-term forced swim stress (FS) on neural activation in multiple cortical and subcortical brain regions, implicated as targets of stress and in the regulation of neuroendocrine stress responses, in male and female rats using Fos as a neural activity marker...
January 10, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29302616/habitual-behavior-is-mediated-by-a-shift-in-response-outcome-encoding-by-infralimbic-cortex
#6
Jacqueline M Barker, W Bailey Glen, David N Linsenbardt, Christopher C Lapish, L Judson Chandler
The ability to flexibly switch between goal-directed actions and habits is critical for adaptive behavior. The infralimbic prefrontal cortex (IfL-C) has been consistently identified as a crucial structure for the regulation of response strategies. To investigate the role of the IfL-C, the present study employed two validated reinforcement schedules that either promote habits or goal-directed actions in mice. The results reveal that information about action-outcome relationships is differentially encoded in the IfL-C during actions and habits as evidenced by encoding of behavioral outcomes during goal-directed actions that is lost during habits...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29250610/increased-neuronal-dna-rna-oxidation-in-the-frontal-cortex-of-mice-subjected-to-unpredictable-chronic-mild-stress
#7
Alfred M Maluach, Keith A Misquitta, Thomas D Prevot, Corey Fee, Etienne Sibille, Mounira Banasr, Ana C Andreazza
Background: Chronic stress is implicated in the development of various psychiatric illnesses including major depressive disorder. Previous reports suggest that patients with major depressive disorder have increased levels of oxidative stress, including higher levels of DNA/RNA oxidation found in postmortem studies, especially within brain regions responsible for the cognitive and emotional processes disrupted in the disorder. Here, we aimed to investigate whether unpredictable chronic mild stress in mice induces neuronal DNA/RNA oxidation in the prelimbic, infralimbic, and cingulate cortices of the frontal cortex and the basolateral amygdala and to explore potential associations with depressive-like behaviors...
January 2017: Chronic Stress
https://www.readbyqxmd.com/read/29246436/prefrontal-cortex-stimulation-enhances-fear-extinction-memory-in-humans
#8
Tommi Raij, Aapo Nummenmaa, Marie-France Marin, Daria Porter, Sharon Furtak, Kawin Setsompop, Mohammed R Milad
BACKGROUND: Animal fear conditioning studies have illuminated neuronal mechanisms of learned associations between sensory stimuli and fear responses. In rats, brief electrical stimulation of the infralimbic cortex has been shown to reduce conditioned freezing during recall of extinction memory. Here, we translated this finding to humans with magnetic resonance imaging-navigated transcranial magnetic stimulation (TMS). METHODS: Subjects (N = 28) were aversively conditioned to two different cues (day 1)...
November 6, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29242822/abstinence-from-cocaine-induced-conditioned-place-preference-produces-discrete-changes-in-glutamatergic-synapses-onto-deep-layer-5-6-neurons-from-prelimbic-and-infralimbic-cortices
#9
José I Pena-Bravo, Carmela M Reichel, Antonieta Lavin
Glutamatergic signaling in the medial prefrontal cortex (mPFC) plays a critical role in drug addiction and relapse. The mPFC is functionally subdivided into dorsal (prelimbic, PL) and ventral (infralimbic, IL) regions, and evidence suggests a differential role of these two divisions in the control of drug seeking and taking; however, there is a dearth of information on the cocaine-induced adaptations in PL- and IL-mPFC synaptic glutamate transmission and their regulation of behavioral responses to cocaine-associated stimuli...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29241651/distinct-roles-of-prelimbic-and-infralimbic-probdnf-in-extinction-of-conditioned-fear
#10
Wei Sun, Xiaoliang Li, Lei An
Brain-derived neurotrophic factor (BDNF) has been investigated for its positive role in regulation of fear acquisition and memory. The precursor of BDNF, proBDNF, has been identified as different protein from its mature form. The prelimbic (PL) and infralimbic (IL) sub-regions of the medial prefrontal cortex (mPFC) are functionally distinct in fear behavior. However, the role of PL and IL proBDNF in fear memory is unclear. Here, through the infusion of cleavage-resistant proBDNF and its antibody, we identified the dissociable roles of PL and IL proBDNF in fear expression and extinction memory as well as explored proBDNF's potential mechanism of action...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29227584/npas4-deficiency-and-prenatal-stress-interact-to-affect-social-recognition-in-mice
#11
Kelsey Heslin, Laurence Coutellier
Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene-by-environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock-out mice to examine a potential interaction between two factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory signaling in the cortex and prenatal stress (PNS) exposure...
December 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29204119/differential-effects-of-inactivation-of-discrete-regions-of-medial-prefrontal-cortex-on-memory-consolidation-of-moderate-and-intense-inhibitory-avoidance-training
#12
María E Torres-García, Andrea C Medina, Gina L Quirarte, Roberto A Prado-Alcalá
It has been found that the medial prefrontal cortex (mPFC) is involved in memory encoding of aversive events, such as inhibitory avoidance (IA) training. Dissociable roles have been described for different mPFC subregions regarding various memory processes, wherein the anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL) are involved in acquisition, retrieval, and extinction of aversive events, respectively. On the other hand, it has been demonstrated that intense training impedes the effects on memory of treatments that typically interfere with memory consolidation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29175155/neuroanatomical-distribution-of-dek-protein-in-corticolimbic-circuits-associated-with-learning-and-memory-in-adult-male-and-female-mice
#13
Valentina Ghisays, Elizabeth T Nguyen, Joshua Streicher, Nicholas A Pease, Maureen Fitzgerald, Christina M Estrada, Ana Franco-Villanueva, Lisa Privette Vinnedge, Matia B Solomon
DEK, a chromatin-remodeling gene expressed in most human tissues, is known for its role in cancer biology and autoimmune diseases. DEK depletion in vitro reduces cellular proliferation, induces DNA damage subsequently leading to apoptosis, and down-regulates canonical Wnt/β-catenin signaling, a molecular pathway essential for learning and memory. Despite a recognized role in cancer (non-neuronal) cells, DEK expression and function is not well characterized in the central nervous system. We conducted a gene ontology analysis (ToppGene), using a cancer database to identify genes associated with DEK deficiency, which pinpointed several genes associated with cognitive-related diseases (i...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29169694/vitamin-e-can-improve-behavioral-tests-impairment-cell-loss-and-dendrite-changes-in-rats-medial-prefrontal-cortex-induced-by-acceptable-daily-dose-of-aspartame
#14
Ali Rafati, Ali Noorafshan, Mahboubeh Jahangir, Leila Hosseini, Saied Karbalay-Doust
Aspartame is an artificial sweetener used in about 6000 sugar-free products. Aspartame consumption could be associated with various neurological disorders. This study aimed to evaluate the effect of aspartame onmedial Prefrontal Cortex (mPFC) as well as neuroprotective effects of vitamin E. The rats were divided into seven groups, including distilled water, corn oil, vitamin E (100mg/kg/day), and low (acceptable daily dose) and high doses of aspartame (40 and 200mg/kg/day) respectively, with or without vitamin E consumption, for 8 weeks...
November 21, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29165654/infusions-of-nerve-growth-factor-into-the-developing-frontal-cortex-leads-to-deficits-in-behavioral-flexibility-and-increased-perseverance
#15
Sagar J Desai, Brian L Allman, Nagalingam Rajakumar
In the pursuit of further establishing a neurodevelopmental animal model to investigate the mechanisms underlying impaired executive function, a core and severely debilitating symptom of schizophrenia, we sought to characterize the deficits in behavioral flexibility in adult rats following neonatal infusions of nerve growth factor (NGF) into the medial part of the developing frontal cortex. Our previous studies using this neonatal frontal cortical lesion model have shown that it leads to adult-onset positive and negative symptom-like features, and several neuropathological abnormalities of schizophrenia...
November 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29134962/role-of-glutamatergic-projections-from-the-ventral-ca1-to-infralimbic-cortex-in-context-induced-reinstatement-of-heroin-seeking
#16
Na Wang, Feifei Ge, Cailian Cui, Yijing Li, Xiaowei Sun, Linlin Sun, Xinjuan Wang, Shuli Liu, Haolin Zhang, Yan Liu, Meng Jia, Mingda Yang
The prelimbic cortex (PL) and infralimbic cortex (IL) play a role in context-induced reinstatement of heroin seeking in an animal model of drug relapse. Both the PL and IL receive direct glutamatergic projections from the ventral CA1 (vCA1), which is also involved in context-induced reinstatement of cocaine and heroin seeking. Here we studied the role of vCA1-PL and vCA1-IL projections in context-induced reinstatement of heroin seeking by using electrophysiological, neuropharmacological, chemogenetic and molecular methods...
November 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29120948/parvalbumin-containing-gaba-cells-and-schizophrenia-experimental-model-based-on-targeted-gene-delivery-through-adeno-associated-viruses
#17
Marta U Woloszynowska-Fraser, Peer Wulff, Gernot Riedel
Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29081007/interplay-of-prefrontal-cortex-and-amygdala-during-extinction-of-drug-seeking
#18
Valeria Oliva, Emilio Cartoni, Emanuele Claudio Latagliata, Stefano Puglisi-Allegra, Gianluca Baldassarre
Extinction of Pavlovian conditioning is a complex process that involves brain regions such as the medial prefrontal cortex (mPFC), the amygdala and the locus coeruleus. In particular, noradrenaline (NA) coming from the locus coeruleus has been recently shown to play a different role in two subregions of the mPFC, the prelimbic (PL) and the infralimbic (IL) regions. How these regions interact in conditioning and subsequent extinction is an open issue. We studied these processes using two approaches: computational modelling and NA manipulation in a conditioned place preference paradigm (CPP) in mice...
October 28, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29061508/endogenous-glutamate-within-the-prelimbic-and-infralimbic-cortices-regulates-the-incubation-of-cocaine-seeking-in-rats
#19
Christina B Shin, Taylor J Templeton, Alvin S Chiu, Jennifer Kim, Ellen S Gable, Philip A Vieira, Tod E Kippin, Karen K Szumlinski
The incubation of cue-reinforced cocaine-seeking coincides with increased extracellular glutamate within the ventromedial prefrontal cortex (vmPFC). The vmPFC is comprised of two subregions that oppositely regulate drug-seeking, with infralimbic (IL) activity inhibiting, and prelimibic (PL) activity facilitating, drug-seeking. Thus, we hypothesized that increasing and decreasing endogenous glutamate within the IL would attenuate and potentiate, respectively, cue-reinforced drug-seeking behavior, with the converse effects observed upon manipulations of endogenous glutamate within the PL...
October 20, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29052618/a-role-for-prefrontal-cortical-nmda-receptors-in-murine-alcohol-heightened-aggression
#20
Emily L Newman, Miho Terunuma, Tiffany Wang, Nishani Hewage, Matthew B Bicakci, Stephen J Moss, Joseph F DeBold, Klaus A Miczek
Alcohol is associated with nearly half of all violent crimes committed in the United States; yet, a potential neural basis for this type of pathological aggression remains elusive. Alcohol may act on NMDA receptors (NMDARs) within cortical circuits to impede processing and to promote aggression. Here, male mice were characterized as alcohol-heightened (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder confrontations after self-administering 1.0 g/kg alcohol (6% w/v) or water. Alcohol produced a pathological-like pattern of aggression in AHAs; these mice shifted their bites to more vulnerable locations on the body of a submissive animal, including the anterior back and ventrum after consuming alcohol...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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