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https://www.readbyqxmd.com/read/28983604/sanggenon%C3%A2-c-protects-against-cardiomyocyte-hypoxia-injury-by-increasing-autophagy
#1
Yang Gu, Lu Gao, Yu Chen, Zhuo Xu, Kun Yu, Dongying Zhang, Gang Zhang, Xiwen Zhang
Sanggenon C is isolated from Morus alba, a plant that has been used for anti‑inflammatory purposes in Oriental medicine. Little is known about the effect of Sanggenon C on cardiomyocyte hypoxia injury. This study, using H9c2 rat cardiomyoblasts, was designed to determine the effects of Sanggenon C on cardiomyocyte hypoxia injury. Inflammatory cytokine levels were measured by reverse transcription‑polymerase chain reaction, reactive oxygen species were measured by 2',7'‑dichlorofluorescin diacetate fluorescent probe, autophagy was detected using the LC3II/I ratio and cell apoptosis was detected by TUNEL staining...
September 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28981257/bacillus-anthracis-prolyl-4-hydroxylase-interacts-with-and-modifies-elongation-factor-tu
#2
Nicholas J Schnicker, Mortezaali Razzaghi, Sanjukta Guha Thakurta, Srinivas Chakravarthy, Mishtu Dey
Prolyl hydroxylation is a very common post-translational modification and has many roles in eukaryotes such as, collagen stabilization, hypoxia sensing, and controlling protein transcription and translation. There is growing evidence suggesting prokaryotes contain prolyl 4-hydroxylases (P4Hs) homologous to the hypoxia-inducible factor (HIF)-prolyl hydroxylase domains (PHDs) that act on elongation factor Tu (EFTu) and are likely involved in the regulation of bacterial translation. Recent biochemical and structural studies with a PHD from Pseudomonas putida (PPHD) determined that it forms a complex with EFTu and hydroxylates a prolyl residue of EFTu...
October 5, 2017: Biochemistry
https://www.readbyqxmd.com/read/28961169/anti-inflammatory-thioredoxin-family-proteins-for-medicare-healthcare-and-aging-care
#3
REVIEW
Junji Yodoi, Yoshiyuki Matsuo, Hai Tian, Hiroshi Masutani, Takashi Inamoto
Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies...
September 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28895799/protective-effects-of-bellidifolin-in-hypoxia-induced-in-pheochromocytoma-cells-pc12-and-underlying-mechanisms
#4
Zhi-Ying Zhao, Yang-Yang Gao, Li Gao, Ming Zhang, He Wang, Chun-Hong Zhang
Bellidifolin, a xanthone compound derived from plants of Gentiana species, is known to exert a variety of pharmacological activities including anti-oxidation, anti-inflammatory and antitumor actions as well as a protective effect on cerebral ischemic nerve injury. The aim of this study was to examine the protective effects of bellidifolin on nerve injury produced by hypoxia and possible underlying mechanisms using pheochromocytoma cells (PC12). Data showed that the viability of PC12 cells subjected to hypoxia resulted in a significant decrease; however; pretreatment with certain concentrations of bellidifolin (20 or 40 μmol/L) prior to hypoxia significantly increased the survival rate...
September 12, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28886525/perillyl-alcohol-protects-human-renal-tubular-epithelial-cells-from-hypoxia-reoxygenation-injury-via-inhibition-of-ros-endoplasmic-reticulum-stress-and-activation-of-pi3k-akt-enos-pathway
#5
Yixiao Xu, Wantie Wang, Keke Jin, Qifan Zhu, Hongzhou Lin, Minye Xie, Dexuan Wang
Ischemia/reperfusion (I/R) injury plays an essential role in renal transplantation, and represents a crucial risk factor for allograft dysfunction and acute renal failure. Modulation of oxidative stress is an effective therapeutic strategy for I/R injury. Perillyl alcohol (POH), a dietary monoterpene with antioxidant activity is found in a variety of plants. The study was carried out to investigate whether treatment of POH could reduce hypoxia/reoxygenation (H/R)-induced injury. H/R induced significant injury in HK-2 cells...
September 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28871532/visisens-technique-to-measure-internal-oxygen-and-respiration-in-barley-roots
#6
Aprajita Kumari, Kapuganti Jagadis Gupta
Respiration is vital for production of energy in plants where oxygen is essential for conducting respiration. Internal oxygen levels in plants depend on respiratory rates. Tissues such as underground roots experience hypoxia due to their isolation from atmospheric oxygen and their internal oxygen depends on tissue size and local oxygen in soil and rhizosphere. Here, we used the ViSisens imaging technique, in which an optical sensor foil (i.e., the planar optode) is attached surface of root. This sensor measures oxygen values from fluorescence...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28871315/laboratory-investigation-of-mineralization-of-refractory-nitrogen-from-sewage-treatment-plants
#7
Gaboury Benoit, Peng Wang
Laboratory studies were conducted and modeled to evaluate whether refractory organic nitrogen in tertiary-treated wastewater effluent could become bioavailable by conversion to mineral forms. Multiday incubations of effluent collected from the Branford and New Haven, Connecticut, waste water treatment plants (WWTP) revealed low but steady conversion of organic nitrogen to nitrate (NO3(-)). In Branford, the principal form of organic nitrogen was dissolved, and in New Haven it was particulate. Modeling suggested that in both the cases conversion to NO3(-) from organic forms occurred at several per cent per day, and appeared to happen via the intermediary NH4(+)...
September 4, 2017: Environmental Management
https://www.readbyqxmd.com/read/28857271/nitric-oxide-is-essential-for-the-development-of-aerenchyma-in-wheat-roots-under-hypoxic-stress
#8
Aakanksha Wany, Aprajita Kumari, Kapuganti Jagadis Gupta
In response to flooding/water-logging, plants develop various anatomical changes including the formation of lysigenous aerenchyma for the delivery of oxygen to roots. Under hypoxia, plants produce high levels of nitric oxide (NO) but the role of this molecule in plant adaptive response to hypoxia is not known. Here, we investigated whether ethylene-induced aerenchyma requires hypoxia-induced NO. Under hypoxic conditions, wheat roots produced NO apparently via nitrate reductase and scavenging of NO led to a marked reduction in aerenchyma formation...
August 30, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28838128/hypoxia-sensing-in-plants-on-a-quest-for-ion-channels-as-putative-oxygen-sensors
#9
Feifei Wang, Zhong-Hua Chen, Sergey Shabala
Over 17 million km2 of land is affected by soil flooding every year, resulting in substantial yield losses and jeopardizing food security across the globe. A key step in resolving this problem and creating stress-tolerant cultivars is an understanding of the mechanisms by which plants sense low-oxygen stress. In this work, we review the current knowledge about the oxygen-sensing and signaling pathway in mammalian and plant systems and postulate the potential role of ion channels as putative oxygen sensors in plant roots...
July 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28834646/phospholipases-atpld%C3%AE-1-and-atpld%C3%AE-2-function-differently-in-hypoxia
#10
Sylvia Lindberg, Albert Premkumar, Ulla Rasmussen, Alexander Schulz, Ida Lager
Besides hydrolysing different membrane phospholipids, plant phospholipases D and molecular species of their byproducts phosphatidic acids (PLDs/PAs) are involved in diverse cellular events such as membrane-cytoskeleton dynamics, hormone regulation and biotic and/or abiotic stress responses at cellular or subcellular levels. Among the twelve Arabidopsis PLD genes, PLDζ1 and PLDζ2 uniquely possess Ca(2+) -independent phox (PX) and pleckstrin (PH) homology domains. Here, we report that mutants deficient in these PLDs, pldζ1 and pldζ2, show differential sensitivities to hypoxia stimulus...
August 23, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28827451/comparative-transcriptomics-indicate-changes-in-cell-wall-organization-and-stress-response-in-seedlings-during-spaceflight
#11
Christina M Johnson, Aswati Subramanian, Sivakumar Pattathil, Melanie J Correll, John Z Kiss
PREMISE OF THE STUDY: Plants will play an important role in the future of space exploration as part of bioregenerative life support. Thus, it is important to understand the effects of microgravity and spaceflight on gene expression in plant development. METHODS: We analyzed the transcriptome of Arabidopsis thaliana using the Biological Research in Canisters (BRIC) hardware during Space Shuttle mission STS-131. The bioinformatics methods used included RMA (robust multi-array average), MAS5 (Microarray Suite 5...
August 21, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28791033/sink-status-and-photosynthetic-rate-of-the-leaflet-galls-induced-by-bystracoccus-mataybae-eriococcidae-on-matayba-guianensis-sapindaceae
#12
Denis C Oliveira, Ana Silvia F P Moreira, Rosy M S Isaias, Vitor Martini, Uiara C Rezende
The galling insect Bystracoccus mataybae (Eriococcidae) induces green and intralaminar galls on leaflets of Matayba guianensis (Sapindaceae), and promotes a high oxidative stress in host plant tissues. This biotic stress is assumed by the histochemical detection of hydrogen peroxide, a reactive oxygen species (ROS), whose production alters gall physiology. Thus, we hypothesize that high levels of nutrients are accumulated during gall development in response to a local maintenance of photosynthesis and to the galling insect activity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28783581/high-doses-of-s-methylcysteine-cause-hypoxia-induced-cardiomyocyte-apoptosis-accompanied-by-engulfment-of-mitochondaria-by-nucleus
#13
Mohammed A El-Magd, Walied S Abdo, Mustafa El-Maddaway, Nasr M Nasr, Rasha A Gaber, Eman S El-Shetry, Ayman A Saleh, Faisal Abdulrahman Ali Alzahrani, Doaa H Abdelhady
Despite its important role as a medicinal plant, some studies reported a toxic effect for garlic (Allium sativum) when given in higher doses. Herein, we investigated the possible cardiotoxic effects of high doses of S-methylcysteine (SMC), a water soluble organosulfur compound present in garlic. Rats were orally administered SMC at a low dose (50mg), high dose (150mg) and very high dose (300mg)/kg body weight, or saline (control) for 10days. High and very high doses of SMC resulted in a significant increase in serum cardiac injury biomarkers [aspartate transaminase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) and cardiac troponin T (cTnT)], as well as oxidative stress marker nitric oxide (NO) concentration in heart and a significant decrease in cardiac superoxide dismutase (SOD) activity...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28777815/biochemical-adaptations-of-four-submerged-macrophytes-under-combined-exposure-to-hypoxia-and-hydrogen-sulphide
#14
Mahfuza Parveen, Takashi Asaeda, Md H Rashid
A hydroponic experiment was performed to investigate the stress responses and biochemical adaptations of four submerged macrophytes, Potamogeton crispus, Myriophyllum spicatum, Egeria densa, and Potamogeton oxyphyllus, to the combined exposure of hypoxia and hydrogen sulfide (H2S, provided by NaHS). The investigated plants were subjected to a control, hypoxia, 0.1mM NaHS, 0.5 mM NaHS, 0.1 mM NaHS+hypoxia and 0.5 mM NaHS+hypoxia conditions. All experimental plants grew optimally under control, hypoxic and NaHS conditions in comparison to that grown in the combined exposure of hypoxia and hydrogen sulfide...
2017: PloS One
https://www.readbyqxmd.com/read/28755319/a-novel-family-of-proline-serine-rich-proteins-which-are-phospho-targets-of-stress-related-mitogen-activated-protein-kinases-differentially-regulates-growth-and-pathogen-defense-in-arabidopsis-thaliana
#15
Mieder Anthony Thomas Palm-Forster, Lennart Eschen-Lippold, Joachim Uhrig, Dierk Scheel, Justin Lee
The molecular actions of mitogen-activated protein kinases (MAPKs) are ultimately accomplished by the substrate proteins where phosphorylation affects their molecular properties and function(s), but knowledge regarding plant MAPK substrates is currently still fragmentary. Here, we uncovered a previously uncharacterized protein family consisting of three proline/serine-rich proteins (PRPs) that are substrates of stress-related MAPKs. We demonstrated the importance of a MAPK docking domain necessary for protein-protein interaction with MAPKs and consequently also for phosphorylation...
July 28, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28741704/methylation-of-protein-phosphatase-2a-influence-of-regulators-and-environmental-stress-factors
#16
Maria T Creighton, Anna Kolton, Amr R A Kataya, Jodi Maple-Grødem, Irina O Averkina, Behzad Heidari, Cathrine Lillo
Protein phosphatase 2A catalytic subunit (PP2A-C) has a terminal leucine subjected to methylation, a regulatory mechanism conserved from yeast to mammals and plants. Two enzymes, LCMT1 and PME1, methylate and demethylate PP2A-C, respectively. The physiological importance of these posttranslational modifications is still enigmatic. We investigated these processes in Arabidopsis thaliana by mutant phenotyping, by global expression analysis, and by monitoring methylation status of PP2A-C under different environmental conditions...
October 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28740502/the-amp-activated-protein-kinase-kin10-is-involved-in-the-regulation-of-autophagy-in-arabidopsis
#17
Liang Chen, Ze-Zhuo Su, Li Huang, Fan-Nv Xia, Hua Qi, Li-Juan Xie, Shi Xiao, Qin-Fang Chen
Autophagy is a highly conserved system in eukaryotes for the bulk degradation and recycling of intracellular components. Autophagy is involved in many physiological processes including development, senescence, and responses to abiotic and biotic stress. The adenosine 5'-monophosphate (AMP)-activated protein kinase AMPK positively regulates autophagy in mammals; however, the potential function of AMPK in plant autophagy remains largely unknown. Here, we identified KIN10, a plant ortholog of the mammalian AMPK, as a positive regulator of plant autophagy and showed that it acts by affecting the phosphorylation of ATG1 (AUTOPHAGY-RELATED GENE 1) proteins in Arabidopsis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28735390/the-role-of-long-noncoding-rnas-in-plant-stress-tolerance
#18
Yuepeng Song, Deqiang Zhang
Plants must adapt to multiple biotic and abiotic stresses ; thus, sensing and responding to environmental signals is imperative for their survival. Moreover, understanding these responses is imperative for efforts to improve plant yield and consistency. Regulation of transcript levels is a key aspect of the plant response to environmental signals. Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years with the advance of high-throughput sequencing technologies. As important biological regulators, lncRNAs have been implicated in a wide range of developmental processes and diseases in animals...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28716182/atp-sensing-in-living-plant-cells-reveals-tissue-gradients-and-stress-dynamics-of-energy-physiology
#19
Valentina De Col, Philippe Fuchs, Thomas Nietzel, Marlene Elsässer, Chia Pao Voon, Alessia Candeo, Ingo Seeliger, Mark D Fricker, Christopher Grefen, Ian Max Møller, Andrea Bassi, Boon Leong Lim, Marco Zancani, Andreas J Meyer, Alex Costa, Stephan Wagner, Markus Schwarzländer
Growth and development of plants is ultimately driven by light energy captured through photosynthesis. ATP acts as universal cellular energy cofactor fuelling all life processes, including gene expression, metabolism, and transport. Despite a mechanistic understanding of ATP biochemistry, ATP dynamics in the living plant have been largely elusive. Here, we establish MgATP(2-) measurement in living plants using the fluorescent protein biosensor ATeam1.03-nD/nA. We generate Arabidopsis sensor lines and investigate the sensor in vitro under conditions appropriate for the plant cytosol...
July 18, 2017: ELife
https://www.readbyqxmd.com/read/28705037/saffron-and-its-derivatives-crocin-crocetin-and-safranal-a-patent-review
#20
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Saffron and its main components have traditionally been used as pharmaceutical agents. Current experimental research projects have also exhibited their applications in a wide spectrum of disorder treatments. Area covered: This review covers the demonstrated findings and patents on therapeutic/pharmaceutical properties of saffron and related derivatives, since 2000 to bold their outstanding merit on human health. An extensive literature review was performed in USP Patent, Patentscope, Espacenet and Google Patent in the field of CNS, cardiovascular, urogenital, dermatological and inflammatory disorders...
July 13, 2017: Expert Opinion on Therapeutic Patents
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