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https://www.readbyqxmd.com/read/28647509/a-review-of-acalypha-indica-l-euphorbiaceae-as-traditional-medicinal-plant-and-its-therapeutic-potential
#1
REVIEW
Nor Syahiran Zahidin, Syafiqah Saidin, Razauden Mohamed Zulkifli, Ida Idayu Muhamad, Harisun Ya'akob, Hadi Nur
ETHNOPHARMACOLOGICAL RELEVANCE: Acalypha indica is an herbal plant that grows in wet, temperate and tropical region, primarily along the earth's equator line. This plant is considered by most people as a weed and can easily be found in these regions. Although this plant is a weed, Acalypha indica has been acknowledged by local people as a useful source of medicine for several therapeutic treatments. They consume parts of the plant for many therapeutics purposes such as anthelmintic, anti-ulcer, bronchitis, asthma, wound healing, anti-bacterial and other applications...
June 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28636266/marap2-4-a-waterlogging-responsive-erf-from-mentha-regulates-bidirectional-sugar-transporter-atsweet10-to-modulate-stress-response-in-arabidopsis
#2
Ujjal J Phukan, Gajendra Singh Jeena, Vineeta Tripathi, Rakesh Kumar Shukla
As waterlogging and successive events severely influence growth and development of economically important plants, we attempted to characterize the role of a waterlogging-responsive Group I (A-6) Ethylene response factor (MaRAP2-4) from Mentha arvensis. Waterlogging, ethylene and Methyl jasmonate rapidly induced the expression of MaRAP2-4. MaRAP2-4 interacted with multiple cis-elements like Dehydration response elements (DRE1/2), Anoxia/Jasmonic acid response element (JARE) and GCC box showing its involvement in multiple responses...
June 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28605408/casparian-bands-and-suberin-lamellae-in-exodermis-of-lateral-roots-an-important-trait-of-roots-system-response-to-abiotic-stress-factors
#3
Edita Tylová, Eva Pecková, Zuzana Blascheová, Aleš Soukup
Background and Aims: Root absorptive characteristics rely on the presence of apoplastic barriers. However, little is known about the establishment of these barriers within a complex root system, particularly in a major portion of them - the lateral roots. In Zea mays L., the exodermis differentiates under the influence of growth conditions. Therefore, the species presents a suitable model to elucidate the cross-talk among environmental conditions, branching pattern and the maturation of barriers within a complex root system involved in the definition of the plant-soil interface...
June 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28579900/imperatorin-protects-h9c2-cardiomyoblasts-cells-from-hypoxia-reoxygenation-induced-injury-through-activation-of-erk-signaling-pathway
#4
Bihong Liao, Ruimian Chen, Feng Lin, Aihuan Mai, Jie Chen, Huimin Li, Shaohong Dong, Zhenglei Xu
BACKGROUND: Imperatorin is a compound found in plants and has been widely used in Chinese medicine for many years. It has many pharmacological effects, including the recently reported anti-apoptotic function, however, the mechanism largely remains unclear. This study is aimed to elucidate the mechanism of Imperatorin's anti-apoptotic function. METHODS: A model of hypoxia and reoxygenation (H/R) treated h9c2 cardiomyoblasts was successfully constructed. The cells were treated with H/R condition, and followed by adding Imperatorin alone, Imperatorin with ERK inhibitor and/or ERK inhibitor alone, to examine the cell viability by Cell Counting Kit-8 assay, cell apoptosis rate by flow cytometry, and ERK expression by Western-blot under different conditions...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28568609/two-minuses-can-make-a-plus-waterlogging-and-elevated-co2-interactions-in-sweet-cherry-prunus-avium-cultivars
#5
Margarita Pérez-Jiménez, María Hernández-Munuera, M Carmen Piñero, Gregorio López-Ortega, Francisco M Del Amor
The increase in the ambient concentration of CO2 and other greenhouse gases is producing climate events that can compromise crop survival. However, high CO2 concentrations are sometimes able to mitigate certain stresses such as salinity or drought. In this experiment, the effects of waterlogging and CO2 are studied in combination to elucidate the eventual response in sweet cherry trees. For this purpose, four sweet cherry cultivars ('Burlat', 'Cashmere', 'Lapins, and 'New Star') were grafted on a typically hypoxia-tolerant rootstock ('Mariana 2624') and were submitted to waterlogging for 7 days at either ambient CO2 concentration (400 µmol mol(-1) ) or at elevated CO2 (800 µmol mol(-1) )...
June 1, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28567028/gelsemium-elegans-poisoning-a-case-with-8%C3%A2-months-of-follow-up-and-review-of-the-literature
#6
Zhou Zhou, Lei Wu, Yuhua Zhong, Xiaobo Fang, Yanmei Liu, Hongbing Chen, Weixi Zhang
BACKGROUND: Gelsemium elegans (G. elegans) is a toxic plant indigenous to Southeast Asia. It is highly poisonous due to its strong respiratory depressive effect. However, G. elegans poisoning cases have not been summarized comprehensively and are rarely reported in English journals. Furthermore, none of the present reports present prognosis in detail. CASE PRESENTATION: A 26-year-old female was found comatose at home and brought to the hospital with deep coma, hypoxia, and acidosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28559476/noncanonical-alternative-polyadenylation-contributes-to-gene-regulation-in-response-to-hypoxia
#7
Laura de Lorenzo, Reed Sorenson, Julia Bailey-Serres, Arthur G Hunt
Stresses from various environmental challenges continually confront plants, and their responses are important for growth and survival. One molecular response to such challenges involves the alternative polyadenylation of mRNA. In plants, it is unclear how stress affects the production and fate of alternative mRNA isoforms. Using a genome-scale approach, we show that in Arabidopsis thaliana, hypoxia leads to increases in the number of mRNA isoforms with polyadenylated 3' ends that map to 5'-UTRs, introns and protein-coding regions...
May 30, 2017: Plant Cell
https://www.readbyqxmd.com/read/28549801/methanolic-extract-of-boswellia-serrata-exhibits-anti-cancer-activities-by-targeting-microsomal-prostaglandin-e-synthase-1-in-human-colon-cancer-cells
#8
Tayebeh Ranjbarnejad, Massoud Saidijam, Shirin Moradkhani, Rezvan Najafi
BACKGROUND: Colorectal cancer (CRC) is the most common cancer. A proper method to reduce mortality of CRC is chemoprevention to prevent initiation and promotion of intestinal tumorgenesis. One of the promising and developing chemopreventive agents is natural compounds found in plants. Frankincense, the resin extract from the Boswellia specious, has been used in traditional and modern medicine for treating various diseases with very minimal side effects. In the current study, we investigated the anti-cancer activity of methanolic extract of Boswellia serrata (B...
May 24, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28543362/commd1-a-multifunctional-regulatory-protein
#9
Mario Riera Romo
The COMMD Protein Family is highly conserved among multicellular eukaryotic organisms and many orthologs of human COMMD genes have been found in different species of plants, invertebrates, lower vertebrates and mammals. COMMD1 is the best characterized member of the family and is conserved among vertebrates. This protein represents a pleiotropic factor involved in the regulation of many cellular and physiological processes that include copper and cholesterol homeostasis, ionic transport, oxidative stress, protein aggregation, protein trafficking, NF-κB-mediated transcription, hypoxia induced transcription, DNA damage response and oncogenesis...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28532102/islet-encapsulated-implantable-composite-hollow-fiber-membrane-based-device-a-bioartificial-pancreas
#10
Rohit S Teotia, Sachin Kadam, Atul Kumar Singh, Surendra Kumar Verma, Ashutosh Bahulekar, Sujata Kanetkar, Jayesh Bellare
Islets from xeno-sources and islet like clusters derived from autologus stem cells have emerged as alternatives to cadaveric pancreas used for treatment of type 1 diabetes. However, the immuno-isolation of these islets from the host immune system suffers from the issue of biocompatibility and hypoxia. To overcome the issues of immunobarrier biocompatibility, we developed a Polysulfone (Psf)/TPGS composite hollow fiber membrane (HFM) using a hollow fiber spinning pilot plant specially developed for this purpose...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28487707/functional-balancing-of-the-hypoxia-regulators-rap2-12-and-hra1-takes-place-in-vivo-in-arabidopsis-thaliana-plants
#11
Beatrice Giuntoli, Francesco Licausi, Hans van Veen, Pierdomenico Perata
Plants are known to respond to variations in cellular oxygen availability and distribution by quickly adapting the transcription rate of a number of genes, generally associated to improved energy usage pathways, oxygen homeostasis and protection from harmful products of anaerobic metabolism. In terrestrial plants, such coordinated gene expression program is promoted by a conserved subfamily of ethylene responsive transcription factors called ERF-VII, which act as master activators of hypoxic gene transcription...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28465235/molecular-and-physiological-characterization-of-athigd1-in-arabidopsis
#12
Soong-Taek Hwang, Huiling Li, Hemasundar Alavilli, Byeong-Ha Lee, Dongsu Choi
Flooding is a principal stress that limits plant productivity. The sensing of low oxygen levels (hypoxia) plays a critical role in the signaling pathway that functions in plants in flooded environments. In this study, to investigate hypoxia response mechanisms in Arabidopsis, we identified three hypoxia-related genes and subjected one of these genes, Arabidopsis thaliana HYPOXIA-INDUCED GENE DOMAIN 1 (AtHIGD1), to molecular characterization including gene expression analysis and intracellular localization of the encoded protein...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28447117/a-new-major-effect-qtl-for-waterlogging-tolerance-in-wild-barley-h-spontaneum
#13
Xuechen Zhang, Yun Fan, Sergey Shabala, Anthony Koutoulis, Lana Shabala, Peter Johnson, Hongliang Hu, Meixue Zhou
We report the first study on the unique allele from wild barley that can improve waterlogging tolerance in cultivated barley with a substantially higher contribution to aerenchyma formation. Waterlogging is one of the major abiotic stresses that dramatically reduce barley crop yield. Direct selection on waterlogging tolerance in the field is less effective due to its viability to environment. The most effective way of selection is to choose traits that make significant contributions to the overall tolerance and are easy to score...
April 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28443120/dissecting-low-atmospheric-pressure-stress-transcriptome-responses-to-the-components-of-hypobaria-in-arabidopsis
#14
Mingqi Zhou, Jordan B Callaham, Matthew Reyes, Michael Stasiak, Alberto Riva, Agata K Zupanska, Mike A Dixon, Anna-Lisa Paul, Robert J Ferl
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology, yet the apparent components of hypobaria are stresses typical of terrestrial ecosystems. High altitude, for example, presents terrestrial hypobaria always with hypoxia as a component stress, since the relative partial pressure of O2 is constant in the atmosphere. Laboratory-controlled hypobaria, however, allows the dissection of pressure effects away from the effects typically associated with altitude, in particular hypoxia, as the partial pressure of O2 can be varied...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28421084/characterization-of-the-heme-pocket-structure-and-ligand-binding-kinetics-of-non-symbiotic-hemoglobins-from-the-model-legume-lotus-japonicus
#15
Laura Calvo-Begueria, Bert Cuypers, Sabine Van Doorslaer, Stefania Abbruzzetti, Stefano Bruno, Herald Berghmans, Sylvia Dewilde, Javier Ramos, Cristiano Viappiani, Manuel Becana
Plant hemoglobins (Hbs) are found in nodules of legumes and actinorhizal plants but also in non-symbiotic organs of monocots and dicots. Non-symbiotic Hbs (nsHbs) have been classified into two phylogenetic groups. Class 1 nsHbs show an extremely high O2 affinity and are induced by hypoxia and nitric oxide (NO), whereas class 2 nsHbs have moderate O2 affinity and are induced by cold and cytokinins. The functions of nsHbs are still unclear, but some of them rely on the capacity of hemes to bind diatomic ligands and catalyze the NO dioxygenase (NOD) reaction (oxyferrous Hb + NO → ferric Hb + nitrate)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28420736/deciphering-the-regulatory-network-between-the-srebp-pathway-and-protein-secretion-in-neurospora-crassa
#16
Lina Qin, Vincent W Wu, N Louise Glass
Sterol regulatory element binding proteins (SREBPs) are conserved from yeast to mammalian cells and function in the regulation of sterol homeostasis. In fungi, the SREBP pathway has been implicated in the adaptation to hypoxia and in virulence. In Neurospora crassa and Trichoderma reesei, the SREBP pathway also negatively regulates protein secretion under lignocellulolytic conditions. Here we utilized global transcriptional profiling combined with genetic and physiological analyses to address the regulatory link between the SREBP pathway and protein secretion in N...
April 18, 2017: MBio
https://www.readbyqxmd.com/read/28356955/ursolic-acid-sensitizes-radioresistant-nsclc-cells-expressing-hif-1%C3%AE-through-reducing-endogenous-gsh-and-inhibiting-hif-1%C3%AE
#17
Bing Song, Qian Zhang, Maohu Yu, Xinrong Qi, Gang Wang, Linlin Xiao, Qiyi Yi, Wensen Jin
In previous studies, the present authors demonstrated that effective sensitization of ionizing radiation-induced death of tumor cells, including non-small cell lung cancer (NSCLC) cells, could be produced by oleanolic acid (OA), a pentacyclic triterpenoid present in plants. In the present study, it was investigated whether ursolic acid (UA), an isomer of OA, had also the capacity of sensitizing radioresistant NSCLC cells. The radioresistant cell line H1299/M-hypoxia inducible factor-1α (HIF-1α) was established by transfection with a recombinant plasmid expressing mutant HIF-1α (M-HIF-1α)...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28346535/caudwell-xtreme-everest-a-prospective-study-of-the-effects-of-environmental-hypoxia-on-cognitive-functioning
#18
Konstadina Griva, Jan Stygall, Mark H Wilson, Daniel Martin, Denny Levett, Kay Mitchell, Monty Mythen, Hugh E Montgomery, Mike P Grocott, Golnar Aref-Adib, Mark Edsell, Tracie Plant, Chris Imray, Debbie Cooke, Jane Harrington, Maryam Khosravi, Stanton P Newman
BACKGROUND: The neuropsychological consequences of exposure to environmental hypobaric hypoxia (EHH) remain unclear. We thus investigated them in a large group of healthy volunteers who trekked to Mount Everest base camp (5,300 m). METHODS: A neuropsychological (NP) test battery assessing memory, language, attention, and executive function was administered to 198 participants (age 44.5±13.7 years; 60% male). These were studied at baseline (sea level), 3,500 m (Namche Bazaar), 5,300 m (Everest Base Camp) and on return to 1,300 m (Kathmandu) (attrition rate 23...
2017: PloS One
https://www.readbyqxmd.com/read/28338729/revealing-the-roles-of-gork-channels-and-nadph-oxidase-in-acclimation-to-hypoxia-in-arabidopsis
#19
Feifei Wang, Zhong-Hua Chen, Xiaohui Liu, Timothy D Colmer, Lana Shabala, Anya Salih, Meixue Zhou, Sergey Shabala
Regulation of root cell K+ is essential for acclimation to low oxygen stress. The potential roles of GORK (depolarization-activated guard cell outward-rectifying potassium) channels and RBOHD (respiratory burst oxidase homologue D) in plant adaptive responses to hypoxia were investigated in the context of tissue specificity (epidermis versus stele; elongation versus mature zone) in roots of Arabidopsis. The expression of GORK and RBOHD was down-regulated by 2- to 3-fold within 1 h and 24 h of hypoxia treatment in Arabidopsis wild-type (WT) roots...
October 19, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28332493/plant-cysteine-oxidases-are-dioxygenases-that-directly-enable-arginyl-transferase-catalysed-arginylation-of-n-end-rule-targets
#20
Mark D White, Maria Klecker, Richard J Hopkinson, Daan A Weits, Carolin Mueller, Christin Naumann, Rebecca O'Neill, James Wickens, Jiayu Yang, Jonathan C Brooks-Bartlett, Elspeth F Garman, Tom N Grossmann, Nico Dissmeyer, Emily Flashman
Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability is controlled by the N-end rule pathway, which proposes that ERF-VII N-terminal cysteine oxidation in normoxia enables arginylation followed by proteasomal degradation. The PLANT CYSTEINE OXIDASEs (PCOs) have been identified as catalysts of this oxidation. ERF-VII stabilization in hypoxia presumably arises from reduced PCO activity...
March 23, 2017: Nature Communications
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