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plant hypoxia

Jung Min Kim, In-Hu Hwang, Ik-Soon Jang, Min Kim, In Seok Bang, Soo Jung Park, Yun-Jo Chung, Jong-Cheon Joo, Min-Goo Lee
Houttuynia cordata Thunb (H cordata), a medicinal plant, has anticancer activity, as it inhibits cell growth and induces cell apoptosis in cancer. However, the potential anti-cancer activity and mechanism of H cordata for human liver cancer cells is not well understood. Recently, we identified hypoxia-inducible factor (HIF)-1A, Forkhead box (FOX)O3, and MEF2A as proapoptotic factors induced by H cordata, suggesting that HIF-1A, FOXO3, and MEF2A contribute to the apoptosis of HepG2 hepatocellular carcinoma cells...
October 3, 2016: Integrative Cancer Therapies
Hadi Ansarihadipour, Mohamadreza Bayatiani
BACKGROUND: Electromagnetic fields (EMF) are associated with oxidative stress, which is in turn associated with reactive oxygen species (ROS), anemia, and hypoxia. OBJECTIVES: This study focused on the synergistic effects of lead ions and EMF on oxidative modifications in hemoglobin (Hb) and plasma proteins. PATIENTS AND METHODS: In this experimental study, the blood samples were obtained from age- and sex-matched healthy subjects at Arak University of Medical Sciences, Arak, Iran...
July 2016: Iranian Red Crescent Medical Journal
Zaigham Shahzad, Matthieu Canut, Colette Tournaire-Roux, Alexandre Martinière, Yann Boursiac, Olivier Loudet, Christophe Maurel
Aerobic organisms survive low oxygen (O2) through activation of diverse molecular, metabolic, and physiological responses. In most plants, root water permeability (in other words, hydraulic conductivity, Lpr) is downregulated under O2 deficiency. Here, we used a quantitative genetics approach in Arabidopsis to clone Hydraulic Conductivity of Root 1 (HCR1), a Raf-like MAPKKK that negatively controls Lpr. HCR1 accumulates and is functional under combined O2 limitation and potassium (K(+)) sufficiency. HCR1 regulates Lpr and hypoxia responsive genes, through the control of RAP2...
September 22, 2016: Cell
Walailak Tatsanakanjanakorn, Surapol Suetrong
Introduction. Foreign body aspiration is an emergency condition and may be fatal. Delayed diagnosis and treatment may be associated with complications. This study evaluated the association between time until treatment and complications due to foreign body aspiration. Methods. This study was a retrospective study conducted at Khon Kaen University Hospital, Thailand. We enrolled patients diagnosed with foreign body aspiration with evidence of foreign body detected using direct laryngobronchoscopy at any area from the larynx to the bronchus...
2016: International Journal of Otolaryngology
Lixia Chen, Guiyang Xia, Feng Qiu, Chunli Wu, Andria P Denmon, Xiaolin Zi
We have purified physapubescin, a predominant steroidal lactone, from medicinal plant Physalis pubescens L., commonly named as "hairy groundcherry" in English and "Deng-Long-Cao" in Chinese. Von Hippel-Lindau (VHL)-null 786-O, RCC4 and A498 Renal Cell Carcinoma (RCC) cell lines expressing high levels of Hypoxia Inducible Factor (HIF)-2α are more sensitive to physapubescin-mediated apoptosis and growth inhibitory effect than VHL wild-type Caki-2 and ACHN RCC cell lines. Restoration of VHL in RCC4 cells attenuated the growth inhibitory effect of physapubescin...
2016: Scientific Reports
Cheng-Cheng Wang, Jia-Rui Yuan, Chun-Fei Wang, Nan Yang, Juan Chen, Dan Liu, Jie Song, Liang Feng, Xiao-Bin Tan, Xiao-Bin Jia
BACKGROUND: Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for a long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, the possible anti-inflammatory mechanism responsible for preventing tumorigenesis of precancerous lung lesions is not well elucidated. MATERIALS AND METHODS: Male A/J mice were randomly divided into 5 groups with 10 mice in each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5 g/kg/d, 10 g/kg/d, administered by gavage), (5) B(a)P + celecoxib (30 mg/kg/d, administered by gavage)...
August 24, 2016: Integrative Cancer Therapies
Yogeswaran Lokanathan, Norazzila Omar, Nur Nabilah Ahmad Puzi, Aminuddin Saim, Ruszymah Hj Idrus
Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional medicine of other Southeast Asian countries including Malaysia. Although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. In addition to past studies, recent studies also discovered and/or reconfirmed that C. asiatica acts as an antioxidant, reducing the effect of oxidative stress in vitro and in vivo...
January 2016: Malaysian Journal of Medical Sciences: MJMS
Renyi Peng, Zhiyuan Bian, Lina Zhou, Wei Cheng, Na Hai, Changquan Yang, Tao Yang, Xinyu Wang, Chongying Wang
Our data present H 2 S in a new role, serving as a multi-faceted transducer to different response mechanisms during NO-induced acquisition of tolerance to flooding-induced hypoxia in maize seedling roots. Nitric oxide (NO), serving as a secondary messenger, modulates physiological processes in plants. Recently, hydrogen sulfide (H2S) has been demonstrated to have similar signaling functions. This study focused on the effects of treatment with H2S on NO-induced hypoxia tolerance in maize seedlings. The results showed that treatment with the NO donor sodium nitroprusside (SNP) enhanced survival rate of submerged maize roots through induced accumulation of endogenous H2S...
November 2016: Plant Cell Reports
Zengyong Qiao, Ya-Wei Xu, Jingyu Yang
Eupatilin, a pharmacologically active flavone derived from the Artemisia plant species, has been reported to have anti-oxidant, anti-inflammatory, anti-allergic, and neuroprotective activities against cerebral ischemia/reperfusion (I/R). However, the role of eupatilin in myocardial I/R injury remains unclear. In the present study, we aimed to investigate the potential molecular mechanisms against hypoxia/reoxygenation (H/R) induced cardiomyocytes apoptosis in vitro. Our results showed that eupatilin markedly improved the cell viability and decreased lactate dehydrogenase (LDH) release...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Juan Ma, Jing Li, Ke Si Wang, Chunliu Mi, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Jung Joon Lee, Xuejun Jin
Perillyl alcohol (POH) is a dietary monoterpene present in a variety of plants with a pure or mixed form, and it is one of the very few natural substances with anticancer activity. However, the mechanism by which POH unleashes its anticancer activity in tumor cells remains unclear. We here demonstrated the effect of POH on hypoxia-inducible factor-1α (HIF-1α) activation. POH showed the potent inhibitory activity against HIF-1 activation induced by hypoxia in various human cancer cell lines and efficient scavenging activity of cellular Reactive oxygen species (ROS) by hypoxia in tumor cells...
October 2016: International Immunopharmacology
Takatoshi Nakamura, Motoka Nakamura
Oxygen use in roots is an important aspect of wetland plant ecophysiology, and it depends on the respiratory costs of three major processes: ion uptake, root growth, and root maintenance. However, O2 allocation in wetland plants has received little attention. This study aimed to determine the O2 allocation and specific respiratory cost of each process under hypoxic conditions, to better understand the strategy and efficiency of O2 use in wetland plants. The root respiration rate, nitrogen uptake, and root growth in three Carex species with different growth rates were examined under hypoxic conditions using different N sources, and the respiratory costs of ion uptake, root growth, and root maintenance were statistically estimated...
November 2016: Oecologia
Melanie Verena Paul, Srignanakshi Iyer, Carmen Amerhauser, Martin Lehmann, Joost T van Dongen, Peter Geigenberger
Subgroup-VII-ethylene-response-factor (ERF-VII) transcription factors are involved in the regulation of hypoxic gene expression and regulated by proteasome-mediated proteolysis via the oxygen-dependent branch of the N-end-rule pathway. While research into ERF-VII mainly focused on their role to regulate anoxic gene expression, little is known on the impact of this oxygen-sensing system in regulating plant metabolism and growth. By comparing Arabidopsis (Arabidopsis thaliana) plants overexpressing N-end-rule-sensitive and insensitive forms of the ERF-VII-factor RAP2...
September 2016: Plant Physiology
Elena Loreti, Hans van Veen, Pierdomenico Perata
Most plant species cannot survive prolonged submergence or soil waterlogging. Crops are particularly intolerant to the lack of oxygen arising from submergence. Rice can instead germinate and grow even if submerged. The molecular basis for rice tolerance was recently unveiled and will contribute to the development of better rice varieties, well adapted to flooding. The oxygen sensing mechanism was also recently discovered. This system likely operates in all plant species and relies on the oxygen-dependent destabilization of the group VII ethylene response factors (ERFVIIs), a cluster of ethylene responsive transcription factors...
June 17, 2016: Current Opinion in Plant Biology
Soong-Taek Hwang, Dongsu Choi
OsHIGDs was identified as a novel hypoxia-responsive protein family. Among them, OsHIGD2 is characterized as a mitochondrial protein and is related to hypoxia signalling through interacting with mitochondrial proteins of critical functions in reducing cell damages caused by hypoxia. Recent evidence supports ethylene as a key factor in modulating plant responses to submergence stress. Meanwhile, there has been general consent that ethylene is not the only signal for the submergence-induced stem growth. In this study, we confirmed that hypoxia also promotes stem elongation in deepwater rice even in the absence of ethylene...
October 2016: Plant Cell Reports
Hung-Chih Lin, Shih-Li Su, Chia-Yang Lu, Ai-Hsuan Lin, Wan-Chun Lin, Chin-San Liu, Ya-Chen Yang, Hsiu-Miao Wang, Chong-Kuei Lii, Haw-Wen Chen
Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α), the regulatory member of the transcription factor heterodimer HIF-1α/β, is one of the most important molecules that responds to hypoxia. Changes in cellular HIF-1α protein level are the result of altered gene transcription and protein stability, with the latter being dependent on prolyl hydroxylases (PHDs)...
June 14, 2016: Environmental Toxicology
Houssein Diab, Anis M Limami
In the context of climatic change, more heavy precipitation and more frequent flooding and waterlogging events threaten the productivity of arable farmland. Furthermore, crops were not selected to cope with flooding- and waterlogging-induced oxygen limitation. In general, low oxygen stress, unlike other abiotic stresses (e.g., cold, high temperature, drought and saline stress), received little interest from the scientific community and less financial support from stakeholders. Accordingly, breeding programs should be developed and agronomical practices should be adapted in order to save plants' growth and yield-even under conditions of low oxygen availability (e...
2016: Plants (Basel, Switzerland)
Françoise Martz, Jaana Vuosku, Anu Ovaskainen, Sari Stark, Pasi Rautio
At high latitudes, the climate has warmed at twice the rate of the global average with most changes observed in autumn, winter and spring. Increasing winter temperatures and wide temperature fluctuations are leading to more frequent rain-on-snow events and freeze-thaw cycles causing snow compaction and formation of ice layers in the snowpack, thus creating ice encasement (IE). By decreasing the snowpack insulation capacity and restricting soil-atmosphere gas exchange, modification of the snow properties may lead to colder soil but also to hypoxia and accumulation of trace gases in the subnivean environment...
2016: PloS One
Suchi Srivastava, Vidisha Bist, Sonal Srivastava, Poonam C Singh, Prabodh K Trivedi, Mehar H Asif, Puneet S Chauhan, Chandra S Nautiyal
Rhizoctonia solani is a necrotrophic fungi causing sheath blight in rice leading to substantial loss in yield. Excessive and persistent use of preventive chemicals raises human health and environment safety concerns. As an alternative, use of biocontrol agents is highly recommended. In the present study, an abiotic stress tolerant, plant growth promoting rhizobacteria Bacillus amyloliquefaciens (SN13) is demonstrated to act as a biocontrol agent and enhance immune response against R. solani in rice by modulating various physiological, metabolic, and molecular functions...
2016: Frontiers in Plant Science
Andreas Leiherer, Kathrin Stoemmer, Axel Muendlein, Christoph H Saely, Elena Kinz, Eva M Brandtner, Peter Fraunberger, Heinz Drexel
Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a hypoxic environment in adipose tissue which leads to a profound change of gene expression in adipocytes. As a consequence, there is a dysregulation of metabolism and adipokine secretion in adipose tissue leading to the development of systemic inflammation and finally resulting in the onset of metabolic diseases. The flavonoid quercetin as well as other secondary plant metabolites also referred to as phytochemicals have anti-oxidant, anti-inflammatory, and anti-diabetic effects known to be protective in view of obesity-related-diseases...
2016: Nutrients
Hsin-Da Tsai, Jui-Sheng Wu, Mei-Han Kao, Jin-Jer Chen, Grace Y Sun, Wei-Yi Ong, Teng-Nan Lin
Many population-based epidemiological studies have unveiled an inverse correlation between intake of herbal plants and incidence of stroke. C. nutans is a traditional herbal medicine widely used for snake bite, viral infection and cancer in Asian countries. However, its role in protecting stroke damage remains to be studied. Despite of growing evidence to support epigenetic regulation in the pathogenesis and recovery of stroke, a clear understanding of the underlying molecular mechanisms is still lacking. In the present study, primary cortical neurons were subjected to in vitro oxygen-glucose deprivation (OGD)-reoxygenation and hypoxic neuronal death was used to investigate the interaction between C...
September 2016: Neuromolecular Medicine
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