keyword
MENU ▼
Read by QxMD icon Read
search

plant hypoxia

keyword
https://www.readbyqxmd.com/read/29620169/lutein-inhibits-proliferation-invasion-and-migration-of-hypoxic-breast-cancer-cells-via-downregulation-of-hes1
#1
Yuan Li, Yuekun Zhang, Xiaosa Liu, Mingchen Wang, Peng Wang, Jianbo Yang, Shanfeng Zhang
An intratumoral hypoxic microenvironment is frequently observed in solid tumors, including breast cancer. Lutein, a plant-derived compound and non-vitamin A carotenoid, has been demonstrated to possess multiple protective properties including anti-inflammation, anti-oxidative stress and antitumor effects. The main objective of the present research was to elucidate the involvement of lutein in the production of reactive oxygen species (ROS) under hypoxia, the activation of hairy and enhancer of split 1 (HES1), and the proliferation, invasion and migration of breast cancer cells...
March 23, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29607928/mechanisms-of-the-ph-and-oxygen-dependent-oxidation-activities-of-artesunate
#2
Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki, Koichiro Tsuchiya
Artemisinin was discovered in 1971 as a constituent of the wormwood genus plant (Artemisia annua). This plant has been used as an herbal medicine to treat malaria since ancient times. The compound artemisinin has a sesquiterpene lactone bearing a peroxide group that offers its biological activity. In addition to anti-malarial activity, artemisinin derivatives have been reported to exert antitumor activity in cancer cells, and have attracted attention as potential anti-cancer drugs. Mechanisms that might explain the antitumor activities of artemisinin derivatives reportedly induction of apoptosis, angiogenesis inhibitory effects, inhibition of hypoxia-inducible factor-1α (HIF-1α) activation, and direct DNA injury...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29590433/interaction-of-nitric-oxide-with-the-components-of-plant-mitochondrial-electron-transport-chain
#3
Kapuganti Jagadis Gupta, Aprajita Kumari, Igor Florez-Sarasa, Alisdair R Fernie, Abir U Igamberdiev
Mitochondria are not only major sites for energy production but also participate in several alternative functions, among these generation of nitric oxide (NO) and its different impacts on this organelle is increasing attention. The inner mitochondrial membrane contains the chain of protein complexes, and electron transfer via oxidation of various organic acids and reducing equivalents leads to generation of proton gradient that results in energy production. Recent evidence suggests that these complexes are sources and targets for NO...
March 24, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29576943/molecular-cloning-and-expression-analysis-of-three-therf-s-involved-in-the-response-to-waterlogging-stress-of-taxodium-zhongshanshan406-and-subcellular-localization-of-the-gene-products
#4
Wencai Fan, Ying Yang, Zhiquan Wang, Yunlong Yin, Chaoguang Yu, Qin Shi, Jinbo Guo, Lei Xuan, Jianfeng Hua
As a subfamily of the APETALA 2/ethylene response element binding protein (AP2/EREBP) transcription factor superfamily, the ethylene response factor (ERF) is widely involved in the regulation of growth and response to various abiotic stresses in plants, and has been shown to be the main transcription factor regulating transcription of the genes related to hypoxia and waterlogging stress. In this study, three ThERF genes, with significant differences in expression profile in response to flooding stress, were identified from the transcriptomics data acquired from Taxodium hybrid 'Zhongshanshan 406' ( T...
2018: PeerJ
https://www.readbyqxmd.com/read/29568285/-leishmania-donovani-activates-hypoxia-inducible-factor-1%C3%AE-and-mir-210-for-survival-in-macrophages-by-downregulation-of-nf-%C3%AE%C2%BAb-mediated-pro-inflammatory-immune-response
#5
Vinod Kumar, Ajay Kumar, Sushmita Das, Ashish Kumar, Kumar Abhishek, Sudha Verma, Abhishek Mandal, Rakesh K Singh, Pradeep Das
Micro RNAs (miRNAs) have emerged as a critical regulator of several biological processes in both animals and plants. They have also been associated with regulation of immune responses in many human diseases during recent years. Visceral leishmaniasis (VL) is the most severe form of leishmaniasis, which is characterized by impairment of both innate and adaptive immune responses. In the present study, we observed that Leishmania establishes hypoxic environment in host macrophages that induces the expression of hypoxia inducible factor-1α (HIF-1α) and miRNA-210...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29486054/sensitivity-of-chickpea-and-faba-bean-to-root-zone-hypoxia-elevated-ethylene-and-carbon-dioxide
#6
Rushna Munir, Dennis Konnerup, Hammad A Khan, Kadambot H M Siddique, Timothy D Colmer
During soil waterlogging, plants experience O2 deficits, elevated ethylene and high CO2 in the root-zone. The effects on chickpea (Cicer arietinum L.) and faba bean (Vicia faba L.) of ethylene (2 μL L-1 ), CO2 (2-20% v/v) or deoxygenated stagnant solution were evaluated. Ethylene and high CO2 reduced root growth of both species, but O2 deficiency had the most damaging effect and especially so for chickpea. Chickpea suffered root tip death when in deoxygenated stagnant solution. High CO2 inhibited root respiration and reduced growth, while sugars accumulated in root tips, of both species...
February 27, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29472641/bigr-is-a-sulfide-sensor-that-regulates-a-sulfur-transferase-dioxygenase-required-for-aerobic-respiration-of-plant-bacteria-under-sulfide-stress
#7
Nayara Patricia Vieira de Lira, Bianca Alves Pauletti, Ana Carolina Marques, Carlos Alberto Perez, Raquel Caserta, Alessandra Alves de Souza, Aníbal Eugênio Vercesi, Adriana Franco Paes Leme, Celso Eduardo Benedetti
To cope with toxic levels of H2 S, the plant pathogens Xylella fastidiosa and Agrobacterium tumefaciens employ the bigR operon to oxidize H2 S into sulfite. The bigR operon is regulated by the transcriptional repressor BigR and it encodes a bifunctional sulfur transferase (ST) and sulfur dioxygenase (SDO) enzyme, Blh, required for H2 S oxidation and bacterial growth under hypoxia. However, how Blh operates to enhance bacterial survival under hypoxia and how BigR is deactivated to derepress operon transcription is unknown...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447166/a-molecular-basis-behind-heterophylly-in-an-amphibious-plant-ranunculus-trichophyllus
#8
Juhyun Kim, Youngsung Joo, Jinseul Kyung, Myeongjune Jeon, Jong Yoon Park, Ho Gyun Lee, Doo Soo Chung, Eunju Lee, Ilha Lee
Ranunculus trichophyllus is an amphibious plant that produces thin and cylindrical leaves if grown under water but thick and broad leaves if grown on land. We found that such heterophylly is widely controlled by two plant hormones, abscisic acid (ABA) and ethylene, which control terrestrial and aquatic leaf development respectively. Aquatic leaves produced higher levels of ethylene but lower levels of ABA than terrestrial leaves. In aquatic leaves, its distinct traits with narrow shape, lack of stomata, and reduced vessel development were caused by EIN3-mediated overactivation of abaxial genes, RtKANADIs, and accompanying with reductions of STOMAGEN and VASCULAR-RELATED NAC-DOMAIN7 (VDN7)...
February 15, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29399660/stress-induced-mutagenesis-implications-in-cancer-and-drug-resistance
#9
Devon M Fitzgerald, P J Hastings, Susan M Rosenberg
Genomic instability underlies many cancers and generates genetic variation that drives cancer initiation, progression, and therapy resistance. In contrast with classical assumptions that mutations occur purely stochastically at constant, gradual rates, microbes, plants, flies, and human cancer cells possess mechanisms of mutagenesis that are upregulated by stress responses. These generate transient, genetic-diversity bursts that can propel evolution, specifically when cells are poorly adapted to their environments-that is, when stressed...
March 2017: Annual Review of Cancer Biology
https://www.readbyqxmd.com/read/29390151/high-co2-hypoxia-responsive-transcription-factor-network-involved-in-persimmon-fruit-deastringency
#10
Qing-Gang Zhu, Zi-Yuan Gong, Miao-Miao Wang, Xian Li, Donald Grierson, Xue-Ren Yin, Kun-Song Chen
Plant responses to anaerobic environments are regulated by ethylene response factors (ERFs) in both vegetative and productive organs, but the roles of other transcription factors (TFs) in hypoxia responses are poorly understood. Here, eight TFs (DkbHLH1, DkMYB9/10/11, DkRH2-1, DkGT3-1, DkAN1-1, DkHSF1) were shown to be strongly up-regulated by AHCA (artificial high CO2 atmosphere, 1 % O2 and 95 % CO2). Dual-luciferase assay indicated some TFs were activators of previously characterized DkERFs, including DkMYB10 for the DkERF9 promoter, DkERF18/19 and DkMYB6 for the DkERF19 promoter, DkERF21/22 for the DkERF10 promoter...
January 30, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29351575/waterlogging-tolerance-tissue-nitrogen-and-oxygen-transport-in-the-forage-legume-melilotus-siculus-a-comparison-of-nodulated-and-nitrate-fed-plants
#11
Dennis Konnerup, Guillermo Toro, Ole Pedersen, Timothy David Colmer
Background and Aims: Soil waterlogging adversely impacts most plants. Melilotus siculus is a waterlogging-tolerant annual forage legume, but data were lacking for the effects of root-zone hypoxia on nodulated plants reliant on N2 fixation. The aim was to compare the waterlogging tolerance and physiology of M. siculus reliant on N2 fixation or with access to NO3-. Methods: A factorial experiment imposed treatments of water level (drained or waterlogged), rhizobia (nil or inoculated) and mineral N supply (nil or 11 mm NO3-) for 21 d on plants in pots of vermiculite in a glasshouse...
March 14, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29336716/reactive-oxygen-species-nitric-oxide-production-and-antioxidant-gene-expression-during-development-of-aerenchyma-formation-in-wheat
#12
Aakanksha Wany, Kapuganti Jagadis Gupta
In response to hypoxia, plant roots produce very high levels of nitric oxide. Recently, it was demonstrated that NO and ethylene both are essential for development of aerenchyma in wheat roots under hypoxia. Increased NO under hypoxia correlated with induction of NADPH oxidase gene expression, ROS production and lipid peroxidation in cortical cells. Tyrosine nitration was prominent in cells developing aerenchyma suggesting that NO and ROS play a key role in development of aerenchyma. However, the role of antioxidant genes during development of aerenchyma is not known, therefore, we checked gene expression of various antioxidants such as SOD1, AOX1A, APX and MnSOD at different time points after hypoxia treatment and found that expression of these genes elevated in 2 h but downregulated in 24 h where development of aerenchyma is prominent...
February 1, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29336037/developmental-control-of-hypoxia-during-bud-burst-in-grapevine
#13
Karlia Meitha, Patricia Agudelo-Romero, Santiago Signorelli, Daniel J Gibbs, John A Considine, Christine H Foyer, Michael J Considine
Dormant or quiescent buds of woody perennials are often dense and in the case of grapevine (Vitis vinifera L.) have a low tissue oxygen status. The precise timing of the decision to resume growth is difficult to predict, but once committed, the increase in tissue oxygen status is rapid and developmentally regulated. Here, we show that more than a third of the grapevine homologues of widely conserved hypoxia-responsive genes and nearly a fifth of all grapevine genes possessing a plant hypoxia-responsive promoter element were differentially regulated during bud burst, in apparent harmony with resumption of meristem identity and cell-cycle gene regulation...
January 15, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29329032/targeting-expression-of-adenosine-receptors-during-hypoxia-induced-angiogenesis-a-study-using-zebrafish-model
#14
Navina Panneerselvan, Malathi Ragunathan
Hypoxia is known to be a major player during pathological angiogenesis and adenosine as a negative feedback signaling to maintain oxygen delivery in pathological ischemic condition. We mimicked hypoxic condition and studied angiogenesis by inducing adenosine receptors using forskolin, a plant compound and NECA analogue of adenosine using zebrafish model. Vascular endothelial growth factor (VEGF) is known to play a key role during pathological angiogenesis and regulated by the factors HIF1a under hypoxic condition and recently Notch is proposed to play a negative feedback loop mechanism along with VEGF signaling but the role of adenosine receptor during the process is not known...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29301054/the-ability-to-regulate-voltage-gated-k-permeable-channels-in-the-mature-root-epidermis-is-essential-for-waterlogging-tolerance-in-barley
#15
Muhammad Bilal Gill, Fanrong Zeng, Lana Shabala, Jennifer Böhm, Guoping Zhang, Meixue Zhou, Sergey Shabala
Oxygen depletion under waterlogged conditions results in a compromised operation of H+-ATPase, with strong implications for membrane potential maintenance, cytosolic pH homeostasis, and transport of all nutrients across membranes. The above effects, however, are highly tissue specific and time dependent, and the causal link between hypoxia-induced changes to the cell's ionome and plant adaptive responses to hypoxia is not well established. This work aimed to fill this gap and investigate the effects of oxygen deprivation on K+ signalling and homeostasis in plants, and potential roles of GORK (depolarization-activated outward-rectifying potassium) channels in adaptation to oxygen-deprived conditions in barley...
January 23, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29275195/nitric-oxide-mediated-integrative-alterations-in-plant-metabolism-to-confer-abiotic-stress-tolerance-no-crosstalk-with-phytohormones-and-no-mediated-post-translational-modifications-in-modulating-diverse-plant-stress
#16
REVIEW
Fareen Sami, Mohammad Faizan, Ahmad Faraz, Husna Siddiqui, Mohammad Yusuf, Shamsul Hayat
Nitric oxide (NO) is a major signaling biomolecule associated with signal transduction in plants. The beneficial role of NO in plants, exposed to several abiotic stresses shifted our understanding as it being not only free radical, released from the toxic byproducts of oxidative metabolism but also helps in plant sustenance. An explosion of research in plant NO biology during the last two decades has revealed that NO is a key signal associated with plant growth, germination, photosynthesis, leaf senescence, pollen growth and reorientation...
February 28, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29223334/expression-of-phytoglobin-affects-nitric-oxide-metabolism-and-energy-state-of-barley-plants-exposed-to-anoxia
#17
Devin W Cochrane, Jay K Shah, Kim H Hebelstrup, Abir U Igamberdiev
Class 1 plant hemoglobins (phytoglobins) are upregulated during low-oxygen stress and participate in metabolism and cell signaling via modulation of the levels of nitric oxide (NO). We studied the effects of overexpression and knockdown of the class 1 phytoglobin gene in barley (Hordeum vulgare L.) under low-oxygen stress. The overexpression of phytoglobin reduced the amount of NO released, while knockdown significantly stimulated NO emission. It has previously been shown that NO inhibits aconitase activity, so decreased aconitase activity in knockdown plants acts as a biomarker for high internal NO levels...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29218074/autophagy-in-endometriosis
#18
REVIEW
Hui-Li Yang, Jie Mei, Kai-Kai Chang, Wen-Jie Zhou, Li-Qing Huang, Ming-Qing Li
Endometriosis (EMS) is a common gynecologic disease that causes chronic pelvic pain, dysmenorrhea, and infertility in women. The doctrine of menstruation back flow planting and defects in the immune system are well known and widely accepted. In recent years, increasing studies have been focused on the role of autophagy in EMS, and have shown that autophagy plays a vital role in EMS. Autophagy, which is known as the non-apoptotic form of programmed cell death induced by a large number of intracellular/extracellular stimuli, is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles in eukaryotic cells...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29212172/safflor-yellow-b-reduces-hypoxia-mediated-vasoconstriction-by-regulating-endothelial-micro-ribonucleic-acid-nitric-oxide-synthase-signaling
#19
Chaoyun Wang, Ying Yang, Miao Li, Xin Liu, Qiaoyun Wang, Wenyu Xin, Hongliu Sun, Qingyin Zheng
Hypoxia-induced generation of vasoconstrictors reduces cerebral blood flow (CBF) while nitric oxide (NO) synthase (NOS) and microRNAs (miRNA) in endothelial cells (ECs) suppress vasoconstriction. Safflor yellow B (SYB), a natural plant compound, previously attenuated angiotensin II-mediated injury of ECs and maintained endothelial function. This study investigated the putative involvement of NOS and miRNAs in SYB-mediated resistance to hypoxia-induced vasoconstriction. In vivo , chronic hypoxia was induced in rats, and SYB was administered intravenously...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208171/ecological-and-biological-studies-on-five-lined-skink-trachylepis-mabuya-quinquetaeniata-inhabiting-two-different-habitats-in-egypt
#20
Mohamed A M Kadry, Hanan R H Mohamed, Mohamed Hosney
This study was carried out to study the diet type, genetic, morphometric and histological variations between two natural populations of Trachylepis quinquetaeniata inhabiting Abu-Rawash, Embaba, North Giza and Garfas-Senoures, El-Faiyum habitats. In this study, morphometric examination showed that Trachylepis quinquetaeniata is a typically ground-dwelling Skink and seems to be frequently associated with grass and below shrubs. Geographic variation in sexual size dimorphism (SSD) and head size dimorphism (HSD) with greater dimensions in Garfas-Senoures, El-Faiyum compared with Abu-Rawash, Embaba, North Giza might be correlated with spatial food availability and abundance or micro-evolutionary change or phenotypic plasticity...
November 30, 2017: Cellular and Molecular Biology
keyword
keyword
65066
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"