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https://www.readbyqxmd.com/read/28318406/use-of-a-shoulder-abduction-brace-after-arthroscopic-rotator-cuff-repair-a-study-on-gait-performance-and-falls
#1
Yuma Sonoda, Takashi Nishioka, Ryo Nakajima, Shinji Imai, Piers Vigers, Taku Kawasaki
BACKGROUND: Fall prevention is essential in patients after arthroscopic rotator cuff repair because of the high risk of re-rupture. However, there are no reports related to falls that occur during the early postoperative period, while the affected limb is immobilized. OBJECTIVES: This study assessed gait performance and falls in patients using a shoulder abduction brace after arthroscopic rotator cuff repair. STUDY DESIGN: Prospective cohort and postoperative repeated measures...
March 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28302013/multicyclic-peptides-as-scaffolds-for-the-development-of-tumor-targeting-agents
#2
Anastasia Loktev, Uwe Haberkorn, Walter Mier
The lack of specificity of traditional cytotoxic drugs triggers the development of anticancer agents with high selectivity to tumor-specific proteins. The unveiling of target structures such as EGFR or Her2 allows the focused development of novel therapies and has strongly advanced tumor treatment. Tumor-specific high-affinity ligands can be identified by using display techniques such as phage, yeast surface, ribosome and mRNA display. These techniques enable the screening of huge libraries, consequently providing a valuable alternative to rational drug development...
March 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28301825/combined-versus-individual-effects-of-a-valgus-knee-brace-and-lateral-wedge-foot-orthotic-during-stair-use-in-patients-with-knee-osteoarthritis
#3
Rebecca Moyer, Trevor Birmingham, Colin Dombroski, Robert Walsh, J Robert Giffin
The aim of this study was to investigate the combined and individual biomechanical effects of a valgus knee brace and a lateral wedge foot orthotic during stair ascent and descent in patients with knee osteoarthritis (OA). Thirty-five patients with varus alignment and medial knee OA were prescribed a custom valgus knee brace and lateral wedge foot orthotic. Knee angles and moments in the frontal and sagittal planes were determined from 3D gait analysis completed under four randomized conditions: (1) control (no knee brace or foot orthotic), (2) knee brace, (3) foot orthotic, and (4) combined knee brace and foot orthotic...
March 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28292494/emerging-guidelines-for-patient-engagement-in-research
#4
John R Kirwan, Maarten de Wit, Lori Frank, Kirstie L Haywood, Sam Salek, Samantha Brace-McDonnell, Anne Lyddiatt, Skye P Barbic, Jordi Alonso, Francis Guillemin, Susan J Bartlett
There is growing recognition that involving patients in the development of new patient-reported outcome measures helps ensure that the outcomes that matter most to people living with health conditions are captured. Here, we describe and discuss different experiences of integrating patients as full patient research partners (PRPs) in outcomes research from multiple perspectives (e.g., researcher, patient, and funder), drawing from three real-world examples. These diverse experiences highlight the strengths, challenges, and impact of partnering with patients to conceptualize, design, and conduct research and disseminate findings...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28290931/prophylactic-ankle-bracing-in-military-settings-a-review-of-the-literature
#5
Thomas M Newman, Michael R Gay, W E Buckley
BACKGROUND: Within athletics and the military, ankle sprains are one of the most common injuries with the potential for long-term functional deficits. Incidence rates for ankle sprains within the military are one of the leading causes of limited duty days, especially during basic combat training, parachute training exercises, and in cadet populations. In 2008, the Department of Defense U.S. Army Center for Health Promotion and Preventative Medicine report recommended that military personnel should wear semirigid ankle braces during parachuting, basketball, soccer, and other similar high-risk activities to reduce ankle sprain injuries...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28275801/-effects-of-double-transparent-pressure-diaphragm-transfer-tray-on-indirect-bonding
#6
Xiao-Hong Huang, Liang Xu, Shan Lin
PURPOSE: To compare the time-consuming and bonding effectiveness of full dental arch and segmented dental arch, when double transparent pressure diaphragm technology was used for indirect bracket bonding. METHODS: Forty-five orthodontic cases were selected, and classified into 3 groups according to different bonding methods and arches. There were 15 cases in each group, a total of 270 brackets and 120 buccal tubes were used. Patients in group A and B received double transparent pressure diaphragm technology to bond brackets indirectly...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28274958/cabozantinib-eradicates-advanced-murine-prostate-cancer-by-activating-anti-tumor-innate-immunity
#7
Akash Patnaik, Kenneth D Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P Gehring, Katja Helenius, Brian M Olson, Athalia R Pyzer, Lily C Wang, Olivier Elemento, Jesse Novak, Thomas B Thornley, John M Asara, Laleh Montaser, Joshua J Timmons, Todd M Morgan, Yugang Wang, Elena Levantini, John G Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M Rosenblatt, David E Avigan, Huihui Ye, Jeffrey M Karp, Sabina Signoretti, Steven P Balk, Lewis C Cantley
Several kinase inhibitors that target aberrant signaling pathways in tumor cells have been deployed in cancer therapy. However, their impact on the tumor immune microenvironment remains poorly understood. The tyrosine kinase inhibitor cabozantinib showed striking responses in cancer clinical trial patients across several malignancies. Here we show that cabozantinib rapidly eradicates invasive, poorly-differentiated PTEN/p53 deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 and HMGB1, resulting in robust infiltration of neutrophils into the tumor...
March 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28274516/the-dynamic-compression-brace-for-pectus-carinatum-intermediate-results-in-286-patients
#8
Sjoerd A de Beer, Martin Gritter, Justin R de Jong, Ernst L W van Heurn
BACKGROUND: Dynamic brace compression is a novel treatment for patients with pectus carinatum. The dynamic compression system contains a device to measure the flexibility of the thoracic wall and regulate the pressure of the brace. METHODS: Patients referred to our pediatric surgical center were screened for treatment with the dynamic compression brace. Patients with a pressure of initial correction (PIC) of 10.0 pounds per square inch or less were offered treatment with the brace...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28274008/to-operate-or-not-to-operate-the-mid-shaft-fractures-of-the-clavicle-a-comparative-study-of-functional-outcomes-of-the-two-methods-of-management
#9
Sanath Kumar Shetty, Ragesh Chandran, Arjun Ballal, Lawrence John Mathias, Anoop Hegde, Ashwin Shetty
INTRODUCTION: Fractures of the clavicle are some of the most common fractures which are seen in the adult population. Mid-shaft fractures of the clavicle are considered the most common form of clavicle fractures and about half of them are displaced fractures. They have been managed non-operatively over the years. However, severe displacement and comminution of these fractures have warranted the requirement of operative intervention, due to increased incidence of mal-union, worsening of shoulder functions etc...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28268770/evaluation-of-a-variable-resistance-orthotic-knee-joint
#10
Andrew Herbert-Copley, Edward D Lemaire, Natalie Baddour
Knee-ankle-foot orthoses (KAFOs) are full leg braces for individuals with knee extensor weakness, designed to support the person during weight bearing activities by preventing knee flexion. KAFOs typically result in an unnatural gait pattern and are primarily used for level ground walking. A novel variable resistance orthotic knee joint, the Ottawalk-Variable Speed (OWVS), was designed to address these limitations. This paper presents a pilot test to evaluate the OWVS functional performance during walking and stair descent...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267751/cost-effectiveness-of-adjunct-non-pharmacological-interventions-for-osteoarthritis-of-the-knee
#11
Beth Woods, Andrea Manca, Helen Weatherly, Pedro Saramago, Eleftherios Sideris, Christina Giannopoulou, Stephen Rice, Mark Corbett, Andrew Vickers, Matthew Bowes, Hugh MacPherson, Mark Sculpher
BACKGROUND: There is limited information on the costs and benefits of alternative adjunct non-pharmacological treatments for knee osteoarthritis and little guidance on which should be prioritised for commissioning within the NHS. This study estimates the costs and benefits of acupuncture, braces, heat treatment, insoles, interferential therapy, laser/light therapy, manual therapy, neuromuscular electrical stimulation, pulsed electrical stimulation, pulsed electromagnetic fields, static magnets and transcutaneous electrical nerve Stimulation (TENS), based on all relevant data, to facilitate a more complete assessment of value...
2017: PloS One
https://www.readbyqxmd.com/read/28265461/a-protocol-for-a-feasibility-randomised-controlled-trial-to-assess-the-difference-between-functional-bracing-and-plaster-cast-for-the-treatment-of-ankle-fractures
#12
Rebecca S Kearney, Nick Parsons, Dipesh Mistry, Jonathan Young, Jaclyn Brown, Joanne O'Beirne-Elliman, Matthew Costa
BACKGROUND: UK Hospital Episode Statistics 2013-2014 recorded 57,286 fractures of the lower limb including the ankle. This figure is expected to continue to increase due to a greater population of older adults. Following an ankle fracture, patients usually have their ankle immobilised with a plaster cast. This provides maximum support for the healing ankle but is associated with stiffness and muscle wasting. A Cochrane Review has concluded that functional bracing may reduce muscle wasting and speed recovery of ankle movement...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28263195/toenail-bracing-complicated-with-group-a-beta-haemolytic-streptococcus-infection
#13
Anca Chiriac, Cristina Birsan, Calin Molnar, Simona Stolnicu
No abstract text is available yet for this article.
March 2, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28260179/treatment-of-extra-articular-proximal-and-middle-phalangeal-fractures-of-the-hand-a-systematic-review
#14
REVIEW
D Verver, L Timmermans, R A Klaassen, C H van der Vlies, D I Vos, N W L Schep
The aim of the study was to systematically review the patient reported and functional outcomes of treatment for extra-articular proximal or middle phalangeal fractures of the hand in order to determine the best treatment options. The review methodology was registered with PROSPERO. A systematic literature search was conducted in electronic bibliographic databases. Two independent reviewers performed screening and data extraction. The evaluation of quality of the included studies was performed using the Structured Effectiveness Quality Evaluation scale...
March 4, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28259710/no-beneficial-effect-of-bracing-after-anterior-cruciate-ligament-reconstruction-in-a-cohort-of-969-athletes-followed-in-rehabilitation
#15
P Bordes, E Laboute, A Bertolotti, J F Dalmay, P Puig, P Trouve, E Verhaegue, P A Joseph, P Dehail, M De Seze
OBJECTIVE: Compare the clinical outcomes of different knee braces in the early phase of rehabilitation after anterior cruciate ligament reconstruction (ACLR) in athletes. MATERIALS AND METHODS: We conducted a retrospective database study of athletes during early rehabilitation in a tertiary referral hospital between 1 February 2008 and 30 October 2010 after ACLR using bone patellar tendon bone (BPTB) or hamstring autograft. Differences in mid-patellar knee circumference, pain, and range of motion were assessed at admission...
March 1, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28259265/benign-natural-history-of-spondylolysis-in-adolescence-with-midterm-follow-up
#16
Ted Sousa, David L Skaggs, Priscella Chan, Kent T Yamaguchi, Jerald Borgella, Christopher Lee, Jeffrey Sawyer, Alice Moisan, John M Flynn, Melissa Gunderson, M Timothy Hresko, Pierre D'Hemecourt, Lindsay M Andras
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To use the Micheli Functional Scale to assess adolescent patients with spondylolysis treated conservatively at midterm follow-up. SUMMARY OF BACKGROUND: Spondylolysis is a common source of back pain for adolescents and is generally managed with bracing and physical therapy. There is little data regarding the results of conservative management of spondylolysis over time. METHODS: Four major academic pediatric institutions performed a retrospective chart review of patients from 5 to 21 years of age with the initial diagnosis of spondylolysis...
March 2017: Spine Deformity
https://www.readbyqxmd.com/read/28251560/scaphoid-fractures-in-the-athlete
#17
REVIEW
Mark J Winston, Andrew J Weiland
Scaphoid fractures are a common wrist injury, especially in athletes. Clinicians should have a high index of suspicion for a scaphoid fracture in any patient complaining of radial-sided wrist pain after a fall on an outstretched hand. Advanced imaging, including CT and MRI scans, may be useful in diagnosis and classification of fracture patterns. Treatment varies based on the fracture location, stability of the fracture, and predictability of the fracture to heal. Treatment involves either non-operative management with a thumb spica cast or brace, or operative fixation with a headless compression screw, k-wires, or scaphoid-specific plates...
March 2, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28248938/bracing-for-the-biosimilar-wave
#18
Asher Mullard
No abstract text is available yet for this article.
March 1, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28241720/-proximal-junctional-kyphosis-after-posterior-hemivertebra-resection-and-instrumented-fusion-in-young-children-with-congenital-scoliosis
#19
X Sun, X Chen, Z H Chen, Z Z Zhu, F Zhu, Z Liu, B P Qian, B Wang, J Qiao, Y Qiu
Objective: To investigate the risk factors of proximal junctional kyphosis(PJK) in young children who underwent posterior hemivertebra resection and instrumented fusion. Methods: This study reviewed the charts and radiographs of 136 consecutive young children with congenital scoliosis who underwent posterior hemivertebra resection and instrumented fusion in Department of Orthopaedics, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from January 2009 to June 2014, including 75 males and 61 females, with an average age of (5...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28238321/-cord-accident-after-external-cephalic-version-reality-or-mostly-myth
#20
J Boujenah, C Fleury, I Pharisien, A Benbara, A Tigaizin, A Bricou, L Carbillon
OBJECTIVES: To study the occurrence of cords accident (nuchal cords, prolapse, and braces) after external cephalic version according to its failure or success. METHODS: Retrospective study between 1998-2015 comparing in the cord accident diagnosed at delivery (by midwife or doctors according to mode of delivery): Patients with attempt ECV: Group 1 cephalic presentation after successful ECV with trial of labor, and Group 2 failed ECV followed by elective cesarean or trial of labor...
January 2017: Gynecol Obstet Fertil Senol
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