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https://www.readbyqxmd.com/read/29929173/influence-of-tranexamic-acid-on-cerebral-hemorrhage-a-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Beilei Huang, Qiusheng Xu, Ru Ye, Jun Xu
Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid on cerebral hemorrhage. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of tranexamic acid on cerebral hemorrhage were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies...
June 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29928762/effect-of-choline-supplementation-on-neurological-cognitive-and-behavioral-outcomes-in-offspring-arising-from-alcohol-exposure-during-development-a-quantitative-systematic-review-of-clinical-and-preclinical-studies
#2
Lisa K Akison, Jenny Kuo, Natasha Reid, Roslyn N Boyd, Karen M Moritz
Prenatal alcohol exposure results in cognitive, behavioral and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline supplementation has been identified as a potential intervention. Our objective was to review preclinical and clinical studies using choline supplementation in known cases of fetal alcohol exposure to determine its effectiveness in ameliorating deficits in offspring. A systematic search of six electronic databases was conducted and studies selected by reviewing titles/abstracts against specific inclusion/exclusion criteria...
June 21, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29925843/intraamniotic-zika-virus-inoculation-of-pregnant-rhesus-macaques-produces-fetal-neurologic-disease
#3
Lark L Coffey, Rebekah I Keesler, Patricia A Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, Kari L Christe, Jodie Usachenko, JoAnn Yee, Victoria A Heng, Eliza Bliss-Moreau, J Rachel Reader, Wilhelm von Morgenland, Anne M Gibbons, Kenneth Jackson, Amir Ardeshir, Holly Heimsath, Sallie Permar, Paranthaman Senthamaraikannan, Pietro Presicce, Suhas G Kallapur, Jeffrey M Linnen, Kui Gao, Robert Orr, Tracy MacGill, Michelle McClure, Richard McFarland, John H Morrison, Koen K A Van Rompay
Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. The GD41-inoculated animal, experiencing fetal death 7 days later, has high virus levels in fetal and placental tissues, implicating ZIKV as cause of death...
June 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29925719/endovascular-intervention-in-basilar-artery-entrapment-within-the-longitudinal-clivus-fracture-a-case-report
#4
Fumiaki Kanamori, Takashi Yamanouchi, Yuya Kano, Naoki Koketsu
Although vascular complications after head trauma is well recognized, basilar artery entrapment within the longitudinal clivus fracture is rare. A 69-year-old man presented with progressive disturbance of consciousness and right hemiplegia after trauma. Computed tomography scan showed a right-sided acute subdural hematoma and multiple skull fractures, including a longitudinal clivus fracture. Magnetic resonance imaging revealed basilar artery occlusion and a small infarction at the ventral part of the pons...
June 20, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29925652/axonal-transport-enables-neuron-to-neuron-propagation-of-hcov-oc43
#5
Mathieu Dubé, Alain Le Coupanec, Alan H M Wong, James M Rini, Marc Desforges, Pierre J Talbot
Human coronaviruses (HCoV) are recognized respiratory pathogens for which accumulating evidence indicates that in vulnerable patients, the infection can cause more severe pathologies. HCoVs are not always confined to the upper respiratory tract and can invade the CNS upon still unclear circumstances. HCoV-induced neuropathologies in human are difficult to diagnose early enough to allow therapeutic interventions. Making use of our already described animal model of HCoV neuropathogenesis, we describe the route of neuropropagation from the nasal cavity to the olfactory bulb, piriform cortex then brainstem...
June 20, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29924787/-staged-treatment-of-a-multilevel-lesion-of-brachiocephalic-arteries-in-combination-with-coronary-and-valvular-pathology-of-the-heart
#6
M A Cherniavskiĭ, A A Gusev, D V Chernova, I V Iarkov, M L Gordeev
Prevention of neurological complications in cardiosurgical and reconstructive vascular surgery is one of the priority tasks of preserving ability to work and decreasing invalidization of patients in the postoperative period. Presented in the article is a clinical case report regarding multiple-stage treatment of a female patient with a combined aortic defect, coronary pathology, and a multilevel bilateral lesion of the brachiocephalic arteries. The first stage consisted in performing a hybrid operation, i. e...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29923980/thoracolumbar-traumatic-nucleus-pulposus-sequestration-combined-with-a-slight-flexion-distraction-fracture-a-rare-case-report-and-literature-review
#7
Ruofeng Yin, Pengyu Chang, Qingsan Zhu, Fei Cheng, Baolin Zhao, Rui Gu, Bo-Yin Zhang
RATIONALE: Traumatic nucleus pulposus sequestration (TNPS) usually occurs concurrently with severe destruction of bone. TNPS combined with a slight thoracolumbar flexion- distraction fracture, triggering a disastrous nerve injury, has rarely been reported. Due to the atypical radiologic manifestations, such a patient can easily be overlooked. PATIENT CONCERNS: Hereby, we present a TNPS patient as well as a slight thoracolumbar flexion-distraction fracture and serious neurologic symptoms...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923041/long-term-health-and-socioeconomic-consequences-of-childhood-and-adolescent-onset-of-meningococcal-meningitis
#8
Line Pickering, Poul Jennum, Rikke Ibsen, Jakob Kjellberg
We estimated the long-term socioeconomic consequences and health care costs of Neisseria meningitidis meningitis (NM). The prospective cohort study included Danish individuals with onset of NM in childhood and adolescence, diagnosed between 1980 and 2009. Health care costs and socioeconomic data were obtained from nationwide administrative and health registers. Two thousand nine hundred two patients were compared with 11,610 controls matched for age, gender, and other sociodemographic characteristics. In the follow-up analysis at the age of 30 years, 1028 patients were compared with 4452 controls...
June 20, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#9
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922968/clinical-pharmacist-interventions-in-managing-drug-related-problems-in-hospitalized-patients-with-neurological-diseases
#10
Mostafa A Sayed Ali, Eman Mohamed Hussein Khedr, Fatma Alzahraa Hassan Ahmed, Nada Nasr Eldin Mohamed
Background Drug-related problems (DRPs) are common in hospitalized patients with neurological diseases. Clinical pharmacy services could minimize drug-related harm and improve patient care. Objective To identify common DRPs in neurology and document clinical pharmacists' medication-related interventions. Setting The wards and intensive care unit of the Department of Neurology at Assiut University Hospital. Method Prospective study of clinical pharmacists' interventions during the routine care work of reviewing patients medical charts over a period of 6 months from January to June 2017...
June 19, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29922641/improvements-in-heart-rate-variability-baroreflex-sensitivity-and-sleep-after-use-of-closed-loop-allostatic-neurotechnology-by-a-heterogeneous-cohort
#11
Hossam A Shaltout, Sung W Lee, Catherine L Tegeler, Joshua R Hirsch, Sean L Simpson, Lee Gerdes, Charles H Tegeler
Background: Heart rate variability (HRV) is an indicator of dynamic adaptability of the autonomic nervous system. Few interventions target upstream, cerebral cortex components of the heart-brain system for autonomic management. We report changes in HRV and baroreflex sensitivity (BRS), associated with use of a noninvasive, closed-loop, allostatic, computer-guided, acoustic stimulation neurotechnology. Methods: Over 5 years, 220 subjects with heterogeneous neurological, cardiovascular, and psychophysiological conditions consecutively enrolled in a naturalistic, single-arm study exploring clinical effects associated with use of the neurotechnology...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29922540/management-of-airway-obstruction-in-infants-with-pierre-robin-sequence
#12
Christopher M Runyan, Armando Uribe-Rivera, Shahryar Tork, Tasneem A Shikary, Zarmina Ehsan, K Nicole Weaver, Md Monir Hossain, Christopher B Gordon, Brian S Pan
Background: Pierre Robin sequence (PRS)-related airway obstruction is often treated surgically; however, objective measures predicting the need for surgery are poorly defined. Methods: A retrospective chart review was performed on 171 neonates with PRS. Infants were grouped based upon intervention modality: nonsurgical (conservative) or surgical [mandibular distraction osteogenesis (MDO) or tracheostomy]. Demographic data, physical examination findings, and study results were compared between groups to determine risk factors for surgical intervention, and to predict long-term success or failure of those interventions...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922535/exploring-the-difference-in-post-procedural-stroke-rates-between-patients-with-aortic-stenosis-who-undergo-transcatheter-aortic-valve-replacement-versus-surgical-aortic-valve-replacement
#13
REVIEW
Heather Burke, Agnieszka Boron, Jung-Hyun Lee, Kudrit Riana Kahlon
Transcatheter aortic valve replacement (TAVR) is a newer alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis. Clinical trials have investigated TAVR's safety and effectiveness. Cerebral embolization is a common complication leading to stroke after TAVR and SAVR; different cerebral protection methods have been studied to prevent this. This paper evaluates the rate of post-procedural stroke rates between TAVR and SAVR and investigates the effect of cerebral protective methods on the stroke risk post-TAVR...
April 17, 2018: Curēus
https://www.readbyqxmd.com/read/29922121/lateral-symmetry-of-synergies-in-lower-limb-muscles-of-acute-post-stroke-patients-after-robotic-intervention
#14
Chun Kwang Tan, Hideki Kadone, Hiroki Watanabe, Aiki Marushima, Masashi Yamazaki, Yoshiyuki Sankai, Kenji Suzuki
Gait disturbance is commonly associated with stroke, which is a serious neurological disease. With current technology, various exoskeletons have been developed to provide therapy, leading to many studies evaluating the use of such exoskeletons as an intervention tool. Although these studies report improvements in patients who had undergone robotic intervention, they are usually reported with clinical assessment, which are unable to characterize how muscle activations change in patients after robotic intervention...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29920522/yield-of-early-postoperative-computed-tomography-after-frontal-ventriculoperitoneal-shunt-placement
#15
Maria Kamenova, Jonathan Rychen, Raphael Guzman, Luigi Mariani, Jehuda Soleman
Despite being widely used, ventriculoperitoneal (VP) shunt placement is a procedure often associated with complications and revision surgeries. Many neurosurgical centers routinely perform early postoperative cranial computer tomography (CT) to detect postoperative complications (e.g., catheter malposition, postoperative bleed, over-drainage). Because guidelines are lacking, our study aimed to evaluate the yield of early routine postoperative CT after shunt placement for adult hydrocephalus. We retrospectively reviewed 173 patients who underwent frontal VP shunting for various neurosurgical conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29920386/extracranial-intracranial-bypass-for-treatment-of-blister-aneurysms-efficacy-and-analysis-of-complications-as-compared-to-alternative-treatment-strategies
#16
Ben A Strickland, Robert C Rennert, Josh Bakhsheshian, Kristine Ravina, Vance Fredrickson, Steven L Giannotta, Jonathan J Russin
Blister aneurysms (BAs) represent a clinical challenge without a consensus treatment strategy. We report our institution's experience with BAs with an emphasis on the use of extracranial-to-intracranial (EC-IC) bypass. 17 patients with BAs (88% [15/17] ruptured) were treated with microsurgical techniques (5 clip wrappings, 4 clip ligations, 4 EC-IC bypasses and clip trappings, 2 internal carotid artery ligations [one combined with clip wrapping], and 2 clip trappings). 6/17 patients experienced intraoperative ruptures...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29920306/pregnancy-as-a-valuable-period-for-preventing-hypoxia-ischemia-brain-damage
#17
REVIEW
C A Netto, E F Sanches, F Odorcyk, L E Duran-Carabali, S V Sizonenko
Neonatal brain Hypoxia-Ischemia (HI) is one of the major causes of infant mortality and lifelong neurological disabilities. The knowledge about the physiopathological mechanisms involved in HI lesion have increased in recent years, however these findings have not been translated into clinical practice. Current therapeutic approaches remain limited; hypothermia, used only in term or near-term infants, is the golden standard. Epidemiological evidence shows a link between adverse prenatal conditions and increased risk for diseases, health problems, and psychological outcomes later in life, what makes pregnancy a relevant period for preventing future brain injury...
June 16, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29920172/the-protection-of-acute-spinal-cord-injury-by-subarachnoid-space-injection-of-danshen-in-animal-models
#18
Yong-Gui Yu, Jian Yang, Xin-Hua Cheng, Wei Shang, Bing-Hao Zhao, Fei Zhao, Zhi-Guo Chen, Zhen-Hua Huang
Context/Objective Following acute spinal cord injury (ASCI) in rabbits, subarachnoid space injection of Danshen was performed to protect the neurological damage. In this study, we established rabbit models of spinal cord injury using a modified Allen's method. Design After the operation introducing the injuries, the rabbits were randomized into two different groups, control group (normal saline, NS) and Danshen, a component extracted from Chinese herb, treatment group. Each rabbit was supplied with either the drug or placebo at 0...
June 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29917225/psychological-treatments-for-adults-and-children-with-epilepsy-evidence-based-recommendations-by-the-international-league-against-epilepsy-psychology-task-force
#19
Rosa Michaelis, Venus Tang, Laura H Goldstein, Markus Reuber, William Curt LaFrance, Tobias Lundgren, Avani C Modi, Janelle L Wagner
Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy...
June 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/29917200/analysis-the-effect-of-hyperbaric-oxygen-preconditioning-on-neuronal-apoptosis-ca2-concentration-and-caspases-expression-after-spinal-cord-injury-in-rats
#20
J-Y Pan, R-X Cai, Y Chen, Y Li, W-W Lin, J Wu, X-D Wang
OBJECTIVE: To investigate the effects of hyperbaric oxygen preconditioning (HBO-PC) on neuronal apoptosis, Ca2+ concentration, and Caspases expression after spinal cord injury (SCI) in rats. MATERIALS AND METHODS: A total of 36 rats were randomly divided into control group (CON group), hyperbaric oxygen preconditioning group (HBO-PC group) and spinal cord injury group (SCI group), with 12 rats in each group. Rats in group HBO-PC were given HBO-PC intervention before modeling...
June 2018: European Review for Medical and Pharmacological Sciences
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