Christopher E J Doppler, Aline Seger, Ezequiel Farrher, Cláudia Régio Brambilla, Lukas Hensel, Christian P Filss, Martin Hellmich, Ana Gogishvili, N Jon Shah, Christoph W Lerche, Bernd Neumaier, Karl-Josef Langen, Gereon R Fink, Michael Sommerauer
BACKGROUND AND OBJECTIVES: Clinical heterogeneity of patients with Parkinson disease (PD) is well recognized. PD with REM sleep behavior disorder (RBD) is a more malignant phenotype with faster motor progression and higher nonmotor symptom burden. However, the neural mechanisms underlying this clinical divergence concerning imbalances in neurotransmitter systems remain elusive. METHODS: Combining magnetic resonance (MR) spectroscopy and [11 C]ABP688 PET on a PET/MR hybrid system, we simultaneously investigated two different mechanisms of glutamate signaling in patients with PD...
May 14, 2024: Neurology