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https://www.readbyqxmd.com/read/28454071/increased-gait-variability-may-not-imply-impaired-stride-to-stride-control-of-walking-in-healthy-older-adults-winner-2013-gait-and-clinical-movement-analysis-society-best-paper-award
#1
Jonathan B Dingwell, Mandy M Salinas, Joseph P Cusumano
Older adults exhibit increased gait variability that is associated with fall history and predicts future falls. It is not known to what extent this increased variability results from increased physiological noise versus a decreased ability to regulate walking movements. To "walk", a person must move a finite distance in finite time, making stride length (Ln) and time (Tn) the fundamental stride variables to define forward walking. Multiple age-related physiological changes increase neuromotor noise, increasing gait variability...
March 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28454027/levels-and-risk-factors-for-urinary-metabolites-of-polycyclic-aromatic-hydrocarbons-in-children-living-in-chongqing-china
#2
Shudan Liu, Qin Liu, Truls Ostbye, Mary Story, Xu Deng, Yiwen Chen, Wenyan Li, Hong Wang, Jingfu Qiu, Junfeng Zhang
AIMS: Since childhood exposure to polycyclic aromatic hydrocarbons (PAHs) have been associated with a variety of adverse health outcomes, the aims of this study were to1) document PAH exposure levels among children in Chongqing, China by measuring urinary concentrations of four PAH metabolites, 1-hydroxypyrene (1-OHPyr), 2-hydroxynaphthalene (2-OHNap), 2-hydroxyfluorine (2-OHFlu) and 9-hydroxyphenanthrene (9-OHPhe), and 2) assess the associations of urinary concentrations of these PAH metabolites with risk factors related to sources of PAHs inhalation and ingestion exposures and with personal attributes such as sex, age, and BMI...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448669/prevalence-of-undiagnosed-age-related-macular-degeneration-in-primary-eye-care
#3
David C Neely, Kevin J Bray, Carrie E Huisingh, Mark E Clark, Gerald McGwin, Cynthia Owsley
Importance: Age-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older adults in the United States, yet little is known about whether AMD is appropriately diagnosed in primary eye care. Objectives: To examine the prevalence of eyes with AMD in patients seen in primary eye care clinics who purportedly have normal macular health per their medical record and the association of AMD with patient and physician characteristics...
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28448593/benzodiazepines-z-drugs-and-the-risk-of-hip-fracture-a-systematic-review-and-meta-analysis
#4
Karen Donnelly, Robert Bracchi, Jonathan Hewitt, Philip A Routledge, Ben Carter
BACKGROUND: Hip fractures in the older person lead to an increased risk of mortality, poorer quality of life and increased morbidity. Benzodiazepine (BNZ) use is associated with increased hip fracture rate, consequently Z-drugs are fast becoming the physician's hypnotic prescription of choice yet data on their use is limited. We compared the risk of hip fracture associated with Z-drugs and BNZ medications, respectively, and examined if this risk varied with longer-term use. METHODS AND FINDINGS: We carried out a systematic review of the literature and meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28448509/better-than-counting-seconds-identifying-fallers-among-healthy-elderly-using-fusion-of-accelerometer-features-and-dual-task-timed-up-and-go
#5
Moacir Ponti, Patricia Bet, Caroline L Oliveira, Paula C Castro
Devices and sensors for identification of fallers can be used to implement actions to prevent falls and to allow the elderly to live an independent life while reducing the long-term care costs. In this study we aimed to investigate the accuracy of Timed Up and Go test, for fallers' identification, using fusion of features extracted from accelerometer data. Single and dual tasks TUG (manual and cognitive) were performed by a final sample (94% power) of 36 community dwelling healthy older persons (18 fallers paired with 18 non-fallers) while they wear a single triaxial accelerometer at waist with sampling rate of 200Hz...
2017: PloS One
https://www.readbyqxmd.com/read/28448461/prospective-study-on-the-impact-of-fear-of-falling-on-functional-decline-among-community-dwelling-elderly-women
#6
Kyungwon Choi, Gyeong-Suk Jeon, Sung-Il Cho
Fear of falling (FOF) is expected to have effects on functional decline in the elderly. In this study, we examined over 2 years the effect of change in FOF on functional decline in community dwelling elderly. We conducted a secondary analysis using data from elderly women, 70 years of age and older, who participated in the Korean Longitudinal Study of Aging (KLoSA). Participants were divided into four categories according to change in FOF between the 2010 and 2012 surveys. Multiple logistic regression analysis was conducted regarding the effects of changes in FOF on functional decline after controlling for variables as known risk factors for functional decline...
April 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28448266/a-prospective-randomized-blinded-controlled-trial-comparing-transdermal-continuous-oxygen-delivery-to-moist-wound-therapy-for-the-treatment-of-diabetic-foot-ulcers
#7
Vickie R Driver, Alexander Reyzelman, Jill Kawalec, Michael French
Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy (TCOT). A prospective, randomized, blinded, multicenter, parallel study was conducted from October 2009 to November 2012 to evaluate healing time and the proportion of DFUs healed after 12 weeks of moist wound therapy (MWT) with or without TCOT. Study participants (persons with type 1 or type 2 diabetes and a nonhealing [>1-month but <1-year duration], 1 cm² to 10 cm² in area, infection-free DFU) were randomized to TCOT or a sham device (control) in addition to receiving MWT...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28448088/individually-tailored-dietary-counseling-among-old-home-care-clients-effects-on-nutritional-status
#8
S Pölönen, M Tiihonen, S Hartikainen, I Nykänen
OBJECTIVE: To evaluate the effect of individually tailored dietary counseling on nutritional status among home care clients aged 75 years or older. DESIGN: Non-randomised controlled study. SETTING AND PARTICIPANTS: The study sample consisted of 224 home care clients (≥ 75 years) (intervention group, n = 127; control group, n = 100) who were at protein-energy malnutrition (PEM) or risk of PEM (MNA score <24 and plasma albumin <35 g/L)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447472/four-year-reciprocal-relationships-between-personality-and-functional-ability-in-older-adults-with-and-without-sensory-impairment-focus-on-neuroticism-and-agreeableness
#9
Markus Wettstein, Hans-Werner Wahl, Vera Heyl
OBJECTIVES: Personality traits have been found to influence health and functional ability (FA) via multiple pathways. However, personality traits may also change in reaction to constraints in FA, particularly in more vulnerable individuals with high risk of decline in independent functioning in daily life (e.g. older adults with sensory impairment). Therefore, conceptually anchored in the World Health Organization's International Classification of Functioning, Disability and Health (ICF model), this study investigated reciprocal relationships between personality, focusing on neuroticism and agreeableness, and indicators of FA (i...
April 27, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28446302/-telomere-length-expression-of-mre11-and-ku80-in-patients-with-aplastic-anemia-and-their-correlation-with-pathogenesis
#10
Yan Wang, Rui-Rong Xu, Ying-Jun DU, Jing-Yi Wang, Kui Liu, Wei Zheng
OBJECTIVE: To detect the expression levels of MRE11 and Ku80 mRNA, and telomere length in bone marrow mononuclear cells of aplastic anemia(AA) patients, and to explore their correlation with pathogenesis of aplastic anemia. METHODS: Bone marrow mononuclear cells were collected from 40 cases of AA and 20 normal controls for detecting mRNA expression of MRE11 and Ku80 and telomere length by using real-time quantitative polymerase chain reaction (qPCR), then MRE11, Ku80 and telomere length were analyzed for their correlation...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28445794/post-transplant-malignancy-after-pediatric-kidney-transplantation-retrospective-analysis-of-incidence-and-risk-factors-in-884-patients-transplanted-between-1963-and-2015-at-the-university-of-minnesota
#11
Oscar K Serrano, Ananta S Bangdiwala, David M Vock, Srinath Chinnakotla, Ty B Dunn, Erik B Finger, Raja Kandaswamy, Timothy L Pruett, John S Najarian, Arthur J Matas, Blanche M Chavers
BACKGROUND: Post-transplant malignancy (PTM) remains a concern among pediatric kidney transplant (PKT) recipients. STUDY DESIGN: Between 1963 and 2015, 884 pediatric (age: 0-17 years old) recipients received 1055 PKTs at our institution. Cox proportional hazards models were constructed to identify risk factors for PTM after PKT with time-to-first-PTM as a primary outcome. Secondly, the hazard of death or graft loss was calculated in patients who developed PTM. RESULTS: Median patient survival was 33 years (interquartile range [IQR]: 18...
April 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28445632/the-association-of-baseline-suicidality-with-treatment-outcome-in-psychotic-depression
#12
Kathleen S Bingham, Anthony J Rothschild, Benoit H Mulsant, Ellen M Whyte, Barnett S Meyers, Samprit Banerjee, Katalin Szanto, Alastair J Flint
OBJECTIVE: To examine the association between baseline suicidality and outcome of major depression in a randomized controlled trial of the pharmacotherapy of psychotic depression and to explore the interaction of suicidality, randomized treatment assignment, and depression outcome. METHODS: This study was a secondary analysis of data from 258 persons aged 18 years or older with DSM-IV-defined major depressive disorder with psychotic features who participated in a 12-week randomized controlled trial (RCT) comparing olanzapine plus sertraline with olanzapine plus placebo (the Study of the Pharmacotherapy of Psychotic Depression [STOP-PD], which ran from 2002 to 2007)...
April 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28445591/screening-endoscopy-finds-high-prevalence-of-helicobacter-pylori-and-intestinal-metaplasia-in-korean-american-with-limited-access-to-health-care
#13
Yanghee Woo, Carolyn E Behrendt, Garrick Trapp, Jae Geun Hyun, Tamas Gonda, Yuman Fong, Timothy Wang
BACKGROUND: Gastric cancer (GC) is the leading cause of cancer death among Korean Americans. Prevention and early detection is improved by screening. METHODS: Between September 2013 and March 2015, ethnic Koreans age 40 or older without history or symptoms of GC and without upper endoscopy (UE) during previous 3 years were enrolled. Participants were offered screening with GC risk assessment followed by UE with biopsies. RESULTS: Risk assessment was provided to 146 participants (age 55...
April 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28444388/apoe%C3%AE%C2%B54-genotype-and-hypertension-modify-8-year-cortical-thinning-five-occasion-evidence-from-the-seattle-longitudinal-study
#14
Philippe Rast, Kristen M Kennedy, Karen M Rodrigue, Paul R A W Robinson, Alden L Gross, Donald G McLaren, Tom Grabowski, K Warner Schaie, Sherry L Willis
We investigated individual differences in longitudinal trajectories of brain aging in cognitively normal healthy adults from the Seattle Longitudinal Study covering 8 years of longitudinal change (across 5 occasions) in cortical thickness in 249 midlife and older adults (52-95 years old). We aimed to understand true brain change; examine the influence of salient risk factors that modify an individual's rate of cortical thinning; and compare cross-sectional age-related differences in cortical thickness to longitudinal within-person cortical thinning...
April 21, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28444349/adult-children-s-education-and-physiological-dysregulation-among-older-parents
#15
Chioun Lee
Objectives: Despite growing awareness that children's education benefits the health of older parents, the underlying mechanisms of this relationship are not well-understood. We investigated (a) the associations between children's education and biological functioning of parents, (b) psychosocial and behavioral factors that explain the associations, and (c) gendered patterns in the associations. Methods: Using longitudinal data from a nationally representative sample of older Taiwanese, we performed mediation analysis of the association between adult children's education and physiological dysregulation of their parents...
April 21, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28444122/acute-hospital-admission-of-the-frail-older-person-an-opportunity-to-discuss-future-care
#16
Lucy V Pocock, Debbie J Sharp
No abstract text is available yet for this article.
April 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28442382/relationship-between-sensorimotor-peripheral-nerve-function-and-indicators-of-cardiovascular-autonomic-function-in-older-adults-from-the-health-aging-and-body-composition-study
#17
Brittney S Lange-Maia, Anne B Newman, John M Jakicic, Jane A Cauley, Robert M Boudreau, Ann V Schwartz, Eleanor M Simonsick, Suzanne Satterfield, Aaron I Vinik, Sasa Zivkovic, Tamara B Harris, Elsa S Strotmeyer
BACKGROUND: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. METHODS: Health, Aging and Body Composition participants (n=2399, age=76.5±2.9years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit...
April 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28442329/association-of-telomere-length-with-myocardial-infarction-a-prospective-cohort-from-the-population-based-hunt-2-study
#18
REVIEW
Ida Beate Øyen Østhus, Stian Lydersen, Håvard Dalen, Javaid Nauman, Ulrik Wisløff
As possible markers of biological age, telomere length (TL) has been associated with age-related diseases such as myocardial infarction (MI) with conflicting findings. We sought to assess the relationship between TL and risk of future MI in 915 healthy participants (51.7% women) 65 years or older from a population-based prospective cohort (the HUNT 2 study, Norway). Mean TL was measured by quantitative PCR expressed as relative T (telomere repeat copy number) to S (single copy gene number) ratio, and log-transformed...
April 22, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28441958/metformin-to-augment-strength-training-effective-response-in-seniors-masters-study-protocol-for-a-randomized-controlled-trial
#19
Doug E Long, Bailey D Peck, Jenny L Martz, S Craig Tuggle, Heather M Bush, Gerald McGwin, Philip A Kern, Marcas M Bamman, Charlotte A Peterson
BACKGROUND: Muscle mass and strength are strong determinants of a person's quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associated muscle atrophy (sarcopenia), the ability of older adults to increase muscle mass and strength in response to training is blunted and highly variable. Thus, finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical...
April 26, 2017: Trials
https://www.readbyqxmd.com/read/28441697/hypertension-management-in-a-population-of-older-adults-in-rural-south-africa
#20
Thiago Veiga Jardim, Sheridan Reiger, Shafika Abrahams-Gessel, F Xavier Gomez-Olive, Ryan G Wagner, Alisha Wade, Till W Bärnighausen, Joshua Salomon, Stephen Tollman, Thomas A Gaziano
OBJECTIVE: Assess awareness, treatment, and control of hypertension, as an indication of its management, in rural South Africa, especially regarding modifiers of these variables. METHODS: A population-representative sample of adults aged at least 40 years residing in the rural Agincourt subdistrict (Mpumalanga Province) covered by a long-term health and sociodemographic surveillance system was recruited. In-person interviews, physical exams, and dried blood spots were collected...
June 2017: Journal of Hypertension
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