Jiaqi He, Lan Wei, Shengan Tan, Birong Liang, Jing Liu, Lu Lu, Ting Wang, Junyan Wang, Yusheng Huang, Zixin Chen, Huan Li, Lu Zhang, Zheng Zhou, Yanhong Cao, Xiaohan Ye, Zhongqi Yang, Shaoxiang Xian, Lingjun Wang
Myocardial fibrosis (MF) is the characteristic pathological feature of various cardiovascular diseases that lead to heart failure (HF) or even fatal outcomes. Alternatively, activated macrophages are involved in the development of fibrosis and tissue remodeling. Although the receptor for advanced glycation end products (RAGE) is involved in MF, its potential role in regulating macrophage function in cardiac fibrosis has not been fully investigated. We aimed to determine the role of macrophage RAGE in transverse aortic constriction (TAC)-induced MF...
November 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology