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https://www.readbyqxmd.com/read/28596512/paricalcitol-as-an-antiproteinuric-agent-can-result-in-the-deterioration-of-renal-and-heart-function-in-a-patient-with-fabry-disease
#1
Tajda Keber, Martin Tretjak, Andreja Cokan Vujkovac, Marija Mravljak, Katja Ravber, Bojan Vujkovac
BACKGROUND Fabry disease is a rare and progressive X-linked inherited disorder of glycosphingolipid metabolism that is due to deficient or absent lysosomal a-galactosidase A activity. Among its other associated signs and symptoms, patients present with renal failure and proteinuria, which are markers of disease progression. Renin-angiotensin-aldosterone system (RAAS) blockers can slow the progression of chronic renal failure and proteinuria. In fact, some studies have shown the beneficial effects of paricalcitol on proteinuria...
June 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28587583/angiotensin-receptor-neprilysin-inhibition
#2
Ofer Havakuk, Uri Elkayam
The novel combination sacubitril/valsartan represents a new therapeutic approach in the management of heart failure. With the simultaneous blockage of the enzyme neprilysin (by sacubitril) and angiotensin II receptors (by valsartan), this combination reduces the degradation of natriuretic peptides and other counterregulatory peptide systems while avoiding the deleterious effect of angiotensin II receptors activation and thereby encompasses a beneficial impact of 2 important neurohormonal pathways activated in heart failure...
July 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28558981/natural-lipids-based-nlc-containing-lidocaine-from-pre-formulation-to-in-vivo-studies
#3
Lígia N M Ribeiro, Márcia C Breitkreitz, Viviane A Guilherme, Gustavo H R da Silva, Verônica M Couto, Simone R Castro, Bárbara O de Paula, Daisy Machado, Eneida de Paula
In a nanotechnological approach we have investigated the use of natural lipids in the preparation of nanostructured lipid carriers (NLC). Three different NLC composed of copaiba oil and beeswax, sweet almond oil and shea butter, and sesame oil and cocoa butter as structural matrices were optimized using factorial analysis; Pluronic® 68 and lidocaine (LDC) were used as the colloidal stabilizer and model encapsulated drug, respectively. The optimal formulations were characterized by different techniques (IR-ATR, DSC, and TEM), and their safety and efficacy were also tested...
May 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28523343/hh-signaling-in-regeneration-of-the-ischemic-heart
#4
REVIEW
Marina Dunaeva, Johannes Waltenberger
Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system...
May 18, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28497823/natural-products-modulating-the-herg-channel-heartaches-and-hope
#5
REVIEW
Jadel M Kratz, Ulrike Grienke, Olaf Scheel, Stefan A Mann, Judith M Rollinger
Covering: 1996-December 2016The human Ether-à-go-go Related Gene (hERG) channel is a voltage-gated potassium channel playing an essential role in the normal electrical activity in the heart. It is involved in the repolarization and termination of action potentials in excitable cardiac cells. Mutations in the hERG gene and hERG channel blockage by small molecules are associated with increased risk of fatal arrhythmias. Several drugs have been withdrawn from the market due to hERG channel-related cardiotoxicity...
May 12, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28423119/importance-of-serca2a-on-early-isolated-diastolic-dysfunction-induced-by-supravalvular-aortic-stenosis-in-rats
#6
C F S M P Silveira, D H S Campos, P P Freire, A F Deus, K Okoshi, C R Padovani, A C Cicogna
Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a known factor that influences function. A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). Our hypothesis was that SERCA2a participates in such dysfunction. Thirty-day-old male Wistar rats (60-80 g) were divided into AoS and Sham groups, which were submitted to surgery with or without aorta clipping, respectively...
April 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28419972/neprilysin-inhibitors-a-new-hope-to-halt-the-diabetic-cardiovascular-and-renal-complications
#7
REVIEW
Vajir Malek, Anil Bhanudas Gaikwad
Diabetes is an enormous and ever-growing calamity and a global public health threat of the 21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin-angiotensin system (RAS) denotes a key pharmacotherapy for the management of cardiovascular (CVD) and chronic kidney diseases (CKD), which are the leading causes of disability and death among diabetic patients. Neprilysin (NEP) inhibition, auxiliary to RAS blockage increases the bioavailability of natriuretic peptides and benefits the cardio-renal system...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28373586/critical-role-of-adamts2-a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-2-in-cardiac-hypertrophy-induced-by-pressure-overload
#8
Xiaodi Wang, Wen Chen, Jie Zhang, Aiman Khan, Liangpeng Li, Fuhua Huang, Zhibing Qiu, Liming Wang, Xin Chen
ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens. However, the role of ADAMTS2 in the heart has not yet been defined. Herein, we observed the upregulated expression of ADAMTS2 in failing human hearts and hypertrophic murine hearts. Mice lacking ADAMTS2 display exacerbated cardiac hypertrophy on pressure overload-induced hypertrophic response, whereas mice with cardiac-specific overexpression of ADAMTS2 display alleviation of this detrimental phenotype...
June 2017: Hypertension
https://www.readbyqxmd.com/read/28287141/myricitrin-alleviates-oxidative-stress-induced-inflammation-and-apoptosis-and-protects-mice-against-diabetic-cardiomyopathy
#9
Bin Zhang, Qiang Shen, Yaping Chen, Ruile Pan, Shihuan Kuang, Guiyan Liu, Guibo Sun, Xiaobo Sun
Diabetic cardiomyopathy (DCM) has been increasingly considered as a main cause of heart failure and death in diabetic patients. At present, no effective treatment exists to prevent its development. In the present study, we describe the potential protective effects and mechanisms of myricitrin (Myr) on the cardiac function of streptozotosin-induced diabetic mice and on advanced glycation end products (AGEs)-induced H9c2 cardiomyocytes. In vitro experiments revealed that pretreatment with Myr significantly decreased AGEs-induced inflammatory cytokine expression, limited an increase in ROS levels, and reduced cell apoptosis, fibrosis, and hypertrophy in H9c2 cells...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28269190/automated-in-vivo-delineation-of-lumen-wall-using-intravascular-ultrasound-imaging
#10
Debarghya China, Manas K Nag, K M Mandana, Anup K Sadhu, Pabitra Mitra, Chandan Chakraborty
This paper presents a novel methodology for automated detection and extraction of the lumen wall from Intravascular Ultrasound (IVUS) frames. IVUS is an in-vivo pull back imaging technique and provides a sequential frame of images for diagnosis of atherosclerotic heart disease. The detection and segmentation of lumen wall is necessary for predicting the arterial wall blockage. Lumen wall is recognized and segmented with the help of seed refinement and random walks algorithms, in tunica and lumen area. The proposed methodology was tested on 147 frames of 13 patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227420/automated-in-vivo-delineation-of-lumen-wall-using-intravascular-ultrasound-imaging
#11
Debarghya China, Manas K Nag, K M Mandana, Anup K Sadhu, Pabitra Mitra, Chandan Chakraborty, Debarghya China, Manas K Nag, K M Mandana, Anup K Sadhu, Pabitra Mitra, Chandan Chakraborty, Chandan Chakraborty, Manas K Nag, Debarghya China, Pabitra Mitra, Anup K Sadhu, K M Mandana
This paper presents a novel methodology for automated detection and extraction of the lumen wall from Intravascular Ultrasound (IVUS) frames. IVUS is an in-vivo pull back imaging technique and provides a sequential frame of images for diagnosis of atherosclerotic heart disease. The detection and segmentation of lumen wall is necessary for predicting the arterial wall blockage. Lumen wall is recognized and segmented with the help of seed refinement and random walks algorithms, in tunica and lumen area. The proposed methodology was tested on 147 frames of 13 patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28165494/novel-protective-role-of-myeloid-differentiation-1-in-pathological-cardiac-remodelling
#12
Xiaojv Xiong, Yu Liu, Yang Mei, Jianye Peng, Zhiqiang Wang, Bin Kong, Peng Zhong, Liang Xiong, Dajun Quan, Qi Li, Guangji Wang, He Huang
Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. Previous studies showed that MD-1 may be restricted in the immune system. In this study, we demonstrated for the first time that MD-1 was highly expressed in both human and animal hearts. We also discovered that cardiac-specific overexpression of MD-1 significantly attenuated pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction, whereas loss of MD-1 had the opposite effects...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164251/state-dependent-block-of-voltage-gated-sodium-channels-by-the-casein-kinase-1-inhibitor-ic261
#13
Karl J Föhr, Uwe Knippschild, Anna Herkommer, Michael Fauler, Christian Peifer, Michael Georgieff, Oliver Adolph
Background and Purpose IC261 (3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one) has previously been introduced as an isoform specific inhibitor of casein kinase 1 (CK1) causing cell cycle arrest or cell death of established tumor cell lines. However, it is reasonable to assume that not all antitumor activities of IC261 are mediated by the inhibition of CK1. Meanwhile there is growing evidence that functional voltage-gated sodium channels are also implicated in the progression of tumors as their blockage suppresses tumor migration and invasion of different tumor cell lines...
June 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28018021/exome-sequencing-identifies-compound-heterozygous-mutations-in-scn5a-associated-with-congenital-complete-heart-block-in-the-thai-population
#14
Chuphong Thongnak, Pornprot Limprasert, Duangkamol Tangviriyapaiboon, Suchaya Silvilairat, Apichaya Puangpetch, Ekawat Pasomsub, Chonlaphat Sukasem, Wasun Chantratita
Background. Congenital heart block is characterized by blockage of electrical impulses from the atrioventricular node (AV node) to the ventricles. This blockage can be caused by ion channel impairment that is the result of genetic variation. This study aimed to investigate the possible causative variants in a Thai family with complete heart block by using whole exome sequencing. Methods. Genomic DNA was collected from a family consisting of five family members in three generations in which one of three children in generation III had complete heart block...
2016: Disease Markers
https://www.readbyqxmd.com/read/28012774/-intermittent-left-bundle-branch-block-reversal-to-normal-conduction-during-general-anesthesia
#15
Ana Maria Oliveira Correia da Silva, Emília Alexandra Gaspar Lima da Silva
BACKGROUND AND OBJECTIVES: Transient changes in intraoperative cardiac conduction are uncommon. Rare cases of the development or remission of complete left bundle branch block under general and locoregional anesthesia associated with myocardial ischemia, hypertension, tachycardia, and drugs have been reported. Complete left bundle branch block is an important clinical manifestation in some chronic hypertensive patients, which may also be a sign of coronary artery disease, aortic valve disease, or underlying cardiomyopathy...
December 21, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28010025/evodiamine-prevents-isoproterenol-induced-cardiac-fibrosis-by-regulating-endothelial-to-mesenchymal-transition
#16
Xiao-Han Jiang, Qing-Qing Wu, Yang Xiao, Yuan Yuan, Zheng Yang, Zhou-Yan Bian, Wei Chang, Qi-Zhu Tang
Evodiamine, a major component of Evodia rutaecarpa, can protect the myocardium against injury induced by atherosclerosis and ischemia-reperfusion. However, the effect of evodiamine against cardiac fibrosis remains unclear. This study aims to investigate the possible effect and mechanism involved in the function of evodiamine on isoproterenol-induced cardiac fibrosis and endothelial-to-mesenchymal transition. Isoproterenol was used to induce cardiac fibrosis in mice, and evodiamine was gavaged simultaneously...
June 2017: Planta Medica
https://www.readbyqxmd.com/read/27845052/management-of-benign-pleural-effusions-using-indwelling-pleural-catheters-a-systematic-review-and-meta-analysis
#17
REVIEW
Monali Patil, Samjot Singh Dhillon, Kristopher Attwood, Marwan Saoud, Abdul Hamid Alraiyes, Kassem Harris
BACKGROUND: The indwelling pleural catheter (IPC), which was initially introduced for the management of recurrent malignant effusions, could be a valuable management option for recurrent benign pleural effusion (BPE), replacing chemical pleurodesis. The purpose of this study is to analyze the efficacy and safety of IPC use in the management of refractory nonmalignant effusions. METHODS: We conducted a systematic review and meta-analysis on the published literature...
March 2017: Chest
https://www.readbyqxmd.com/read/27781167/divergent-relationship-of-circulating-ctrp3-levels-between-obesity-and-gender-a-cross-sectional-study
#18
Roy Marshal Wagner, Kamesh Sivagnanam, William Andrew Clark, Jonathan M Peterson
C1q TNF Related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine, which has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little is known about CTRP3 in regards to human health. The purpose of this project was to examine circulating CTRP3 levels in a clinical population, patients with symptoms requiring heart catheterization in order to identify the presence of obstructive coronary artery disease (CAD)...
2016: PeerJ
https://www.readbyqxmd.com/read/27776179/3d-real-time-echocardiography-combined-with-mini-pressure-wire-generate-reliable-pressure-volume-loops-in-small-hearts
#19
Ulrike Herberg, Katharina Linden, Oliver Dewald, Eva Gatzweiler, Matthias Seehase, Georg Daniel Duerr, Jonas Dörner, Stephanie Kleppe, Dennis Ladage, Johannes Breuer
BACKGROUND: Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data...
2016: PloS One
https://www.readbyqxmd.com/read/27574952/functional-role-and-mechanism-of-microrna-28b-in-atrial-myocyte-in-a-persistent-atrial-fibrillation-rat-model
#20
Yongbin Wang, Weiqiang Kang, Xu Wang, Meina Chen, Qiaoji Qin, Minglei Guo, Zhiming Ge
BACKGROUND Persistent atrial fibrillation has been indicated to be related with microRNA-28b. However, the exact role of microRNA-28b in persistent atrial fibrillation needs to be further elucidated. Therefore, this study aimed to establish a rat model of persistent atrial fibrillation to investigate the level of microRNA-28b in atrial myocytes and to explore the molecular mechanism involved. MATERIAL AND METHODS A persistent atrial fibrillation model was established in rats by using chronic rapid atrial pacing induction...
August 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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