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https://www.readbyqxmd.com/read/27845052/the-management-of-benign-pleural-effusions-using-indwelling-pleural-catheters-a-systematic-review-and-meta-analysis
#1
Monali Patil, Samjot Singh Dhillon, Kristopher Attwood, Marwan Saoud, Abdul H Alraiyes, Kassem Harris
INTRODUCTION: Indwelling pleural catheter (IPC), which was initially introduced for the management of recurrent malignant effusions, could be a valuable management option for recurrent benign pleural effusions (BPE) in place of chemical pleurodesis. The purpose of this study is to analyze the efficacy and safety of IPC in the management of refractory non-malignant effusions. METHODS: We conducted a systematic review and meta-analysis on the published literature...
November 11, 2016: Chest
https://www.readbyqxmd.com/read/27781167/divergent-relationship-of-circulating-ctrp3-levels-between-obesity-and-gender-a-cross-sectional-study
#2
Roy Marshal Wagner, Kamesh Sivagnanam, William Andrew Clark, Jonathan M Peterson
: C1q TNF Related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine, which has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little is known about CTRP3 in regards to human health. The purpose of this project was to examine circulating CTRP3 levels in a clinical population, patients with symptoms requiring heart catheterization in order to identify the presence of obstructive coronary artery disease (CAD)...
2016: PeerJ
https://www.readbyqxmd.com/read/27776179/3d-real-time-echocardiography-combined-with-mini-pressure-wire-generate-reliable-pressure-volume-loops-in-small-hearts
#3
Ulrike Herberg, Katharina Linden, Oliver Dewald, Eva Gatzweiler, Matthias Seehase, Georg Daniel Duerr, Jonas Dörner, Stephanie Kleppe, Dennis Ladage, Johannes Breuer
BACKGROUND: Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data...
2016: PloS One
https://www.readbyqxmd.com/read/27574952/functional-role-and-mechanism-of-microrna-28b-in-atrial-myocyte-in-a-persistent-atrial-fibrillation-rat-model
#4
Yongbin Wang, Weiqiang Kang, Xu Wang, Meina Chen, Qiaoji Qin, Minglei Guo, Zhiming Ge
BACKGROUND Persistent atrial fibrillation has been indicated to be related with microRNA-28b. However, the exact role of microRNA-28b in persistent atrial fibrillation needs to be further elucidated. Therefore, this study aimed to establish a rat model of persistent atrial fibrillation to investigate the level of microRNA-28b in atrial myocytes and to explore the molecular mechanism involved. MATERIAL AND METHODS A persistent atrial fibrillation model was established in rats by using chronic rapid atrial pacing induction...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27572150/novel-protective-role-for-ubiquitin-specific-protease-18-in-pathological-cardiac-remodeling
#5
Xiaoying Ying, Yichao Zhao, Tianbao Yao, Ancai Yuan, Longwei Xu, Lingchen Gao, Song Ding, Hongyi Ding, Jun Pu, Ben He
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 is expressed in heart, the role of USP18 in the heart and in cardiac diseases remains unknown. Here, we show that USP18 expression is elevated in both human dilated hearts and hypertrophic murine models. Cardiomyocyte-specific overexpression of USP18 in mice significantly blunted cardiac remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, and preserved ejection function, whereas USP18-deficient mice displayed exacerbated cardiac remodeling under the same pathological stimuli...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27563459/cellular-and-molecular-pathology-of-age-related-macular-degeneration-potential-role-for-proteoglycans
#6
REVIEW
Othman Al Gwairi, Lyna Thach, Wenhua Zheng, Narin Osman, Peter J Little
Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of central vision with retained peripheral vision but eventual blindness occurs in many cases. The initiation site of AMD development is Bruch's membrane (BM) where multiple changes occur including the deposition of plasma derived lipids, accumulation of extracellular debris, changes in cell morphology, and viability and the formation of drusen. AMD manifests as early and late stage; the latter involves cell proliferation and neovascularization in wet AMD...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27513640/effect-of-epidural-dexmedetomidine-combined-with-ropivacaine-in-labor-analgesia-a-randomized-double-blinded-controlled-study
#7
Yang Zhao, Yan Xin, Yongbo Liu, Xuanlong Yi, Yingzhi Liu
BACKGROUD: The purpose of our study is to evaluate the effect of adding dexmedetomidine to epidural ropivacaine in patients undergoing labor epidural analgesia. METHODS: Eighty healthy women were randomly assigned to two groups: control group(R; n=40) received epidural 0.125% ropivacaine for labor analgesia, whereas the study group (D; n=40) received epidural 0.125% ropivacaine with dexmedetomidine in addition. The blood pressure, heart rate, and the severity of pain of the parturient was assessed, the duration of the first stage and the second stage of labor time, the rate of instrumental delivery and the rate of cesarean section were recorded...
August 10, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27484819/eutrophication-ammonia-intoxication-and-infectious-diseases-interdisciplinary-factors-of-mass-mortalities-in-cultured-nile-tilapia
#8
Nermeen M Abu-Elala, Reham M Abd-Elsalam, Sherif Marouf, Mohamed Abdelaziz, Mohamed Moustafa
The present study was designed to assess the possible causes of the mass mortalities of Nile Tilapia Oreochromis niloticus at El-Behera Governorate, Egypt, in relationship to environmental and microbiotic factors. Water samples were collected from fish farms at different locations and from Lake Edku to analyze water temperature, water pH, salinity, biological oxygen demand, dissolved oxygen, total ammonia nitrogen, and un-ionized ammonia. A number of moribund and freshly dead fish were sampled and submitted to our laboratory for microbiological, molecular, and histopathological examination...
September 2016: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/27462292/cognitive-emotional-and-psychosocial-functioning-of-girls-treated-with-pharmacological-puberty-blockage-for-idiopathic-central-precocious-puberty
#9
Slawomir Wojniusz, Nina Callens, Stefan Sütterlin, Stein Andersson, Jean De Schepper, Inge Gies, Jesse Vanbesien, Kathleen De Waele, Sara Van Aken, Margarita Craen, Claus Vögele, Martine Cools, Ira R Haraldsen
Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation. CPP is associated with lower adult height and increased risk for development of psychological problems. Standard treatment of CPP is based on postponement of pubertal development by blockade of the HPG axis with gonadotropin releasing hormone analogs (GnRHa) leading to abolition of gonadal sex hormones synthesis. Whereas the hormonal and auxological effects of GnRHa are well-researched, there is a lack of knowledge whether GnRHa treatment influences psychological functioning of treated children, despite the fact that prevention of psychological problems is used as one of the main reasons for treatment initiation...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27405766/dehydrated-basella-alba-fruit-juice-as-a-novel-natural-colorant-pigment-stability-in-vivo-food-safety-evaluation-and-anti-inflammatory-mechanism-characterization
#10
Fu-Long Huang, Robin Y-Y Chiou, Wei-Cheng Chen, Huey-Jiun Ko, Li-Jung Lai, Shu-Mei Lin
Flesh of Basella alba L. mature fruits bearing deep-violet juice provides a novel and potential source of natural colorant. To minimize the pigment purification process and warrant safety acceptability, B. alba colorant powder (BACP) was prepared using mature fruits through a practical batch preparation and subjected to fundamental pigment characterization, food safety assessment and bio-function evaluation. Yield of the dehydrated B. alba colorant powder (BACP) was 37 g/kg fresh fruits. Reconstituted aqueous solution of the BACP exhibited an identical visible spectrum (400-700 nm) as that of fresh juice...
September 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27366871/hypoxia-suppresses-myocardial-survival-pathway-through-hif-1%C3%AE-igfbp-3-dependent-signaling-and-enhances-cardiomyocyte-autophagic-and-apoptotic-effects-mainly-via-foxo3a-induced-bnip3-expression
#11
Chih-Chung Feng, Chien-Chung Lin, Yi-Ping Lai, Tung-Sheng Chen, Shibu Marthandam Asokan, Jing-Ying Lin, Kuan-Ho Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
The HIF-1α transcriptional factor and the BH-3 only protein BNIP3 are known to play fundamental roles in response to hypoxia. The objective of this research is to investigate the molecular mechanisms and the correlation of HIF-1α, BNIP3 and IGFBP-3 in hypoxia-induced cardiomyocytes injuries. Heart-derived H9c2 cells and neonatal rat ventricular myocytes (NRVMs) were incubated in normoxic or hypoxic conditions. Hypoxia increased HIF-1α expression and activated the downstream BNIP3 and IGFBP-3 thereby triggered mitochondria-dependent apoptosis...
August 2016: Growth Factors
https://www.readbyqxmd.com/read/27366565/the-efficacy-of-femoral-block-and-unilateral-spinal-anaesthesia-on-analgesia-haemodynamics-and-mobilization-in-patients-undergoing-endovenous-ablation-in-the-lower-extremity
#12
Tülün Öztürk, Eralp Çevikkalp, Funda Nizamoglu, Alper Özbakkaloğlu, İsmet Topcu
OBJECTIVE: This study aimed to investigate the efficacy of femoral block and unilateral spinal anaesthesia on analgesia, haemodynamics and mobilization during endovenous ablation in patients with lower extremity venous insufficiency. METHODS: Forty patients of ASA physical status I and II, with ages ranging between 30 and 45 years, and who were scheduled for endovenous laser ablation for varicose veins were prospectively enrolled in this study. Patients were randomized into a unilateral spinal anaesthesia group (group HS, n=20) or a femoral block group (group F, n=20)...
April 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27352901/stress-induced-decrease-of-uterine-blood-flow-in-sheep-is-mediated-by-alpha-1-adrenergic-receptors
#13
Michelle Dreiling, Sabine Bischoff, Rene Schiffner, Sven Rupprecht, Michael Kiehntopf, Harald Schubert, Otto W Witte, Peter W Nathanielsz, Matthias Schwab, Florian Rakers
Prenatal maternal stress can be transferred to the fetus via a catecholamine-dependent decrease of uterine blood flow (UBF). However, it is unclear which group of adrenergic receptors mediates this mechanism of maternal-fetal stress transfer. We hypothesized that in sheep, alpha 1-adrenergic receptors may play a key role in catecholamine mediated UBF decrease, as these receptors are mainly involved in peripheral vasoconstriction and are present in significant number in the uterine vasculature. After chronic instrumentation at 125 ± 1 days of gestation (dGA; term 150 dGA), nine pregnant sheep were exposed at 130 ± 1 dGA to acute isolation stress for one hour without visual, tactile, or auditory contact with their flockmates...
September 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27298797/aortic-root-translocation-with-arterial-switch-for-transposition-of-the-great-arteries-or-double-outlet-right-ventricle-with-ventricular-septal-defect-and-pulmonary-stenosis
#14
Han Pil Lee, Ji Hyun Bang, Jae-Suk Baek, Hyun Woo Goo, Jeong-Jun Park, Young Hwee Kim
Double outlet right ventricle (DORV) and transposition of the great arteries (TGA) with ventricular septal defect (VSD) and pulmonary stenosis (PS) are complex heart diseases, the treatment of which remains a surgical challenge. The Rastelli procedure is still the most commonly performed treatment. Aortic root translocation including an arterial switch operation is advantageous anatomically since it has a lower possibility of conduit blockage and the left ventricle outflow tract remains straight. This study reports successful aortic root transpositions in two patients, one with DORV with VSD and PS and one with TGA with VSD and PS...
June 2016: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27270942/role-of-%C3%AE-adrenoceptors-and-l-type-ca-2-channels-in-the-mechanism-of-reperfusion-induced-heart-injury
#15
Yu B Lishmanov, L N Maslov, A V Mukhomedzyanov
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca(2+)-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca(2+)-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca(2+)-channels prevents reoxygenation-induced myocardial injury...
May 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27270216/cinnamaldehyde-and-allopurinol-reduce-fructose-induced-cardiac-inflammation-and-fibrosis-by-attenuating-cd36-mediated-tlr4-6-irak4-1-signaling-to-suppress-nlrp3-inflammasome-activation
#16
Lin-Lin Kang, Dong-Mei Zhang, Chun-Hua Ma, Jian-Hua Zhang, Ke-Ke Jia, Jia-Hui Liu, Rong Wang, Ling-Dong Kong
Fructose consumption induces metabolic syndrome to increase cardiovascular disease risk. Cinnamaldehyde and allopurinol possess anti-oxidative and anti-inflammatory activity to relieve heart injury in metabolic syndrome. But the mechanisms of fructose-induced cardiac injury, and cardioprotective effects of cinnamaldehyde and allopurinol are not completely understood. In this study, fructose-fed rats displayed metabolic syndrome with elevated serum ox-LDL, cardiac oxidative stress, inflammation and fibrosis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27226520/monocyte-exosomes-induce-adhesion-molecules-and-cytokines-via-activation-of-nf-%C3%AE%C2%BAb-in-endothelial-cells
#17
Norina Tang, Bing Sun, Archana Gupta, Hans Rempel, Lynn Pulliam
HIV-infected individuals have activated monocytes with an IFNα phenotype and elevated levels of circulating LPS. These individuals also have a risk of premature cardiovascular disease. The effect of activated monocyte exosomes (Exos) on endothelial cells is unknown. To determine whether Exos from immune-activated monocytes could alter endothelial cell expression and contribute to monocyte/macrophage transmigration and adhesion, we isolated Exos from monocytes stimulated with IFNα, LPS, or both (I/L). We show that monocyte Exos contain different inflammatory microRNA cargo depending on stimulation...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27157625/successful-manual-aspiration-thrombectomy-in%C3%A2-a%C3%A2-pediatric-patient
#18
Gregory M Weiner, Rafey A Feroze, Nitin Agarwal, David M Panczykowski, William J Ares, Ali Kooshkabadi, Dana D Cummings, Vincent Carson, Amin Aghaebrahim, Brian T Jankowitz
BACKGROUND: Timely recognition of stroke at major pediatric medical centers is improving, and although treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment in the absence of adequate information regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement after endovascular retrieval therapy in adults with acute large vessel occlusive stroke...
August 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27146519/mortality-and-pathology-in-birds-due-to-plasmodium-giovannolaia-homocircumflexum-infection-with-emphasis-on-the-exoerythrocytic-development-of-avian-malaria-parasites
#19
Mikas Ilgūnas, Dovilė Bukauskaitė, Vaidas Palinauskas, Tatjana A Iezhova, Nora Dinhopl, Nora Nedorost, Christiane Weissenbacher-Lang, Herbert Weissenböck, Gediminas Valkiūnas
BACKGROUND: Species of avian malaria parasites (Plasmodium) are widespread, but their virulence has been insufficiently investigated, particularly in wild birds. During avian malaria, several cycles of tissue merogony occur, and many Plasmodium spp. produce secondary exoerythrocytic meronts (phanerozoites), which are induced by merozoites developing in erythrocytic meronts. Phanerozoites markedly damage organs, but remain insufficiently investigated in the majority of described Plasmodium spp...
May 4, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27134474/risk-factors-of-transient-ischemic-attack-an-overview
#20
REVIEW
Supreet Khare
Transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused due to loss of blood flow to the brain or spinal cord without acute infarction. Depending on the area of the brain involved, symptoms of TIA vary widely from patient to patient. Since the blockage period in TIA is very short-lived, there is no permanent damage. Risk factors for TIA include family history of stroke or TIA, age above 55 years or older, higher risk of TIA in males than females, high blood pressure, diabetes mellitus, and tobacco smoking...
January 2016: Journal of Mid-life Health
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