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Cognitive function

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https://www.readbyqxmd.com/read/29169021/is-interference-control-in-children-with-specific-language-impairment-similar-to-that-of-children-with-autistic-spectrum-disorder
#1
Klara Marton, Zsuzsanna Kovi, Tímea Egri
AIMS: The purpose of the study was to examine resistance to proactive interference, which is strongly associated with working memory (WM) performance and language processing, in children with specific language impairment (SLI), with autism spectrum disorder (ASD), and with typical development (TD). METHODS: Sixty children (eight to ten years; matched in age and nonverbal IQ) participated in the study. Resistance to proactive interference was measured using a verbal conflict paradigm...
November 20, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29168883/prevalence-of-frailty-and-associated-factors-in-the-community-dwelling-population-of-china
#2
Lina Ma, Zhe Tang, Li Zhang, Fei Sun, Yun Li, Piu Chan
BACKGROUND/OBJECTIVES: Frailty in older adults predicts dependence and mortality and is a major challenge for healthcare systems in countries with rapidly aging populations. Little is known about frailty in China. We investigated the prevalence and associated risk factors of frailty in older adults in China. DESIGN: Cross-sectional. SETTING: Data were obtained from the China Comprehensive Geriatric Assessment Study, conducted in 2011-12, which was the first uniform comprehensive assessment system adopted in China...
November 23, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29168792/zinc-signal-in-brain-diseases
#3
REVIEW
Stuart D Portbury, Paul A Adlard
The divalent cation zinc is an integral requirement for optimal cellular processes, whereby it contributes to the function of over 300 enzymes, regulates intracellular signal transduction, and contributes to efficient synaptic transmission in the central nervous system. Given the critical role of zinc in a breadth of cellular processes, its cellular distribution and local tissue level concentrations remain tightly regulated via a series of proteins, primarily including zinc transporter and zinc import proteins...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168741/dose-dependent-effects-of-oral-tyrosine-administration-on-plasma-tyrosine-levels-and-cognition-in-aging
#4
Ondine van de Rest, Mirjam Bloemendaal, Rianne de Heus, Esther Aarts
The effects of tyrosine on plasma response and cognition in aging are unknown. We assessed the dose-dependent response to tyrosine administration in older adults in both plasma tyrosine concentrations and working memory performance. In this double blind randomized cross-over trial 17 older adults (aged 60-75 years) received a single administration of 100, 150, or 200 mg/kg body weight of tyrosine. For comparison, 17 young adults (aged 18-35 years) received a dose of 150 mg/kg body weight of tyrosine. Tyrosine plasma concentrations were determined before and 90, 120, 150, 180, 210, and 240 min after tyrosine intake...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168603/eye-gaze-perception-in-bipolar-disorder-self-referential-bias-but-intact-perceptual-sensitivity
#5
Beier Yao, Savanna A Mueller, Tyler B Grove, Merranda McLaughlin, Katharine Thakkar, Vicki Ellingrod, Melvin G McInnis, Stephan F Taylor, Patricia J Deldin, Ivy F Tso
OBJECTIVES: Deficits in social cognition predict poor functional outcome in severe mental illnesses such as schizophrenia and autism. However, research findings on social cognition in bipolar disorder (BD) are sparse and inconsistent. This study aimed to characterize a critical social cognitive process-eye gaze perception-and examine its functional correlates in BD to inform psychopathological mechanisms. METHODS: Thirty participants with BD, 37 healthy controls (HC), and 46 psychiatric controls with schizophrenia (SZ) completed an eye-contact perception task...
November 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29168555/skeletal-open-bite-treatment-with-zygomatic-anchorage-for-a-child-with-mental-retardation-a-new-modality
#6
Y Rajmohan Shetty, Anisha Keshan, Amitha M Hegde, Manju R, Ashutosh Shetty
Anterior open bite (AOB) is one of the most difficult malocclusions to treat and maintain in orthodontics. Malocclusion occurs more frequently in children with disabilities than in healthy children. Surgical correction of severe AOB often requires maxillary impaction to reduce the anterior facial height. The zygomatic buttress area could be a valuable anchorage site to achieve intrusion of maxillary posterior teeth. A 16-year-old boy with mental retardation showing signs of persistence of infantile behavior, decreased cognitive functioning, and psychomotor skill deficits (no identified syndrome) with an AOB was treated by intrusion of maxillary posterior teeth using I-shaped multipurpose titanium miniplate (SK Surgicals, India)...
November 23, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29168451/intraindividual-cognitive-variability-an-examination-of-anam4-tbi-mil-simple-reaction-time-data-from-service-members-with-and-without-mild-traumatic-brain-injury
#7
Wesley R Cole, Emma Gregory, Jacques P Arrieux, F Jay Haran
OBJECTIVES: The Automated Neuropsychological Assessment Metrics 4 TBI-MIL (ANAM4) is a computerized cognitive test often used in post-concussion assessments with U.S. service members (SMs). However, existing evidence remains mixed regarding ANAM4's ability to identify cognitive issues following mild traumatic brain injury (mTBI). Studies typically examine ANAM4 using standardized scores and/ or comparisons to a baseline. A more fine-grained approach involves examining inconsistency within an individual's performance (i...
November 23, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29168225/gaba-modulating-phytomedicines-for-anxiety-a-systematic-review-of-preclinical-and-clinical-evidence
#8
REVIEW
Karen Savage, Joseph Firth, Con Stough, Jerome Sarris
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168169/response-to-clobazam-in-continuous-spike-wave-during-sleep
#9
Clemente Vega, Ivan Sánchez Fernández, Jurriaan Peters, Maria S Thome-Souza, Michele Jackson, Masanori Takeoka, Greta N Wilkening, Phillip L Pearl, Kevin Chapman, Tobias Loddenkemper
AIM: To evaluate the efficacy of clobazam treatment in reducing epileptiform discharges and modifying neuropsychological function in continuous spike-wave during slow wave sleep. METHOD: We performed a prospective clinical trial in patients with continuous spike-wave during sleep aged 4 to 10 years. Patients underwent neuropsychological assessment and overnight electroencephalographic monitoring before treatment, and subsequent repeat assessment and overnight electroencephalographic monitoring 3 months after treatment...
November 23, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29168082/a-pilot-study-of-neuropsychological-functions-apoe-and-amyloid-imaging-in-patients-with-gliomas
#10
D D Correa, M Kryza-Lacombe, X Zhou, R E Baser, B J Beattie, Z Beiene, J Humm, L M DeAngelis, I Orlow, W Weber, J Osborne
Brain tumor patients treated with radiotherapy (RT) often develop cognitive dysfunction, and recent studies suggest that the APOE ε-4 allele may influence cognitive outcome. The ε-4 allele is known to promote beta (β) amyloid deposition in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation contributes to treatment neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using (18)F-florbetaben (FBB) PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions...
November 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29168052/change-in-health-related-quality-of-life-and-social-cognitive-outcomes-in-obese-older-adults-in-a-randomized-controlled-weight-loss-trial-does-physical-activity-behavior-matter
#11
Jason Fanning, Michael P Walkup, Walter T Ambrosius, Lawrence R Brawley, Edward H Ip, Anthony P Marsh, W Jack Rejeski
This article compared the effect of dietary weight loss administered alone (WL) or in combination with aerobic training (WL + AT) or resistance training (WL + RT) on health related quality of life, walking self-efficacy, stair climb self-efficacy, and satisfaction with physical function in older adults with cardiovascular disease or the metabolic syndrome. Participants (N = 249; M age = 66.9) engaged in baseline assessments and were randomly assigned to one of three interventions, each including a 6-month intensive phase and a 12-month follow-up...
November 22, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29167904/prevalence-characteristics-and-treatment-patterns-of-hearing-difficulty-in-the-united-states
#12
Hossein Mahboubi, Harrison W Lin, Neil Bhattacharyya
Importance: Hearing loss is one of the most prevalent chronic conditions in the United States and has been associated with negative physical, social, cognitive, economic, and emotional consequences. Despite the high prevalence of hearing loss, substantial gaps in the utilization of amplification options, including hearing aids and cochlear implants (CI), have been identified. Objective: To investigate the contemporary prevalence, characteristics, and patterns of specialty referral, evaluation, and treatment of hearing difficulty among adults in the United States...
November 22, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29167901/association-of-neurocognitive-deficits-with-radiotherapy-or-chemoradiotherapy-for-patients-with-head-and-neck-cancer
#13
Alona Zer, Gregory R Pond, Albiruni R Abdul Razak, Kattleya Tirona, Hui K Gan, Eric X Chen, Brian O'Sullivan, John Waldron, David P Goldstein, Ilan Weinreb, Andrew J Hope, John J Kim, Kelvin K W Chan, Andrew K Chan, Lillian L Siu, Lori J Bernstein
Importance: Neurocognitive deficits (NCD) have been observed in noncentral nervous system cancers, yet short- and long-term neurocognitive data on patients treated for head and neck cancer (HNC) are lacking. Objective: To assess objective neurocognitive function before and after definitive radiation therapy for HNC. Design, Setting, and Participants: In a prospective, longitudinal study, neurocognitive function and self-reported symptoms were assessed in 80 patients with histologically proven HNC requiring definitive chemoradiotherapy or radiotherapy and in 40 healthy controls 4 times (baseline, 6, 12, and 24 months after baseline) prior to commencing treatment at Princess Margaret Cancer Centre, Toronto, Canada...
November 22, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29167833/disorder-specific-and-shared-brain-abnormalities-during-vigilance-in-autism-and-obsessive-compulsive-disorder
#14
Christina O Carlisi, Luke Norman, Clodagh M Murphy, Anastasia Christakou, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, Declan G Murphy, David Mataix-Cols, Katya Rubia
Background: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are often comorbid and share similarities across some cognitive phenotypes, including certain aspects of attention. However, no functional magnetic resonance imaging studies have compared the underlying neural mechanisms contributing to these shared phenotypes. Methods: Age- and IQ-matched boys (11-17 years old) with ASD (n = 20), boys with OCD (n = 20), and healthy control boys (n = 20) performed a parametrically modulated psychomotor vigilance functional magnetic resonance imaging task...
November 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29167810/the-pre-parasubiculum-a-hippocampal-hub-for-scene-based-cognition
#15
REVIEW
Marshall A Dalton, Eleanor A Maguire
Internal representations of the world in the form of spatially coherent scenes have been linked with cognitive functions including episodic memory, navigation and imagining the future. In human neuroimaging studies, a specific hippocampal subregion, the pre/parasubiculum, is consistently engaged during scene-based cognition. Here we review recent evidence to consider why this might be the case. We note that the pre/parasubiculum is a primary target of the parieto-medial temporal processing pathway, it receives integrated information from foveal and peripheral visual inputs and it is contiguous with the retrosplenial cortex...
October 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29167722/behavioral-cognitive-and-neural-markers-of-asperger-syndrome
#16
REVIEW
Farnaz Faridi, Reza Khosrowabadi
Asperger syndrome (AS) is a subtype of Autism Spectrum Disorder (ASD) characterized by major problems in social and nonverbal communication, together with limited and repetitive forms of behavior and interests. The linguistic and cognitive development in AS is preserved which help us to differentiate it from other subtypes of ASD. However, significant effects of AS on cognitive abilities and brain functions still need to be researched. Although a clear cut pathology for Asperger has not been identified yet, recent studies have largely focused on brain imaging techniques to investigate AS...
September 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29167670/the-cholinergic-system-modulates-memory-and-hippocampal-plasticity-via-its-interactions-with-non-neuronal-cells
#17
REVIEW
Sara V Maurer, Christina L Williams
Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially in Alzheimer's disease. Much of the evidence surrounding cholinergic impacts on the neuroimmune system focuses on the α7 nicotinic acetylcholine (ACh) receptor, as stimulation of this receptor prevents many of the effects of immune activation. Microglia and astrocytes both express this receptor, so it is possible that some cholinergic effects may be via these non-neuronal cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29167639/disrupted-thalamus-white-matter-anatomy-and-posterior-default-mode-network-effective-connectivity-in-amnestic-mild-cognitive-impairment
#18
Thomas Alderson, Elizabeth Kehoe, Liam Maguire, Dervla Farrell, Brian Lawlor, Rose A Kenny, Declan Lyons, Arun L W Bokde, Damien Coyle
Alzheimer's disease (AD) and its prodromal state amnestic mild cognitive impairment (aMCI) are characterized by widespread abnormalities in inter-areal white matter fiber pathways and parallel disruption of default mode network (DMN) resting state functional and effective connectivity. In healthy subjects, DMN and task positive network interaction are modulated by the thalamus suggesting that abnormal task-based DMN deactivation in aMCI may be a consequence of impaired thalamo-cortical white matter circuitry...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29167591/identifying-hiv-associated-neurocognitive-disorder-using-large-scale-granger-causality-analysis-on-resting-state-functional-mri
#19
Adora M DSouza, Anas Z Abidin, Lutz Leistritz, Axel Wismüller
We investigate the applicability of large-scale Granger Causality (lsGC) for extracting a measure of multivariate information flow between pairs of regional brain activities from resting-state functional MRI (fMRI) and test the effectiveness of these measures for predicting a disease state. Such pairwise multivariate measures of interaction provide high-dimensional representations of connectivity profiles for each subject and are used in a machine learning task to distinguish between healthy controls and individuals presenting with symptoms of HIV Associated Neurocognitive Disorder (HAND)...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29167525/lineage-divergence-of-activity-driven-transcription-and-evolution-of-cognitive-ability
#20
REVIEW
Giles E Hardingham, Priit Pruunsild, Michael E Greenberg, Hilmar Bading
Excitation-transcription coupling shapes network formation during brain development and controls neuronal survival, synaptic function and cognitive skills in the adult. New studies have uncovered differences in the transcriptional responses to synaptic activity between humans and mice. These differences are caused both by the emergence of lineage-specific activity-regulated genes and by the acquisition of signal-responsive DNA elements in gene regulatory regions that determine whether a gene can be transcriptionally induced by synaptic activity or alter the extent of its inducibility...
November 23, 2017: Nature Reviews. Neuroscience
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