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https://www.readbyqxmd.com/read/28103460/-pneumocystis-pneumonia-in-107-hiv-infected-patients-admitted-to-the-department-of-infectious-diseases-at-santa-maria-hospital-lisbon-2002-2013
#1
Vilma Grilo, Aida Pereira
INTRODUCTION: Pneumocystis jirovecii pneumonia remains one of the most common opportunistic illnesses in patients infected with the human immunodeficiency virus. It is currently the most reported AIDS-defining infection in Portugal. The aims of this study were to analyze the features of a human immunodeficiency virus /Pneumocystis jirovecii pneumonia coinfected population, to compare it with the current literature, and to evaluate comparatively subpopulations of patients based on the previous knowledge of the human immunodeficiency virus infection, Pneumocystis jirovecii pneumonia diagnostic method and discharge results...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28102932/antileukemic-action-of-novel-diamine-pt-ii-halogenido-complexes-comparison-of-the-representative-novel-pt-ii-with-corresponding-pt-iv-complex
#2
Sonja Misirlić Denčić, Jelena Poljarević, Andjelka M Isakovic, Ivanka Marković, Tibor J Sabo, Sanja Grgurić-Šipka
This study presents the synthesis, characterization and antitumor action of five new Pt(II) halogenido, chlorido and iodido, complexes with edda type of ligands. (S,S)-ethylendiamine-N,N'-di-2-(3-cyclohexyl)propanoic acid dihydrochloride and its methyl, ethyl and n-propyl esters, were prepared according to the previously reported procedure. All investigated complexes were characterized by IR, ESI-MS, ((1) H, (13) C and HMBC) NMR spectroscopy and elemental analysis. Their cytotoxic action was investigated in four human tumor cell lines: promyelocytic (HL-60) and lymphocytic (REH) leukemia, glioma (U251) and lung carcinoma (H460)...
January 19, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28101628/rho-kinase-inhibitor-fasudil-mitigates-high-cholesterol-diet-induced-hypercholesterolemia-and-vascular-damage
#3
Nibrass Taher Abdali, Awny H Yaseen, Eman Said, Tarek M Ibrahim
The current study was designed to investigate the potential beneficial therapeutic outcome of Rho kinase inhibitor (fasudil) against hypercholesterolemia-induced myocardial and vascular injury in rabbits together with diet modification. Sixteen male rabbits were randomly divided into four groups: normal control group which received standard rabbit chow, hypercholesterolemic control group, and treated groups which received cholesterol-rich rabbit chow (1.5% cholesterol) for 8 weeks. Treated groups received either fasudil (100 mg/kg/day) or rosuvastatin (2...
January 18, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28101469/concurrent-inflammation-augments-antimalarial-drugs-induced-liver-injury-in-rats
#4
Hossein Niknahad, Reza Heidari, Roya Firuzi, Farzaneh Abazari, Maral Ramezani, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi, Arastoo Saeedi
Purpose: Accumulating evidence suggests that drug exposure during a modest inflammation induced by bacterial lipopolysaccharide (LPS) might increase the risk of drug-induced liver injury. The current investigation was designed to test if antimalarial drugs hepatotoxicity is augmented in LPS‑treated animals. Methods: Rats were pre-treated with LPS (100 µg/kg, i.p). Afterward, non-hepatotoxic doses of amodiaquine (25, 50 and 100 mg/kg, oral) and chloroquine (25, 50 and 100 mg/kg, oral) were administered. Results: Interestingly, liver injury was evident only in animals treated with both drug and LPS as estimated by pathological changes in serum biochemistry (ALT, AST, LDH, and TNF-α), and liver tissue (severe hepatitis, endotheliitis, and sinusoidal congestion)...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28101235/protective-effect-of-selenium-against-cisplatin-induced-nasopharyngeal-cancer-in-male-albino-rats
#5
Kan Zhu, Lei Jiang, Yun Chu, Yong-Sheng Zhang
The present study evaluated the protective effect of selenium against cisplatin-induced nasopharyngeal cancer in the cardiac tissue of adult rats. Male Wistar rats were divided into 4 groups of 6 rats each. Different combinations of selenium and cisplatin were administered for 45 days, following which the animals were sacrificed and the nasopharyngeal tissue was surgically removed. Lipid peroxidation, reduced glutathione, and the antioxidant enzymes superoxide dismutase (SOD), catalase and lactate dehydrogenase (LDH) were measured...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101129/a-traditional-poly-herbal-medicine-le-pana-guliya-induces-apoptosis-in-hepg2-and-hela-cells-but-not-in-cc1-cells-an-in-vitro-assessment
#6
Nekadage Don Amal Wageesha, Preethi Soysa, Keerthi Atthanayake, Muhammad Iqbal Choudhary, Mahinda Ekanayake
"Le Pana Guliya" (LPG) is a polyherbal formulation which is used to treat different types of cancers in traditional medicine. In this study we describe in vitro efficacy and mechanism of action of LPG on two cancer cell lines (HepG2 and HeLa) compared with a normal cell line CC1. The MTT, LDH assays and protein synthesis were used to study antiproliferative activity of LPG while NO synthesis and GSH content were assayed to determine the oxidative stress exerted by LPG. Rhodamine 123 staining, caspase 3 activity, DNA fragmentation and microscopic examination of cells stained with ethidium bromide/acridine orange were used to identify the apoptosis mechanisms associated with LPG...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28100899/effectiveness-of-computed-tomography-attenuation-values-in-characterization-of-pericardial-effusion
#7
Mehmet Serkan Çetin, Elif Hande Özcan Çetin, Mustafa Özdemir, Serkan Topaloğlu, Dursun Aras, Ahmet Temizhan, Sinan Aydoğdu
OBJECTIVE: The aim of this study was to evaluate the effectiveness of computed tomography (CT) attenuation values in the characterization of pericardial effusion. METHODS: This study consisted of 96 patients with pericardial effusion who underwent pericardiocentesis. For further diagnostic evaluation of pericardial effusion, all the patients were assessed by thorax CT. CT attenuation values were measured from at least 5 different areas of pericardial fluid by specifying the largest region of interest...
January 17, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28100897/x-indening-oral-liquid-improves-cardiac-function-of-rats-with-chronic-cardiac-failure-via-tgf-%C3%A3-1-smad3-and-p38-mapk-pathway
#8
Yunliang Wei, Changsheng Guo, Jingsheng Zhao, Jun Yang, Weiguo Yi, Hong Liu, Xinwei Lin, Zhengchen Zhang
OBJECTIVE: Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved. METHODS: Transverse aortic constriction (TAC) was conducted to induce a CHF rat model in this study. Sixty male Wistar rats were randomly assigned to six groups 28 days after TAC: sham; CHF model; Xin at concentrations of 5 ml/kg, 10 mL/kg, and 20 mL/kg; and QiLi 0...
January 17, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28100842/prognostic-value-of-thymidine-kinase-activity-in-patients-with-chronic-lymphocytic-leukemia
#9
Piotr Stelmach, Jerzy Z Błoński
Thymidine kinase (TK) activity is a marker of biological activity that allows the indolent and aggressive forms of chronic lymphocytic leukemia (CLL) to be distinguished. The aims of the study were to determine the relationship between TK activity and clinical status and prognosis, as well as to compare its activity with that of other prognostic and predictive factors. TK activity was measured in patient sera at the time of diagnosis using the DiviTum method, with the mean value being 439 Du/L. A correlation was found between TK activity and risk of disease progression (p=0...
December 30, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28099768/effects-of-metmyoglobin-reducing-activity-and-thermal-stability-of-nadh-dependent-reductase-and-lactate-dehydrogenase-on-premature-browning-in-ground-beef
#10
Blanchefort A Djimsa, Anupam Abraham, Gretchen G Mafi, Deborah L VanOverbeke, Ranjith Ramanathan
Premature browning is a condition wherein ground beef exhibits a well-done appearance before reaching the USDA recommended internal cooked meat temperature of 71.1 °C; however, the mechanism is unclear. The objectives of this study were: (1) to determine the effects of packaging and temperature on metmyoglobin reducing activity (MRA) of cooked ground beef patties and (2) to assess the effects of temperature and pH on thermal stability of NADH-dependent reductase, lactate dehydrogenase (LDH), and oxymyoglobin (OxyMb) in-vitro...
January 18, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28099529/a-possible-role-of-the-full-length-nascent-protein-in-post-translational-ribosome-recycling
#11
Debasis Das, Dibyendu Samanta, Arpita Bhattacharya, Arunima Basu, Anindita Das, Jaydip Ghosh, Abhijit Chakrabarti, Chanchal Das Gupta
Each cycle of translation initiation in bacterial cell requires free 50S and 30S ribosomal subunits originating from the post-translational dissociation of 70S ribosome from the previous cycle. Literature shows stable dissociation of 70S from model post-termination complexes by the concerted action of Ribosome Recycling Factor (RRF) and Elongation Factor G (EF-G) that interact with the rRNA bridge B2a/B2b joining 50S to 30S. In such experimental models, the role of full-length nascent protein was never considered seriously...
2017: PloS One
https://www.readbyqxmd.com/read/28099399/the-association-of-serum-25-hydroxyvitamin-d-with-biomarkers-of-hemolysis-in-pediatric-patients-with-sickle-cell-disease
#12
Samuel A Adegoke, Josefina A P Braga, Adekunle D Adekile, Maria S Figueiredo
Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017; r=0.45, P=0.006, respectively); inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0...
January 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28098967/synthesis-of-fluorinated-graphene-coal-layered-double-hydroxide-composites-as-electrode-materials-for-supercapacitors
#13
Weijun Peng, Hongqiang Li, Shaoxian Song
CoAl-layered double hydroxide/fluorinated graphene (CoAl-LDH/FGN) composites were fabricated via a two-step hydrothermal method. The synthesized CoAl-LDH/FGN composites have been characterised by Powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Transmission electron microscopy (TEM), Field-emission scanning electron microscopy (FESEM) and Energy dispersive X-ray spectroscopy (EDS), and Electrochemical measurements. The results indicated that the fluorinated carbon with various configuration forms were grafted onto the framework of graphene, and the C-F bond configuration and fluorine content could be tuned by the fluorination time...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28097245/consideration-of-proper-operative-route-for-interlaminar-approach-for-percutaneous-endoscopic-lumbar-discectomy
#14
Juichi Tonosu, Yasushi Oshima, Ryutaro Shiboi, Akihiko Hayashi, Yuichi Takano, Hirohiko Inanami, Hisashi Koga
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) is one of the less invasive treatments of lumbar disc herniation (LDH), and has three different operative approaches. This study focused on the interlaminar approach (ILA) and investigated the appropriate operative route for this approach. METHODS: ILA was performed in 41 patients with LDH. The width of the interlaminar space, LDH size, and positional relation between LDH and the corresponding nerve root were radiologically evaluated...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28096493/combining-standard-clinical-blood-values-for-improving-survival-prediction-in-patients-with-newly-diagnosed-brain-metastases-development-and-validation-of-the-labbm-score
#15
Anna S Berghoff, Fabian Wolpert, Tim Holland-Letz, Romina Koller, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Rupert Bartsch, Christoph C Zielinski, Michael Weller, Matthias Preusser
BACKGROUND: We aimed to investigate the potential of standard hematologic and serum biochemical parameters to provide an independent and substantial contribution to the prediction of survival in patients with newly diagnosed brain metastases (BM). METHODS: Hemoglobin, white blood cell count, platelet count, serum albumin, creatinine, lactate dehydrogenase (LDH), and C-reactive protein (CRP) were assessed at diagnosis of BM in a discovery cohort of 1200 cancer patients...
January 17, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28093478/long-non-coding-rna-malat1-regulates-cerebrovascular-pathologies-in-ischemic-stroke
#16
Xuejing Zhang, Xuelian Tang, Kai Liu, Milton H Hamblin, Ke-Jie Yin
: The study is designed to determine the role of long non-coding RNA (lncRNA), metastasis associated lung adenocarcinoma transcript 1 (Malat1), in ischemic stroke outcome. Primary mouse brain microvascular endothelial cells (BMECs) were cultured and treated with Malat1 GapmeR prior to 16h oxygen and glucose depravation (OGD). Cell death was assayed by LDH and MTT methods. Malat1 knockout and wildtype mice were subjected to 1h of middle cerebral artery occlusion (MCAO) and 24-72h of reperfusion...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28093198/mild-hypothermia-pretreatment-protects-hepatocytes-against-ischemia-reperfusion-injury-via-down-regulating-mir-122-and-igf-1r-akt-pathway
#17
Qi Xiao, Qi-Fa Ye, Wei Wang, Bi-Qi Fu, Zhi-Ping Xia, Zhong-Zhong Liu, Xing-Jian Zhang, Yan-Feng Wang
BACKGROUND: Mild hypothermia has been well known as an effective way to reduce ischemia reperfusion injury (IRI), while the mechanisms are still unclear. More and more evidences have indicated that miRNAs should been involved in the regulation of IRI and expecially some miRNAs have shown temp-responsiveness for temperature variation. Therefore, the role of miR-122 in mild hypothermia pretreatment after IRI was investigated. METHODS: We established a LO2 cell anoxia-reoxygenation injury model to simulate liver IRI...
January 13, 2017: Cryobiology
https://www.readbyqxmd.com/read/28092839/effect-and-mechanism-of-sorbus-pohuashanensis-hante-hedl-flavonoids-protect-against-arsenic-trioxide-induced-cardiotoxicity
#18
Xiaojin Yu, Zhenyu Wang, Zunpeng Shu, Zhengqing Li, Yuan Ning, Keli Yun, Haina Bai, Ruihai Liu, Wenli Liu
The cardiotoxicity of arsenic trioxide (ATO) limits its clinical application in cancer treatment. Evidences suggest that sorbus has antioxidant activity and its consumption has been linked with improved cardioprotection. In this study, we investigated the cardio-protective effect and mechanisms of Sorbus pohuashanensis (Hante) Hedl. flavonoids (SPF) against ATO in BALB/c mice and H9c2 cells. Eleven major flavonoids were confirmed by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-Q-TOF-MS)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28091818/lumbar-microdiscectomy-for-sciatica-in-adolescents-a-multicentre-observational-registry-based-study
#19
Sasha Gulati, Mattis A Madsbu, Tore K Solberg, Andreas Sørlie, Charalampis Giannadakis, Marius K Skram, Øystein P Nygaard, Asgeir S Jakola
BACKGROUND: Lumbar disc herniation (LDH) is rare in the adolescent population. Factors predisposing to LDH in adolescents differ from adults with more cases being related to trauma or structural malformations. Further, there are limited data on patient-reported outcomes after lumbar microdiscectomy in adolescents. Our aim was to compare clinical outcomes at 1 year following single-level lumbar microdiscectomy in adolescents (13-19 years old) compared to younger adults (20-50 years old) with LDH...
January 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28091737/impact-of-pelvic-fractures-on-the-early-clinical-outcomes-of-severely-injured-trauma-patients
#20
K Almahmoud, R Pfeifer, K Al-Kofahi, A Hmedat, W Hyderabad, F Hildebrand, A B Peitzman, H-C Pape
BACKGROUND: Pelvic fractures contribute to morbidity and mortality following injury. We sought to study the impact of pelvic fractures on the clinical course and outcomes of trauma patients with a pelvic fracture in comparison to patients with similar injury severity without pelvic fracture to identify potential parameters to track patients' clinical course post-injury. METHODS: A cohort of 206 consecutive blunt trauma survivors, studied over a 5-year period in a level I trauma center of which 75 patients (36...
January 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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