keyword
https://read.qxmd.com/read/38520136/comparisons-of-financial-hardship-in-cancer-care-by-family-structure-and-among-those-with-and-without-minor-children-using-nationally-representative-data
#21
JOURNAL ARTICLE
Patricia I Jewett, Himal Purani, Rachel I Vogel, Helen M Parsons, Maria Borrero, Anne Blaes
INTRODUCTION: While demographic risk factors of cancer-related financial hardships have been studied, having minor children or being single have rarely been assessed in the context of healthcare-related financial hardships. METHODS: Using data from the 2015 to 2018 National Health Interview Survey, we assessed financial hardship (material and psychological hardship; behavioral coping due to costs: delaying/foregoing care, reducing prescription costs, or skipping specialists or follow-up care) among adults aged 18-59 years with cancer (N = 2844) by minor child parenting status and family structure...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38519674/medication-related-osteonecrosis-of-the-jaw-in-a-paediatric-patient-taking-denosumab-a-case-report
#22
REVIEW
Dominic Innes-Taylor, Vicky Adams
Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive and anti-angiogenic therapies in adults. Increasingly, these drugs are being prescribed for children with a variety of conditions, such as osteogenesis imperfecta and cancers of the bone. Review of the literature, however, reveals no reported paediatric MRONJ cases to date. We present such a case in a nine-year-old female patient with a vertebral aneurysmal bone cyst, who received dental extractions subsequent to denosumab therapy...
March 2024: British Dental Journal
https://read.qxmd.com/read/38519388/female-fertility-cryopreservation-outcomes-in-childhood-cancer-a-systematic-review
#23
REVIEW
Srinithya R Gillipelli, Luca Pio, Paul D Losty, Abdelhafeez H Abdelhafeez
BACKGROUND AND AIMS: As survival rates in childhood cancer progress significantly, health outcomes in adulthood are pivotal to quality of life (QoL). Female patients undergoing chemotherapy and radiation for childhood cancer may experience adverse effects such as gonadotoxicity-related ovarian insufficiency. Ovarian tissue cryopreservation (OTC) is well studied in adults, but has only recently started to be explored in an effort to preserve fertility in young patients with childhood cancer...
March 1, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38519054/targeting-pediatric-cancers-via-t-cell-recognition-of-the-monomorphic-mhc-class-i-related-protein-mr1
#24
JOURNAL ARTICLE
Annelisa M Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Ester Dunnebach, Marliek van Hoesel, Thomas A Kluiver, Ana P Lopes, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Denise A M H van den Beemt, Juliane L Buhl, Aimee du Chatinier, Farnaz Barneh, Yuyan Lu, Luca Lo Nigro, Anja Krippner-Heidenreich, Zsolt Sebestyén, Jurgen Kuball, Esther Hulleman, Jarno Drost, Sebastiaan van Heesch, Olaf T Heidenreich, Weng Chuan Peng, Stefan Nierkens
Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds. A subpopulation of atypical, major histocompatibility complex-I related protein 1 (MR1)-restricted T-cells, distinctive from mucosal-associated invariant T-cells (MAITs), was recently identified recognizing currently unidentified MR1-presented cancer-specific metabolites. It is hypothesized that the MC.7.G5 MR1T-clone has potential as a pan-cancer, pan-population T-cell immunotherapy approach...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38519053/targeting-refractory-recurrent-neuroblastoma-and-osteosarcoma-with-anti-cd3%C3%A3-anti-gd2-bispecific-antibody-armed-t-cells
#25
JOURNAL ARTICLE
Maxim Yankelevich, Archana Thakur, Shakeel Modak, Roland Chu, Jeffrey Taub, Alissa Martin, Dana Schalk, Amy Schienshang, Sarah Whitaker, Katie Rea, Daniel W Lee, Qin Liu, Anthony F Shields, Nai-Kong V Cheung, Lawrence G Lum
BACKGROUND: The survival benefit observed in children with neuroblastoma (NB) and minimal residual disease who received treatment with anti-GD2 monoclonal antibodies prompted our investigation into the safety and potential clinical benefits of anti-CD3×anti-GD2 bispecific antibody (GD2Bi) armed T cells (GD2BATs). Preclinical studies demonstrated the high cytotoxicity of GD2BATs against GD2+cell lines, leading to the initiation of a phase I/II study in recurrent/refractory patients...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38518545/advances-in-pediatric-emergency-from-2023
#26
REVIEW
Joshua S Easter, Emily Rose
Most children receive emergency care by general emergency physicians and not in designated children's hospitals. There are unique considerations in the care of children that differ from the care of adults. Many management principles can be extrapolated from adult studies, but the unique pathophysiology of pediatric disease requires specialized attention and management updates. This article highlights ten impactful articles from the year 2023 whose findings can improve the care of children in the Emergency Department (ED)...
March 15, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38517960/childhood-cancer-mutagenesis-caused-by-transposase-derived-pgbd5
#27
JOURNAL ARTICLE
Makiko Yamada, Ross R Keller, Rodrigo Lopez Gutierrez, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Phillip Demarest, N Sumru Bayin, Luz Jubierre Zapater, Casie Reed, Steven Hébert, Ignas Masilionis, Ronan Chaligne, Nicholas D Socci, Michael D Taylor, Claudia L Kleinman, Alexandra L Joyner, G Praveen Raju, Alex Kentsis
Genomic rearrangements are a hallmark of most childhood tumors, including medulloblastoma, one of the most common brain tumors in children, but their causes remain largely unknown. Here, we show that PiggyBac transposable element derived 5 (Pgbd5) promotes tumor development in multiple developmentally accurate mouse models of Sonic Hedgehog (SHH) medulloblastoma. Most Pgbd5-deficient mice do not develop tumors, while maintaining normal cerebellar development. Ectopic activation of SHH signaling is sufficient to enforce cerebellar granule cell progenitor-like cell states, which exhibit Pgbd5-dependent expression of distinct DNA repair and neurodevelopmental factors...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38517077/pancreatic-enzyme-use-reduces-pancreatitis-frequency-in-children-with-acute-recurrent-or-chronic-pancreatitis-a-report-from-insppire
#28
JOURNAL ARTICLE
A Jay Freeman, Kenneth Ng, Fuchenchu Wang, Maisam A Abu-El-Haija, Ankur Chugh, Gretchen A Cress, Douglas S Fishman, Cheryl E Gariepy, Matthew J Giefer, Praveen Goday, Tanja Y Gonska, Amit S Grover, Douglas Lindblad, Quin Y Liu, Asim Maqbool, Jacob A Mark, Brian A McFerron, Megha S Mehta, Veronique D Morinville, Robert A Noel, Chee Y Ooi, Emily R Perito, Sarah Jane Schwarzenberg, Zachary M Sellers, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Dana K Andersen, Mark E Lowe, Aliye Uc
BACKGROUND: Among children who suffer from acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP), acute pancreatitis (AP) episodes are painful, often require hospitalization, and contribute to disease complications and progression. Despite this recognition, there are currently no interventions to prevent AP episodes. In this retrospective cohort study, we assessed the impact of pancreatic enzyme therapy (PERT) use on clinical outcomes among children with pancreatic sufficient ARP or CP...
March 22, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38516781/sesn1-functions-as-a-new-tumor-suppressor-gene-via-toll-like-receptor-signaling-pathway-in-neuroblastoma
#29
JOURNAL ARTICLE
Zhongyan Hua, Bo Chen, Baocheng Gong, Meizhen Lin, Yifan Ma, Zhijie Li
AIMS: Neuroblastoma (NB) is the most common extracranial solid tumor in children, with a 5-year survival rate of <50% in high-risk patients. MYCN amplification is an important factor that influences the survival rate of high-risk patients. Our results indicated MYCN regulates the expression of SESN1. Therefore, this study aimed to investigate the role and mechanisms of SESN1 in NB. METHODS: siRNAs or overexpression plasmids were used to change MYCN, SESN1, or MyD88's expression...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38516352/reintegration-into-school-kindergarten-and-work-in-families-of-childhood-cancer-survivors-after-a-family-oriented-rehabilitation-program
#30
JOURNAL ARTICLE
Laura Inhestern, Mona L Nasse, Konstantin A Krauth, Daniela Kandels, Stefan Rutkowski, Gabriele Escherich, Corinna Bergelt
OBJECTIVE: To describe the situation of childhood cancer survivors and their parents before and one year after a family-oriented rehabilitation program (FOR) and to identify factors influencing reintegration. METHODS: We included parents of children diagnosed with leukemia or central nervous system tumor. We assessed parental functioning using the functioning subscale of the Ulm Quality of Life Inventory for Parents (ULQIE) and children's school/kindergarten related quality of life (parental assessment, subscale KINDL-R)...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38515317/the-relationship-between-hematologic-malignancies-on-male-hypogonadism-a-scoping-review
#31
JOURNAL ARTICLE
Bradley Roth, Muhammed A Moukhtar Hammad, Daniel I Sanford, Molly Piper, David W Barham, Faysal A Yafi, Lawrence C Jenkins
INTRODUCTION: The associated symptoms of hypogonadism have been reported in patients with various types of cancer. However, the prevalence and significance of hypogonadism among certain hematologic malignancies have not been completely summarized in recent literature. OBJECTIVE: In this review we aimed to examine the current literature on hypogonadism in patients with hematologic malignancies, with emphasis on leukemias, lymphomas, and multiple myeloma (MM). METHODS: This review included relevant studies published before July 2023 that were retrieved through a search of PubMed using the keywords "hematologic cancer," "hematologic malignancy," blood cancer," "leukemia," "lymphoma," "hypogonadism," "multiple myeloma," and "testosterone...
March 21, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38514935/local-treatment-of-children-suffering-from-parameningeal-rhabdomyosarcoma-a-retrospective-single-center-study-from-china
#32
JOURNAL ARTICLE
Xiaomin Peng, Xilin Xiong, Yang Li, Chunmou Li, Zhixuan Wang, Yu Wu, Mingwei Su, Wenjun Weng, Ke Huang, Dunhua Zhou, Jianpei Fang
BACKGROUND: Treatment for parameningeal rhabdomyosarcoma (PM-RMS) has been a challenge since local control is difficult. The goal of this study was to analyse the impact of different local treatment approaches on childhood PM-RMS patients and help dispel the doubt that whether secondary radical surgery (SRS) should be encouraged in the management of PM-RMS. METHODS: A total of 17 children with PM-RMS who received unified systemic chemotherapy and individualized local therapy such as radiotherapy (RT) and/or SRS were included in this retrospective study...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38514855/rnf126-mediated-ubiquitination-of-fsp1-affects-its-subcellular-localization-and-ferroptosis
#33
JOURNAL ARTICLE
Wanqun Xie, Jiajia Wang, Shuaiwei Tian, Heng Zhao, Liangliang Cao, Zhuangzhuang Liang, Jian Yang, Yang Zhao, Baocheng Wang, Feng Jiang, Jie Ma
Medulloblastoma (MB) is a prevalent malignant brain tumor among children, which can be classified into four primary molecular subgroups. Group 3 MB (G3-MB) is known to be highly aggressive and associated with a poor prognosis, necessitating the development of novel and effective therapeutic interventions. Ferroptosis, a regulated form of cell death induced by lipid peroxidation, has been identified as a natural tumor suppression mechanism in various cancers. Nevertheless, the potential role of ferroptosis in the treatment of G3-MB remains unexplored...
March 21, 2024: Oncogene
https://read.qxmd.com/read/38514765/determination-and-risk-assessment-of-aflatoxin-b1-in-the-kernel-of-imported-raw-hazelnuts-from-eastern-azerbaijan-province-of-iran
#34
JOURNAL ARTICLE
Parnian Samimi, Ramin Aslani, Ebrahim Molaee-Aghaee, Parisa Sadighara, Nabi Shariatifar, Gholamreza Jahed Khaniki, Sibel Ozcakmak, Zahra Reshadat
Aflatoxin B1 (AFB1) is widespread and seriously threatens public health worldwide. This study aimed to investigate AFB1 in imported hazelnut samples in northwest of Iran (Eastern Azerbaijan Province) using High-Performance Liquid Chromatography with a Fluorescent Detector (HPLC-FLD). In all tested samples AFB1 was detected. The mean concentration of AFB1 was 4.20 μg/kg and ranged from 3.145 to 8.13 μg/kg. All samples contained AFB1 levels within the maximum acceptable limit except for one sample...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38514496/brochure-intervention-to-manage-bothersome-taste-changes-in-pediatric-patients-receiving-cancer-therapy
#35
JOURNAL ARTICLE
Hadeel Hassan, Seye Oloyede, Gillian Villanueva, Serena Zahra, Zakia Joseph-Frederick, Gloria Green, Tal Schechter, Sue Zupanec, L Lee Dupuis, Lillian Sung
BACKGROUND: Primary objective was to determine if a patient informational brochure describing potentially useful strategies could help manage specific taste changes. Secondary objective was to describe the specific strategies used and whether the strategies were perceived as being helpful. PROCEDURE: This single-center study included pediatric patients with cancer or hematopoietic cell transplant recipients receiving active treatment who experienced bothersome taste changes in the last month...
March 21, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38513800/disparities-in-mortality-risk-after-diagnosis-of-hematological-malignancies-in-185-countries-a-global-data-analysis
#36
JOURNAL ARTICLE
Jing Yang, Xin Liu, Qiu-Zi Zhong, Yong Yang, Tao Wu, Si-Ye Chen, Bo Chen, Yong-Wen Song, Hui Fang, Shu-Lian Wang, Yue-Ping Liu, Jing Jin, Ning Li, Ning-Ning Lu, Hao Jing, Yuan Tang, Fan Chen, Xi-Mei Zhang, Wenwen Zhang, Yirui Zhai, Shu-Nan Qi, Ye-Xiong Li
This study was to report proxy measures for mortality risk in patients with hematological malignancies across 185 countries globally and explore its association with their socioeconomic status and treatment. The incidence, mortality, and 5-year prevalence data were extracted from the GLOBOCAN database. The data regarding the human development index (HDI), gross national income (GNI), vulnerability index, and concordance with cancer Essential Medicines List (EML) were obtained from open-source reports. The ratio of mortality to 5-year-prevalence (MPR) and that of mortality to incidence (MIR) were calculated and age-standardized using Segi's world standard population...
March 19, 2024: Cancer Letters
https://read.qxmd.com/read/38512345/prevalence-of-burnout-and-psycho-emotional-disorders-among-non-health-workers-a-single-tertiary-care-pediatric-oncology-center-experience
#37
JOURNAL ARTICLE
Antonella Guido, Paolo E Santoro, Domenica A DE Cata, Laura Peruzzi, Daniela P Chieffo, Maria R Gualano, Maria F Rossi, Umberto Moscato, Antonio Ruggiero
BACKGROUND: According to scientific literature, burnout can be described as a multidimensional syndrome with three fundamental dimensions: emotional exhaustion, depersonalization and reduced personal accomplishment. Every day, clown-doctors, play therapists, teachers and volunteers, such as ceramic art therapists, work in pediatric cancer wards to improve the quality of life of hospitalized children and activate positive resources during their therapeutic journey. METHODS: This study investigated burnout levels and the relationship between work-related stress and resilience in a total of 36 operators (clown-doctors, in-hospital teachers, play therapists, and ceramic art therapists), working at the Unit of Pediatric Oncology of IRCCS A...
March 21, 2024: Minerva pediatrics
https://read.qxmd.com/read/38511139/looking-beyond-year-1-in-the-molecular-era-of-pediatric-brain-tumor-diagnosis-confirmatory-testing-of-germline-variants-found-on-tumor-sequencing
#38
JOURNAL ARTICLE
Brittany L Greene, Shannon M Stasi, Michelle A Ting, Natalie Waligorski, Bonnie L Cole, Christina M Lockwood, Vera A Paulson, Jillian G Buchan, Amy Lee, Jeffrey G Ojemann, Richard G Ellenbogen, Jeffrey Stevens, Sarah E S Leary
PURPOSE: Somatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous system neoplasms. Here, we report follow-up targeted germline evaluation for patients with possible germline variants following tumor only testing in the initial year in which somatic molecular testing was implemented at a single institution. PATIENTS AND METHODS: Somatic testing was completed for all tumors of the central nervous system (CNS) undergoing diagnostic workup at Seattle Children's Hospital during the study period of November 2015 to November 2016...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38511136/assessing-quality-of-life-in-childhood-cancer-survivors-at-risk-for-hearing-loss-a-comparison-of-hear-ql-and-promis-measures
#39
JOURNAL ARTICLE
Anne Spence, Allison J L'Hotta, Susan S Hayashi, Kara Felts, Emily LaFentres, Megan Jones-White, Judith E C Lieu, Allison A King, Robert J Hayashi
BACKGROUND: Childhood cancer survivors (CCS) exposed to platinum chemotherapy are at an increased risk of developing hearing loss and reporting decreased quality of life (QOL). This study compared two QOL measures; one developed for children with hearing loss, The Hearing Environments and Refection on Quality of Life (HEAR-QL), and one validated in CCS, the Patient-Reported Outcomes Measurement Information System (PROMIS), to assess their ability to evaluate QOL deficits in this population...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38509981/-tet3-gene-rs828867%C3%A2-g-a-polymorphism-reduces-neuroblastoma-risk-in-chinese-children
#40
JOURNAL ARTICLE
Xinxin Zhang, Bo Wang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He
OBJECTIVE: Neuroblastoma (NB) is a prevalent pediatric tumor originating from primordial neural crest cells. As one of the latest epigenetics investigations focuses, RNA 5-methylcytosine (m5C) is closely related to cancer risk. TET methylcytosine dioxygenase 3 (TET3) is a demethylase for m5C modification. Whether there is an association between TET3 gene polymorphisms and neuroblastoma risk remains unclear. METHODS: We conducted an epidemiological study in 402 patients and 473 controls to evaluate the relationship between TET3 gene SNPs (rs7560668 T > C, rs828867 G > A, and rs6546891 A > G) and NB susceptibility...
March 30, 2024: Heliyon
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