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https://www.readbyqxmd.com/read/28922678/serum-uric-acid-concentrations-can-predict-hypertension-a-longitudinal-population-based-epidemiological-study
#1
Rongjiong Zheng, Tianmeng Yang, Qingmei Chen, Changxi Chen, Yushan Mao
An elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide. However, whether the elevation is causal or a consequence of hypertension among the Chinese population remains unclear. This study was designed to investigate the longitudinal relationship between the serum uric acid concentrations and hypertension among Chinese individuals. This study included 5105 subjects, initially without hypertension, who were followed up for 9 years. The subjects were divided into four groups based on the serum uric acid quartile...
September 18, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28922565/-metabolically-healthy-obesity-and-hyperuricemia-increase-risk-for-hypertension-and-diabetes-5-year-japanese-cohort-study
#2
Masanari Kuwabara, Remi Kuwabara, Ichiro Hisatome, Koichiro Niwa, Carlos A Roncal-Jimenez, Petter Bjornstad, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Minoru Ohno, James O Hill, Miguel A Lanaspa, Richard J Johnson
OBJECTIVE: Whether obesity without metabolic syndrome (i.e., "metabolically healthy" obesity) confers similar or less metabolic risk remains controversial. METHODS: A retrospective 5-year cohort study of 9,721 Japanese subjects (48.5 ± 10.5 years, 4,160 men) was conducted in 2004 and reevaluated 5 years later. Subjects were excluded if they were hypertensive or diabetic or were receiving medications for dyslipidemia and/or gout or hyperuricemia in 2004. Study subjects were categorized according to baseline BMI  ≥ 25 kg/m(2) (overweight/obesity) and < 25 kg/m(2) (lean/normal weight) and also whether they had metabolic syndrome...
September 18, 2017: Obesity
https://www.readbyqxmd.com/read/28922477/reference-intervals-for-serum-bilirubin-urea-and-uric-acid-in-healthy-chinese-geriatric-population
#3
Yuanqing Yang, Hongmin Jiang, Aiguo Tang, Zhongyuan Xiang
OBJECTIVES: The study aims to establish the reference intervals (RIs) for total bilirubin (TBIL), direct bilirubin (DBIL), urea (UR), and uric acid (UA) in healthy Chinese geriatric population. METHODS: Eight hundred and twenty cases from six representative geographical regions in China (including male 413 cases and female 407 cases) of apparently healthy individuals aged 60-96 years were recruited. Serum TBIL, DBIL, UR, and UA were analyzed by automatic biochemical analyzer and RIs were determined following CLSI C28-A3 guidelines using a non-parametric method...
September 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28922153/sex-dependent-associations-of-serum-uric-acid-with-brain-function-during-aging
#4
Alexandra M Kueider, Yang An, Toshiko Tanaka, Melissa H Kitner-Triolo, Stephanie Studenski, Luigi Ferrucci, Madhav Thambisetty
Serum uric acid (SUA) is an abundant natural antioxidant which could reduce the burden of cellular oxidation, a major cause of neurodegenerative disease. In line with this, SUA levels are lower in those with Alzheimer's disease; however, the association between SUA and cognition remains unclear. Results from studies examining the effects of SUA on cognition may be difficult to interpret in the context of normal versus pathological aging. This study examined sex-specific associations of baseline SUA with cognition during aging...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28920818/biochemistry-panel-reference-intervals-for-juvenile-goldfish-carassius-auratus
#5
Laura A Adamovicz, Macy R Trosclair, Gregory A Lewbart
Reference intervals for diagnostic tests are vitally important for clinical decision making. Despite the popularity of pet goldfish (Carassius auratus), reference intervals have not been generated for routine biochemistry panel analytes in this species. This study establishes de novo reference intervals for packed cell volume and total solids, using 47 apparently healthy immature goldfish, and for 11 common chemistry panel analytes (albumin, aspartate aminotransferase, calcium, creatine kinase, globulin, blood glucose, sodium, potassium, phosphorous, total protein, and uric acid) using 39 immature goldfish...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28919677/influence-of-microclimatic-ammonia-levels-on-productive-performance-of-different-broilers-breeds-estimated-with-univariate-and-multivariate-approaches
#6
Essam S Soliman, Sherif A Moawed, Rania A Hassan
BACKGROUND AND AIM: Birds litter contains unutilized nitrogen in the form of uric acid that is converted into ammonia; a fact that does not only affect poultry performance but also has a negative effect on people's health around the farm and contributes in the environmental degradation. The influence of microclimatic ammonia emissions on Ross and Hubbard broilers reared in different housing systems at two consecutive seasons (fall and winter) was evaluated using a discriminant function analysis to differentiate between Ross and Hubbard breeds...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28917761/graphene-nanoribbon-fept-bimetallic-nanoparticles-uric-acid-as-a-novel-magnetic-sensing-layer-of-screen-printed-electrode-for-sensitive-determination-of-ampyra
#7
Pegah Hashemi, Hasan Bagheri, Abbas Afkhami, Salimeh Amidi, Tayyebeh Madrakian
A novel electrochemical sensor for sensitive determination of ampyra (Am) based on graphene nanoribbons modified by iron-platinum bimetallic nanoparticles and uric acid (SPCE/FePtGNR/UA) dropped on the screen-printed carbon electrode (SPCE) surface and magnetically captured onto an SPCE working electrode surface is reported in the present work. The modified nanocomposite and sensing layer was characterized by different techniques, including cyclic voltammetry (CV), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray powdered diffraction (XRD)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917232/compressed-food-with-added-functional-oligopeptides-improves-performance-during-military-endurance-training
#8
Zhi-Qiang Zheng, Zhan-Hui Geng, Jia-Xi Liu, Shun-Tang Guo
BACKGROUND AND OBJECTIVES: Oligosaccharide or oligopeptide supplementation may have a significant impact on endurance performance. This study evaluated the effects of adding maltooligosaccharides (MO) or soy oligopeptides (SO) to compressed food (CF) on the physical response of soldiers to daily military training. METHODS AND STUDY DESIGN: Twelve soldiers were randomized to four diet groups: regular meals, CF, CFMO, and CFSO (crossover design). They participated in exercise tests including 90 minutes running at 55-65% VO2max and exhaustive running...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917195/uric-acid-in-major-depressive-and-anxiety-disorders
#9
Catherine N Black, Mariska Bot, Peter G Scheffer, Harold Snieder, Brenda W J H Penninx
BACKGROUND: Uric acid has neuroprotective effects, owing to its antioxidant properties. Lowered antioxidant capacity, causing increased oxidative stress, may be involved in affective disorders and might be altered by antidepressants. This study investigated the association of plasma uric acid, the greatest contributor to blood antioxidant capacity, with major depressive disorder (MDD) and anxiety disorders. METHODS: Data were from the Netherlands Study of Depression and Anxiety including patients with current (N = 1648), remitted (N = 609) MDD and/or anxiety disorders (of which N = 710 antidepressant users) and 618 controls...
September 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28917083/effects-of-single-or-combined-administration-of-salmon-calcitonin-and-omega-3-fatty-acids-versus-diclofenac-sodium-in-sodium-monoiodoacetate-induced-knee-osteoarthritis-in-male-wistar-rats
#10
Wale J Adeyemi, Luqman A Olayaki
BACKGROUND: There is a continuous search for a better therapy in osteoarthritis (OA) management. Therefore, this study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3) relative to diclofenac sodium (DF) in induced knee osteoarthritic male Wistar rats. METHODS: The 40 rats that were used in this study were divided into 8 groups (n=5 rats), viz: Normal control; OA control; OA+N-3; OA+Low dose of Sct (Sct.Lw); OA+High dose of Sct (Sct...
September 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28916241/relationship-of-echocardiographic-epicardial-fat-thickness-and-epicardial-fat-volume-by-computed-tomography-with-coronary-artery-calcification-data-from-the-caesar-study
#11
Byung Jin Kim, Jung Gyu Kang, Sung Ho Lee, Jong Young Lee, Ki Chul Sung, Bum Soo Kim, Jin Ho Kang
BACKGROUND AND AIMS: No study has assessed the association between echocardiographic epicardial fat thickness (EFT) and computed tomography (CT)-based epicardial fat volume (EFV) and coronary artery calcification. The aim of this study is to evaluate the association between EFT and EFV and coronary artery calcification. METHODS: Among the 2,299 individuals enrolled in the CArdiometabolic risk, Epicardial fat, and Subclinical Atherosclerosis Registry (CAESAR) study, 2,276 (1,851 men; mean age 45 ± 8...
September 12, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28915449/increased-expression-of-nlrp3-inflammasome-in-placentas-from-pregnant-women-with-severe-preeclampsia
#12
Ingrid C Weel, Mariana Romão-Veiga, Mariana L Matias, Eduardo G Fioratti, Jose C Peraçoli, Vera T Borges, João P Araujo, Maria T Peraçoli
Preeclampsia is a pregnancy disorder characterized by imbalance between pro- and anti-inflammatory cytokines associated with high plasma levels of uric acid and Interleukin-1 beta (IL-1β). The inflammasome is a protein complex that mediates innate immune responses via caspase-1 activation promoting secretion of IL-1β and IL-18 in their active forms, and also release of the high-mobility group box 1 protein (HMGB1). As the placenta seems to play an important role in the pathogenesis of PE, the present study investigated the expression of genes and proteins related to the inflammasome in placentas from pregnant women with severe preeclampsia...
September 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28914432/relationship-between-the-peroxidation-of-leukocytes-index-ratio-and-a-functional-mathematical-index-including-uric-acid-levels-and-health-related-habits-a-pilot-study
#13
Ilaria Peluso, Raffaella Reggi, Nagendra Sastry Yarla, Yaroslava Longhitano, Maura Palmery
No abstract text is available yet for this article.
September 15, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28913357/the-association-of-uric-acid-calculi-with-obesity-prediabetes-type-2-diabetes-mellitus-and-hypertension
#14
Fang-Yeh Chu, Chih-Chun Chang, Pin-Hao Huang, Yi-Ning Lin, Po-Wen Ku, Jen-Tang Sun, Jung-Li Ho, Tzung-Hai Yen, Ming-Jang Su
OBJECTIVES: To disclose the link between the composition of urolithiasis, especially that of uric acid calculi, and obesity, prediabetes, type 2 diabetes mellitus, and hypertension. MATERIALS AND METHODS: Patients who had urinary calculi and underwent surgical treatment were registered in the study. The composition of urinary calculi was analyzed and correlated with clinical features and biomedical profiles of the patients before surgical intervention. RESULTS: A total of 666 patients with urolithiasis who underwent surgical management were registered and analyzed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912866/compositional-analysis-of-various-layers-of-upper-urinary-tract-stones-by-infrared-spectroscopy
#15
Zhang He, Zhang Jing, Zheng Jing-Cun, Hu Chuan-Yi, Gao Fei
The objective of the present study was to determine the composition of various layers of upper urinary stones and assess the mechanisms of stone nucleation and aggregation. A total of 40 integrated urinary tract stones with a diameter of >0.8 cm were removed from the patients. All of the stones were cut in half perpendicularly to the longitudinal axis. Samples were selected from nuclear, internal and external layers of each stone. Fourier transform infrared spectroscopy (FT-IR) was adopted for qualitative and quantitative analysis of all of the fragments and compositional differences among nuclear, internal and external layers of various types of stone were subsequently investigated...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912863/a-novel-mutation-in-the-hepatocyte-nuclear-factor-1%C3%AE-gene-in-maturity-onset-diabetes-of-the-young-5-with-multiple-renal-cysts-and-pancreas-hypogenesis-a-case-report
#16
You Lv, Zhuo Li, Kan He, Ying Gao, Xianchao Xiao, Yujia Liu, Guixia Wang
A 17-year-old Chinese male was hospitalized exhibiting hyperglycemia and increased serum urea nitrogen and creatinine levels in addition to weight loss. The patient was treated with gliclazide. The patient was 150 cm tall, weighed 35 kg and had no family history of diabetes or kidney disease. Physical examination revealed cephalus quadratus, rachitic rosary and a visible toe-out gait. Laboratory examinations revealed that the patient's fasting plasma glucose and glycosylated hemoglobin levels were markedly increased, fasting plasma C-peptide level was slightly increased and no peak 2 h postprandial was observed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912753/food-addiction-in-patients-with-newly-diagnosed-type-2-diabetes-in-northeast-china
#17
Fan Yang, Aihua Liu, Yongze Li, Yaxin Lai, Guixia Wang, Chenglin Sun, Guang Sun, Zhongyan Shan, Weiping Teng
AIM: The aim of the study was to explore the prevalence of food addiction (FA) in individuals with newly diagnosed type 2 diabetes mellitus (T2DM) in China and to analyze risk factors of FA. METHODS: A total of 624 subjects [312 individuals with newly diagnosed T2DM, 312 age-matched and body mass index (BMI)-matched healthy participants] were recruited. All participants were asked to complete the Yale Food Addiction Scale (YFAS) and received physical and lab examinations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28911689/effect-of-oleuropein-against-chemotherapy-drug-induced-histological-changes-oxidative-stress-and-dna-damages-in-rat-kidney-injury
#18
Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek
Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of pharmacological beneficial properties. In this study we investigated whether OLE could provide sufficient protection against cisplatin-induced nephrotoxicity. With this aim, Sprague-Dawley rats were divided into eight groups: control; 7 mg/kg/d cisplatin, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE; and treatment with OLE for 3 days starting at 24 hours following cisplatin injection...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911646/evaluating-the-urate-lowering-effects-of-different-microbial-fermented-extracts-in-hyperuricemic-models-accompanied-with%C3%A2-a%C3%A2-safety-study
#19
Rong-Jane Chen, Mei-Huei Chen, Yen-Lin Chen, Ching-Mao Hsiao, Hsiu-Min Chen, Siao-Jhen Chen, Ming-Der Wu, Yi-Jen Yech, Gwo-Fang Yuan, Ying-Jan Wang
Uric acid (UA) is an end product of purine metabolism by the enzyme xanthine oxidase (XOD). Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders. XOD inhibitors or uricase (catalyzes UA to the more soluble end product) can prevent these chronic diseases. However, currently available hypouricemic agents induce severe side effects. Therefore, we developed new microbial fermented extracts (MFEs) with substantial XOD inhibition activity from Lactobacillus (MFE-21) and Acetobacter (MFE-25), and MFE-120 with high uricase activity from Aspergillus...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911644/nephroprotective-effect-of-paeonia-emodi-via-inhibition-of-advanced-glycation-end-products-and-oxidative-stress-in-streptozotocin-nicotinamide-induced-diabetic-nephropathy
#20
Lalit Kishore, Navpreet Kaur, Randhir Singh
The present study aimed to evaluate the effect of alcohol (PA) and hydroalcohol (PHA) extract of Paeonia emodi Royale roots in treatment of streptozotocin-nicotinamide induced diabetic nephropathy. Diabetes mellitus was induced in male Wistar rats by streptozotocin (65 mg/kg intraperitoneally) 15 minutes after nicotinamide (230 mg/kg, intraperitoneally) administration and diabetic nephropathy was assessed by measuring serum glucose, renal parameters (urea, uric acid, creatinine, and blood urea nitrogen level) and lipid profile...
July 2017: Journal of Food and Drug Analysis
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