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https://www.readbyqxmd.com/read/28528279/first-validation-of-the-gout-activity-score-against-gout-impact-scale-in-a-primary-care-based-gout-cohort
#1
Jonathan La-Crette, Wendy Jenkins, Gwen Fernandes, Ana M Valdes, Michael Doherty, Abhishek Abhishek
OBJECTIVES: To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. METHODS: This was a single-centre cross-sectional study. People with gout who participated in previous research at Academic Rheumatology, University of Nottingham, UK, and consented for participation in future studies were mailed a questionnaire in September 2015. Those returning completed questionnaires were invited to attend for a study visit at which blood was collected and musculoskeletal examination was performed...
May 17, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28527691/food-and-water-intake-body-temperature-and-metabolic-consequences-of-interleukin-1%C3%AE-microinjection-into-the-cingulate-cortex-of-the-rat
#2
B Csetényi, E Hormay, I Szabó, G Takács, B Nagy, K László, Z Karádi
In order to elucidate whether cytokine mechanisms of the cingulate cortex (cctx) are important in the central regulation of homeostasis, in the present study, feeding-metabolic effects of direct bilateral microinjection of interleukin-1β (IL-1β) into the cctx of the rat have been investigated. Short- (2h), medium (12h) and long-term (24h) food and water intakes and body temperature were measured after the intracerebral administration of this primary cytokine or vehicle solution, with or without paracetamol pretreatment...
May 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28527616/catalase-increases-ethanol-oxidation-through-the-purine-catabolism-in-rat-liver
#3
Daniel Villalobos-García, Rolando Hernández-Muñoz
Hepatic ethanoloxidationincreases according to its concentration and is raised to near-saturation levels of alcohol dehydrogenase (ADH); therefore, re-oxidation of NADH becomes rate limiting in ethanol metabolism by the liver. Adenosine is able to increase liver ethanol oxidation in both in vivo and in vitro conditions; the enhancement being related with the capacity of the nucleoside to accelerate the transport of cytoplasmic reducing equivalents to mitochondria, by modifying the subcellular distribution of the malate-aspartate shuttle components...
May 17, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28527105/association-between-lumbar-bone-mineral-density-and-serum-uric-acid-in-postmenopausal-women-a-cross-sectional-study-of-healthy-chinese-population
#4
Wen Han, Xiaojuan Bai, Nan Wang, Lulu Han, Xuefeng Sun, Xiangmei Chen
Partial correlation and regression analyses were used in this study. We showed that there is a linear relationship between bone mineral density and serum uric acid within the normal physiologic range, and higher serum uric acid levels had a protective effect on bone loss in postmenopausal osteoporosis. PURPOSE: The significance of the relationship between lumbar bone mineral density (()BMD) and serum uric acid (SUA) levels is unclear. The aims of this study were to investigate on a population-level the association between lumbar BMD and SUA within the normal physiologic range and to determine whether SUA plays a protective role in bone loss in healthy postmenopausal Chinese women...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28525944/oxidative-stress-and-some-biochemical-alterations-due-to-scorpion-leiurus-quinquestriatus-crude-venom-in-rats
#5
Muhammad M A Salman, Seddik Hammad
Scorpion envenomation is a common medical problem in many countries; it is an important cause of morbidity and mortality. The venom of Leiurus quinquestriatus (LQ) is responsible for a number of deaths in children and adults. It has been stated that specific pathophysiological conditions such as generation of oxygen free radicals may trigger the onset of multiple organ dysfunction; therefore, the present study aimed to assess the oxidative stress mediated by LQ crude venom and its effect on the biochemical parameters in rats...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28524828/relationships-of-inflammatory-factors-and-risk-factors-with-different-target-organ-damage-in-essential-hypertension-patients
#6
Chun-Lin Lai, Jin-Ping Xing, Xiao-Hong Liu, Jie Qi, Jian-Qiang Zhao, You-Rui Ji, Wu-Xiao Yang, Pu-Juan Yan, Chun-Yan Luo, Lu-Fang Ruan
BACKGROUND: Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its clinical significance. METHODS: A total of 294 EH patients were selected and divided into four groups according to their conditions of TOD. Forty-eight healthy subjects were selected as control...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28523594/the-relationship-between-coronary-artery-calcium-scores-and-left-atrium-size-in-hemodialysis-patients
#7
Ismail Baloglu, Kultigin Turkmen, H Zeki Tonbul, N Yılmaz Selcuk
PURPOSE: Hemodialysis patients have extremely increased cardiovascular mortality. The coronary artery calcification score (CACS) in uremic patients receiving hemodialysis reflects the severity of atherosclerotic vascular disease and predicts the cardiovascular events. In cardiac conditions, left atrial (LA) size has a prognostic importance. In this study, relationship between coronary artery calcification and left atrial size was investigated. METHODS: This was a cross-sectional study involving 32 hemodialysis patients (16 females, 16 males; mean age, 52...
May 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28523032/serum-uric-acid-level-in-the-severity-of-congestive-heart-failure-chf
#8
Adnan Khan, Mohammad Hassan Shah, Sarbiland Khan, Umama Shamim, Sanan Arshad
BACKGROUND AND OBJECTIVE: It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure. METHODS: We analyze 285 patients with a diagnosis of Congestive heart failure admitted in Lady Reading Hospital Peshawar from March 1(st) to August 2016. Age group of patients was 17- 67 years. New York Health Association (NYHA) scoring were used to access the severity of Congestive Heart Failure...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28522875/serum-uric-acid-is-associated-with-erectile-dysfunction-a-population-based-cross-sectional-study-in-chinese-men
#9
Fengbin Gao, Boren Jiang, Zhen Cang, Ningjian Wang, Bing Han, Qin Li, Yi Chen, Yingchao Chen, Fangzhen Xia, Hualing Zhai, Chi Chen, Meng Lu, Ying Meng, Yingli Lu, Zhoujun Shen
The role that serum uric acid (UA) plays in the pathophysiological development of erectile dysfunction (ED) is controversial. We aimed to screen the factors related with ED, and to examine the association between serum UA and ED. Our data were derived from a cross-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014-2015. Questionnaire of International Index of Erectile Dysfunction-5 was used for assessment of ED. Data were collected in three general communities respectively...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521871/relation-of-antioxidant-capacity-of-diet-and-markers-of-oxidative-status-with-c-reactive-protein-and-adipocytokines-a-prospective-study
#10
Najada Stringa, Adela Brahimaj, Asija Zaciragic, Abbas Dehghan, Mohammad Arfan Ikram, Albert Hofman, Taulant Muka, Jessica C Kiefte-de Jong, Oscar H Franco
BACKGROUND: The role of dietary antioxidants and plasma oxidant-antioxidant status in low-grade chronic inflammation and adipocytokine levels is not established yet. OBJECTIVES: We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines. METHODS: Data of 4506 participants aged ≥55years from the Rotterdam Study were analyzed...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521802/identification-of-chronic-kidney-disease-patient-characteristics-influencing-the-renoprotective-effects-of-febuxostat-therapy-a-retrospective-follow-up-study
#11
Akinori Yamaguchi, Makoto Harada, Yosuke Yamada, Koji Hashimoto, Yuji Kamijo
BACKGROUND: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD. METHODS: This was a single-center, retrospective, follow-up study. One-hundred and seventy-eight CKD patients with hyperuricemia who received febuxostat therapy were included in this study...
May 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28521370/salvia-plebeia-extract-inhibits-xanthine-oxidase-activity-in-vitro-and-reduces-serum-uric-acid-in-an-animal-model-of-hyperuricemia
#12
Jin Kyu Kim, Woo Jung Kim, Jung Mi Hyun, Jong Suk Lee, Jin Gwan Kwon, Changon Seo, Myung-Jin Song, Chun Whan Choi, Seong Su Hong, Kyuhee Park, Pansoo Kim, Hachang Sung, Jin Koo Lee, Yongmun Choi
Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia, S...
May 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/28521051/efficiency-of-early-single-dose-probiotic-administration-methods-on-performance-small-intestinal-morphology-blood-biochemistry-and-immune-response-of-japanese-quail
#13
Kazem Seifi, Mohammad Amir Karimi Torshizi, Shaban Rahimi, Mohammad Kazemifard
The aim of the present study was to investigate the efficacy of early probiotics (single dose) administered in different ways, on quails' performance, small intestine morphology, blood biochemistry, and immune response. In total, 192 day-old chicks were used in one of the following experimental groups before being transferred to a raising room: 1) Control (no probiotic administered), 2) oral gavage, 3) spray, and 4) vent lip. Four replicates of 12 chicks per cage were considered for each treatment and birds were raised up to 35 d in the same conditions...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28521012/the-effect-of-dl-l-isomers-and-dl-hydroxy-analog-administered-at-2-levels-as-dietary-sources-of-methionine-on-the-metabolic-and-antioxidant-parameters-and-growth-performance-of-turkeys
#14
J Jankowski, K Ognik, M Kubinska, A Czech, J Juskiewicz, Z Zdunczyk
A hypothesis was verified that dietary methionine (Met) improves the growth and antioxidant status of turkeys, and that its effects depend on dietary inclusion levels and sources. A total of 816 female Hybrid Converter turkeys was fed wheat-soybean meal-based diets supplemented with 3 sources of Met: DL-, L-isomers and DL-hydroxy analog (DLM, LM, and MHA, respectively). In 4 4-week periods (from one to 16 wk of age), dietary Met content corresponded to NRC (1994) recommendations or was increased by approximately 50% (in one to 8 wk by 44 to 46% and in 9 to 16 wk by 55 to 56% vs...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28520613/uric-acid-and-blood-pressure-exploring-the-role-of-uric-acid-production-in-the-maastricht-study
#15
Lieke E J M Scheepers, Annelies Boonen, Pieter C Dagnelie, Miranda T Schram, Carla J H van der Kallen, Ronald M A Henry, Abraham A Kroon, Coen D A Stehouwer, Ilja C W Arts
OBJECTIVE: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration 24-h urinary uric acid excretion, as proxy for uric acid production, and ambulatory 24-h BP and hypertension. METHODS: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60...
May 17, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28516889/an-update-on-the-animal-models-in-hyperuricaemia-research
#16
REVIEW
Yantong Zhu, Xiaofei Peng, Guanghui Ling
Hyperuricaemia is a metabolic disease caused by purine metabolic abnormalities, mainly due to the increased formation or reduced excretion of uric acid. In recent years, it has been proved that hyperuricaemia is an important risk factor for chronic kidney disease (CKD) and cardiovascular disease, and it also takes part in the pathophysiology of metabolic syndrome. In addition, more attention has been concentrated on the pathogenesis or treatment of hyperuricaemia. Since establishing an animal model on hyperuricaemia is the foundation for further researches, several methods to establish the hyperuricaemia model have been developed...
May 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28514939/antioxidant-properties-of-drugs-used-in-type-2-diabetes-management-could-they-contribute-to-confound-or-conceal-effects-of-antioxidant-therapy
#17
Siu Wai Choi, Cyrus K Ho
OBJECTIVES: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. METHODS: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid...
May 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28513237/t-cell-subsets-are-associated-with-serum-homocysteine-concentration-in-patients-with-essential-hypertension
#18
Huifeng Xu, Huan Zheng, Junling Huang, Yi Shen, Ming Luo
OBJECTIVE: To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension. PATIENTS AND METHODS: A total of 218 essential hypertension patients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensive patients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3(+)%, CD4(+)%, CD8(+) T%, CD4(+)/CD8(+)) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28512120/serum-albumin-and-disease-severity-of-non-cystic-fibrosis-bronchiectasis
#19
Seung Jun Lee, Hyo-Jung Kim, Ju-Young Kim, Sunmi Ju, Sujin Lim, Jung Wan Yoo, Sung-Jin Nam, Gi Dong Lee, Hyun Seop Cho, Rock Bum Kim, Yu Ji Cho, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee
BACKGROUND: A clinical classification system has been developed to define the severity and predict the prognosis of subjects with non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). We aimed to identify laboratory parameters that are correlated with the bronchiectasis severity index (BSI) and FACED score. METHODS: The medical records of 107 subjects with non-CF bronchiectasis for whom BSI and FACED scores could be calculated were retrospectively reviewed...
May 16, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28511908/potential-anti-gout-constituents-as-xanthine-oxidase-inhibitor-from-the-fruits-of-stauntonia-brachyanthera
#20
Dan Liu, Dandan Wang, Wei Yang, Dali Meng
With the aim of finding a better xanthine oxidase inhibitor with potential anti-gout properties, the studies on the fruit of Stauntonia brachyanthera were carried out, which led to the isolation of 12 glycosides, including 4 new nor-oleanane triterpenoids. Their structures were determined by comprehensive spectroscopic (NMR and HR MS) analysis. Two compounds (4 and 11) exhibited significant inhibitory activities on xanthine oxidase with IC50 values of 5.22 and 1.60µM, respectively. Another five compounds (1, 2, 3, 8 and 10) showed qualified activities...
May 6, 2017: Bioorganic & Medicinal Chemistry
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