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https://www.readbyqxmd.com/read/29156749/high-uric-acid-ua-downregulates-bone-alkaline-phosphatase-balp-expression-through-inhibition-of-its-promoter-activity
#1
Zhi-Qi Wu, Xiao-Ting Chen, Yan-Yan Xu, Ming-Jie Tian, Hai-Yan Chen, Guo-Ping Zhou, Hua-Guo Xu
Bone metastases often occur in prostate cancers, lung cancers and breast cancers. Bone alkaline phosphatase (BALP) is one of the most commonly used serological markers for clinical evaluation of bone metabolism. Here, we reported that high concentrations of uric acid (UA) caused decrease of BALP levels and revealed that the effect of high concentrations of UA on the BALP expression was through inhibition of its promoter activity. Our results suggested physicians to think about serum UA status of patients with advanced cancer to avoid misdiagnosis when BALP was used to diagnose or assess the extent of bone metastases...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154722/association-of-kidney-function-and-waist-circumference-with-uric-acid-levels-in-south-africans
#2
Nomandla Daphne Madala, Thozama Dubula, Alain Guy Honoré Assounga, Saraladevi Naicker
BACKGROUND: Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. METHODS: This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29153695/posterior-encephalopathy-syndrome-in-women-with-eclampsia-predictors-and-outcome
#3
Anand Kumar Verma, Ravindra Kumar Garg, Yashodhara Pradeep, Hardeep Singh Malhotra, Imran Rizvi, Neeraj Kumar, Neera Kohli, Shweta Pandey
BACKGROUND: This study aims to study predictors of posterior encephalopathy syndrome in eclampsia and the impact of posterior encephalopathy syndrome on outcome. MATERIAL AND METHODS: This prospective study enrolled consecutive women with eclampsia. These women were subjected to magnetic resonance imaging of the brain. Predictors of posterior encephalopathy syndrome were determined using univariate, followed by multivariate, analysis. Women were followed for 30days...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153684/impact-of-maternal-serum-uric-acid-on-perinatal-outcome-in-women-with-hypertensive-disorders-of-pregnancy-a-prospective-study
#4
Naina Kumar, Amit Kant Singh, Bhavya Maini
INTRODUCTION: Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. AIM: To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. METHODOLOGY: Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153396/the-prognostic-value-of-serum-uric-acid-in-the-acute-phase-of-ischemic-stroke-in-black-africans
#5
Yacouba Njankouo Mapoure, Chia Mark Ayeah, Hamadou Ba, Romuald Hentchoya, Henry Namme Luma
BACKGROUND: The association between hyperuricemia and stroke outcome still remains controversial worldwide. This study aims to determine the prevalence of hyperuricemia and its association with the outcome of patients with acute ischemic stroke in a tertiary care hospital. METHODS: This was a hospital-based prospective cohort study that included patients with ischemic stroke with baseline uric acid levels and 3-month post-stroke follow-up data. Associations between hyperuricemia and stroke outcomes were analyzed using multiple logistic regression, Kaplan-Meier, and Cox proportional hazards regression analysis...
November 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29153025/annals-express-gestational-age-specific-reference-intervals-for-15-biochemical-measurands-during-normal-pregnancy-in-china
#6
Yanpeng Dai, Junjie Liu, Enwu Yuan, Yushan Lee, Quanxian Wang, Liting Jia, Linkai Wang, Yanhua Su
AIMS: Physiological changes that occur during pregnancy can influence biochemical parameters. Therefore, using reference intervals based on specimens from non-pregnant women to interpret laboratory results during pregnancy may be inappropriate. This study aimed to establish essential to establish reference intervals for a range of analytes during pregnancy. METHODS: The cross-sectional study was performed in 13656 healthy pregnant and 2634 non-pregnant women. Fifteen biochemical measurands relating to renal and hepatic function were analyzed using an Olympus AU5400 analyzer (Olympus, Tokyo, Japan)...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29152793/effects-of-dietary-tryptophan-levels-on-performance-and-biochemical-variables-of-plasma-and-intestinal-mucosa-in-yellow-feathered-broiler-breeders
#7
S Q Jiang, Z Y Gou, X J Lin, L Li
The effects of dietary tryptophan (Trp) levels on performance and biochemical variables of plasma and intestinal mucosa in broiler breeder hens were investigated in this study. A total of 780 Lingnan yellow-feathered broiler breeder hens were randomly assigned in one of five dietary treatments with six replicates per treatment (26 birds per replicate). The breeder hens were fed either the basal diet (0.11% Trp) or the basal diet supplemented to 0.15%, 0.19%, 0.23% and 0.27% Trp, from 197 to 259 days of age...
November 19, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29151480/the-refinement-of-risk-stratification-for-atrial-thrombus-or-spontaneous-echo-contrast-in-nonvalvular-atrial-fibrillation
#8
Wenna Ning, Yang Li, Chunyan Ma, Liangxian Qiu, Bo Yu
As for nonvalvular atrial fibrillation (NVAF) patients with left atrial thrombus or spontaneous echo contrast (LAT/SEC), we evaluated the additional predictive value of serum uric acid (SUA) and Left atrial diameter (LAD) for CHADS2 and CHA2DS2-VASc, and explored the influence from the level of SUA and LAD to LAT/SEC in moderate risk group. Thus, we put forward the concept of a borderline high risk group to guide clinical anticoagulant therapy in patients with NVAF.A total of 284 NVAF patients without the history of anticoagulant prior to hospitalization were enrolled...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29149990/simultaneous-determination-of-renal-function-biomarkers-in-urine-using-a-validated-paper-based-microfluidic-analytical-device
#9
Eduardo Luiz Rossini, Maria Izabel Milani, Emanuel Carrilho, Leonardo Pezza, Helena Redigolo Pezza
In this paper, we describe a validated paper-based microfluidic analytical device for the simultaneous quantification of two important biomarkers of renal function in urine. This paper platform provides an inexpensive, simple, and easy to use colorimetric method for the quantification of creatinine (CRN) and uric acid (UA) in urine samples. The microfluidic paper-based analytical device (μPAD) consists of a main channel with three identical arms, each containing a circular testing zone and a circular uptake zone...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29148979/role-of-caftaric-acid-in-lead-associated-nephrotoxicity-in-rats-via-antidiuretic-antioxidant-and-anti-apoptotic-activities
#10
Khaled M M Koriem, Mahmoud S Arbid
Background Lead is a toxic metal that is widely distributed in the environment where caftaric acid (CA) is the ester form of caffeic acid where CA is the major dietary polyphenol present in various foods and beverages. The aim of this study was to evaluate the effect of CA in lead acetate (LA)-associated nephrotoxicity through antidiuretic, antioxidant and anti-apoptotic activities. Methods Forty-eight male albino rats divided into six equal groups; group 1 control injected intraperitoneally (ip) with saline (1 mL/kg of bw) over two weeks period, group 2 injected ip with CA (80 mg/kg of bw) over two weeks period, groups 3, 4, 5 and 6 injected ip with 100 μmol/kg of bw LA over two weeks period where groups 4, 5 & 6 co-injected ip with 1-deamino-8-D-arginine vasopressin (dDAVP) drug (1 mg/kg of bw), CA (40 mg/kg of bw), and CA (80 mg/kg of bw), respectively...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29146253/isolation-and-characterisation-of-theobromine-degrading-filamentous-fungi
#11
Daniel Oduro-Mensah, Augustine Ocloo, Sammy T Lowor, Evelyn Y Bonney, Laud K N A Okine, Naa Ayikailey Adamafio
Strategies for achieving global food security include identification of alternative feedstock for use as animal feed, to contribute towards efforts at increasing livestock farming. The presence of theobromine in cocoa pod husks, a major agro-waste in cocoa-producing countries, hinders its utilisation for this purpose. Cheap treatment of cocoa pod husks to remove theobromine would allow largescale beneficial use of the millions of metric tonnes generated annually. The aim of this study was to isolate theobromine-degrading filamentous fungi that could serve as bioremediation agents for detheobromination of cocoa pod husks...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29145836/clinical-utility-of-computed-tomography-hounsfield-characterization-for-percutaneous-nephrolithotomy-a-cross-sectional-study
#12
Andrea Gallioli, Elisa De Lorenzis, Luca Boeri, Maurizio Delor, Stefano Paolo Zanetti, Fabrizio Longo, Alberto Trinchieri, Emanuele Montanari
BACKGROUND: Computed Tomography (CT) is considered the gold-standard for the pre-operative evaluation of urolithiasis. However, no Hounsfield (HU) variable capable of differentiating stone types has been clearly identified. The aim of this study is to assess the predictive value of HU parameters on CT for determining stone composition and outcomes in percutaneous nephrolithotomy (PCNL). METHODS: Seventy seven consecutive cases of PCNL between 2011 and 2016 were divided into 4 groups: 40 (52%) calcium, 26 (34%) uric acid, 5 (6%) struvite and 6 (8%) cystine stones...
November 16, 2017: BMC Urology
https://www.readbyqxmd.com/read/29145399/point-mutation-in-d8c-domain-of-tamm-horsfall-protein-uromodulin-in-transgenic-mice-causes-progressive-renal-damage-and-hyperuricemia
#13
Lijie Ma, Yan Liu, Nichole K Landry, Tarek M El-Achkar, John C Lieske, Xue-Ru Wu
Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains unclear. Here we show that targeted expression in transgenic mice of a mutation within the domain of 8 cysteines of THP in kidneys' thick ascending limb (TAL) caused unfolded protein response in younger (1-month old) mice and apoptosis in older (12-month old) mice. While the young mice had urine concentration defects and polyuria, such defects progressively reversed in the older mice to marked oliguria, highly concentrated urine, fibrotic kidneys and reduced creatinine clearance...
2017: PloS One
https://www.readbyqxmd.com/read/29145198/heavy-alcohol-consumption-effects-on-blood-pressure-and-on-kidney-structure-persist-after-long-term-withdrawal
#14
Sandra Leal, Dinis-Oliveira Ricardo Jorge, Barbosa Joana, Silva Susana Maria, Sá Susana Isabel
BACKGROUND/AIMS: Heavy ethanol consumption is a risk factor for hypertension and prompts organ damage. There is no information regarding the impact of long-term heavy ethanol consumption on kidney structure and function linking to their hypertensive effects nor the repercussions after withdrawal. METHODS: Rats were exposed to ethanol for 24 weeks and, afterwards, a group was assigned to withdrawal for 8 weeks. Blood pressure (BP) was measured and serum biochemical parameters were quantified...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29144608/the-relationship-between-urine-ph-and-abnormal-glucose-tolerance-in-a-community-based-study
#15
Sakiko Yoshida, Teruki Miyake, Shin Yamamoto, Shinya Furukawa, Tetsuji Niiya, Hidenori Senba, Sayaka Kanzaki, Osamu Yoshida, Toru Ishihara, Mitsuhito Koizumi, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
AIMS/INTRODUCTION: The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we conducted a community-based, cross-sectional study to investigate sex-specific associations between these values, possible indicators of prediabetes, and type 2 diabetes. MATERIALS AND METHODS: We enrolled 4,945 Japanese subjects (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, subjects were divided into three groups based on their fasting plasma glucose levels (<6...
November 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29143180/oxidative-stress-in-adult-growth-hormone-deficiency-different-plasma-antioxidant-patterns-in-comparison-with-metabolic-syndrome
#16
Antonio Mancini, Chantal Di Segni, Carmine Bruno, Giulio Olivieri, Francesco Guidi, Andrea Silvestrini, Elisabetta Meucci, Patrick Orlando, Sonia Silvestri, Luca Tiano, Alfredo Pontecorvi
BACKGROUND AND AIMS: Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern...
November 15, 2017: Endocrine
https://www.readbyqxmd.com/read/29142395/biological-effect-of-cynara-cardunculus-on-kidney-status-of-hypercholesterolemic-rats
#17
Abdullah Glil Alkushi
Context: Cynara cardunculus or artichoke thistle belongs to the sunflower family and has a variety of cultivable forms. Historically, it was cultivated as a vegetable, but more recently, it is being used in cheese and biofuel preparation. Artichoke leaf extracts are also known for its medicinal purposes, particularly in reducing the elevated cholesterol levels in blood. Hypercholesterolemia (HC) is also associated with other complications such as impaired renal function and diabetes mellitus...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140472/uric-acid-predicts-adverse-outcomes-in-chronic-kidney-disease-a-novel-insight-from-trajectory-analyses
#18
Ching-Wei Tsai, Hsien-Tsai Chiu, Han-Chun Huang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo
Background: Very little is known about longitudinal trajectories of serum uric acid (SUA) over the course of chronic kidney disease (CKD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of end-stage renal disease (ESRD) and all-cause mortality among CKD patients. Methods: We conducted a prospective cohort study from a 13-year multidisciplinary pre-ESRD care registry. The final study population consisted of 5090 CKD patients aged 20-90 years between 2003 and 2015...
November 10, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29139092/effects-of-allopurinol-on-endothelial-function-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#19
REVIEW
Arrigo F G Cicero, Matteo Pirro, Gerald F Watts, Dimitri P Mikhailidis, Maciej Banach, Amirhossein Sahebkar
INTRODUCTION: Uric acid (UA), the final product of purine catabolism, may be associated with an increased risk of cardiovascular disease. AIM: The aim of this meta-analysis of randomized placebo-controlled trials was to evaluate whether lowering serum UA (SUA) levels with allopurinol is associated with improved flow-mediated dilation (FMD), a validated marker of early vascular damage. METHODS: A literature search was carried out from inception until 20 June 2017...
November 14, 2017: Drugs
https://www.readbyqxmd.com/read/29138950/improvement-of-amperometric-transducer-selectivity-using-nanosized-phenylenediamine-films
#20
O V Soldatkina, I S Kucherenko, V M Pyeshkova, S A Alekseev, O O Soldatkin, S V Dzyadevych
In this work, we studied the conditions of deposition of a semipermeable polyphenylenediamine (PPD)-based membrane on amperometric disk platinum electrodes. Restricting an access of interfering substances to the electrode surface, the membrane prevents their impact on the sensor operation. Two methods of membrane deposition by electropolymerization were compared-at varying potential (cyclic voltammetry) and at constant potential. The cyclic voltammetry was shown to be easier in performing and providing better properties of the membrane...
November 14, 2017: Nanoscale Research Letters
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