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https://www.readbyqxmd.com/read/28930108/terra-firma-forme-dermatosis-misdiagnosed-as-nevoid-acanthosis-nigricans
#1
Gulsen Tukenmez Demirci, Ayse Tulin Mansur, Ebru Demiralay
Terra firma-forme dermatosis (TFFD) is a clinical condition characterized by brown-gray, velvety, pigmented patches or plaques, resembling dirt on the skin. Nevoid acanthosis nigricans (NAN) is a rare and recently described form of acanthosis nigricans occurring during childhood or early adulthood. Herein we describe a patient with TFFD, initially misdiagnosed as NAN. The patient had developed hyperkeratotic and hyperpigmented plaques on and around the umbilicus during pregnancy. Though regular in bathing practices, she could not clear away the lesions and concerned marks for inesthetic appearance...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28928255/anisocoria-secondary-to-inadvertent-contact-with-scopolamine-patch
#2
Janki Shah, Alice Jiang, Zoltan Fekete
A unilaterally fixed mydriasis, also known as a 'blown pupil,' is considered an ominous sign concerning for intracranial pathology. Causes of anisocoria can range from benign to immediately life-threatening. When a patient presents with anisocoria, the concern for a fatal diagnosis leads the clinician to obtain numerous tests, many of which may be unnecessary. The authors present a case of a healthy woman in her 30s who presented with an acute unilateral mydriasis likely secondary to inadvertent contact with a scopolamine patch...
September 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28925012/a-new-negative-allosteric-modulator-ap14145-for-the-study-of-small-conductance-calcium-activated-potassium-channels
#3
Rafel Simó-Vicens, Jeppe E Kirchhoff, Bernardo Dolce, Lea Abildgaard Jensen, Tobias Speerschneider, Ulrik S Sørensen, Morten Grunnet, Jonas G Diness, Bo H Bentzen
BACKGROUND AND PURPOSE: Small conductance Ca(2+) -activated K(+) (KCa 2) channels represent a promising atrial-selective target for treatment of atrial fibrillation (AF). Here, we establish the mechanism of KCa 2 inhibition by the new compound AP14145. EXPERIMENTAL APPROACH: Using site directed mutagenesis binding determinants for AP14145 inhibition were explored. AP14145 selectivity and mechanism of action were investigated by patch clamp recordings of heterologously expressed KCa 2 channels...
September 19, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28922933/a-case-of-a-paediatric-patient-with-allergic-contact-dermatitis-to-benzoyl-peroxide
#4
Matthew Sandre, Sandra Skotnicki-Grant
Allergic contact dermatitis to benzoyl peroxide can occur in up to 6.5% of those with a history of exposure to this potential allergen. Conversely, irritant contact dermatitis is very common with benzoyl peroxide and can be differentiated from allergic contact dermatitis based on the patient's history and clinical signs and symptoms. We present a case of a paediatric patient with patch test-confirmed severe allergic contact dermatitis to benzoyl peroxide requiring hospitalisation and systemic treatment.
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28919761/effects-of-bromadiolone-poisoning-on-the-central-nervous-system
#5
Meiling Wang, Yanfeng Yang, Yiwei Hou, Wenbin Ma, Rui Jia, Jinbo Chen
Cases of rodenticide poisoning (second-generation long-acting dicoumarin rodenticide, superwarfarin) have occasionally been reported. The main symptoms of bromadiolone poisoning are skin mucosa hemorrhage, digestive tract hemorrhage, and hematuresis. However, the symptoms of central nervous system toxicity have rarely been reported. Our case reports on a 41-year-old male who had no contact with bromadiolone. His main symptoms were dizziness, unsteady gait, and abnormal behavior. Laboratory test results revealed the presence of bromadiolone in his blood and urine, a longer prothrombin time, activated partial thromboplastin time, and a high international normalized ratio...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28919217/population-based-beat-to-beat-qt-analysis-from-holter-recordings-in-the-long-qt-syndrome
#6
Alex Page, Scott McNitt, Xiaojuan Xia, Wojciech Zareba, Jean-Philippe Couderc
The increasing dissemination of wearable ECG recorders (e.g. Holter, patches, and strap sensors) enables the acquisition of large amounts of data during long periods of time. However, the clinical value of these long-term continuous recordings is hindered by the lack of automatic tools to extract clinically relevant information (other than non-sinus and life-threatening rhythms) from such long-term data, particularly when targeting population-based research. In this work, we propose and test a new tool for analyzing beat-to-beat interval measurements and extracting features from Holter ECGs...
August 10, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28917552/crispr-correction-of-the-prkag2-gene-mutation-in-the-patient-s-ipsc-derived-cardiomyocytes-eliminates-the-electrophysiological-and-structural-abnormalities
#7
Ronen Ben Jehuda, Binyamin Eisen, Yuval Shemer, Lucy N Mekies, Agnes Szantai, Irina Reiter, Huanhuan Cui, Kaomei Guan, Shiraz Haron-Khun, Dov Freimark, Silke R Sperling, Mihaela Gherghiceanu, Michael Arad, Ofer Binah
BACKGROUND: Mutations in the PRKAG2 gene encoding the γ-subunit of adenosine monophosphate-kinase (AMPK) cause hypertrophic cardiomyopathy (HCM) and familial-Wolff-Parkinson-White syndrome (WPW). Patients carrying the R302Q mutation in PRKAG2 present sinus bradycardia, escape rhythms, ventricular pre-excitation, supraventricular tachycardia and atrioventricular block. This mutation affects AMPK activity and increases glycogen storage in cardiomyocytes. The link between glycogen storage, WPW, HCM and arrhythmias remains unknown...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28917483/recalcitrant-chronic-leg-ulcer-an-indication-for-patch-testing-for-hydrocolloid-dressing
#8
Che-Yuan Hsu, Woan-Ruoh Lee, Yi-Hsien Shih
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28913780/anxiolytic-like-effects-of-%C3%AE-asarone-in-a-mouse-model-of-chronic-pain
#9
Jiao Tian, Zhen Tian, Shu-Li Qin, Pu-Yu Zhao, Xun Jiang, Zhen Tian
α-asarone (ASR) is a major bioactive compound isolated from the rhizome of Acorus tatarinowii Schott and it has extensive biological effects. Clinically, anxiety disorder is a common comorbidity of chronic pain. However, limited information is available regarding the effects of ASR on chronic pain-related anxiety. This study aims to evaluate the anxiolytic effects of ASR in chronic pain mice. Chronic inflammatory pain was induced by hind-paw injection of complete Freund's adjuvant (CFA). Behavioral tests, western-blot analysis and whole-cell patch recordings were performed to evaluate the subsequent events...
September 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28912492/epicutaneous-allergen-application-preferentially-boosts-specific-t-cell-responses-in-sensitized-patients
#10
Raffaela Campana, Katharina Moritz, Angela Neubauer, Hans Huber, Rainer Henning, Tess M Brodie, Alexandra Kaider, Federica Sallusto, Stefan Wöhrl, Rudolf Valenta
The effects of epicutaneous allergen administration on systemic immune responses in allergic and non-allergic individuals has not been investigated with defined allergen molecules. We studied the effects of epicutaneous administration of rBet v 1 and rBet v 1 fragments on systemic immune responses in allergic and non-allergic subjects. We conducted a clinical trial in which rBet v 1 and two hypoallergenic rBet v 1 fragments were applied epicutaneously by atopy patch testing (APT) to 15 birch pollen (bp) allergic patients suffering from atopic dermatitis, 5 bp-allergic patients suffering from rhinoconjunctivitis only, 5 patients with respiratory allergy without bp allergy and 5 non-allergic individuals...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905874/ovarian-hormones-and-transdermal-nicotine-administration-independently-and-synergistically-suppress-tobacco-withdrawal-symptoms-and-smoking-reinstatement-in-the-human-laboratory
#11
Raina D Pang, Madalyn M Liautaud, Matthew G Kirkpatrick, Jimi Huh, John Monterosso, Adam M Leventhal
Modeling intra-individual fluctuations in estradiol and progesterone may provide unique insight into the effects of ovarian hormones on the etiology and treatment of nicotine dependence. This randomized placebo-controlled laboratory study tested the independent and interactive effects of intra-individual ovarian hormone variation and nicotine on suppression of tobacco withdrawal symptoms and smoking behavior. Female smokers randomized to 21 mg. nicotine (TNP; n=37) or placebo (PBO; n=43) transdermal patch following overnight abstinence completed three sessions occurring during hormonally distinct menstrual cycle phases...
September 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28903827/pharmacokinetics-of-a-transdermal-fentanyl-solution-in-suffolk-sheep-ovis-aries
#12
Kimberly Y Jen, Melissa C Dyson, Patrick A Lester, Jean A Nemzek
Sheep used as surgical models require appropriate pain management, and the commonly used transdermal fentanyl patches require a long predosing period to achieve adequate plasma concentrations. The aim of this study was to assess the pharmacokinetic parameters of an FDA-approved transdermal fentanyl solution (TFS) that has yet to be tested in sheep. In this study, we compared TFS at 2.7 mg/kg (n = 2), 1.7 mg/kg (n = 3), and 0.5 mg/kg (n = 3) with the control fentanyl patch at 2 μg/kg/h (n = 1); both products were applied topically to the intrascapular region...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28892233/hyaluronic-acid-microneedle-patch-for-the-improvement-of-crow-s-feet-wrinkles
#13
Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28891928/high-performance-wireless-ammonia-gas-sensors-based-on-reduced-graphene-oxide-and-nano-silver-ink-hybrid-material-loaded-on-a-patch-antenna
#14
Bian Wu, Xingfei Zhang, Beiju Huang, Yutong Zhao, Chuantong Cheng, Hongda Chen
Reduced graphene oxide (rGO) has been studied as a resistive ammonia gas sensor at room temperature. The sensitive hybrid material composed of rGO and nano-silver ink (Ag-ink) was loaded on a microstrip patch antenna to realize high-performance wireless ammonia sensors. The material was investigated using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Firstly, interdigital electrodes (IDEs) printed on the polyethylene terephthalate (PET) by direct printing were employed to measure the variation of resistance of the sensitive material with the ammonia concentration...
September 9, 2017: Sensors
https://www.readbyqxmd.com/read/28889150/screening-for-skin-sensitizing-allergens-among-patients-with-clinically-suspected-allergic-contact-dermatitis
#15
Zahid Shakoor, Ahlam S Al-Mutairi, Afnan M Al-Shenaifi, Areej M Al-Abdulsalam, Bashayer Z Al-Shirah, Shahad A Al-Harbi
To detect common skin-sensitizing agents among patients experiencing allergic contact dermatitis (ACD). Methods: This was a retrospective study of 152 patients with clinically suspected ACD who underwent patch testing in an allergy clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 2012 and February 2015. Of these patients, only 74 (48%) patients reacted to one or more contact allergens. This group of patients included 58 (78.4%) women and 16 (21.6%) men (mean age: 37...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28886921/concomitance-of-oligotrophy-and-low-grazing-pressure-is-essential-for-the-resilience-of-mediterranean-subtidal-forests
#16
Luigi Piazzi, Giulia Ceccherelli
The study aimed at investigating factors influencing the recovery of the canopy seaweed Cystoseira brachycarpa. A manipulative experiment was done to test if in barren patches the recovery of Cystoseira I) is enhanced by the removal of the urchins, II) is prevented by eutrophication, III) depends on the time of patch clearance and IV) decreases with the distance from Cystoseira bed edge within the barren patch. The effects of the same factors on the structure of the macroalgal assemblage were also tested. Cystoseira recovered abundantly only in clearings where nutrients were not added and urchins were removed...
September 5, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28886045/maternal-treatment-with-short-chain-fatty-acids-modulates-the-intestinal-microbiota-and-immunity-and-ameliorates-type-1-diabetes-in-the-offspring
#17
James C Needell, Diana Ir, Charles E Robertson, Miranda E Kroehl, Daniel N Frank, Danny Zipris
We recently hypothesized that the intestinal microbiota and the innate immune system play key roles in the mechanism of Kilham Rat Virus-induced type 1 diabetes in the LEW1.WR1 rat. We used this animal model to test the hypothesis that maternal therapy with short-chain fatty acids can modulate the intestinal microbiota and reverse virus-induced proinflammatory responses and type 1 diabetes in rat offspring. We observed that administration of short-chain fatty acids to rat breeders via drinking water prior to pregnancy and further treatment of the offspring with short-chain fatty acids after weaning led to disease amelioration...
2017: PloS One
https://www.readbyqxmd.com/read/28885682/selective-targeting-of-m-type-potassium-channel-kv7-4-demonstrates-its-key-role-in-regulating-of-dopaminergic-neuronal-excitability-and-depression-like-behaviour
#18
Li Li, Hui Sun, Jie Ding, Chenxu Niu, Min Su, Ludi Zhang, Yingmin Li, Chuan Wang, Nikita Gamper, Xiaona Du, Hailin Zhang
BACKGROUND AND PURPOSE: The mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) is implicated in the development of depression, and firing patterns of VTA DA neurons are key determinants in this process. Here, we describe a crucial role of the M-type potassium channel Kv7.4 in modulation of VTA DA neuronal excitability and in the development of depressive behaviour in mice. EXPERIMENTAL APPROACH: We used Kv7.4 knock-out mice and a social defeat model of depression in combination with various electrophysiological techniques (patch clamp recording and in vivo single unit recordings), immunohistochemistry, single-cell PCR and behavioural analyses (social interaction time and glucose preference tests) to investigate VTA circuits involved in development of depression-like behaviour...
September 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28885313/benzalkonium-chloride-an-irritant-and-sensitizer
#19
Jahdonna Isaac, Pamela L Scheinman
BACKGROUND: Benzalkonium chloride (BAK) is a known irritant, and potentially cross-reacting quaternary ammonium compounds are commonly used as preservatives in personal care products. OBJECTIVE: The aim of the study was to review positive reactions to BAK in 615 patients patch tested for suspected allergic contact dermatitis. METHODS: A retrospective chart review was performed in 615 patients patch tested from June 2015 to October 2016. All patients were tested to a Modified American Contact Dermatitis Society core series of 70 allergens including BAK (0...
September 5, 2017: Dermatitis
https://www.readbyqxmd.com/read/28885310/contact-allergy-to-hydroperoxides-of-linalool-and-d-limonene-in-a-us-population
#20
Neel Som Nath, Beiyu Liu, Cynthia Green, Amber Reck Atwater
BACKGROUND: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several European and international studies. OBJECTIVE: The aim of the study was to investigate the prevalence of contact allergy to the hydroperoxides of linalool and D-limonene in a US population. METHODS: In this retrospective study, 103 patients with suspected fragrance allergy were patch tested to linalool 10% petrolatum (pet), hydroperoxides of linalool 1% pet, D-limonene 10% pet, and/or the hydroperoxides of D-limonene 0...
September 2017: Dermatitis
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