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https://www.readbyqxmd.com/read/29150838/gi-530159-a-novel-selective-mechano-sensitive-k2p-channel-opener-reduces-rat-dorsal-root-ganglion-drg-neuron-excitability
#1
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Mathie
BACKGROUND AND PURPOSE: TREK two pore domain potassium channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pathophysiological conditions, has been severely hampered by the lack of potent and/or selective activators and inhibitors. In this study we describe a new, selective opener of TREK channels, GI-530159 (4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline)...
November 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29148057/clinical-patterns-of-compositae-dermatitis-in-danish-monosensitized-patients
#2
Evy Paulsen, Klaus E Andersen
BACKGROUND: Compositae dermatitis was originally described as airborne contact dermatitis. More recent studies have reported a wider clinical spectrum, but often in polysensitized patients. OBJECTIVE: To evaluate the clinical features of patients sensitized to Compositae only. PATIENTS/METHODS: Consecutive Compositae-sensitive eczema patients, tested between 1990 and 2015, who, at the patch testing session diagnosing their Compositae allergy, were found to be sensitized only to the plant family, were included...
November 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29147871/an-optimized-and-feasible-preparation-technique-for-the-industrial-production-of-hydrogel-patches
#3
Wei-Ze Li, Wen-Xia Han, Xu-Liang Hao, Ning Zhao, Xi-Feng Zhai, Li-Bin Yang, Shu-Miao He, Yu-Chuan Cheng, Han Zhang, Li-Na Fu, Yan Zhang, Ze Liang
For hydrogel patches, the laboratory tests could not fully reveal the existing problems of full scale of industrial production, and there are few studies about the preparation technique for the industrial manufacturing process of hydrogel patches. So, the purpose of this work was to elucidate the effects of mainly technological operation and its parameters on the performance of hydrogel patches at the industrial-scale production. The results revealed the following: (1) the aqueous phase was obtained by polyvinylpyrrolidone (PVP) along with tartaric acid dissolved in purified water, then feeding this into a vacuum mixer as a whole in one batch, thus extended the crosslinking reaction time of hydrogel paste (matrix) and allowed the operation of coating/cutting-off to be carried out easily, and there was no permeation of backing layer; (2) the gel strength of the hydrogel patches increased with the increase of working temperature, however, once the temperature exceeded 35 ± 2 °C, the hydrogel paste would lose water severely and the resultant physical crosslinking structure which has lower gel/cohesive strength would easily bring gelatinization/residues during application; (3) the relative humidity (RH) of the standing-workshop was dynamically controlled (namely at 35 ± 2 °C, keeping the RH at 55 ± 5% for 4 days, then 65 ± 5% for 2 days), which would make patches with satisfactory characteristics such as better flexibility, higher adhesive force, smooth flat matrix surface, and without gelatinization/residues and warped edge during the using process; (4) the aging of the packaged hydrogel patches was very sensitive to storage temperature, higher temperature, higher gel strength and lower adhesiveness...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29147477/vanishing-vasculitis-a-case-of-acute-necrotic-skin-findings-without-pathologic-features-of-vasculitis-from-adulterated-cocaine
#4
Adnan Asif Parvez Ghias, Patrick Brine
While the usage of illicit drugs in itself carries significant health risks and associated toxicities, drugs that are adulterated to give them volume, alter their psychogenic properties, and make them cheaper to produce are to be considered even more dangerous. Cocaine is one of them, and it is now most commonly being adulterated with levamisole. We report a case of a 37-year-old female with the chief complaint of painful skin lesions and wounds on both of her upper and lower extremities for three weeks duration...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146151/a-new-two-component-compression-system-turning-an-elastic-bandage-into-an-inelastic-compression-device-interface-pressure-stiffness-and-haemodynamic-effectiveness
#5
Giovanni Mosti, Hugo Partsch
INTRODUCTION: Bandage application does not exert consistent compression pressure, leading to extremely variable compression when applied to patients. A new elastic bandage can exert a predefined pressure independently of healthcare providers and the size of the wrapped limb. The bandage system includes a series of non-stretchable patches that when applied to the bandage make it stiff. The aim of this work was to assess, in an experimental setting, the venous ejection fraction (EF) from the lower leg and the tolerability of this new bandage in a group of patients affected by superficial venous incompetence...
November 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29143966/drug-interaction-at-herg-channel-in-vitro-assessment-of-the-electrophysiological-consequences-of-drug-combinations-and-comparison-against-theoretical-models
#6
Barbara Wiśniowska, Bartosz Lisowski, Magdalena Kulig, Sebastian Polak
Drugs carry a proarrhythmic risk, which gets even greater when they are used in combination. In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug-drug interactions, including those involving active metabolites. Here we present the results of an in vitro study of potential drug-drug interactions at the level of the hERG channel for the combination of up to three compounds: loratadine, desloratadine and ketoconazole. Experiments were performed at room temperature on an automated patch-clamp device CytoPatch 2, with the use of heterogeneously, stably transfected HEK cells...
November 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29143366/patch-testing-in-israeli-children-with-suspected-allergic-contact-dermatitis-a-retrospective-study-and-literature-review
#7
Yaron Zafrir, Akiva Trattner, Emmillia Hodak, Oren Eldar, Moshe Lapidoth, Dan Ben Amitai
BACKGROUND/OBJECTIVES: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature. METHODS: The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11...
November 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29142336/multi-atlas-based-ct-synthesis-from-conventional-mri-with-patch-based-refinement-for-mri-based-radiotherapy-planning
#8
Junghoon Lee, Aaron Carass, Amod Jog, Can Zhao, Jerry L Prince
Accurate CT synthesis, sometimes called electron density estimation, from MRI is crucial for successful MRI-based radiotherapy planning and dose computation. Existing CT synthesis methods are able to synthesize normal tissues but are unable to accurately synthesize abnormal tissues (i.e., tumor), thus providing a suboptimal solution. We propose a multi-atlas-based hybrid synthesis approach that combines multi-atlas registration and patch-based synthesis to accurately synthesize both normal and abnormal tissues...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29139375/kitty-litter-dermatitis-from-bromo-2-nitropropane-1-3-diol
#9
John W Sullenbarger, Brooke Hensley, Jeffrey B Travers
70-year-old white man presented with a 6-week history of an acute pruritic eruption in the axillary vaults, inguinal folds, and central lumbar area. Due to the severity of the pruritus, the patient was evaluated in the emergency department. He was treated with intramuscular triamcinolone, oral fluconazole, clobetasol cream, and miconazole powder, which provided only minimal relief. The patient had presented with brightly erythematous patches in the axillary vaults and inguinal folds with numerous erythematous, scaly, coalescing papules and plaques agminated on the lumbar region (Figure)...
2017: Skinmed
https://www.readbyqxmd.com/read/29138124/comparison-of-allergen-responses-based-on-the-true-test-and-iq-chamber-system-in-korean-patients
#10
Won Joo Kwon, Joo Yeon Ko, Young Suck Ro, Myung Hwa Kim, Byung Soo Kim, Hye One Kim, Jae Hui Nam, Ga-Young Lee, Mi Youn Park, Sang Wook Son, Jun Mo Yang, Dong Hun Lee, Ai Young Lee, Jun Young Lee, Sung Eun Chang, Hae Young Choi, Eun Joo Park
A comparison between responses to allergens based on the TRUE Test(®)(TT) and IQ(®) Chamber (IQC) in Europeans has been previously reported, however, no such study has been performed in Asians. To compare allergen responses using the TT and IQC (using the Korean standard series) in order to gather more information regarding the positive response rates for each allergen and the clinical value of IQC. Suspected contact dermatitis patients were enrolled and tested with 18 allergens using the TT and IQC. The test was performed in 214 patients...
November 14, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29137988/tms-eeg-reveals-hemispheric-asymmetries-in-top-down-influences-of-posterior-intraparietal-cortex-on-behavior-and-visual-event-related-potentials
#11
Mika Koivisto, Simone Grassini, Mikko Hurme, Niina Salminen-Vaparanta, Henry Railo, Victor Vorobyev, Jussi Tallus, Teemu Paavilainen, Antti Revonsuo
Clinical data and behavioral studies using transcranial magnetic stimulation (TMS) suggest right-hemisphere dominance for top-down modulation of visual processing in humans. We used concurrent TMS-EEG to directly test for hemispheric differences in causal influences of the right and left intraparietal cortex on visual event-related potentials (ERPs). We stimulated the left and right posterior part of intraparietal sulcus (IPS1) while the participants were viewing and rating the visibility of bilaterally presented Gabor patches...
November 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29136445/effect-of-varying-doses-of-epicutaneous-immunotherapy-vs-placebo-on-reaction-to-peanut-protein-exposure-among-patients-with-peanut-sensitivity-a-randomized-clinical-trial
#12
Hugh A Sampson, Wayne G Shreffler, William H Yang, Gordon L Sussman, Terri F Brown-Whitehorn, Kari C Nadeau, Amarjit S Cheema, Stephanie A Leonard, Jacqueline A Pongracic, Christine Sauvage-Delebarre, Amal H Assa'ad, Frederic de Blay, J Andrew Bird, Stephen A Tilles, Franck Boralevi, Thierry Bourrier, Jacques Hébert, Todd D Green, Roy Gerth van Wijk, André C Knulst, Gisèle Kanny, Lynda C Schneider, Marek L Kowalski, Christophe Dupont
Importance: Epicutaneous immunotherapy may have potential for treating peanut allergy but has been assessed only in preclinical and early human trials. Objective: To determine the optimal dose, adverse events (AEs), and efficacy of a peanut patch for peanut allergy treatment. Design, Setting, and Participants: Phase 2b double-blind, placebo-controlled, dose-ranging trial of a peanut patch in peanut-allergic patients (6-55 years) from 22 centers, with a 2-year, open-label extension (July 31, 2012-July 31, 2014; extension completed September 29, 2016)...
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29135681/piercing-and-metal-sensitivity-extended-analysis-of-the-north-american-contact-dermatitis-group-data-2007-2014
#13
Erin M Warshaw, Kelly A Aschenbeck, Joel G DeKoven, Howard I Maibach, James S Taylor, Denis Sasseville, Donald V Belsito, Joseph F Fowler, Kathryn A Zug, Matthew J Zirwas, Anthony F Fransway, Vincent A DeLeo, James G Marks, Melanie D Pratt, Toby Mathias
BACKGROUND: Body piercing provides a unique route of metal exposure. OBJECTIVE: The aim of this study was to update previous analyses using the North American Contact Dermatitis Group data comparing pierced and unpierced individuals. METHODS: This was a retrospective cross-sectional analysis of 17,912 patients patch tested by the North American Contact Dermatitis Group from 2007 to 2014 for demographics, positive reactions to metals (nickel, cobalt, chromium), and detailed analysis of nickel reactions by age, sex, and source of exposure...
November 2017: Dermatitis
https://www.readbyqxmd.com/read/29124350/role-of-trh-ucn3-neurons-of-the-perifornical-area-bed-nucleus-of-stria-terminalis-region-in-the-regulation-of-the-anorexigenic-pomc-neurons-of-the-arcuate-nucleus-in-male-mice-and-rats
#14
Zoltán Péterfi, Erzsébet Farkas, Kata Nagyunyomi-Sényi, Andrea Kádár, Szenci Ottó, András Horváth, Tamás Füzesi, Ronald M Lechan, Csaba Fekete
Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In this study, therefore, we tested the hypothesis that the TRH/UCN3 neurons regulate food intake by influencing feeding-related neuropeptide Y (NPY) and/or proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC)...
November 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29124097/safety-data-on-single-application-of-emu-and-macadamia-nut-oil-on-human-skin
#15
Tadayoshi Miyashita, Ryosuke Koizumi, Yoshimasa Sagane, Kazuhiro Minami, Minoru Ito, Toshihiro Watanabe, Koichi Niwa
This data article provides the results of skin sensitization testing for emu and macadamia nut oil on 20 participants (ages 22-59 years old), including 3 men and 17 women. The test was carried out by performing a standard patch test using a Finn Chamber on Scanpor tape. The oils were applied to the participant's back using the tape and left in place for 24 h. After 1- and 24-h from removal of the tape, the reaction of the participant's skin was judged based on a scoring method recommended by Japanese Patch Test Research Group...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29121497/mannosylcalix-n-arenes-as-multivalent-ligands-for-dc-sign
#16
Ilaria Morbioli, Vanessa Porkolab, Andrea Magini, Alessandro Casnati, Franck Fieschi, Francesco Sansone
DC-SIGN is a receptor protruded from the membrane of immature dendritic cells (DCs) that participates in the activation of the immune response through the recognition of pathogen-associated molecular patterns (PAMPs). On the other hand, HIV exploits the interaction between high-mannose structures of its envelope glycoprotein gp120 and DC-SIGN to be transported towards and infect T-cells. DC-SIGN is involved in the recognition process in the form of a tetramer and the multiple exposition of carbohydrate recognition sites (CRSs) is amplified by the formation on the DCs membrane of patches of tetramers...
October 31, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29118035/single-channel-analysis-of-isoflurane-and-ethanol-enhancement-of-taurine-activated-glycine-receptors
#17
Dean Kirson, Jelena Todorovic, S John Mihic
The amino acid taurine is an endogenous ligand acting on glycine receptors and is released by astrocytes in many brain regions, such as the nucleus accumbens and prefrontal cortex. Taurine is a partial agonist with an efficacy significantly lower than that of glycine. Allosteric modulators such as ethanol and isoflurane produce leftward shifts of glycine concentration-response curves but have no effects at saturating glycine concentrations. In contrast, in whole-cell electrophysiology studies these modulators increase the effects of saturating taurine concentrations...
November 8, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29114901/allergic-contact-dermatitis-caused-by-calcipotriol
#18
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. OBJECTIVES: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. METHODS: Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines...
November 8, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29110079/old-and-emerging-concepts-on-adrenal-chromaffin-cell-stimulus-secretion-coupling
#19
EDITORIAL
Ricardo Borges, Luis Gandía, Emilio Carbone
The chromaffin cells (CCs) of the adrenal medulla play a key role in the control of circulating catecholamines to adapt our body function to stressful conditions. A huge research effort over the last 35 years has converted these cells into the Escherichia coli of neurobiology. CCs have been the testing bench for the development of patch-clamp and amperometric recording techniques and helped clarify most of the known molecular mechanisms that regulate cell excitability, Ca(2+) signals associated with secretion, and the molecular apparatus that regulates vesicle fusion...
November 6, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29100867/the-combined-utility-of-ex%C3%A2-vivo-ifn-%C3%AE-release-enzyme-linked-immunospot-assay-and-in%C3%A2-vivo-skin%C3%A2-testing-in-patients-with-antibiotic-associated-severe-cutaneous-adverse-reactions
#20
Jason A Trubiano, Kaija Strautins, Alec J Redwood, Rebecca Pavlos, Katherine C Konvinse, Ar Kar Aung, Monica A Slavin, Karin A Thursky, M Lindsay Grayson, Elizabeth J Phillips
BACKGROUND: For severe cutaneous adverse reactions (SCARs) associated with multiple antibiotics dosed concurrently, clinical causality is challenging and diagnostic approaches are limited, leading to constricted future antibiotic choices. OBJECTIVE: To examine the combined utility of in vivo and ex vivo diagnostic approaches at assigning drug causality in a cohort of patients with antibiotic-associated (AA)-SCARs. METHODS: Patients with AA-SCARs were prospectively recruited between April 2015 and February 2017...
October 31, 2017: Journal of Allergy and Clinical Immunology in Practice
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